Fibrosis of the pancreas: The initial tissue damage and the resulting pattern

Virchows Archiv

Volumn 445, Issue 1, 2004, Pages 1-8

  Klöppel, Günter ^a   Detlefsen, Sönke ^a   Feyerabend, Bernd ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Cytokines; Fibrosis pattern; Pancreatic fibrosis; Pancreatic stellate cells; Tissue damage

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; DESMIN; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; PANCREAS ENZYME; PLATELET DERIVED GROWTH FACTOR; SERINE PROTEINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1; TRYPSINOGEN;

ACINAR CELL; ALCOHOLIC PANCREATITIS; AUTOCRINE EFFECT; CELL DEATH; CELL INFILTRATION; CYSTIC FIBROSIS; CYTOKINE RELEASE; ENZYME ACTIVATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE MUTATION; HUMAN; IMMUNE MEDIATED INJURY; LYMPHOCYTE; MACROPHAGE; MESENCHYME CELL; NEUTROPHIL; PANCREAS INJURY; PANCREATITIS; PARACRINE SIGNALING; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; STELLATE CELL; THROMBOCYTE;

FIBROSIS; HUMANS; PANCREAS; PANCREATIC DISEASES;

EID: 3843149424     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, Albores-Saavedra J, Hruban RH (2003) Eosinophilic pancreatitis and increased eosinophils in the pancreas. Am J Surg Pathol 27:334-342
2. Ammann RW, Heitz PU, Klöppel G (1996) Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study. Gastroenterology 111:224-231
3. Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, Nakamura F, Shintani Y, Fujiyama Y, Bamba T (2000) Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 119:211-219
4. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1998) Periacinar stellate-shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128-133
5. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1999) Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44:534-541
6. Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, Wilson JS (2000) Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118:780-794
7. Bedossa P, Paradis V (2003) Liver extracellular matrix in health and disease. J Pathol 200:504-515
8. Ebert M, Kasper HU, Hernberg S, Friess H, Büchler MW, Roessner A, Korc M, Malfertheiner P (1998) Overexpression of platelet-derived growth factor (PDGF) B chain and type β PDGF receptor in human chronic pancreatitis. Dig Dis Sci 43:567-574
9. Ectors N, Maillet B, Aerts R, Geboes K, Donner A, Borchard F, Lankisch P, Stolte M, Lüttges J, Kremer B, Klöppel G (1997) Non-alcoholic duct destructive chronic pancreatitis. Gut 41:263-268
10. Elsässer HP, Adler G, Kern HF (1989) Fibroblast structure and function during regeneration from hormone-induced acute pancreatitis in the rat. Pancreas 4:169-178
11. Etemad B, Whitcomb DC (2001) Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology 120:682-707
12. Friess H, Yamanaka Y, Büchler M, Beger HG, Do DA, Kobrin MS, Korc M (1994) Increased expression of acidic and basic fibroblast growth factors in chronic pancreatitis. Am J Pathol 144:117-128
13. Gabbiani G (2003) The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200:500-503
14. Haber PS, Keogh GW, Apte MV, Moran CS, Stewart NL, Crawford DHG, Pirola RC, McCaughan GW, Ramm GA, Wilson JS (1999) Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 155:1087-1095
15. Hultquist GT, Jönsson LE (1965) Ligation of the pancreatic duct in rats. Acta Soc Med Upsal 70:82-88
16. Isaksson G, Ihse I, Lundquist I (1983) Influence of pancreatic duct ligation on endocrine and exocrine rat pancreas. Acta Physiol Scand 117:281-286
17. Izumi M, Suda K, Torii A, Inadama E (2001) Pancreatic ductal myofibroblasts. Proliferative patterns in various pathologic situations. Virchows Arch 438:442-450
18. Kawaguchi K, Koike M, Tsuruta K, Okamoto A, Tabata I, Fujita N (1991) Lymphoplasmacytic sclerosing pancreatitis with cholangitis: variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 22:387-395
19. Klöppel G (1997) Morphology of acute pancreatitis in relation to etiology and pathogenesis. In: Malfertheiner P, Domínguez-Muñoz JE, Schulz HU, Lippert H (eds) Diagnostic procedures in pancreatic disease. Springer, Berlin Heidelberg New York, pp 13-20
20. Klöppel G (1998) Chronic pancreatitis. Etiology, pathophysiology, and pathology. In: Howard J , Idezuki Y, Ihse I, Prinz R (eds) Surgical diseases of the pancreas, 3rd edn. Williams & Wilkins, Baltimore, pp 321-328
21. Klöppel G (1999) Progression from acute to chronic pancreatitis. A pathologist's view. Surg Clin North Am 79:801-814
22. Klöppel G, Lüttges J, Lohr M, Zamboni G, Longnecker D (2003) Autoimmune pancreatitis: pathological, clinical, and immunological features. Pancreas 27:14-19
23. Klöppel G, Maillet B (1991) Chronic pancreatitis: evolution of the disease. Hepatogastroenterology 38:408-412
24. Klöppel G, Maillet B (1992) The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis. Virchows Arch [A] Pathol Anat 420:1-4
25. Konishi K, Izumi T, Kato O, Yamaguchi A, Miyazaki I (1981) Experimental pancreatolithiasis in the dog. Surgery 89:687-691
26. Kuroda J, Suda K, Hosokawa Y (1998) Periacinar collagenization in patients with chronic alcoholism. Pathol Int 48:857-868
27. Lack EE (2003) Cystic fibrosis and selected disorders with pancreatic insufficiency. In: Lack EE (ed) Pathology of the pancreas, gallbladder, extrahepatic biliary tract, and ampullary region. Oxford University Press, Oxford, pp 63-80
28. Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, Grünert A, Bachem MG (2000) Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implication in pathogenesis of pancreas fibrosis. Lab Invest 80:47-55
29. Martin ED (1984) Different pathomorphological aspects of pancreatic fibrosis, correlated with etiology: anatomical study of 300 cases. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis: concepts and classification. Elsevier, Amsterdam, pp 77-82
30. Masi L, Malentacchi C, Campanacci D, Franchi A (2002) Transforming growth factor-beta isoform and receptor expression in chondrosarcoma of bone. Virchows Arch 440:491-497
31. Notohara K, Burgart LJ, Yadav D, Chari S, Smyrk TC (2003) Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases. Am J Surg Pathol 27:1119-1127
32. Saurer L, Reber P, Schaffner T, Büchler MW, Buri C, Kappeler A, Walz A, Friess H, Mueller C (2000) Differential expression of chemokines in normal pancreas and in chronic pancreatitis. Gastroenterology 118:356-367
33. Seifert G (1984) Cystic fibrosis and haemochromatosis. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Churchill Livingstone, Edinburgh, pp 32-43
34. Shek FWT, Benyon RC, Walker FM, McCrudden PR, Pender SLF, Williams EJ, Johnson PA, Johnson CD, Bateman AC, Fine DR, Iredale JP (2002) Expression of transforming growth factor-β1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 160:1787-1798
35. Stamenkovic I (2003) Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol 200:448-464
36. Suda K, Takase M, Takei K, Kumasaka T, Suzuki F (2000) Histopathologic and immunohistochemical studies on the mechanism of interlobular fibrosis of the pancreas. Arch Pathol Lab Med 124:1302-1305
37. Weber SM, Cubukcu-Dimopulo O, Palesty JA, Suriawinata A, Klimstra D, Brennan MF, Conlon K (2003) Lymphoplasmacytic sclerosing pancreatitis: inflammatory mimic of pancreatic carcinoma. J Gastrointest Surg 7:129-139
38. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD (1996) Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 14:141-145
39. Witt H, Becker M (2002) Genetics of chronic pancreatitis. J Pediatr Gastroenterol Nutr 34:125-136
40. Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M (2000) Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 25:213-216
41. Wreesmann V, van Eijck CHJ, Naus DCWH, van Velthuysen MLF, Jeekel J, Mooi WJ (2001) Inflammatory pseudotumour (inflammatory myofibroblastic tumour) of the pancreas: a report of six cases associated with obliterative phlebitis. Histopathology 38:105-110