Non-coding RNA transcripts: Sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease

Neuroscience Letters

Volumn 466, Issue 2, 2009, Pages 81-88

  St Laurent III, Georges ^a,b   Faghihi, Mohammad Ali ^c   Wahlestedt, Claes ^c  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Neuronal stress; Non coding RNA; Synaptic plasticity; Transcriptome

Indexed keywords

BETA SECRETASE; GENE PRODUCT; TRANSCRIPTOME; UNTRANSLATED RNA;

ALZHEIMER DISEASE; CELL STRESS; CELLULAR STRESS RESPONSE; CENTRAL NERVOUS SYSTEM; FRAGILE X SYNDROME; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR MECHANICS; MOLECULAR SENSOR; NERVE CELL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROANATOMY; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; RNA PROCESSING; RNA TRANSCRIPTION;

ALZHEIMER DISEASE; ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; NEURONAL PLASTICITY; OXIDATIVE STRESS; RNA, UNTRANSLATED; SYNAPSES;

EID: 70350128252     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.08.032     Document Type: Review

References (76)

1. Abelson J.F., Kwan K.Y., O'Roak B.J., Baek D.Y., Stillman A.A., Morgan T.M., Mathews C.A., Pauls D.L., Rasin M.R., Gunel M., Davis N.R., Ercan-Sencicek A.G., Guez D.H., Spertus J.A., Leckman J.F., Dure L.S.t., Kurlan R., Singer H.S., Gilbert D.L., Farhi A., Louvi A., Lifton R.P., Sestan N., and State M.W. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310 (2005) 317-320
2. Berezikov E., Thuemmler F., van Laake L.W., Kondova I., Bontrop R., Cuppen E., and Plasterk R.H. Diversity of microRNAs in human and chimpanzee brain. Nat Genet 38 (2006) 1375-1377
3. Beveridge N.J., Tooney P.A., Carroll A.P., Gardiner E., Bowden N., Scott R.J., Tran N., Dedova I., and Cairns M.J. Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet 17 (2008) 1156-1168
4. Boissonneault V., Plante I., Rivest S., and Provost P. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J. Biol. Chem. 284 (2009) 1971-1981
5. Brookheart R.T., Michel C.I., Listenberger L.L., Ory D.S., and Schaffer J.E. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. J. Biol. Chem. 284 (2009) 7446-7454
6. Brosius J. Waste not, want not-transcript excess in multicellular eukaryotes. Trends Genet. 21 (2005) 287-288
7. Campisi J. Aging, tumor suppression and cancer: high wire-act!. Mech. Ageing Dev. 126 (2005) 51-58
8. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 (2005) 513-522
9. Cao Q., Huang Y.S., Kan M.C., and Richter J.D. Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol. Cell. Biol. 25 (2005) 10930-10939
10. Cayre A., Rossignol F., Clottes E., and Penault-Llorca F. aHIF but not HIF-1alpha transcript is a poor prognostic marker in human breast cancer. Breast Cancer Res. 5 (2003) R223-R230
11. Centonze D., Rossi S., Napoli I., Mercaldo V., Lacoux C., Ferrari F., Ciotti M.T., De Chiara V., Prosperetti C., Maccarrone M., Fezza F., Calabresi P., Bernardi G., and Bagni C. The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum. J Neurosci 27 (2007) 8885-8892
12. 2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons. Biochem. Biophys. Res. Commun. 338 (2005) 1913-1919
13. Dinger M.E., Mercer T.R., and Mattick J.S. RNAs as extracellular signaling molecules. J. Mol. Endocrinol. 40 (2008) 151-159
14. Esposito G., De Filippis D., Steardo L., Scuderi C., Savani C., Cuomo V., and Iuvone T. CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons. Neurosci Lett 404 (2006) 342-346
15. Eyman M., Cefaliello C., Ferrara E., De Stefano R., Lavina Z.S., Crispino M., Squillace A., van Minnen J., Kaplan B.B., and Giuditta A. Local synthesis of axonal and presynaptic RNA in squid model systems. Eur J Neurosci 25 (2007) 341-350
16. Faghihi M.A., Modarresi F., Khalil A.M., Wood D.E., Sahagan B.G., Morgan T.E., Finch C.E., St Laurent G., 3rd P.J., Kenny C., and Wahlestedt. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 14 (2008) 723-730
17. Gagen M.J., and Mattick J.S. Accelerating, hyperaccelerating, and decelerating networks. Phys. Rev. E: Stat. Nonlin. Soft Matter Phys. 72 (2005) 016123
18. Hebert S.S., Horre K., Nicolai L., Bergmans B., Papadopoulou A.S., Delacourte A., and De Strooper B. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis 33 (2009) 422-428
19. Hu X., Hicks C.W., He W., Wong P., Macklin W.B., Trapp B.D., and Yan R. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci 9 (2006) 1520-1525
20. Huang Y.Y., and Kandel E.R. Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus. Learn. Mem. 13 (2006) 298-306
21. Iqbal K., Liu F., Gong C.X., Alonso A.D., and Grundke-Iqbal I. Mechanisms of tau-induced neurodegeneration. Acta Neuropathol. (2009)
22. Katayama S., Tomaru Y., Kasukawa T., Waki K., Nakanishi M., Nakamura M., Nishida H., Yap C.C., Suzuki M., Kawai J., Suzuki H., Carninci P., Hayashizaki Y., Wells C., Frith M., Ravasi T., Pang K.C., Hallinan J., Mattick J., Hume D.A., Lipovich L., Batalov S., Engstrom P.G., Mizuno Y., Faghihi M.A., Sandelin A., Chalk A.M., Mottagui-Tabar S., Liang Z., Lenhard B., and Wahlestedt C. Antisense transcription in the mammalian transcriptome. Science 309 (2005) 1564-1566
23. Khalil A.M., Faghihi M.A., Modarresi F., Brothers S.P., and Wahlestedt C. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS ONE 3 (2008) e1486
24. Kitano H., and Oda K. Robustness trade-offs and host-microbial symbiosis in the immune system. Mol. Syst. Biol. 2 (2006) 0022
25. Kiyosawa H., Yamanaka I., Osato N., Kondo S., and Hayashizaki Y. Antisense transcripts with FANTOM2 clone set and their implications for gene regulation. Genome Res. 13 (2003) 1324-1334
26. Kocerha J., Faghihi M.A., Lopez-Toledano M.A., Huang J., Ramsey A.J., Caron M.G., Sales N., Willoughby D., Elmen J., Hansen H.F., Orum H., Kauppinen S., Kenny P.J., and Wahlestedt C. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A 106 (2009) 3507-3512
27. Korneev S.A., Park J.H., and O'Shea M. Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene. J. Neurosci. 19 (1999) 7711-7720
28. Kosik K.S. The neuronal microRNA system. Nat. Rev. Neurosci. 7 (2006) 911-920
29. Kwon Y.K., and Cho K.H. Coherent coupling of feedback loops: a design principle of cell signaling networks. Bioinformatics 24 (2008) 1926-1932
30. Ladd P.D., Smith L.E., Rabaia N.A., Moore J.M., Georges S.A., Hansen R.S., Hagerman R.J., Tassone F., Tapscott S.J., and Filippova G.N. An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals. Hum Mol Genet 16 (2007) 3174-3187
31. Laird F.M., Cai H., Savonenko A.V., Farah M.H., He K., Melnikova T., Wen H., Chiang H.C., Xu G., Koliatsos V.E., Borchelt D.R., Price D.L., Lee H.K., and Wong P.C. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25 (2005) 11693-11709
32. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U., Novosel A., Muller R.U., Schermer B., Bissels U., Inman J., Phan Q., Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H.I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou F.N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., and Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129 (2007) 1401-1414
33. Lein E.S., Hawrylycz M.J., Ao N., Ayres M., Bensinger A., Bernard A., Boe A.F., Boguski M.S., Brockway K.S., Byrnes E.J., Chen L., Chen L., Chen T.M., Chin M.C., Chong J., Crook B.E., Czaplinska A., Dang C.N., Datta S., Dee N.R., Desaki A.L., Desta T., Diep E., Dolbeare T.A., Donelan M.J., Dong H.W., Dougherty J.G., Duncan B.J., Ebbert A.J., Eichele G., Estin L.K., Faber C., Facer B.A., Fields R., Fischer S.R., Fliss T.P., Frensley C., Gates S.N., Glattfelder K.J., Halverson K.R., Hart M.R., Hohmann J.G., Howell M.P., Jeung D.P., Johnson R.A., Karr P.T., Kawal R., Kidney J.M., Knapik R.H., Kuan C.L., Lake J.H., Laramee A.R., Larsen K.D., Lau C., Lemon T.A., Liang A.J., Liu Y., Luong L.T., Michaels J., Morgan J.J., Morgan R.J., Mortrud M.T., Mosqueda N.F., Ng L.L., Ng R., Orta G.J., Overly C.C., Pak T.H., Parry S.E., Pathak S.D., Pearson O.C., Puchalski R.B., Riley Z.L., Rockett H.R., Rowland S.A., Royall J.J., Ruiz M.J., Sarno N.R., Schaffnit K., Shapovalova N.V., Sivisay T., Slaughterbeck C.R., Smith S.C., Smith K.A., Smith B.I., Sodt A.J., Stewart N.N., Stumpf K.R., Sunkin S.M., Sutram M., Tam A., Teemer C.D., Thaller C., Thompson C.L., Varnam L.R., Visel A., Whitlock R.M., Wohnoutka P.E., Wolkey C.K., Wong V.Y., Wood M., Yaylaoglu M.B., Young R.C., Youngstrom B.L., Yuan X.F., Zhang B., Zwingman T.A., and Jones A.R. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445 (2007) 168-176
34. Levanon K., Eisenberg E., Rechavi G., and Levanon E.Y. Letter from the editor: adenosine-to-inosine RNA editing in Alu repeats in the human genome. EMBO Rep. 6 (2005) 831-835
35. Ma H., Lesne S., Kotilinek L., Steidl-Nichols J.V., Sherman M., Younkin L., Younkin S., Forster C., Sergeant N., Delacourte A., Vassar R., Citron M., Kofuji P., Boland L.M., and Ashe K.H. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U S A 104 (2007) 8167-8172
36. Mandelkow E.M., Stamer K., Vogel R., Thies E., and Mandelkow E. Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol. Aging 24 (2003) 1079-1085
37. Mattick J.S. RNA regulation: a new genetics?. Nat Rev Genet 5 (2004) 316-323
38. Mattick J.S. A new paradigm for developmental biology. J. Exp. Biol. 210 (2007) 1526-1547
39. Mattick J.S., and Mehler M.F. RNA editing, DNA recoding and the evolution of human cognition. Trends Neurosci. 31 (2008) 227-233
40. Mehler M.F., and Mattick J.S. Non-coding RNAs in the nervous system. J. Physiol. 575 (2006) 333-341
41. Mercer T.R., Dinger M.E., Sunkin S.M., Mehler M.F., and Mattick J.S. Specific expression of long noncoding RNAs in the mouse brain. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 716-721
42. Moucadel V., Lopez F., Ara T., Benech P., and Gautheret D. Beyond the 3′ end: experimental validation of extended transcript isoforms. Nucleic Acids Res. 35 (2007) 1947-1957
43. Mus E., Hof P.R., and Tiedge H. Dendritic BC200 RNA in aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 10679-10684
44. Nardai G., Vegh E.M., Prohaszka Z., and Csermely P. Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks. Trends Immunol. 27 (2006) 74-79
45. Nelson P.T., Wang W.X., and Rajeev B.W. MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol. 18 (2008) 130-138
46. Nilsen J., Chen S., Irwin R.W., Iwamoto S., and Brinton R.D. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. BMC Neurosci. 7 (2006) 74
47. Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., Birney E., and Hayashizaki Y. Analysis of the mouse transcriptome based on functional annotation of 60. 770 full-length cDNAs. Nature 420 (2002) 563-573
48. Perkins D.O., Jeffries C.D., Jarskog L.F., Thomson J.M., Woods K., Newman M.A., Parker J.S., Jin J., and Hammond S.M. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol 8 (2007) R27
49. Pietrzykowski A.Z., Friesen R.M., Martin G.E., Puig S.I., Nowak C.L., Wynne P.M., Siegelmann H.T., and Treistman S.N. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron 59 (2008) 274-287
50. Pollard K.S., Salama S.R., Lambert N., Lambot M.A., Coppens S., Pedersen J.S., Katzman S., King B., Onodera C., Siepel A., Kern A.D., Dehay C., Igel H., Ares Jr. M., Vanderhaeghen P., and Haussler D. An RNA gene expressed during cortical development evolved rapidly in humans. Nature 443 (2006) 167-172
51. Ray P.S., Jia J., Yao P., Majumder M., Hatzoglou M., and Fox P.L. A stress-responsive RNA switch regulates VEGFA expression. Nature 457 (2009) 915-919
52. Richter J.D., and Klann E. Making synaptic plasticity and memory last: mechanisms of translational regulation. Genes Dev. 23 (2009) 1-11
53. Sandberg R., Neilson J.R., Sarma A., Sharp P.A., and Burge C.B. Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites. Science 320 (2008) 1643-1647
54. Savvateeva-Popova E., Medvedeva A., Popov A., and Evgen'ev M. Role of non-coding RNAs in neurodegeneration and stress response in Drosophila. Biotechnol. J. 3 (2008) 1010-1021
55. Scheele C., Petrovic N., Faghihi M.A., Lassmann T., Fredriksson K., Rooyackers O., Wahlestedt C., Good L., and Timmons J.A. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics 8 (2007) 74
56. Sempere L.F., Cole C.N., McPeek M.A., and Peterson K.J. The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint. J Exp Zoolog B Mol Dev Evol 306 (2006) 575-588
57. Sempere L.F., Cole C.N., McPeek M.A., and Peterson K.J. The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint. J. Exp. Zoolog. B: Mol. Dev. Evol. 306 (2006) 575-588
58. Shamovsky I., Ivannikov M., Kandel E.S., Gershon D., and Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature 440 (2006) 556-560
59. Shankar G.M., Li S., Mehta T.H., Garcia-Munoz A., Shepardson N.E., Smith I., Brett F.M., Farrell M.A., Rowan M.J., Lemere C.A., Regan C.M., Walsh D.M., Sabatini B.L., and Selkoe D.J. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14 (2008) 837-842
60. Si K., Lindquist S., and Kandel E.R. A neuronal isoform of the aplysia CPEB has prion-like properties. Cell 115 (2003) 879-891
61. Smalheiser N.R. Synaptic enrichment of microRNAs in adult mouse forebrain is related to structural features of their precursors. Biol. Direct 3 (2008) 44
62. Snyder E.M., Nong Y., Almeida C.G., Paul S., Moran T., Choi E.Y., Nairn A.C., Salter M.W., Lombroso P.J., Gouras G.K., and Greengard P. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8 (2005) 1051-1058
63. Solda G., Boi S., Duga S., Fornasari D., Benfante R., Malcovati M., and Tenchini M.L. In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs. Gene 345 (2005) 155-164
64. St. Laurent III G., and Wahlestedt C. Noncoding RNAs: couplers of analog and digital information in nervous system function?. Trends Neurosci. 30 (2007) 612-621
65. Steiner E., Holzmann K., Pirker C., Elbling L., Micksche M., Sutterluty H., and Berger W. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. J Cell Sci 119 (2006) 459-469
66. Szalay M.S., Kovacs I.A., Korcsmaros T., Bode C., and Csermely P. Stress-induced rearrangements of cellular networks: Consequences for protection and drug design. FEBS Lett. 581 (2007) 3675-3680
67. Taft R.J., Pheasant M., and Mattick J.S. The relationship between non-protein-coding DNA and eukaryotic complexity. Bioessays 29 (2007) 288-299
68. Thrash-Bingham C.A., and Tartof K.D. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. J. Natl. Cancer Inst. 91 (1999) 143-151
69. Tiedge H., Fremeau Jr. R.T., Weinstock P.H., Arancio O., and Brosius J. Dendritic location of neural BC1 RNA. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 2093-2097
70. Uchida T., Rossignol F., Matthay M.A., Mounier R., Couette S., Clottes E., and Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 279 (2004) 14871-14878
71. Wang W.X., Rajeev B.W., Stromberg A.J., Ren N., Tang G., Huang Q., Rigoutsos I., and Nelson P.T. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28 (2008) 1213-1223
72. Wang X., Arai S., Song X., Reichart D., Du K., Pascual G., Tempst P., Rosenfeld M.G., Glass C.K., and Kurokawa R. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 454 (2008) 126-130
73. Westmark C.J., and Malter J.S. FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 5 (2007) e52
74. Willem M., Garratt A.N., Novak B., Citron M., Kaufmann S., Rittger A., DeStrooper B., Saftig P., Birchmeier C., and Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314 (2006) 664-666
75. Willingham A.T., and Gingeras T.R. TUF love for "junk" DNA. Cell 125 (2006) 1215-1220
76. Zhu D., Lai Y., Shelat P.B., Hu C., Sun G.Y., and Lee J.C. Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction. J Neurosci 26 (2006) 11111-11119