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Volumn 60, Issue 10, 2011, Pages 1379-1388

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DIPHTHERIA TOXIN; TRANSCRIPTION FACTOR RELA; TRYPSIN; TRYPSINOGEN;

EID: 80052586196     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.226175     Document Type: Article
Times cited : (94)

References (48)
  • 2
    • 33646676272 scopus 로고    scopus 로고
    • Clinical practice. Acute pancreatitis
    • Whitcomb D.C. Clinical practice. Acute pancreatitis. N Engl J Med 2006;354:2142-2150
    • (2006) N Engl J Med , vol.354 , pp. 2142-2150
    • Whitcomb, D.C.1
  • 3
    • 34247197621 scopus 로고    scopus 로고
    • Chronic Pancreatitis: Challenges and Advances in Pathogenesis, Genetics, Diagnosis, and Therapy
    • DOI 10.1053/j.gastro.2007.03.001, PII S0016508507004957
    • Witt H., Apte M.V., Keim V., et al. Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 2007;132:1557-1573 (Pubitemid 46627604)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1557-1573
    • Witt, H.1    Apte, M.V.2    Keim, V.3    Wilson, J.S.4
  • 5
    • 0002616496 scopus 로고
    • Über die Selbstverdauung des menschlichen Pankreas
    • Chiari H. Über die Selbstverdauung des menschlichen Pankreas. Z Heilk 1896;17:69-96.
    • (1896) Z Heilk , vol.17 , pp. 69-96
    • Chiari, H.1
  • 7
    • 0022651240 scopus 로고
    • Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation
    • Rinderknecht H. Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig Dis Sci 1986;31:314-321 (Pubitemid 16123978)
    • (1986) Digestive Diseases and Sciences , vol.31 , Issue.3 , pp. 314-321
    • Rinderknecht, H.1
  • 10
    • 0040624999 scopus 로고    scopus 로고
    • Trypsinogen stabilization by mutation Arg117→His: A unifying pathomechanism for hereditary pancreatitis?
    • DOI 10.1006/bbrc.1999.1565
    • Sahin-Toth M., Graf L., Toth M. Trypsinogen stabilization by mutation Arg117 → His: A unifying pathomechanism for hereditary pancreatitis? Biochem Biophys Res Commun 1999;264:505-508 (Pubitemid 29516116)
    • (1999) Biochemical and Biophysical Research Communications , vol.264 , Issue.2 , pp. 505-508
    • Sahin-Toth, M.1    Graf, L.2    Toth, M.3
  • 11
    • 0040625000 scopus 로고    scopus 로고
    • Hereditary pancreatitis-associated mutation asn(21) → ile stabilizes rat trypsinogen in vitro
    • Sahin-Toth M. Hereditary pancreatitis-associated mutation asn(21) → ile stabilizes rat trypsinogen in vitro. J Biol Chem 1999;274:29699-29704
    • (1999) J Biol Chem , vol.274 , pp. 29699-29704
    • Sahin-Toth, M.1
  • 12
    • 33747010658 scopus 로고    scopus 로고
    • Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis
    • DOI 10.1002/humu.20343
    • Teich N., Rosendahl J., Toth M., et al. Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis. Hum Mutat 2006;27:721-730 (Pubitemid 44205064)
    • (2006) Human Mutation , vol.27 , Issue.8 , pp. 721-730
    • Teich, N.1    Rosendahl, J.2    Toth, M.3    Mossner, J.4    Sahin-Toth, M.5
  • 13
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    • DOI 10.1038/76088
    • Witt H., Luck W., Hennies H.C., et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000;25:213-216 (Pubitemid 30394996)
    • (2000) Nature Genetics , vol.25 , Issue.2 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3    Classen, M.4    Kage, A.5    Lass, U.6    Landt, O.7    Becker, M.8
  • 14
    • 34948901262 scopus 로고    scopus 로고
    • Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation
    • DOI 10.1136/gut.2006.115725
    • Kiraly O., Wartmann T., Sahin-Toth M. Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut 2007;56:1433-1438 (Pubitemid 47517840)
    • (2007) Gut , vol.56 , Issue.10 , pp. 1433-1438
    • Kiraly, O.1    Wartmann, T.2    Sahin-Toth, M.3
  • 16
    • 0031913740 scopus 로고    scopus 로고
    • Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis
    • Mithofer K., Fernandez-del Castillo C., Rattner D., et al. Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis. Am J Physiol 1998;274:G71-G79
    • (1998) Am J Physiol , vol.274
    • Mithofer, K.1    Fernandez-del Castillo, C.2    Rattner, D.3
  • 17
    • 0031867966 scopus 로고    scopus 로고
    • Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats
    • Hofbauer B., Saluja A.K., Lerch M.M., et al. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol 1998;275:G352-G362
    • (1998) Am J Physiol , vol.275
    • Hofbauer, B.1    Saluja, A.K.2    Lerch, M.M.3
  • 18
    • 0036007501 scopus 로고    scopus 로고
    • NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response
    • Chen X., Ji B., Han B., et al. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 2002;122:448-457 (Pubitemid 34116996)
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 448-457
    • Chen, X.1    Ji, B.2    Han, B.3    Ernst, S.A.4    Simeone, D.5    Logsdon, C.D.6
  • 22
    • 67650513305 scopus 로고    scopus 로고
    • Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation
    • Ji B., Gaiser S., Chen X., et al. Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation. J Biol Chem 2009;284:17488-17498
    • (2009) J Biol Chem , vol.284 , pp. 17488-17498
    • Ji, B.1    Gaiser, S.2    Chen, X.3
  • 23
    • 52049101359 scopus 로고    scopus 로고
    • Robust acinar cell transgene expression of CreErT via BAC recombineering
    • Ji B., Song J., Tsou L., et al. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 2008;46:390-395
    • (2008) Genesis , vol.46 , pp. 390-395
    • Ji, B.1    Song, J.2    Tsou, L.3
  • 24
    • 0038029879 scopus 로고    scopus 로고
    • Human anionic trypsinogen. Properties of autocatalytic activation and degradation and implications in pancreatic diseases
    • DOI 10.1046/j.1432-1033.2003.03581.x
    • Kukor Z., Toth M., Sahin-Toth M. Human anionic trypsinogen: Properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem 2003;270:2047-2058 (Pubitemid 36560827)
    • (2003) European Journal of Biochemistry , vol.270 , Issue.9 , pp. 2047-2058
    • Kukor, Z.1    Toth, M.2    Sahin-Toth, M.3
  • 27
  • 28
    • 0032246276 scopus 로고    scopus 로고
    • Early NF-kappaB activation is associated with hormone-induced pancreatitis
    • Gukovsky I., Gukovskaya A.S., Blinman T.A., et al. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275:G1402-G1414
    • (1998) Am J Physiol , vol.275
    • Gukovsky, I.1    Gukovskaya, A.S.2    Blinman, T.A.3
  • 29
    • 0011770646 scopus 로고    scopus 로고
    • CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells
    • Han B., Ji B., Logsdon C.D. CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells. Am J Physiol Cell Physiol 2001;280:C465-C472
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Han, B.1    Ji, B.2    Logsdon, C.D.3
  • 30
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • Halangk W., Lerch M.M., Brandt-Nedelev B., et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000;106:773-781
    • (2000) J Clin Invest , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3
  • 32
    • 33947376068 scopus 로고    scopus 로고
    • Why does pancreatic overstimulation cause pancreatitis?
    • DOI 10.1146/annurev.physiol.69.031905.161253
    • Saluja A.K., Lerch M.M., Phillips P.A., et al. Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol 2007;69:249-269 (Pubitemid 46457643)
    • (2007) Annual Review of Physiology , vol.69 , pp. 249-269
    • Saluja, A.K.1    Lerch, M.M.2    Phillips, P.A.3    Dudeja, V.4
  • 35
    • 70450248392 scopus 로고    scopus 로고
    • Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death
    • Kereszturi E., Sahin-Toth M. Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death. J Biol Chem 2009;284:33392-33399
    • (2009) J Biol Chem , vol.284 , pp. 33392-33399
    • Kereszturi, E.1    Sahin-Toth, M.2
  • 36
    • 4944257738 scopus 로고    scopus 로고
    • The continuing challenge of early mortality in acute pancreatitis
    • DOI 10.1002/bjs.4750
    • McKay C.J., Imrie C.W. The continuing challenge of early mortality in acute pancreatitis. Br J Surg 2004;91:1243-1244 (Pubitemid 39331447)
    • (2004) British Journal of Surgery , vol.91 , Issue.10 , pp. 1243-1244
    • McKay, C.J.1    Imrie, C.W.2
  • 37
    • 0028783295 scopus 로고
    • Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis
    • Kaiser A.M., Saluja A.K., Sengupta A., et al. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-C1304
    • (1995) Am J Physiol , vol.269
    • Kaiser, A.M.1    Saluja, A.K.2    Sengupta, A.3
  • 40
    • 0031869923 scopus 로고    scopus 로고
    • Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats
    • Hahm K.B., Kim J.H., You B.M., et al. Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. Pancreas 1998;17:153-157
    • (1998) Pancreas , vol.17 , pp. 153-157
    • Hahm, K.B.1    Kim, J.H.2    You, B.M.3
  • 42
    • 0028295094 scopus 로고
    • Progression of alcoholic acute to chronic pancreatitis
    • Ammann R.W., Muellhaupt B. Progression of alcoholic acute to chronic pancreatitis. Gut 1994;35:552-556 (Pubitemid 24131256)
    • (1994) Gut , vol.35 , Issue.4 , pp. 552-556
    • Ammann, R.W.1    Muellhaupt, B.2
  • 43
    • 0026595479 scopus 로고
    • The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis
    • Kloppel G., Maillet B. The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis. Virchows Arch A Pathol Anat Histopathol 1992;420:1-4.
    • (1992) Virchows Arch A Pathol Anat Histopathol , vol.420 , pp. 1-4
    • Kloppel, G.1    Maillet, B.2
  • 46
    • 33845664588 scopus 로고    scopus 로고
    • A Mouse Model of Hereditary Pancreatitis Generated by Transgenic Expression of R122H Trypsinogen
    • DOI 10.1053/j.gastro.2006.09.049, PII S0016508506022177
    • Archer H., Jura N., Keller J., et al. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology 2006;131:1844-1855 (Pubitemid 44958518)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1844-1855
    • Archer, H.1    Jura, N.2    Keller, J.3    Jacobson, M.4    Bar-Sagi, D.5
  • 47
    • 33751233226 scopus 로고    scopus 로고
    • Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
    • Selig L., Sack U., Gaiser S., et al. Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen. BMC Gastroenterol 2006;6:30.
    • (2006) BMC Gastroenterol , vol.6 , pp. 30
    • Selig, L.1    Sack, U.2    Gaiser, S.3
  • 48
    • 69249148349 scopus 로고    scopus 로고
    • Ras activity levels control the development of pancreatic diseases
    • Ji B., Tsou L., Wang H., et al. Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009;137:1072-1082
    • (2009) Gastroenterology , vol.137 , pp. 1072-1082
    • Ji, B.1    Tsou, L.2    Wang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.