-
1
-
-
33750594065
-
Genetics of Parkinson's disease and parkinsonism
-
Hardy, J., Cai, H., Cookson, M.R., Gwinn-Hardy, K. and Singleton, A. (2006) Genetics of Parkinson's disease and parkinsonism. Ann. Neurol. 60, 389-398.
-
(2006)
Ann. Neurol
, vol.60
, pp. 389-398
-
-
Hardy, J.1
Cai, H.2
Cookson, M.R.3
Gwinn-Hardy, K.4
Singleton, A.5
-
2
-
-
33644610520
-
The genetics of Parkinson disease: Implications for neurological care
-
Klein, C. and Schlossmacher, M.G. (2006) The genetics of Parkinson disease: Implications for neurological care. Nat. Clin. Pract. Neurol.. 2, 136-146.
-
(2006)
Nat. Clin. Pract. Neurol
, vol.2
, pp. 136-146
-
-
Klein, C.1
Schlossmacher, M.G.2
-
3
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A.R., Healy, D.G. et al. (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science, 304, 1159-1160.
-
(2004)
Science
, vol.304
, pp. 1159-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
-
4
-
-
4444274910
-
PINK1 mutations are associated with sporadic early-onset parkinsonism
-
Valente, E.M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A.E., Caputo, V., Romito, L., Albanese, A., Dallapiccola, B. and Bentivoglio, A.R. (2004) PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann. Neurol., 56, 336-341.
-
(2004)
Ann. Neurol
, vol.56
, pp. 336-341
-
-
Valente, E.M.1
Salvi, S.2
Ialongo, T.3
Marongiu, R.4
Elia, A.E.5
Caputo, V.6
Romito, L.7
Albanese, A.8
Dallapiccola, B.9
Bentivoglio, A.R.10
-
5
-
-
17644365438
-
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
-
Beilina, A., Van Der Brug, M., Ahmad, R., Kesavapany, S., Miller, D.W., Petsko, G.A. and Cookson, M.R. (2005) Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc. Natl Acad. Sci. USA, 102 5703-5708.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 5703-5708
-
-
Beilina, A.1
Van Der Brug, M.2
Ahmad, R.3
Kesavapany, S.4
Miller, D.W.5
Petsko, G.A.6
Cookson, M.R.7
-
6
-
-
27944444154
-
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
-
Silvestri, L., Caputo, V., Bellacchio, E., Atorino, L., Dallapiccela, B., Valente, E.M. and Casari, G. (2005) Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum. Mol. Genet., 14, 3477-3492.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 3477-3492
-
-
Silvestri, L.1
Caputo, V.2
Bellacchio, E.3
Atorino, L.4
Dallapiccela, B.5
Valente, E.M.6
Casari, G.7
-
7
-
-
33750220194
-
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
-
Sim, C.H., Lio, D.S., Mok, S.S., Masters, C.L., Hill, A.F. Culvenor, J.G. and Cheng, H.C. (2006) C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. Hum. Moll Genet., 15 3251-3262.
-
(2006)
Hum. Moll Genet
, vol.15
, pp. 3251-3262
-
-
Sim, C.H.1
Lio, D.S.2
Mok, S.S.3
Masters, C.L.4
Hill, A.F.5
Culvenor, J.G.6
Cheng, H.C.7
-
8
-
-
33746923419
-
Recessive Parkinson's disease
-
Kubo, S., Halton, N. and Mizuto, Y. (2006) Recessive Parkinson's disease. Mov. Disord., 21, 885-893.
-
(2006)
Mov. Disord
, vol.21
, pp. 885-893
-
-
Kubo, S.1
Halton, N.2
Mizuto, Y.3
-
9
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park. J., Lee, S B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.M, et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature, 441, 1157-1161.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.M.10
-
10
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.W., Yang, L., BW, M.F., Vogel, H. and Lu, B. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl Acad. Sci. USA, 103, 10793-10798.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
Huang, Z.4
Ouyang, Y.5
Wang, J.W.6
Yang, L.7
BW, M.F.8
Vogel, H.9
Lu, B.10
-
11
-
-
33745589773
-
(200) Drosophila pink1 is required for mitochondrial function and interacts genetically wit parkin
-
Clark, I.E., Dodson, M.W., Jiang, C., Can, J.H., Huh, J.R., Seol, J.H., Yoo,, S.J., Hay, B.A. and Guo, M. (200) Drosophila pink1 is required for mitochondrial function and interacts genetically wit parkin. Nature 441, 1162-1166.
-
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Can, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
12
-
-
27144469287
-
Small interfering RNA targeting the PINK1-induces apoptosis in dopaminergic cells SH-SY5Y
-
Deng, H., Jankovic, J., Guo, Y., Xie, W. and Le, W. (2005) Small interfering RNA targeting the PINK1-induces apoptosis in dopaminergic cells SH-SY5Y. Biochem. Biophys. Res. Commun., 337, 1133-1138.
-
(2005)
Biochem. Biophys. Res. Commun
, vol.337
, pp. 1133-1138
-
-
Deng, H.1
Jankovic, J.2
Guo, Y.3
Xie, W.4
Le, W.5
-
13
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis,and chemoresistance
-
MacKeigan, J.P., Murphy, L.O. and Blenis, J. (2005) Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis,and chemoresistance. Nat. Cell. Biol., 7, 591-600.
-
(2005)
Nat. Cell. Biol
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
14
-
-
26644440926
-
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
-
Petit, A., Kawarai, T., Paitel, E., Sanjo, N., Maj, M., Scheid, M., Chen, F., Gu, Y., Hasegawa, H., Salehi-Rad, S. et al. (2005) Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem., 280, 34025-34032.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 34025-34032
-
-
Petit, A.1
Kawarai, T.2
Paitel, E.3
Sanjo, N.4
Maj, M.5
Scheid, M.6
Chen, F.7
Gu, Y.8
Hasegawa, H.9
Salehi-Rad, S.10
-
15
-
-
34547127902
-
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1
-
Pridgeon, J.W., Olzmann, J.A., Chin, L.S. and Li, L. (2007) PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1. PLoS Biol., 5, e172.
-
(2007)
PLoS Biol
, vol.5
-
-
Pridgeon, J.W.1
Olzmann, J.A.2
Chin, L.S.3
Li, L.4
-
16
-
-
33744760852
-
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
-
Tang, B., Xiong, H., Sun, P., Zhang, Y., Wang, D., Hu, Z., Zhu, Z., Ma, H., Pan, Q., Xia, J.H. et al. (2006) Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum. Mol. Genet., 15, 1916-1925.
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 1916-1925
-
-
Tang, B.1
Xiong, H.2
Sun, P.3
Zhang, Y.4
Wang, D.5
Hu, Z.6
Zhu, Z.7
Ma, H.8
Pan, Q.9
Xia, J.H.10
-
17
-
-
33745087689
-
PINK1 protein in normal human brain and Parkinson's disease
-
Gandhi S., Muqit, M.M., Stanyer, L., Healy, D.G., Abou-Sleiman, P.M., Hargreaves, I., Heales, S., Ganguly, M., Parsons, L., Lees, A.J. et al. (2006) PINK1 protein in normal human brain and Parkinson's disease. Brain, 129, 1730-1731.
-
(2006)
Brain
, vol.129
, pp. 1730-1731
-
-
Gandhi, S.1
Muqit, M.M.2
Stanyer, L.3
Healy, D.G.4
Abou-Sleiman, P.M.5
Hargreaves, I.6
Heales, S.7
Ganguly, M.8
Parsons, L.9
Lees, A.J.10
-
18
-
-
33745068109
-
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
-
Muqit, M.M., Abou-Sleiman, P.M., Saurin, A.T. Harvey K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M.D., Vennef, K., Matilla, A. et al. (2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J. Neurochem., 98, 156-164.
-
(2006)
J. Neurochem
, vol.98
, pp. 156-164
-
-
Muqit, M.M.1
Abou-Sleiman, P.M.2
Saurin, A.T.3
Harvey, K.4
Gandhi, S.5
Deas, E.6
Eaton, S.7
Payne Smith, M.D.8
Vennef, K.9
Matilla, A.10
-
19
-
-
33846651282
-
Molecular chaperones and protein kinase quality control
-
Caplan, A.J., Mandal, A.K. and Theodoraki, M.A. (2007) Molecular chaperones and protein kinase quality control. Trends Cell. Biol., 17, 87-92.
-
(2007)
Trends Cell. Biol
, vol.17
, pp. 87-92
-
-
Caplan, A.J.1
Mandal, A.K.2
Theodoraki, M.A.3
-
20
-
-
0034718540
-
Modulation of Akt kinase activity by binding to Hsp90
-
Sato, S., Fujita, N. and Tsuruo, T. (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl Acad. Sci. USA, 97, 10832-10837.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
21
-
-
0036852712
-
Pharmacological prevention of Parkinson disease in Drosophila
-
Auluck, P.K. and Bonini, N.M. (2002) Pharmacological prevention of Parkinson disease in Drosophila. Nat. Med., 8, 1185-1186.
-
(2002)
Nat. Med
, vol.8
, pp. 1185-1186
-
-
Auluck, P.K.1
Bonini, N.M.2
-
22
-
-
0037428164
-
Molecular chaperones Nsp90 and Hsp70 deliver prcproteins to the mitochondrial. import receptor Tom70
-
Young, T.C., Hoogenraad, N.J. and Hartl, F.U. (2003) Molecular chaperones Nsp90 and Hsp70 deliver prcproteins to the mitochondrial. import receptor Tom70. Cell, 112, 41-50.
-
(2003)
Cell
, vol.112
, pp. 41-50
-
-
Young, T.C.1
Hoogenraad, N.J.2
Hartl, F.U.3
-
23
-
-
0037352446
-
Structural and functional analysis of the middle segment of hsp90: Implications for ATP hydrolysis and client protein and cochaperone interactions
-
Meyer, P., Prodromou, C., Hu, B., Vaughan, C., Roe, S.M., Panaretou, B., Piper, P. W. and Pearl, L,H. (2003) Structural and functional analysis of the middle segment of hsp90: Implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell, 11, 647-658.
-
(2003)
Mol Cell
, vol.11
, pp. 647-658
-
-
Meyer, P.1
Prodromou, C.2
Hu, B.3
Vaughan, C.4
Roe, S.M.5
Panaretou, B.6
Piper, P.W.7
Pearl, L.H.8
-
24
-
-
33746381708
-
Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site
-
Hadden, M.K. Lubbers, D.J. and Blagg, B.S. (2006) Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site. Curr. Top. Med. Chem., 6, 1173-1182.
-
(2006)
Curr. Top. Med. Chem
, vol.6
, pp. 1173-1182
-
-
Hadden, M.K.1
Lubbers, D.J.2
Blagg, B.S.3
-
25
-
-
25444501262
-
A client-binding site of Cdc37
-
Terasawa, K. and Minami, Y. (2005) A client-binding site of Cdc37. FEBS J., 272, 4684-4690.
-
(2005)
FEBS J
, vol.272
, pp. 4684-4690
-
-
Terasawa, K.1
Minami, Y.2
-
26
-
-
0042527167
-
Cdc37 goes beyond Hsp90 and kinases
-
MacLean, M. and Picard, D. (2003) Cdc37 goes beyond Hsp90 and kinases. Cell Stress Chaperones, 8, 114-119.
-
(2003)
Cell Stress Chaperones
, vol.8
, pp. 114-119
-
-
MacLean, M.1
Picard, D.2
-
27
-
-
33244482539
-
Mutational analysis of the PINK1 gene in early-onset parkinsonism in: Europe and North Africa
-
Ibanez, P., Lesage, S., Lohmann, E., Thobois, S., De Michele, G., Borg, M., Agid, Y., Durr, A. and Brice, A. (2006) Mutational analysis of the PINK1 gene in early-onset parkinsonism in: Europe and North Africa. Brain, 129, 686-694.
-
(2006)
Brain
, vol.129
, pp. 686-694
-
-
Ibanez, P.1
Lesage, S.2
Lohmann, E.3
Thobois, S.4
De Michele, G.5
Borg, M.6
Agid, Y.7
Durr, A.8
Brice, A.9
-
28
-
-
33646434793
-
Parkin blushed by PINK1
-
Tan, J.M. and Dawson, T.M. (2006) Parkin blushed by PINK1. Neuron, 50, 521-529.
-
(2006)
Neuron
, vol.50
, pp. 521-529
-
-
Tan, J.M.1
Dawson, T.M.2
-
29
-
-
0033055908
-
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function
-
Grammatikakis, N., Lin, J.H., Grammatikakis, A., Tsichlis, P.N. and Cochran, B.H. (1999) p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol. Cell Biol., 19, 1661-1672.
-
(1999)
Mol. Cell Biol
, vol.19
, pp. 1661-1672
-
-
Grammatikakis, N.1
Lin, J.H.2
Grammatikakis, A.3
Tsichlis, P.N.4
Cochran, B.H.5
-
30
-
-
0032189258
-
Signal sequences: More than just greasy peptides
-
Martoglio, B. and Dobberstein, B. (1998) Signal sequences: More than just greasy peptides. Trends Cell. Biol., 8, 410-415.
-
(1998)
Trends Cell. Biol
, vol.8
, pp. 410-415
-
-
Martoglio, B.1
Dobberstein, B.2
-
31
-
-
33750445482
-
Mitochondrial fusion and fission in mammals
-
Chan, D.C. (2006) Mitochondrial fusion and fission in mammals. Annu. Rev. Cell. Dev. Biol., 22, 79-99.
-
(2006)
Annu. Rev. Cell. Dev. Biol
, vol.22
, pp. 79-99
-
-
Chan, D.C.1
-
32
-
-
4444327827
-
Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
-
Jiang, H., Ren, Y., Zhao, J. and Feng, J. (2004) Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum. Mol. Genet., 13, 1745-1754,
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 1745-1754
-
-
Jiang, H.1
Ren, Y.2
Zhao, J.3
Feng, J.4
-
33
-
-
10644281090
-
Lentiviral vector delivery of parkin prevents dopaminergic degdneration in an alpha-synuclein rat model of Parkinson's disease
-
Lo Bianco, C., Schneider, B.L., Bauer, M., Sajadi, A., Brice, A., Iwatsubo, T. and Aebischer, P. (2004) Lentiviral vector delivery of parkin prevents dopaminergic degdneration in an alpha-synuclein rat model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 101 17510-17515.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 17510-17515
-
-
Lo Bianco, C.1
Schneider, B.L.2
Bauer, M.3
Sajadi, A.4
Brice, A.5
Iwatsubo, T.6
Aebischer, P.7
-
34
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-piotein ligase
-
Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-piotein ligase. Nat. Genet., 25, 302-305.
-
(2000)
Nat. Genet
, vol.25
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Kubo, S.3
Mizuno, Y.4
Asakawa, S.5
Minoshima, S.6
Shimizu, N.7
Iwai, K.8
Chiba, T.9
Tanaka, K.10
|