Acute kidney injury

Annual Review of Medicine

Volumn 67, Issue , 2016, Pages 293-307

  Zuk, Anna ^a   Bonventre, Joseph V ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Biomarkers; Chronic kidney disease progression; Maladaptive repair; Nephrotoxicity; Pathophysiology; Renal ischemia reperfusion

Indexed keywords

BIOLOGICAL MARKER;

ACUTE KIDNEY FAILURE; ARTICLE; AUTOPHAGY; CELLULAR STRESS RESPONSE; CHRONIC KIDNEY DISEASE; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; END STAGE RENAL DISEASE; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM; HUMAN; INFLAMMATION; INNATE IMMUNITY; KIDNEY BLOOD VESSEL; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; MACROPHAGE; MORBIDITY; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; PERICYTE; PRIORITY JOURNAL; SURVIVAL; UNFOLDED PROTEIN RESPONSE; ACUTE KIDNEY INJURY; ANIMAL; BLOOD; INJURY SCALE; KIDNEY; MICROVASCULATURE; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; URINE; VASCULARIZATION;

ABBREVIATED INJURY SCALE; ACUTE KIDNEY INJURY; ANIMALS; AUTOPHAGY; BIOMARKERS; ENDOPLASMIC RETICULUM STRESS; HUMANS; INFLAMMATION; KIDNEY; MICROVESSELS; MITOCHONDRIA;

EID: 84954510169     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-050214-013407     Document Type: Article

References (94)

1. Mehta RL, Cerda J, Burdmann EA, et al. (2015). International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 385: 1-28
2. Yang L, Xing G, Wang L, et al. (2015). Acute kidney injury in China: a cross-sectional survey. Lancet 386: 1465-71
3. Cerda J, Bagga A, Kher V, Chakravarthi RM. (2008). The contrasting characteristics of acute kidney injury in developed and developing countries. Nat. Clin. Pract. Nephrol. 4: 138-53
4. Jha V, Parameswaran S. (2013). Community-Acquired acute kidney injury in tropical countries. Nat. Rev. Nephrol. 9: 278-90
5. Chawla LS, Eggers PW, Star RA, Kimmel PL. (2014). Acute kidney injury and chronic kidney disease as interconnected syndromes. N. Engl. J. Med. 371: 58-66
6. Ishani A, Xue JL, Himmelfarb J, et al. (2009). Acute kidney injury increases risk of ESRD among elderly. J. Am. Soc. Nephrol. 20: 223-28
7. Coca SG, Singanamala S, Parikh CR. (2012). Chronic kidney disease after acute kidney injury: a systematic review and meta-Analysis. Kidney Int. 81: 442-48
8. Clements ME, Chaber CJ, Ledbetter SR, Zuk A. (2013). Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury. PLoS ONE 8: e70464
9. Peng J, Li X, Zhang D, et al. (2015). Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int. 87: 137-50
10. Polichnowski AJ, Lan R, Geng H, et al. (2014). Severe renal mass reduction impairs recovery and promotes fibrosis after AKI. J. Am. Soc. Nephrol. 25: 1496-507
11. Bonventre JV, Yang L. (2011). Cellular pathophysiology of ischemic acute kidney injury. J. Clin. Investig. 121: 4210-21
12. Ferenbach DA, Bonventre JV. (2015). Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. Nat. Rev. Nephrol. 11: 264-76
13. Molitoris BA. (2014). Therapeutic translation in acute kidney injury: the epithelial/endothelial axis. J. Clin. Investig. 124: 2355-63
14. Aksu U, Demirci C, Ince C. (2011). The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib. Nephrol. 174: 119-28
15. Basile DP, Donohoe D, Roethe K, Osborn JL. (2001). Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-Term function. Am. J. Physiol. Ren. Physiol. 281: F887-99
16. Inagi R. (2009). Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury. Exp. Nephrol. 112: e1-e9
17. Zhang K, Kaufman RJ. (2008). From endoplasmic-reticulum stress to the inflammatory response. Nature 454: 455-62
18. Senft D, Ronai ZA. (2015). UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem. Sci. 40: 141-48
19. Hetz C. (2012). The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 13: 89-102
20. Hodeify R, Megyesi J, Tarcsafalvi A, et al. (2013). Gender differences control the susceptibility to ER stress-induced acute kidney injury. Am. J. Physiol. Ren. Physiol. 304: F875-82
21. Pallet N, Fougeray S, Beaune P, et al. (2009). Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation. Transplantation 88: 605-13
22. Peyrou M, Hanna PE, Cribb AE. (2007). Cisplatin, gentamicin, and p-Aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol. Sci. 99: 346-53
23. Lhotak S, Sood S, Brimble E, et al. 2012.ERstress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death. Am. J. Physiol. Ren. Physiol. 303: F266-78
24. Bando Y, Tsukamoto Y, Katayama T, et al. (2004). ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J. 18: 1401-3
25. Gao X, Fu L, Xiao M, et al. (2012). The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Basic Clin. Pharmacol. Toxicol. 111: 14-23
26. B'Chir W, Maurin AC, Carraro V, et al. (2013). The eIF2alpha/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 41: 7683-99
27. Dong B, Zhou H, Han C, et al. (2014). Ischemia/reperfusion-inducedCHOPexpression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4. PLoS ONE 9: e110944
28. Chiang CK, Hsu SP, Wu CT, et al. (2011). Endoplasmic reticulum stress implicated in the development of renal fibrosis. Mol. Med. 17: 1295-305
29. Raturi A, Simmen T. (2013). Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-Associated membrane (MAM). Biochim. Biophys. Acta 1833: 213-24
30. Venkatachalam MA, Griffin KA, Lan R, et al. (2010). Acute kidney injury: a springboard for progression in chronic kidney disease. Am. J. Physiol. Ren. Physiol. 298: F1078-94
31. Brooks C, Wei Q, Cho SG, Dong Z. (2009). Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J. Clin. Investig. 119: 1275-85
32. Zhan M, Brooks C, Liu F, et al. (2013). Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int. 83: 568-81
33. Birk AV, Liu S, Soong Y, et al. (2013). Themitochondrial-Targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J. Am. Soc. Nephrol. 24: 1250-61
34. Szeto HH, Liu S, Soong Y, et al. (2011). Mitochondria-Targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. J. Am. Soc. Nephrol. 22: 1041-52
35. Liu S, Soong Y, Seshan SV, Szeto HH. (2014). Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis. Am. J. Physiol. Ren. Physiol. 306: F970-80
36. Funk JA, Odejinmi S, Schnellmann RG. (2010). SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J. Pharmacol. Exp. Ther. 333: 593-601
37. Funk JA, Schnellmann RG. (2013). Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1aactivation following ischemia-reperfusion injury. Toxicol. Appl. Pharmacol. 273: 345-54
38. Hasegawa K, Wakino S, Yoshioka K, et al. (2010). Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J. Biol. Chem. 285: 13045-56
39. He W, Wang Y, Zhang MZ, et al. (2010). Sirt1 activation protects the mouse renal medulla from oxidative injury. J. Clin. Investig. 120: 1056-68
40. Rasbach KA, Schnellmann RG. (2008). Isoflavones promote mitochondrial biogenesis. J. Pharmacol. Exp. Ther. 325: 536-43
41. Funk JA, Schnellmann RG. (2012). Persistent disruption of mitochondrial homeostasis after acute kidney injury. Am. J. Physiol. Ren. Physiol. 302: F853-64
42. Tran M, Tam D, Bardia A, et al. (2011). PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J. Clin. Investig. 121: 4003-14
43. Jeskiney SR, Funk JA, Stallons LJ, et al. (2015). Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury. J. Am. Soc. Nephrol. 25: 1157-62
44. Garrett SM, Whitaker RM, Beeson CC, Schnellmann RG. (2014). Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J. Pharmacol. Exp. Ther. 350: 257-64
45. Whitaker RM, Wills LP, Stallons LJ, Schnellmann RG. (2013). cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury. J. Pharmacol. Exp. Ther. 347: 626-34
46. Gall JM, Wang Z, Bonegio RG, et al. (2015). Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J. Am. Soc. Nephrol. 26: 1092-102
47. Morigi M, Perico L, Rota C, et al. (2015). Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. J. Clin. Investig. 125: 715-26
48. Jiang M, Wei Q, Dong G, et al. (2012). Autophagy in proximal tubules protects against acute kidney injury. Kidney Int. 82: 1271-83
49. He L, Livingston MJ, Dong Z. (2014). Autophagy in acute kidney injury and repair. Nephron Clin. Pract. 127: 56-60
50. Brooks CR, Yeung MY, Brooks YS, et al. (2015). KIM-1/TIM-1-mediated phagocytosis links ATG5/ULK1-dependent clearance of apoptotic cells to antigen presentation. EMBO J. 34(19): 2441-64
51. Yang L, Brooks CR, Xiao S, et al. (2015). KIM-1-mediated phagocytosis reduces acute injury to the kidney. J. Clin. Investig. 125: 1620-36
52. Bonventre JV, Zuk A. (2004). Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66: 480-85
53. Jang HR, Rabb H. (2015). Immune cells in experimental acute kidney injury. Nat. Rev. Nephrol. 11: 88-101
54. Kinsey GR, Okusa MD. (2012). Role of leukocytes in the pathogenesis of acute kidney injury. Crit. Care 16: 214
55. Ysebaert DK. (2000). Identification and kinetics of leukocytes after severe ischemia/reperfusion renal injury. Nephrol. Dial. Transpl. 15: 1562-74
56. Zuk A, Gershenovich M, Ivanova Y, et al. (2014). CXCR4 anatagonism as a therapeutic approach to prevent acute kidney injury. Am. J. Physiol. Ren. Physiol. 307: F783-F97
57. Gigliotti JC, Huang L, Ye H, et al. (2013). Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. J. Am. Soc. Nephrol. 24: 1451-60
58. Bonventre JV. (2003). Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J. Am. Soc. Nephrol. 14(Suppl. 1): S55-61
59. Humphreys BD, Czerniak S, DiRocco DP, et al. (2011). Repair of injured proximal tubule does not involve specialized progenitors. PNAS 108: 9226-31
60. Humphreys BD, Valerius MT, Kobayashi A, et al. (2008). Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2: 284-91
61. Eardley KS, Zehnder D, Quinkler M, et al. (2006). The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease. Kidney Int. 69: 1189-97
62. Italiani P, Boraschi D. (2014). From monocytes to M1/M2 macrophages: phenotypical versus functional differentiation. Front. Immunol. 5: 514
63. Clements M, Gershenovich M, Chaber C, et al. (2015). Differential Ly6C expression after renal ischemiareperfusion identifies unique macrophage populations. J. Am. Soc. Nephrol. In press
64. Lee S, Huen S, Nishio H, et al. (2011). Distinct macrophage phenotypes contribute to kidney injury and repair. J. Am. Soc. Nephrol. 22: 317-26
65. Zhang MZ, Yao B, Yang S, et al. (2012). CSF-1 signaling mediates recovery from acute kidney injury. J. Clin. Investig. 122: 4519-32
66. Humphreys BD, Xu F, Sabbisetti V, et al. (2013). Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J. Clin. Investig. 123: 4023-35
67. Yang L, Besschetnova TY, Brooks CR, et al. (2010). Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat. Med. 16: 535-43
68. Venkatachalam MA, Weinberg JM, Kriz W, Bidani AK. (2015). Failed tubule recovery, AKI-CKD transition, and kidney disease progression. J. Am. Soc. Nephrol. 26: 1765-76
69. Yang H, Fogo AB. (2010). Cell senescence in the aging kidney. J. Am. Soc. Nephrol. 21: 1436-39
70. Freund A, Orjalo AV, Desprez PY, Campisi J. (2010). Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 16: 238-46
71. Barnes JL, GlassWF 2nd. (2011). Renal interstitial fibrosis: a critical evaluation of the origin of myofibroblasts. Contrib. Nephrol. 169: 73-93
72. Broekema M, Harmsen MC, van Luyn MJ, et al. (2007). Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J. Am. Soc. Nephrol. 18: 165-75
73. Lin F, Cordes K, Li L, et al. (2003). Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischema-reperfusion injury in mice. J. Am. Soc. Nephrol. 14: 1188-99
74. Ludin A, Itkin T, Gur-Cohen S, et al. (2012). Monocytes-macrophages that express a-smoothmuscle actin preserve primitive hematopoietic cells in the bone marrow. Nat. Immunol. 13: 1072-82
75. Kriz W, Kaissling B, Le Hir M. (2011). Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J. Clin. Investig. 121: 468-74
76. Gomez IG, Duffield JS. (2014). The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury. Kidney Int. Suppl. 4: 26-33
77. Anders HJ, Schaefer L. (2014). Beyond tissue injury-damage-Associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis. J. Am. Soc. Nephrol. 25: 1387-400
78. Leemans JC, Kors L, Anders HJ, Florquin S. (2014). Pattern recognition receptors and the inflammasome in kidney disease. Nat. Rev. Nephrol. 10: 398-414
79. Sallustio F, Constantino V, Cox SN, et al. (2013). Human renal stem/progenitor cells repair tubular epithelial cell injury throughTLR-2 driven inhibin-A and microvesicle-shuttled decorin. Kidney Int. 83: 392-403
80. Kulkarni OP, Hartter I, Mulay SR, et al. (2014). Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J. Am. Soc. Nephrol. 25: 978-89
81. Wang W, Wang X, Chun J, et al. (2013). Inflammasome-independent NLRP3 augments TGF-βsignaling in kidney epithelium. J. Immunol. 190: 1239-49
82. Koyner JL, Garg AX, Coca SG, et al. (2012). Biomarkers predict progression of acute kidney injury after cardiac surgery. J. Am. Soc. Nephrol. 23: 905-14
83. Alge JL, Arthur JM. (2015). Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications. Clin. J. Am. Soc. Nephrol. 10: 147-55
84. Kashani K, Kellum JA. (2015). Novel biomarkers indicating repair or progression after acute kidney injury. Curr. Opin. Nephrol. Hypertens. 24: 21-27
85. Sabbisetti VS, Waikar SS, Antoine DJ, et al. (2014). Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J. Am. Soc. Nephrol. 25: 2177-86
86. Fassett RG, Venuthurupalli SK, Gobe GC, et al. (2011). Biomarkers in chronic kidney disease: a review. Kidney Int. 80: 806-21
87. Ko GJ, Grigoryev DN, Linfert D, et al. (2010). Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-To-CKD progression. Am. J. Physiol. Ren. Physiol. 298: F1472-F83
88. Go AS, Parikh CR, Ikizler TA, et al. (2010). The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol. 11: 22
89. Ho J, Dart A, Rigatto C. (2014). Proteomics in acute kidney injury-current status and future promise. Pediatr. Nephrol. 29: 163-71
90. Sun J, Shannon M, Ando Y, et al. (2012). Serum metabolomic profiles from patients with acute kidney injury: a pilot study. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 893-894: 107-13
91. Lee CG, Kim JG, Kim HJ, et al. (2014). Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury. Kidney Int. 86: 943-53
92. Ramachandran K, Saikumar J, Bijol V, et al. (2013). Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury. Clin. Chem. 59: 1742-52
93. Endo K, Kito N, Fukushima Y, et al. (2014). A novel biomarker for acute kidney injury usingTaqMan-based unmethylated DNA-specific polymerase chain reaction. Biomed. Res. 35: 207-13
94. Salih M, Zietse R, Hoorn EJ. (2014). Urinary extracellular vesicles and the kidney: biomarkers and beyond. Am. J. Physiol. Ren. Physiol. 306: F1251-59