The Pancreatic Duct and its Arteriovenous Relationship: An Underutilized Aid in the Diagnosis and Distinction of Pancreatic Adenocarcinoma from Pancreatic Intraepithelial Neoplasia. A Study of 126 Pancreatectomy Specimens

American Journal of Surgical Pathology

Volumn 28, Issue 5, 2004, Pages 613-620

  Sharma, Shobha ^a   Green, Kevin B ^a  

^a EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

Pancreatic adenocarcinoma; Pancreatic vasculature; PanIN

Indexed keywords

ARTICLE; ATROPHY; CANCER GRADING; CANCER INFILTRATION; CARCINOMA IN SITU; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PANCREAS ADENOCARCINOMA; PANCREAS BLOOD FLOW; PANCREAS DUCT; PANCREAS RESECTION; RELIABILITY; TISSUE STRUCTURE;

EID: 2342629331     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200405000-00008     Document Type: Article

References (20)

1. Abraham SC, Wilentz RE, Yeo CJ, et al. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all "chronic pancreatitis?" Am J Surg Pathol. 2003;27:110-120.
2. Allen-Mersh TG. What is the significance of pancreatic ductal mucinous hyperplasia? Gut. 1985;26:825-833.
3. Andea AA, Sarkar F, Cheng J, et al. A comparative analysis of pancreatic intraepithelial neoplasia (PanIN) in pancreata with ductal adenocarcinoma versus those without primary tumors [Abstract]. Mod Pathol. 2002; 15:282.
4. Chen J, Baithun SI, Ramsay MA. Histogenesis of pancreatic carcinomas: a study based on 248 cases. J Pathol. 1985;146:65-76.
5. Colby TV, Yousem SA. Lungs. In: Sternberg SS, ed. Histology for Pathologists, 2nd ed. Philadelphia: Lippincott-Raven, 1997:433-458.
6. Cubilla AL, Fitzgerald PJ. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res. 1976;36: 2690-2698.
7. Davis WG, Laszik ZG. Prevalence of pancreatic intraepithelial neoplasia (PanIN) in association with pancreatic adenocarcinoma [Abstract]. Mod Pathol. 2003;16:272.
8. Hruban RH, Volkan AN, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001;25:579-586.
9. Klein WM, Hruban RH, Andres JP, et al. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol. 2002;15:441-447.
10. Klimstra DS. Pancreas. In: Sternberg SS, ed. Histology for Pathologists, 2nd ed. Philadelphia: Lippincott-Raven, 1997:613-647.
11. Kozuka S, Sassa R, Taki T, et al. Relation of pancreatic duct hyperplasia to carcinoma. Cancer. 1979;43:1418-1428.
12. Martinez-Madrigal F, Bosq J, Casiraghi O. Major salivary glands. In: Sternberg SS, ed. Histology for Pathologists, 2nd ed. Philadelphia: Lippincott-Raven, 1997:405-429.
13. Pour PM, Sayed S, Sayed G. Hyperplastic, preneoplastic and neoplastic lesions found in 83 pancreases. Am J Clin Pathol. 1982;77:137-152.
14. Proca DM, Ellison EC, Frankel WL. Pancreatic intraepithelial neoplasia in chronic pancreatitis [Abstract]. Mod Pathol. 2002;15:292.
15. Romanes GJ. Pancreas. In: Cunningham's Manual of Practical Anatomy, vol. 2. Thorax and Abdomen, 15th ed. Hong Kong: Oxford University Press, 1986:153-155.
16. Sadler TW, ed. Digestive system. In: Langman's Medical Embryology, 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:286-287.
17. Stamm BH. Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol. 1984;15: 677-683.
18. Thung SN, Gerber MA. Liver. In: Sternberg SS, ed, Histology for Pathologists, 2nd ed. Philadelphia: Lippincott-Raven, 1997:575-591.
19. Volkholz H, Stolte M, Becker V. Epithelial dysplasias in chronic pancreatitis. Virchows Arch. 1982;396:331-349.
20. Wilentz RE, Iacobuzio-Donahue CA, Argani P, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60:2002-2006.