Evidence that ternary complex (eIF2-GTP-tRNAiMet)-Deficient preinitiation complexes are core constituents of mammalian stress granules

Molecular Biology of the Cell

Volumn 13, Issue 1, 2002, Pages 195-210

  Kedersha, Nancy ^a   Chen, Samantha ^a   Gilks, Natalie ^a   Li, Wei ^a   Miller, Ira J ^a   Stahl, Joachim ^a   Anderson, Paul ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; MESSENGER RNA; RNA BINDING PROTEIN; TRANSFER RNA;

ANIMAL CELL; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; RIBOSOME SUBUNIT; RNA TRANSLATION; STRESS; TRANSLATION INITIATION;

ANIMALS; ARSENITES; CENTRIFUGATION, DENSITY GRADIENT; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASMIC GRANULES; EUKARYOTIC INITIATION FACTOR-2; GUANOSINE TRIPHOSPHATE; HUMANS; MACROMOLECULAR SUBSTANCES; MALE; MICROSCOPY, FLUORESCENCE; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PEPTIDE INITIATION FACTORS; PHOSPHORYLATION; RNA, MESSENGER; RNA, RIBOSOMAL; RNA, TRANSFER, MET; RNA-BINDING PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0036154218     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-05-0221     Document Type: Article

References (30)

1. Characterization of the hemin-sensitive eukaryotic initiation factor 2a kinase from mouse nonerythroid cells
2. Molecular aspects of arsenic stress
3. Chaperone Hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes
4. The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5′ splice site
5. Translation initiation: Adept at adapting
6. Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis
7. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
8. HuR binding to cytoplasmic mRNA is perturbed by heat shock
9. Control of translation initiation in animals
10. Regulated translation initiation controls stress-induced gene expression in mammalian cells
11. Conservation and diversity in the structure of translation initiation factor EIF3 from humans and yeast
12. The pathway and mechanism of initiation of protein synthesis
13. Translational control of GCN4: Gene-specific regulation by phosphorylation of eIF2
14. Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome
15. Nucleoside diphosphate regulation of overall rates of protein synthesis acting at the level of initiation
16. Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules
17. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
18. TIA-1 and TIAR activate splicing of alternative exons with weak 5′ splice sites followed by a U-rich stretch on their own pre-mRNAs
19. Immunoelectron microscopic studies on the location of ribosomal proteins on the surface of the 40S ribosomal subunit from rat liver
20. Cytoplasmic heat shock granules are formed from precursor particles and are associated with a specific set of mRNAs
21. Formation of cytoplasmic heat shock granules in tomato cell cultures and leaves
22. Lipoxygenase mRNA silencing in erythroid differentiation: The 3′ UTR regulatory complex controls 60S ribosomal subunit joining
23. Ribosome recruitment and scanning: What's new?
24. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha
25. The tomato Hsf system: HsfA2 needs interaction with HsfA1 for efficient nuclear import and may be localized in cytoplasmic heat stress granules
26. Phosphorylation of eIF2alpha mediates apoptosis in response to activation of the double stranded RNA-dependent protein kinase
27. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death
28. Binding of initiator methionyl-tRNA to ribosomes
29. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
30. Preferential regulation of protein synthesis initiation complex formation by purine nucleotides