Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Nath, Aritro ^a   Chan, Christina ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; TRANSCRIPTOME;

ADENOCARCINOMA; DISEASE COURSE; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; HUMAN; KAPLAN MEIER METHOD; LIPID METABOLISM; METABOLISM; MORTALITY; MUTATION; PROGNOSIS; SECONDARY; TRANSPORT AT THE CELLULAR LEVEL;

ADENOCARCINOMA; BIOLOGICAL TRANSPORT; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY ACIDS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; LIPID METABOLISM; METABOLIC NETWORKS AND PATHWAYS; MUTATION; PROGNOSIS; TRANSCRIPTOME;

EID: 84952894855     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18669     Document Type: Article

References (67)

1. Mehlen, P. & Puisieux, A. Metastasis: A question of life or death. Nat Rev Cancer 6, 449-458 (2006).
2. Klein, C. A. Parallel progression of primary tumours and metastases. Nat Rev Cancer 9, 302-312 (2009).
3. Yokota, J. Tumor progression and metastasis. Carcinogenesis 21, 497-503 (2000).
4. Cairns, R. A., Harris, I. S. & Mak, T. W. Regulation of cancer cell metabolism. Nat Rev Cancer 11, 85-95 (2011).
5. Hanahan, D. & Weinberg, Robert A. Hallmarks of Cancer: The Next Generation. Cell 144, 646-674 (2011).
6. Shaw, R. J. Glucose metabolism and cancer. Curr Opin Cell Biol 18, 598-608 (2006).
7. Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029-1033 (2009).
8. Kuhajda, F. P. Fatty Acid Synthase and Cancer: New Application of an Old Pathway. Cancer Res 66, 5977-5980 (2006).
9. Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 25, 1041-1051 (2011).
10. Zhou, W. et al. HIF1alpha induced switch from bivalent to exclusively glycolytic metabolism during ESC-To-EpiSC/hESC transition. EMBO J 31, 2103-2116 (2012).
11. Simsek, T. et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7, 380-390 (2010).
12. Knobloch, M. et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature 493, 226-230 (2013).
13. Ito, K. et al. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 18, 1350-1358 (2012).
14. Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3, 895-902 (2003).
15. Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells-An integrated concept of malignant tumour progression. Nat Rev Cancer 5, 744-749 (2005).
16. Mani, S. A. et al. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells. Cell 133, 704-715 (2008).
17. Singh, A. & Settleman, J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 29, 4741-4751 (2010).
18. Dang, C. V. Links between metabolism and cancer. Genes Dev 26, 877-890 (2012).
19. Carracedo, A., Cantley, L. C. & Pandolfi, P. P. Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer 13, 227-232 (2013).
20. Musso, G., Gambino, R. & Cassader, M. Recent insights into hepatic lipid metabolism in non-Alcoholic fatty liver disease (NAFLD). Prog Lipid Res 48, 1-26 (2009).
21. Currie, E., Schulze, A., Zechner, R., Walther, Tobias C. & Farese, Robert V. Cellular Fatty Acid Metabolism and Cancer. Cell Metab 18, 153-161 (2013).
22. Nath, A., Li, I., Roberts, L. R. & Chan, C. Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. Sci Rep 5, 14752 (2015).
23. Salt, M. B., Bandyopadhyay, S. & McCormick, F. Epithelial-To-Mesenchymal Transition Rewires the Molecular Path to PI3KDependent Proliferation. Cancer Discov 4, 186-199 (2013).
24. Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339 (2013).
25. Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
26. Uyeda, K. & Repa, J. J. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4, 107-110 (2006).
27. Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D. & Uyeda, K. From The Cover: Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101, 7281-7286 (2004).
28. Tailleux, A., Wouters, K. & Staels, B. Roles of PPARs in NAFLD: Potential therapeutic targets. Biochim Biophys Acta 1821, 809-818 (2012).
29. Sotgia, F. et al. Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms. Annu Rev Pathol-Mech 7, 423-467 (2012).
30. Ayala, G. et al. Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. J Pathol 231, 77-87 (2013).
31. Huang, C. et al. A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis. Cancer Res 72, 655-665 (2011).
32. Nam, K. H. et al. Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer. Pathobiology 80, 87-94 (2013).
33. DeFilippis, R. A. et al. CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues. Cancer Discov 2, 826-839 (2012).
34. Hale, J. S. et al. Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression. Stem Cells 32, 1746-1758 (2014).
35. Kuemmerle, N. B. et al. Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation. Mol Cancer Ther 10, 427-436 (2011).
36. Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650-1653 (2006).
37. Matoba, S. p53 Regulates Mitochondrial Respiration. Science 312, 1650-1653 (2006).
38. Leary, S. C., Sasarman, F., Nishimura, T. & Shoubridge, E. A. Human SCO2 is required for the synthesis of CO II and as a thioldisulphide oxidoreductase for SCO1. Hum Mol Genet 18, 2230-2240 (2009).
39. Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4, 891-899 (2004).
40. Kueck, A. et al. Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol 107, 450-457 (2007).
41. Visca, P. et al. Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res 24, 4169-4173 (2004).
42. Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 25, 1041-1051 (2011).
43. Porubsky, P. R., Meneely, K. M. & Scott, E. E. Structures of Human Cytochrome P-450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J Biol Chem 283, 33698-33707 (2008).
44. Orellana, M. et al. Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-Alcoholic fatty liver disease patients. Hepatol Res 34, 57-63 (2006).
45. Aubert, J., Begriche, K., Knockaert, L., Robin, M. A. & Fromenty, B. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role. Clin Res Hepatol Gastroenterol 35, 630-637 (2011).
46. Leung, T. et al. Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res 15, R107 (2013).
47. Trafalis, D. T., Panteli, E. S., Grivas, A., Tsigris, C. & Karamanakos, P. N. CYP2E1 and risk of chemically mediated cancers. Expert Opin Drug Metab Toxicol 6, 307-319 (2010).
48. Zhao, Y., Butler, E. B. & Tan, M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 4, e532 (2013).
49. Tennant, D. A., Duran, R. V. & Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 10, 267-277 (2010).
50. Vander Heiden, M. G. Targeting cancer metabolism: A therapeutic window opens. Nat Rev Drug Discov 10, 671-684 (2011).
51. Hardie, D. G. Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology 131, 973; author reply 974-975 (2006).
52. Guppy, M., Leedman, P., Zu, X. & Russell, V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 364, 309-315 (2002).
53. Rodríguez-Enríquez, S. et al. Energy metabolism transition in multi-cellular human tumor spheroids. J Cell Physiol 216, 189-197 (2008).
54. Kamphorst, J. J. et al. Hypoxic and Ras-Transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci USA 110, 8882-8887 (2013).
55. Young, R. M. et al. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev 27, 1115-1131 (2013).
56. Furukawa, S. et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114, 1752-1761 (2004).
57. Schumacker, P. T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10, 175-176 (2006).
58. Fruehauf, J. P. & Meyskens, F. L., Jr. Reactive oxygen species: A breath of life or death? Clin Cancer Res 13, 789-794 (2007).
59. Ishikawa, K. et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320, 661-664 (2008).
60. Zhang, Q., Piston, D. W. & Goodman, R. H. Regulation of corepressor function by nuclear NADH. Science 295, 1895-1897 (2002).
61. Zhang, Q. et al. Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci USA 103, 9029-9033 (2006).
62. Santidrian, A. F. et al. Mitochondrial complex I activity and NAD+ /NADH balance regulate breast cancer progression. J Clin Invest 123, 1068-1081 (2013).
63. Goldman, M. et al. The UCSC Cancer Genomics Browser: update 2013. Nucleic Acids Res 41, D949-D954 (2012).
64. Lopez, B. Thread 4: Data discovery, transparency and visualization. Nat Genet (2013).
65. Cerami, E. et al. The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data. Cancer Discov 2, 401-404 (2012).
66. Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545-15550 (2005).
67. Reich, M. et al. GenePattern 2.0. Nat Genet 38, 500-501 (2006).