Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

Autophagy

Volumn 11, Issue 9, 2015, Pages 1484-1498

  Meissner, Cathrin ^a   Lorenz, Holger ^a   Hehn, Beate ^a   Lemberg, Marius K ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dual protein targeting; Intramembrane proteolysis; Neurodegenerative disease; Protein homeostasis; Selective autophagy

Indexed keywords

PARK2 PROTEIN; PARKIN; PARL PROTEIN; PROTEINASE; PTEN INDUCED KINASE 1; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; METALLOPROTEINASE; MITOCHONDRIAL PROTEIN; MUTANT PROTEIN; PARL PROTEIN, HUMAN; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE TRANSLOCATION; MITOPHAGY; MUTANT; NEGATIVE FEEDBACK; OUTER MEMBRANE; PARKINSON DISEASE; QUALITY CONTROL; BIOCATALYSIS; BIOLOGICAL MODEL; ENZYMOLOGY; HEK293 CELL LINE; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PATHOLOGY; PROTEIN PROCESSING; SOLUBILITY;

BIOCATALYSIS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; HEK293 CELLS; HUMANS; INTRACELLULAR MEMBRANES; METALLOPROTEASES; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MUTANT PROTEINS; PARKINSON DISEASE; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SOLUBILITY; UBIQUITIN-PROTEIN LIGASES;

EID: 84953848628     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1063763     Document Type: Article

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