Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: Evidence for a pro-amyloidogenic role of MT1-MMP

Frontiers in Aging Neuroscience

Volumn 6, Issue SEP, 2014, Pages

  Py, Nathalie A ^a   Bonnet, Amandine E ^a   Bernard, Anne ^a   Marchalant, Yannick ^a,d   Charrat, Eliane ^a   Checler, Frédéric ^b   Khrestchatisky, Michel ^a   Baranger, Kévin ^a,c   Rivera, Santiago ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c TIMONE HOSPITAL   (France)

^d CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

ADAM; Amyloid; Cytokines; Metalloproteinases; MMP 2; MMP 9; Neuroinflammation; TIMP

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

5XFAD MOUSE; AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENCEPHALITIS; GENE EXPRESSION; GENE MUTATION; GROUPS BY AGE; HEK293 CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MOUSE MODEL; NEUROPATHOLOGY; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; WESTERN BLOTTING;

EID: 84907927401     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00247     Document Type: Article

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