Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor

Biochemical and Biophysical Research Communications

Volumn 461, Issue 1, 2015, Pages 115-121

  Kato, Haruo ^a   Sekine, Yoshitaka ^a   Furuya, Yosuke ^a   Miyazawa, Yoshiyuki ^a   Koike, Hidekazu ^a   Suzuki, Kazuhiro ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

IGF 1 receptor; Metformin; PC 3; Prostate cancer

Indexed keywords

IGF1 PROTEIN, HUMAN; METFORMIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

CELL MOTION; CELL PROLIFERATION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; METFORMIN; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; RECEPTOR, IGF TYPE 1;

EID: 84937511483     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.178     Document Type: Article

References (25)

1. J.M. Evans, L.A. Donelly, A.M. Emslie-Smith, D.R. Alessi, and A.D. Morris Metformin and reduced risk of cancer in diabetic patients BMJ 330 2005 1304 1305
2. D. Margel, D.R. Urbach, L.L. Lipscombe, C.M. Bell, G. Kulkami, P.C. Austin, and N. Fleshner Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes J. Clin. Oncol. 31 2013 3069 3075
3. I. Ben-Sahra, K. Laurent, A. Loubat, S. Giorgetti-Peraldi, P. Colosetti, P. Auberger, J.F. Tanti, Y. Le Marchand-Brustel, and F. Bost The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level Oncogene 27 2008 3576 3586
4. M. Pollak, W. Beamer, and J.C. Zhang Insulin-like growth factors and prostate cancer Cancer. Metastasis. Rev. 17 1998 383 390
5. N. Reinmuth, W. Liu, F. Fan, Y.D. Jung, S.A. Ahmad, O. Stoeltzing, C.D. Bucana, R. Radinsky, and L.M. Ellis Blockade of insulin like growth factor I receptor function inhibits growth and angiogenesis of colon cancer Clin. Cancer. Res. 8 2002 3259 3269
6. J.D. Wu, A. Odman, L.M. Higgins, K. Haugk, R. Vessella, D.L. Ludwig, and S.R. Plymate In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors Clin. Cancer. Res. 11 2005 3065 3074
7. H. Hartog, J. Wesseling, H.M. Boezen, and W.T. van der Graaf The insulin-like growth factor 1 receptor in cancer: old focus, new future Eur. J. Cancer 43 2007 1895 1904
8. K. Suzuki, H. Koike, H. Matsui, Y. Ono, M. Hasumi, H. Nakazato, H. Okugi, Y. Sekine, K. Oki, K. Ito, T. Yamamoto, Y. Fukabori, K. Kurokawa, and H. Yamanaka Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3 Int. J. Cancer 99 2002 846 852
9. Y. Sekine, Y. Furuya, M. Nishii, H. Koike, H. Matsui, and K. Suzuki Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth facter 1 receptor Biochem. Biophys. Res. Commun. 372 2008 356 361
10. S. Persad, S. Attwell, V. Gray, M. Delcommenne, A. Troussard, J. Sanghera, and S. Dedhar Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells Proc. Natl. Acad. Sci. U. S. A. 97 2000 3207 3212
11. A. Clements, B. Gao, S.H. Yeap, M.K. Wong, S.S. Ali, and H. Gurney Metformin in prostate cancer: two for the price of one Ann. Oncol. 22 2011 2556 2560
12. D.E. Spratt, C. Zhang, Z.S. Zumsteg, X. Pei, Z. Zhang, and M.J. Zelefsky Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality Eur. Urol. 63 2013 709 716
13. B.J. Park, J.I. Park, D.S. Byun, J.H. Park, and S.G. Chi Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer Cancer. Res. 60 2000 3031 3038
14. T.O. Khor, Y.S. Keum, W. Lin, J.H. Kim, R. Hu, G. Shen, C. Xu, A. Gopalakrishnan, B. Reddy, X. Zheng, A.H. Conney, and A.N. Kong Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice Cancer. Res. 66 2006 613 621
15. J. Chaves, and M.W. Saif IGF system in cancer: from bench to clinic Anti-Cancer Drugs 22 2011 206 212
16. R. Subramani, R. Lopez-Valdez, A. Arumugam, S. Nandy, T. Boopalan, and R. Lakshmanaswamy Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis PLoS One 9 2014 e97016
17. M.E. Cox, M.E. Gleave, M. Zakikhani, R.H. Bell, E. Piura, E. Vickers, M. Cunningham, O. Larsson, L. Fazli, and M. Pollak Insulin receptor expression by human prostate cancers Prostate 69 2009 33 40
18. G.O. Hellawell, G.D. Turner, D.R. Davies, R. Poulsom, S.F. Brewster, and V.M. Macaulay Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease Cancer. Res. 62 2002 2942 2950
19. J. Fang, Q. Zhou, X.L. Shi, and B.H. Jiang Luteolin inhibits insulin like growth factor 1 receptor signaling in prostate cancer cells Carcinogenesis 28 2007 713 723
20. M.A. Rochester, J. Riedemann, G.O. Hellawell, S.F. Brewster, and V.M. Macaulay Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer Cancer Gene Ther. 12 2005 90 100
21. G. Pandini, R. Mineo, F. Frasca, C.T. Roberts Jr., M. Marcelli, R. Vigneri, and A. Belfiore Androgens up-regulate the insulin-like growth factor-1 receptor in prostate cancer cells Cancer. Res. 65 2005 1849 1857
22. R. Malaguarnera, A. Sacco, A. Morcavallo, S. Squatrito, A. Migliaccio, A. Morrione, M. Maggiolini, and A. Belfiore Metformin inhibits androgen-induced IGF-1R up-regulation in prostate cancer cells by disrupting membrane initiated androgen signaling Endocrinology 155 2014 1207 1221
23. A. Frid, G.N. Sterner, M. Löndahl, C. Wiklander, A. Cato, E. Vinge, and A. Andersson Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations Diabetes. Care 33 2010 1291 1293
24. M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem. J. 348 2000 607 614
25. C. Wilcock, and C.J. Bailey Accumulation of metformin by tissues of the normal and diabetic mouse Xenobiotica 24 1994 49 57