-
1
-
-
33845604556
-
DNA double-strand break repair: All's well that ends well
-
Wyman, C. & Kanaar, R. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 40, 363-383 (2006).
-
(2006)
Annu. Rev. Genet.
, vol.40
, pp. 363-383
-
-
Wyman, C.1
Kanaar, R.2
-
2
-
-
38049155945
-
Regulation of DNA double-strand break repair pathway choice
-
Shrivastav, M., De Haro, L. P. & Nickoloff, J. A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18, 134-147 (2008).
-
(2008)
Cell Res.
, vol.18
, pp. 134-147
-
-
Shrivastav, M.1
De Haro, L.P.2
Nickoloff, J.A.3
-
3
-
-
50649100744
-
Mechanism of eukaryotic homologous recombination
-
San Filippo, J., Sung, P. & Klein, H. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77, 229-257 (2008).
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 229-257
-
-
San Filippo, J.1
Sung, P.2
Klein, H.3
-
4
-
-
80055104335
-
Analysis of DNA double-strand break (DSB) repair in mammalian cells
-
Seluanov, A., Mao, Z. & Gorbunova, V. Analysis of DNA double-strand break (DSB) repair in mammalian cells. J. Vis. Exp. 43, e2002 (2010).
-
(2010)
J. Vis. Exp.
, vol.43
, pp. e2002
-
-
Seluanov, A.1
Mao, Z.2
Gorbunova, V.3
-
5
-
-
84866388311
-
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
-
Mattiroli, F. et al. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 150, 1182-1195 (2012).
-
(2012)
Cell
, vol.150
, pp. 1182-1195
-
-
Mattiroli, F.1
-
6
-
-
84865386136
-
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair
-
Chapman, J. R., Sossick, A. J., Boulton, S. J. & Jackson, S. P. BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. J. Cell Sci. 125, 3529-3534 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 3529-3534
-
-
Chapman, J.R.1
Sossick, A.J.2
Boulton, S.J.3
Jackson, S.P.4
-
7
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil, C. et al. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435-446 (2009).
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
-
8
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand, N. et al. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131, 887-900 (2007).
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
-
9
-
-
84865364870
-
Playing the end game: DNA double-strand break repair pathway choice
-
Chapman, J. R., Taylor, M. R. & Boulton, S. J. Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47, 497-510 (2012).
-
(2012)
Mol. Cell
, vol.47
, pp. 497-510
-
-
Chapman, J.R.1
Taylor, M.R.2
Boulton, S.J.3
-
10
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber, M. R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem. 79, 181-211 (2010).
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
11
-
-
38349145553
-
Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: The trans-S double-strand break repair model
-
Delacote, F. & Lopez, B. S. Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: the trans-S double-strand break repair model. Cell Cycle 7, 33-38 (2008).
-
(2008)
Cell Cycle
, vol.7
, pp. 33-38
-
-
Delacote, F.1
Lopez, B.S.2
-
12
-
-
67349246802
-
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
-
Yun, M. H. & Hiom, K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459, 460-463 (2009).
-
(2009)
Nature
, vol.459
, pp. 460-463
-
-
Yun, M.H.1
Hiom, K.2
-
13
-
-
68949221567
-
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
-
Cao, L. et al. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol. Cell 35, 534-541 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 534-541
-
-
Cao, L.1
-
14
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P. et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol. 17, 688-695 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
-
15
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S. F. et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141, 243-254 (2010).
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
-
16
-
-
77952109779
-
Loss of 53BP1 is a gain for BRCA1 mutant cells
-
Kass, E. M., Moynahan, M. E. & Jasin, M. Loss of 53BP1 is a gain for BRCA1 mutant cells. Cancer Cell 17, 423-425 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 423-425
-
-
Kass, E.M.1
Moynahan, M.E.2
Jasin, M.3
-
17
-
-
0036500691
-
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
-
Joo, W. S. et al. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev. 16, 583-593 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 583-593
-
-
Joo, W.S.1
-
18
-
-
84876527317
-
RIF1 counteracts BRCA1-mediated end resection during DNA repair
-
Feng, L., Fong, K. W., Wang, J., Wang, W. & Chen, J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J. Biol. Chem. 288, 11135-11143 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11135-11143
-
-
Feng, L.1
Fong, K.W.2
Wang, J.3
Wang, W.4
Chen, J.5
-
19
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Diaz, C. et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49, 872-883 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
-
20
-
-
84876855215
-
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
-
Chapman, J. R. et al. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49, 858-871 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 858-871
-
-
Chapman, J.R.1
-
21
-
-
84873488846
-
53BP1 regulates DSB repair using Rif1 to control 5′ end resection
-
Zimmermann, M., Lottersberger, F., Buonomo, S. B., Sfeir, A. & de Lange, T. 53BP1 regulates DSB repair using Rif1 to control 5′ end resection. Science 339, 700-704 (2013).
-
(2013)
Science
, vol.339
, pp. 700-704
-
-
Zimmermann, M.1
Lottersberger, F.2
Buonomo, S.B.3
Sfeir, A.4
De Lange, T.5
-
22
-
-
84873526612
-
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
-
Di Virgilio, M. et al. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339, 711-715 (2013).
-
(2013)
Science
, vol.339
, pp. 711-715
-
-
Di Virgilio, M.1
-
23
-
-
84878893538
-
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
-
Callen, E. et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 153, 1266-1280 (2013).
-
(2013)
Cell
, vol.153
, pp. 1266-1280
-
-
Callen, E.1
-
24
-
-
84875883306
-
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9
-
Liu, X. et al. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat. Commun. 4, 1563 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 1563
-
-
Liu, X.1
-
25
-
-
34648833002
-
UHRF1 plays a role in maintaining DNA methylation in mammalian cells
-
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760-1764 (2007).
-
(2007)
Science
, vol.317
, pp. 1760-1764
-
-
Bostick, M.1
-
26
-
-
80052429757
-
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
-
Hu, L., Li, Z., Wang, P., Lin, Y. & Xu, Y. Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell Res. 21, 1374-1378 (2011).
-
(2011)
Cell Res.
, vol.21
, pp. 1374-1378
-
-
Hu, L.1
Li, Z.2
Wang, P.3
Lin, Y.4
Xu, Y.5
-
27
-
-
79960464001
-
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression
-
Rajakumara, E. et al. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Mol. Cell 43, 275-284 (2011).
-
(2011)
Mol. Cell
, vol.43
, pp. 275-284
-
-
Rajakumara, E.1
-
28
-
-
84893758816
-
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
-
Mudbhary, R. et al. UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell 25, 196-209 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 196-209
-
-
Mudbhary, R.1
-
29
-
-
84902652431
-
Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate
-
Gelato, K. A. et al. Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. Mol. Cell 54, 905-919 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 905-919
-
-
Gelato, K.A.1
-
30
-
-
33750686660
-
Isolation and characterization of a novel human radiosusceptibility gene, NP95
-
Muto, M. et al. Isolation and characterization of a novel human radiosusceptibility gene, NP95. Radiat. Res. 166, 723-733 (2006).
-
(2006)
Radiat. Res.
, vol.166
, pp. 723-733
-
-
Muto, M.1
-
31
-
-
84874685709
-
DNA damage regulates UHRF1 stability via the SCF(beta-TrCP) E3 ligase
-
Chen, H. et al. DNA damage regulates UHRF1 stability via the SCF(beta-TrCP) E3 ligase. Mol. Cell Biol. 33, 1139-1148 (2013).
-
(2013)
Mol. Cell Biol.
, vol.33
, pp. 1139-1148
-
-
Chen, H.1
-
32
-
-
79952850692
-
UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis
-
Tien, A. L. et al. UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochem. J. 435, 175-185 (2011).
-
(2011)
Biochem. J
, vol.435
, pp. 175-185
-
-
Tien, A.L.1
-
33
-
-
0037072831
-
Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks
-
Muto, M. et al. Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks. J. Biol. Chem. 277, 34549-34555 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 34549-34555
-
-
Muto, M.1
-
34
-
-
84925956835
-
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold
-
Tian, Y. et al. UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Rep. 10, 1957-1966 (2015).
-
(2015)
Cell Rep.
, vol.10
, pp. 1957-1966
-
-
Tian, Y.1
-
35
-
-
84925938228
-
UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway
-
Liang, C. C. et al. UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 10, 1947-1956 (2015).
-
(2015)
Cell Rep.
, vol.10
, pp. 1947-1956
-
-
Liang, C.C.1
-
36
-
-
0142147272
-
The BRCT domain is a phospho-protein binding domain
-
Yu, X., Chini, C. C., He, M., Mer, G. & Chen, J. The BRCT domain is a phospho-protein binding domain. Science 302, 639-642 (2003).
-
(2003)
Science
, vol.302
, pp. 639-642
-
-
Yu, X.1
Chini, C.C.2
He, M.3
Mer, G.4
Chen, J.5
-
37
-
-
0142240342
-
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
-
Manke, I. A., Lowery, D. M., Nguyen, A. & Yaffe, M. B. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302, 636-639 (2003).
-
(2003)
Science
, vol.302
, pp. 636-639
-
-
Manke, I.A.1
Lowery, D.M.2
Nguyen, A.3
Yaffe, M.B.4
-
38
-
-
84855416370
-
UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis
-
Chu, J. et al. UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol. Biol. Cell 23, 59-70 (2012).
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 59-70
-
-
Chu, J.1
-
39
-
-
84859475181
-
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability
-
Ma, H. et al. M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc. Natl Acad. Sci. USA 109, 4828-4833 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 4828-4833
-
-
Ma, H.1
-
40
-
-
78650967451
-
UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation
-
Mistry, H. et al. UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation. Genome Integr. 1, 7 (2010).
-
(2010)
Genome Integr
, vol.1
, pp. 7
-
-
Mistry, H.1
-
41
-
-
46249131123
-
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
-
Bennardo, N., Cheng, A., Huang, N. & Stark, J. M. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 4, e1000110 (2008).
-
(2008)
PLoS Genet.
, vol.4
-
-
Bennardo, N.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
42
-
-
0035099044
-
BRCA2 is required for homology-directed repair of chromosomal breaks
-
Moynahan, M. E., Pierce, A. J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263-272 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 263-272
-
-
Moynahan, M.E.1
Pierce, A.J.2
Jasin, M.3
-
43
-
-
77649225150
-
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells
-
Fattah, F. et al. Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells. PLoS Genet. 6, e1000855 (2010).
-
(2010)
PLoS Genet.
, vol.6
-
-
Fattah, F.1
-
44
-
-
28644448228
-
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth
-
Jenkins, Y. et al. Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. Mol. Biol. Cell 16, 5621-5629 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5621-5629
-
-
Jenkins, Y.1
-
45
-
-
84869087517
-
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
-
Rothbart, S. B. et al. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat. Struct. Mol. Biol. 19, 1155-1160 (2012).
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 1155-1160
-
-
Rothbart, S.B.1
-
46
-
-
84885577142
-
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
-
Nishiyama, A. et al. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature 502, 249-253 (2013).
-
(2013)
Nature
, vol.502
, pp. 249-253
-
-
Nishiyama, A.1
-
47
-
-
77956186851
-
UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer
-
Jin, W. et al. UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res. Treat. 123, 359-373 (2010).
-
(2010)
Breast Cancer Res. Treat
, vol.123
, pp. 359-373
-
-
Jin, W.1
-
48
-
-
36849072573
-
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
-
Sharif, J. et al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 450, 908-912 (2007).
-
(2007)
Nature
, vol.450
, pp. 908-912
-
-
Sharif, J.1
-
49
-
-
75549090255
-
Mammalian Rif1 contributes to replication stress survival and homology-directed repair
-
Buonomo, S. B., Wu, Y., Ferguson, D. & de Lange, T. Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187, 385-398 (2009).
-
(2009)
J. Cell Biol.
, vol.187
, pp. 385-398
-
-
Buonomo, S.B.1
Wu, Y.2
Ferguson, D.3
De Lange, T.4
-
50
-
-
57049132043
-
53BP1 promotes nonhomologous end joining of telomeres by increasing chromatin mobility
-
Dimitrova, N., Chen, Y. C., Spector, D. L. & de Lange, T. 53BP1 promotes nonhomologous end joining of telomeres by increasing chromatin mobility. Nature 456, 524-528 (2008).
-
(2008)
Nature
, vol.456
, pp. 524-528
-
-
Dimitrova, N.1
Chen, Y.C.2
Spector, D.L.3
De Lange, T.4
-
51
-
-
3543064379
-
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
-
Silverman, J., Takai, H., Buonomo, S. B., Eisenhaber, F. & de Lange, T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 18, 2108-2119 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2108-2119
-
-
Silverman, J.1
Takai, H.2
Buonomo, S.B.3
Eisenhaber, F.4
De Lange, T.5
-
52
-
-
84860343773
-
Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks
-
Harding, S. M. & Bristow, R. G. Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks. Cell Cycle 11, 1432-1444 (2012).
-
(2012)
Cell Cycle
, vol.11
, pp. 1432-1444
-
-
Harding, S.M.1
Bristow, R.G.2
-
53
-
-
84921444088
-
DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos
-
Jacob, V. et al. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development 142, 510-521 (2015).
-
(2015)
Development
, vol.142
, pp. 510-521
-
-
Jacob, V.1
-
54
-
-
84908130650
-
UHRF1: A master regulator in prostate cancer
-
Jazirehi, A. R., Arle, D. & Wenn, P. B. UHRF1: a master regulator in prostate cancer. Epigenomics 4, 251-252 (2012).
-
(2012)
Epigenomics
, vol.4
, pp. 251-252
-
-
Jazirehi, A.R.1
Arle, D.2
Wenn, P.B.3
-
55
-
-
84864981284
-
UHRF1 promotes cell growth and metastasis through repression of p16(ink(4)a) in colorectal cancer
-
Wang, F. et al. UHRF1 promotes cell growth and metastasis through repression of p16(ink(4)a) in colorectal cancer. Ann. Surg. Oncol. 19, 2753-2762 (2012).
-
(2012)
Ann. Surg. Oncol.
, vol.19
, pp. 2753-2762
-
-
Wang, F.1
-
56
-
-
84877862860
-
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation
-
Krifa, M. et al. Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation. J. Exp. Clin. Cancer Res. 32, 30 (2013).
-
(2013)
J. Exp. Clin. Cancer Res.
, vol.32
, pp. 30
-
-
Krifa, M.1
-
57
-
-
79955109834
-
Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties
-
Alhosin, M. et al. Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. J. Exp. Clin. Cancer Res. 30, 41 (2011).
-
(2011)
J. Exp. Clin. Cancer Res.
, vol.30
, pp. 41
-
-
Alhosin, M.1
-
58
-
-
79952034429
-
UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer
-
Daskalos, A. et al. UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer 117, 1027-1037 (2011).
-
(2011)
Cancer
, vol.117
, pp. 1027-1037
-
-
Daskalos, A.1
-
59
-
-
0842329805
-
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability
-
Richardson, C., Stark, J. M., Ommundsen, M. & Jasin, M. Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene 23, 546-553 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 546-553
-
-
Richardson, C.1
Stark, J.M.2
Ommundsen, M.3
Jasin, M.4
-
60
-
-
79954528832
-
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
-
Hu, Y. et al. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 25, 685-700 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 685-700
-
-
Hu, Y.1
-
61
-
-
80052493266
-
Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger
-
Wang, C. et al. Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger. Cell Res. 21, 1379-1382 (2011).
-
(2011)
Cell Res.
, vol.21
, pp. 1379-1382
-
-
Wang, C.1
-
62
-
-
53649089723
-
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
-
Hashimoto, H. et al. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature 455, 826-829 (2008).
-
(2008)
Nature
, vol.455
, pp. 826-829
-
-
Hashimoto, H.1
-
63
-
-
84872348770
-
Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein
-
Cheng, J. et al. Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein. J. Biol. Chem. 288, 1329-1339 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 1329-1339
-
-
Cheng, J.1
-
64
-
-
79959869345
-
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein
-
Nady, N. et al. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J. Biol. Chem. 286, 24300-24311 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 24300-24311
-
-
Nady, N.1
-
65
-
-
78049510229
-
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination
-
Du, Z. et al. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci. Signal. 3, ra80 (2010).
-
(2010)
Sci. Signal
, vol.3
, pp. ra80
-
-
Du, Z.1
-
66
-
-
79251489223
-
Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1
-
Qin, W., Leonhardt, H. & Spada, F. Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J. Cell Biochem. 112, 439-444 (2011).
-
(2011)
J. Cell Biochem.
, vol.112
, pp. 439-444
-
-
Qin, W.1
Leonhardt, H.2
Spada, F.3
-
67
-
-
59449092185
-
Single-vector inducible lentiviral RNAi system for oncology target validation
-
Wiederschain, D. et al. Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle 8, 498-504 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 498-504
-
-
Wiederschain, D.1
-
68
-
-
84890013296
-
PCNA promotes processive DNA end resection by Exo1
-
Chen, X., Paudyal, S. C., Chin, R. I. & You, Z. PCNA promotes processive DNA end resection by Exo1. Nucleic Acids Res. 41, 9325-9338 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 9325-9338
-
-
Chen, X.1
Paudyal, S.C.2
Chin, R.I.3
You, Z.4
-
69
-
-
72149103012
-
CtIP links DNA double-strand break sensing to resection
-
You, Z. et al. CtIP links DNA double-strand break sensing to resection. Mol. Cell 36, 954-969 (2009).
-
(2009)
Mol. Cell
, vol.36
, pp. 954-969
-
-
You, Z.1
|