Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy

ACS Chemical Biology

Volumn 10, Issue 12, 2015, Pages 2706-2715

  Rzuczek, Suzanne G ^a   Southern, Mark R ^a   Disney, Matthew D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; HYDROGEN; MESSENGER RNA; MYOTONIC DYSTROPHY PROTEIN KINASE; NITROGEN; RNA; TROPONIN T; MBNL1 PROTEIN, HUMAN; MOLECULAR LIBRARY; RNA BINDING PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR LIBRARY; MYOTONIC DYSTROPHY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA BINDING; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER AIDED DESIGN; DRUG DELIVERY SYSTEM; IC50; METABOLISM; PATHOPHYSIOLOGY; PHARMACOLOGY; PRECLINICAL STUDY;

COMPUTER-AIDED DESIGN; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MYOTONIC DYSTROPHY; RNA; RNA-BINDING PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84952845702     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00430     Document Type: Article

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