Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2α kinase activity of HRI

Biochemistry

Volumn 42, Issue 21, 2003, Pages 6536-6544

  Rafie Kolpin, Maryam ^b   Han, An Ping ^a   Chen, Jane Jane ^a  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b Interleukin Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CATALYST ACTIVITY; ENZYME INHIBITION; SYNTHESIS (CHEMICAL);

PROTEIN SYNTHESIS;

PROTEINS;

ALANINE; ARSENIC TRIOXIDE; HEME DERIVATIVE; INITIATION FACTOR 2; PHOSPHOPEPTIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE R; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN SYNTHESIS;

ALANINE; AMINO ACID SEQUENCE; ASPARTIC ACID; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; EUKARYOTIC INITIATION FACTOR-2; HEME; HEMIN; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; THREONINE; TRYPSIN;

ANIMALIA;

EID: 0038728800     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034005v     Document Type: Article

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