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Volumn 35, Issue 7, 2011, Pages 981-988

Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: A clue to the diagnosis

Author keywords

hyaline globules; islet cell tumor; pancreas; pancreatic neuroendocrine tumor; solid pseudopapillary tumor

Indexed keywords

BETA CATENIN; CTNNB1 PROTEIN, HUMAN; HYALIN; MEMBRANE METALLOENDOPEPTIDASE; TUMOR MARKER;

EID: 79959635340     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31821a9a14     Document Type: Article
Times cited : (43)

References (59)
  • 2
    • 28844497945 scopus 로고    scopus 로고
    • Clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas: A clinicopathologic study of three cases and review of the literature
    • DOI 10.1002/dc.20365
    • Bhanot P, Nealon WH, Walser EM, et al. Clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas: a clinicopathologic study of three cases and review of the literature. Diagn Cytopathol. 2005;33:421-428. (Pubitemid 41780466)
    • (2005) Diagnostic Cytopathology , vol.33 , Issue.6 , pp. 421-428
    • Bhanot, P.1    Nealon, W.H.2    Walser, E.M.3    Bhutani, M.S.4    Tang, W.W.5    Logrono, R.6
  • 7
    • 59449096122 scopus 로고    scopus 로고
    • Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution
    • Ekeblad S, Skogseid B, Dunder K, et al. Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. Clin Cancer Res. 2008;14:7798-7803.
    • (2008) Clin Cancer Res , vol.14 , pp. 7798-7803
    • Ekeblad, S.1    Skogseid, B.2    Dunder, K.3
  • 8
    • 78649754940 scopus 로고    scopus 로고
    • Biological targeted therapies in patients with advanced enteropancreatic neuroendocrine carcinomas
    • Fazio N, Cinieri S, Lorizzo K, et al. Biological targeted therapies in patients with advanced enteropancreatic neuroendocrine carcinomas. Cancer Treat Rev. 2010;36(Suppl 3):S87-S94.
    • (2010) Cancer Treat Rev , vol.36 , Issue.SUPPL. 3
    • Fazio, N.1    Cinieri, S.2    Lorizzo, K.3
  • 9
    • 43549103792 scopus 로고    scopus 로고
    • Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas
    • Fischer L, Kleeff J, Esposito I, et al. Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas. Br J Surg. 2008;95:627-635.
    • (2008) Br J Surg , vol.95 , pp. 627-635
    • Fischer, L.1    Kleeff, J.2    Esposito, I.3
  • 10
    • 0023718784 scopus 로고
    • Ectopic ACTH syndrome due to islet cell carcinoma in a 12 year old child
    • Garg SK, Vashist R, Pathak IC, et al. Ectopic ACTH syndrome due to islet cell carcinoma in a 12 year old child. Indian J Pediatr. 1988; 55:155-160.
    • (1988) Indian J Pediatr , vol.55 , pp. 155-160
    • Garg, S.K.1    Vashist, R.2    Pathak, I.C.3
  • 12
    • 0036605747 scopus 로고    scopus 로고
    • Prognostic factors in pancreatic endocrine neoplasms: An analysis of 136 cases with a proposal for low-grade and intermediate-grade groups
    • DOI 10.1200/JCO.2002.10.030
    • Hochwald SN, Zee S, Conlon KC, et al. Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J Clin Oncol. 2002;20:2633-2642. (Pubitemid 34575635)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.11 , pp. 2633-2642
    • Hochwald, S.N.1    Zee, S.2    Conlon, K.C.3    Colleoni, R.4    Louie, O.5    Brennan, M.F.6    Klimstra, D.S.7
  • 13
    • 71749086394 scopus 로고    scopus 로고
    • Expression and activation of mTOR in neuroendocrine tumors. Effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation and signalling in neuroendocrine cell lines
    • Horsch D, Tielke S, Schrader J. Expression and activation of mTOR in neuroendocrine tumors. Effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation and signalling in neuroendocrine cell lines. J Clin Oncol. 2007;25:10570.
    • (2007) J Clin Oncol , vol.25 , pp. 10570
    • Horsch, D.1    Tielke, S.2    Schrader, J.3
  • 14
    • 0026872893 scopus 로고
    • Cystic islet cell tumors of the pancreas: A clinico-pathological report of two nonfunctioning cases and review of the literature
    • Iacono C, Serio G, Fugazzola C, et al. Cystic islet cell tumors of the pancreas: a clinico-pathological report of two nonfunctioning cases and review of the literature. Int J Pancreatol. 1992;11: 199-208.
    • (1992) Int J Pancreatol , vol.11 , pp. 199-208
    • Iacono, C.1    Serio, G.2    Fugazzola, C.3
  • 15
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX MEN1 and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1 and mTOR Pathway Genes are Frequently Altered in Pancreatic Neuroendocrine Tumors. Science Express. 2011;331:1199-1203.
    • (2011) Science Express , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 16
    • 0022977485 scopus 로고
    • Papillary cystic neoplasm of the pancreas: A curable pancreatic tumor
    • DOI 10.1007/BF01655258
    • Kaufman SL, Reddick RL, Stiegel M, et al. Papillary cystic neoplasm of the pancreas: a curable pancreatic tumor. World J Surg. 1986;10:851-859. (Pubitemid 17197540)
    • (1986) World Journal of Surgery , vol.10 , Issue.5 , pp. 851-859
    • Kaufman, S.L.1    Reddick, R.L.2    Stiegel, M.3
  • 17
    • 34248385189 scopus 로고    scopus 로고
    • Nonductal neoplasms of the pancreas
    • Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20(Suppl 1):S94-112.
    • (2007) Mod Pathol , vol.20 , Issue.SUPPL. 1
    • Klimstra, D.S.1
  • 18
    • 0034008119 scopus 로고    scopus 로고
    • Solid-pseudopapillary tumor of the pancreas: A typically cystic carcinoma of low malignant potential
    • Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol. 2000;17:66-80. (Pubitemid 30132100)
    • (2000) Seminars in Diagnostic Pathology , vol.17 , Issue.1 , pp. 66-80
    • Klimstra, D.S.1    Wenig, B.M.2    Heffess, C.S.3
  • 20
    • 56249088940 scopus 로고    scopus 로고
    • Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    • La Rosa S, Klersy C, Uccella S, et al. Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors. Hum Pathol. 2009;40:30-40.
    • (2009) Hum Pathol , vol.40 , pp. 30-40
    • La Rosa, S.1    Klersy, C.2    Uccella, S.3
  • 21
    • 0023634683 scopus 로고
    • Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas. With immunohistochemical and ultrastructural observations
    • Ladanyi M, Mulay S, Arseneau J, et al. Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas. With immunohistochemical and ultrastructural observations. Cancer. 1987;60:1604-1611. (Pubitemid 17141015)
    • (1987) Cancer , vol.60 , Issue.7 , pp. 1604-1611
    • Ladanyi, M.1    Mulay, S.2    Arseneau, J.3    Bettez, P.4
  • 22
    • 33645561727 scopus 로고    scopus 로고
    • Malignant solid and pseudopapillary tumor of the pancreas: Clinicohistological, immunohistochemical, and flow cytometric evaluation
    • Lai HW, Su CH, Li AF, et al. Malignant solid and pseudopapillary tumor of the pancreas: clinicohistological, immunohistochemical, and flow cytometric evaluation. Hepatogastroenterology. 2006;53: 291-295.
    • (2006) Hepatogastroenterology , vol.53 , pp. 291-295
    • Lai, H.W.1    Su, C.H.2    Li, A.F.3
  • 23
    • 0032825416 scopus 로고    scopus 로고
    • Pancreatic solid-cystic-papillary tumor: Clinicopathologic features in eight patients from Hong Kong and review of the literature
    • DOI 10.1007/s002689900621
    • Lam KY, Lo CY, Fan ST. Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature. World J Surg. 1999;23:1045-1050. (Pubitemid 29451723)
    • (1999) World Journal of Surgery , vol.23 , Issue.10 , pp. 1045-1050
    • Lam, K.Y.1    Lo, C.Y.2    Fan, S.T.3
  • 24
    • 60549092757 scopus 로고    scopus 로고
    • Clinical comparison of distal pancreatectomy with or without splenectomy
    • Lee SE, Jang JY, Lee KU, et al. Clinical comparison of distal pancreatectomy with or without splenectomy. J Korean Med Sci. 2008;23:1011-1014.
    • (2008) J Korean Med Sci , vol.23 , pp. 1011-1014
    • Lee, S.E.1    Jang, J.Y.2    Lee, K.U.3
  • 25
    • 0023154028 scopus 로고
    • Solid and papillary epithelial neoplasm of the pancreas. An ultrastructural and immunocytochemical study of six cases
    • DOI 10.1097/00000478-198702000-00001
    • Lieber MR, Lack EE, Roberts JR Jr, et al. Solid and papillary epithelial neoplasm of the pancreas: an ultrastructural and immunocytochemical study of six cases. Am J Surg Pathol. 1987; 11:85-93. (Pubitemid 17004961)
    • (1987) American Journal of Surgical Pathology , vol.11 , Issue.2 , pp. 85-93
    • Lieber, M.R.1    Lack, E.E.2    Roberts Jr., J.R.3
  • 26
    • 0033505944 scopus 로고    scopus 로고
    • Distal pancreatectomy: Indications and outcomes in 235 patients
    • Lillemoe KD, Kaushal S, Cameron JL, et al. Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg. 1999;229: 693-698.
    • (1999) Ann Surg , vol.229 , pp. 693-698
    • Lillemoe, K.D.1    Kaushal, S.2    Cameron, J.L.3
  • 27
    • 33751358959 scopus 로고    scopus 로고
    • Solid-pseudopapillary neoplasm of the pancreas: Three cases with a literature review
    • DOI 10.1097/01.pai.0000194763.86513.e4, PII 0012903920061200000014
    • Liu X, Rauch TM, Siegal GP, et al. Solid-pseudopapillary neoplasm of the pancreas: three cases with a literature review. Appl Immunohistochem Mol Morphol. 2006;14:445-453. (Pubitemid 44813707)
    • (2006) Applied Immunohistochemistry and Molecular Morphology , vol.14 , Issue.4 , pp. 445-453
    • Liu, X.1    Rauch, T.M.2    Siegal, G.P.3    Jhala, N.4
  • 28
    • 77649266429 scopus 로고    scopus 로고
    • Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas
    • Liu BA, Li ZM, Su ZS, et al. Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas. World J Gastroenterol. 2010;16:1025-1030.
    • (2010) World J Gastroenterol , vol.16 , pp. 1025-1030
    • Liu, B.A.1    Li, Z.M.2    Su, Z.S.3
  • 31
    • 0023514931 scopus 로고
    • Papillary cystic tumor of the pancreas. An analysis of cellular differentiation by electron microscopy and immunohistochemistry
    • DOI 10.1097/00000478-198711000-00004
    • Miettinen M, Partanen S, Fraki O, et al. Papillary cystic tumor of the pancreas: an analysis of cellular differentiation by electron microscopy and immunohistochemistry. Am J Surg Pathol. 1987; 11:855-865. (Pubitemid 18003395)
    • (1987) American Journal of Surgical Pathology , vol.11 , Issue.11 , pp. 855-865
    • Miettinen, M.1    Partanen, S.2    Fraki, O.3    Kivilaakso, E.4
  • 32
    • 74949122343 scopus 로고    scopus 로고
    • Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway
    • Missiaglia E, Dalai I, Barbi S, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol. 2010;28:245-255.
    • (2010) J Clin Oncol , vol.28 , pp. 245-255
    • Missiaglia, E.1    Dalai, I.2    Barbi, S.3
  • 34
    • 0033771871 scopus 로고    scopus 로고
    • Solid-pseudopapillary tumor of the pancreas: Immunohistochemical localization of neuroendocrine markers and CD10
    • Notohara K, Hamazaki S, Tsukayama C, et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol. 2000; 24:1361-1371.
    • (2000) Am J Surg Pathol , vol.24 , pp. 1361-1371
    • Notohara, K.1    Hamazaki, S.2    Tsukayama, C.3
  • 35
    • 46449106452 scopus 로고    scopus 로고
    • Solid pseudopapillary neoplasm: pathological diagnosis and distinction from other solid cellular tumours of the pancreas
    • DOI 10.1016/j.mpdhp.2008.04.003, PII S1756231708000674
    • Notohara K, Wani Y, Fujisawa M. Solid pseudopapillary neoplasm: pathological diagnosis and distinction from other solid cellular tumours of the pancreas. Diagnostic Histopathology. 2008;14: 266-274. (Pubitemid 351932175)
    • (2008) Diagnostic Histopathology , vol.14 , Issue.6 , pp. 266-274
    • Notohara, K.1    Wani, Y.2    Fujisawa, M.3
  • 36
    • 0034177614 scopus 로고    scopus 로고
    • Hepatoid carcinoma of the pancreas
    • DOI 10.1002/(SICI)1097-0142(20000401)88:7<1582::AID-CNCR12>3.0. CO;2-A
    • Paner GP, Thompson KS, Reyes CV. Hepatoid carcinoma of the pancreas. Cancer. 2000;88:1582-1589. (Pubitemid 30183143)
    • (2000) Cancer , vol.88 , Issue.7 , pp. 1582-1589
    • Paner, G.P.1    Thompson, K.S.2    Reyes, C.V.3
  • 37
    • 19744378856 scopus 로고    scopus 로고
    • Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in english literature
    • DOI 10.1016/j.jamcollsurg.2005.02.011, PII S1072751505001262
    • Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200:965-972. (Pubitemid 40744806)
    • (2005) Journal of the American College of Surgeons , vol.200 , Issue.6 , pp. 965-972
    • Papavramidis, T.1    Papavramidis, S.2
  • 38
    • 48249124512 scopus 로고    scopus 로고
    • Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors
    • Pape UF, Jann H, Muller-Nordhorn J, et al. Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer. 2008;113:256-265.
    • (2008) Cancer , vol.113 , pp. 256-265
    • Pape, U.F.1    Jann, H.2    Muller-Nordhorn, J.3
  • 40
    • 0026490094 scopus 로고
    • Papillary cystic tumor of the pancreas. A clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature
    • Pettinato G, Manivel JC, Ravetto C, et al. Papillary cystic tumor of the pancreas. A clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature. Am J Clin Pathol. 1992;98:478-488.
    • (1992) Am J Clin Pathol , vol.98 , pp. 478-488
    • Pettinato, G.1    Manivel, J.C.2    Ravetto, C.3
  • 41
    • 0031444497 scopus 로고    scopus 로고
    • Pancreaticoduodenectomy for selected periampullary neuroendocrine tumors: Fifty patients
    • Phan GQ, Yeo CJ, Cameron JL, et al. Pancreaticoduodenectomy for selected periampullary neuroendocrine tumors: fifty patients. Surgery. 1997;122:989-996.
    • (1997) Surgery , vol.122 , pp. 989-996
    • Phan, G.Q.1    Yeo, C.J.2    Cameron, J.L.3
  • 42
    • 4844222961 scopus 로고    scopus 로고
    • Clear cell ductal adenocarcinoma of pancreas: A case report and review of the literature
    • Ray S, Lu Z, Rajendiran S. Clear cell ductal adenocarcinoma of pancreas: a case report and review of the literature. Arch Pathol Lab Med. 2004;128:693-696. (Pubitemid 41490434)
    • (2004) Archives of Pathology and Laboratory Medicine , vol.128 , Issue.6 , pp. 693-696
    • Ray, S.1    Lu, Z.2    Rajendiran, S.3
  • 44
    • 34948850439 scopus 로고    scopus 로고
    • Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid pseudopapillary tumor of the pancreas: A case report and literature review
    • Salla C, Chatzipantelis P, Konstantinou P, et al. Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid pseudopapillary tumor of the pancreas: a case report and literature review. World J Gastroenterol. 2007;13:5158-5163. (Pubitemid 47527357)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.38 , pp. 5158-5163
    • Salla, C.1    Chatzipantelis, P.2    Konstantinou, P.3    Karoumpalis, I.4    Pantazopoulou, A.5    Dappola, V.6
  • 46
    • 0025853305 scopus 로고
    • Solid and cystic pancreatic tumors: Clinical, histochemical, and electron microscopic features in ten cases
    • Stommer P, Kraus J, Stolte M, et al. Solid and cystic pancreatic tumors: clinical, histochemical, and electron microscopic features in ten cases. Cancer. 1991;67:1635-1641.
    • (1991) Cancer , vol.67 , pp. 1635-1641
    • Stommer, P.1    Kraus, J.2    Stolte, M.3
  • 47
    • 34547143614 scopus 로고    scopus 로고
    • Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapy
    • DOI 10.1159/000102969
    • Strosberg J, Hoffe S, Gardner N, et al. Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapy. Neuroendocrinology. 2007;85:216-220. (Pubitemid 47123456)
    • (2007) Neuroendocrinology , vol.85 , Issue.4 , pp. 216-220
    • Strosberg, J.1    Hoffe, S.2    Gardner, N.3    Choi, J.4    Kvols, L.5
  • 48
    • 73649116730 scopus 로고    scopus 로고
    • Intraductal oncocytic papillary carcinoma of the pancreas showing numerous hyaline globules in the lumen
    • Tajiri T, Inagaki T, Ohike N, et al. Intraductal oncocytic papillary carcinoma of the pancreas showing numerous hyaline globules in the lumen. Pathol Int. 2010;60:48-54.
    • (2010) Pathol Int , vol.60 , pp. 48-54
    • Tajiri, T.1    Inagaki, T.2    Ohike, N.3
  • 50
    • 15744366918 scopus 로고    scopus 로고
    • Clinically aggressive solid pseudopapillary tumors of the pancreas: A report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases
    • DOI 10.1097/01.pas.0000155159.28530.88
    • Tang LH, Aydin H, Brennan MF, et al. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol. 2005;29:512-519. (Pubitemid 40411185)
    • (2005) American Journal of Surgical Pathology , vol.29 , Issue.4 , pp. 512-519
    • Tang, L.H.1    Aydin, H.2    Brennan, M.F.3    Klimstra, D.S.4
  • 51
    • 0026502849 scopus 로고
    • Radiotherapy for unresectable endocrine pancreatic carcinomas
    • Tennvall J, Ljungberg O, Ahren B, et al. Radiotherapy for unresectable endocrine pancreatic carcinomas. Eur J Surg Oncol. 1992;18:73-76.
    • (1992) Eur J Surg Oncol , vol.18 , pp. 73-76
    • Tennvall, J.1    Ljungberg, O.2    Ahren, B.3
  • 52
    • 33745111552 scopus 로고    scopus 로고
    • Malignant potential of solid pseudopapillary neoplasm of the pancreas
    • DOI 10.1002/bjs.5334
    • Tipton SG, Smyrk TC, Sarr MG, et al. Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br J Surg. 2006;93: 733-737. (Pubitemid 43886027)
    • (2006) British Journal of Surgery , vol.93 , Issue.6 , pp. 733-737
    • Tipton, S.G.1    Smyrk, T.C.2    Sarr, M.G.3    Thompson, G.B.4
  • 53
    • 0023270102 scopus 로고
    • Radiotherapy in the management of pancreatic islet cell tumor
    • DOI 10.1002/1097-0142(19870915)60:6<1226::AID-CNCR2820600611>3.0. CO;2-7
    • Torrisi JR, Treat J, Zeman R, et al. Radiotherapy in the management of pancreatic islet cell tumors. Cancer. 1987;60:1226-1231. (Pubitemid 17152898)
    • (1987) Cancer , vol.60 , Issue.6 , pp. 1226-1231
    • Torrisi, J.R.1    Treat, J.2    Zeman, R.3    Dritschilo, A.4
  • 56
    • 78650495298 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multicenter phase III trial of everolimus in patients with advanced pancreatic neuroendocrine tumors (pNET) (RADIANT-3)
    • Yao JC, Shah MH, Ito T, et al. A randomized, double-blind, placebo-controlled, multicenter phase III trial of everolimus in patients with advanced pancreatic neuroendocrine tumors (pNET) (RADIANT-3). Ann Oncol. 2010;21.
    • (2010) Ann Oncol. , pp. 21
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 57
    • 8444241166 scopus 로고    scopus 로고
    • Neoplasms of the endocrine pancreas
    • Greenfield LJ Mulholland MW, Oldham KT, eds Philadelphia, PA: Lippincott
    • Yeo CJ. Neoplasms of the endocrine pancreas. In: Greenfield LJ, Mulholland MW, Oldham KT, eds. Surgery: Scientific Principles and Practice. Philadelphia, PA: Lippincott; 2001:899-913.
    • (2001) Surgery: Scientific Principles and Practice , pp. 899-913
    • Yeo, C.J.1


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