Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells

Oncotarget

Volumn 6, Issue 41, 2015, Pages 43927-43943

  Adjibade, Pauline ^a   St Sauveur, Valérie Grenier ^a   Huberdeau, Miguel Quevillon ^a   Fournier, Marie Josée ^a   Savard, Andreanne ^a   Coudert, Laetitia ^a   Khandjian, Edouard W ^a,b   Mazroui, Rachid ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

Author keywords

ATF4; EIF2a; PERK; Sorafenib; Stress granules

Indexed keywords

CYTOPLASMIC RNA; FLUOROURACIL; INITIATION FACTOR 2; MESSENGER RNA; PROTEASOME INHIBITOR; RNA; SORAFENIB; STRESS GRANULE; UNCLASSIFIED DRUG; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; ATF4 PROTEIN, HUMAN; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENVIRONMENTAL STRESS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN PHOSPHORYLATION; SMALL RIBOSOMAL SUBUNIT; TRANSLATION INITIATION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL GRANULE; DRUG EFFECTS; DRUG RESISTANCE; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; LIVER TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOPLASMIC GRANULES; DRUG RESISTANCE, NEOPLASM; EUKARYOTIC INITIATION FACTOR-2; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER NEOPLASMS; NIACINAMIDE; PHENYLUREA COMPOUNDS; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TRANSFECTION;

EID: 84952935587     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5980     Document Type: Article

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