Modulation of Aire regulates the expression of tissue-restricted antigens

Molecular Immunology

Volumn 45, Issue 1, 2008, Pages 25-33

  Kont, Vivian ^a   Laan, Martti ^a   Kisand, Kai ^a   Merits, Andres ^a   Scott, Hamish S ^b   Peterson, Pärt ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Autoimmune regulator; Autoimmunity; Thymus; Tissue restricted antigens

Indexed keywords

ANTIGEN; AUTOIMMUNE REGULATOR PROTEIN; TISSUE RESTRICTED ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; EPITHELIUM CELL; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; THYMUS; UPREGULATION;

ANIMALS; ANTIGENS; EMBRYO; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; INSULIN; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCINS; ORGAN SPECIFICITY; PROTEINS; SALIVARY PROTEINS; STROMAL CELLS; THYMUS GLAND; TRANSCRIPTION FACTORS;

LOTUS; MUS;

EID: 34548285420     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.05.014     Document Type: Article

References (46)

1. Akiyama T., Maeda S., Yamane S., Ogino K., Kasai M., Kajiura F., Matsumoto M., and Inoue J. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 (2005) 248-251
2. Anderson G., Jenkinson W.E., Jones T., Parnell S.M., Kinsella F.A., White A.J., Pongrac'z J.E., Rossi S.W., and Jenkinson E.J. Establishment and functioning of intrathymic microenvironments. Immunol. Rev. 209 (2006) 10-27
3. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., and Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 (2002) 1395-1401
4. Bjorses P., Pelto-Huikko M., Kaukonen J., Aaltonen J., Peltonen L., and Ulmanen I. Localization of the APECED protein in distinct nuclear structures. Hum. Mol. Genet. 8 (1999) 259-266
5. Blechschmidt K., Schweiger M., Wertz K., Poulson R., Christensen H.M., Rosenthal A., Lehrach H., and Yaspo M.L. The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. Genome Res. 9 (1999) 158-166
6. Boehm T., Scheu S., Pfeffer K., and Bleul C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J. Exp. Med. 198 (2003) 757-769
7. Burkly L., Hession C., Ogata L., Reilly C., Marconi L.A., Olson D., Tizard R., Cate R., and Lo D. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373 (1995) 531-536
8. Chentoufi A.A., and Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51 (2002) 1383-1390
9. Chin R.K., Lo J.C., Kim O., Blink S.E., Christiansen P.A., Peterson P., Wang Y., Ware C., and Fu Y.X. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4 (2003) 1121-1127
10. Cook D.L., Gerber A.N., and Tapscott S.J. Modeling stochastic gene expression: implications for haploinsufficiency. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 15641-15646
11. Derbinski J., Gabler J., Brors B., Tierling S., Jonnakuty S., Hergenhahn M., Peltonen L., Walter J., and Kyewski B. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202 (2005) 33-45
12. Derbinski J., Schulte A., Kyewski B., and Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2 (2001) 1032-1039
13. Dickinson D.P., Abel K., Near J., Taylor B.A., and Gross K.W. Genetic and tissue-specific variation in the expression of a closely linked murine multigene family on chromosome 15 that encodes salivary and lacrimal proteins. Biochem. Genet. 27 (1989) 613-637
14. Everett R.D., and Chelbi-Alix M.K. PML and PML nuclear bodies: implications in antiviral defence. Biochimie (2007)
15. Gillard G.O., Dooley J., Erickson M., Peltonen L., and Farr A.G. Aire-dependent alterations in medullary thymic epithelium indicate a role for aire in thymic epithelial differentiation. J. Immunol. 178 (2007) 3007-3015
16. Gotter J., and Kyewski B. Regulating self-tolerance by deregulating gene expression. Curr. Opin. Immunol. 16 (2004) 741-745
17. Gray D.H., Seach N., Ueno T., Milton M.K., Liston A., Lew A.M., Goodnow C.C., and Boyd R.L. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108 (2006) 3777-3785
18. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2509-2514
19. Heino M., Peterson P., Kudoh J., Nagamine K., Lagerstedt A., Ovod V., Ranki A., Rantala I., Nieminen M., Tuukkanen J., Scott H.S., Antonarakis S.E., Shimizu N., and Krohn K. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257 (1999) 821-825
20. Heino M., Peterson P., Sillanpaa N., Guerin S., Wu L., Anderson G., Scott H.S., Antonarakis S.E., Kudoh J., Shimizu N., Jenkinson E.J., Naquet P., and Krohn K.J. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30 (2000) 1884-1893
21. Hoffmann W., and Jagla W. Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. Int. Rev. Cytol. 213 (2002) 147-181
22. Jay P.Y., Rozhitskaya O., Tarnavski O., Sherwood M.C., Dorfman A.L., Lu Y., Ueyama T., and Izumo S. Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. Faseb J. 19 (2005) 1495-1497
23. Jenkinson E.J., Anderson G., and Owen J.J. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176 (1992) 845-853
24. Jenkinson W.E., Jenkinson E.J., and Anderson G. Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors. J. Exp. Med. 198 (2003) 325-332
25. Jenkinson W.E., Rossi S.W., Jenkinson E.J., and Anderson G. Development of functional thymic epithelial cells occurs independently of lymphostromal interactions. Mech. Dev. 122 (2005) 1294-1299
26. Jiang W., Anderson M.S., Bronson R., Mathis D., and Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202 (2005) 805-815
27. Kaern M., Elston T.C., Blake W.J., and Collins J.J. Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet. 6 (2005) 451-464
28. Karam S.M., Tomasetto C., and Rio M.C. Trefoil factor 1 is required for the commitment programme of mouse oxyntic epithelial progenitors. Gut 53 (2004) 1408-1415
29. Kinoshita D., Hirota F., Kaisho T., Kasai M., Izumi K., Bando Y., Mouri Y., Matsushima A., Niki S., Han H., Oshikawa K., Kuroda N., Maegawa M., Irahara M., Takeda K., Akira S., and Matsumoto M. Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance. J. Immunol. 176 (2006) 3995-4002
30. Kumar P.G., Laloraya M., Wang C.Y., Ruan Q.G., Davoodi-Semiromi A., Kao K.J., and She J.X. The autoimmune regulator (AIRE) is a DNA-binding protein. J. Biol. Chem. 276 (2001) 41357-41364
31. Kuroda N., Mitani T., Takeda N., Ishimaru N., Arakaki R., Hayashi Y., Bando Y., Izumi K., Takahashi T., Nomura T., Sakaguchi S., Ueno T., Takahama Y., Uchida D., Sun S., Kajiura F., Mouri Y., Han H., Matsushima A., Yamada G., and Matsumoto M. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174 (2005) 1862-1870
32. Kyewski B., and Klein L. A central role for central tolerance. Annu. Rev. Immunol. 24 (2006) 571-606
33. Lee J.W., Epardaud M., Sun J., Becker J.E., Cheng A.C., Yonekura A.R., Heath J.K., and Turley S.J. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat. Immunol. 8 (2007) 181-190
34. Liston A., Gray D.H., Lesage S., Fletcher A.L., Wilson J., Webster K.E., Scott H.S., Boyd R.L., Peltonen L., and Goodnow C.C. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200 (2004) 1015-1026
35. Liston A., Lesage S., Wilson J., Peltonen L., and Goodnow C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4 (2003) 350-354
36. Mizuochi T., Kasai M., Kokuho T., Kakiuchi T., and Hirokawa K. Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells. J. Exp. Med. 175 (1992) 1601-1605
37. Nagamine K., Peterson P., Scott H.S., Kudoh J., Minoshima S., Heino M., Krohn K.J., Lalioti M.D., Mullis P.E., Antonarakis S.E., Kawasaki K., Asakawa S., Ito F., and Shimizu N. Positional cloning of the APECED gene. Nat. Genet. 17 (1997) 393-398
38. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Clin. Endocrinol. Metab. 91 (2006) 2843-2850
39. Peterson P., and Peltonen L. Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity. J. Autoimmun. 25 (2005) 49-55
40. Pitkanen J., Doucas V., Sternsdorf T., Nakajima T., Aratani S., Jensen K., Will H., Vahamurto P., Ollila J., Vihinen M., Scott H.S., Antonarakis S.E., Kudoh J., Shimizu N., Krohn K., and Peterson P. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275 (2000) 16802-16809
41. Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Kampe O., Eskelin P., Pelto-Huikko M., and Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11 (2002) 397-409
42. Shaw P.H., Held W.A., and Hastie N.D. The gene family for major urinary proteins: expression in several secretory tissues of the mouse. Cell 32 (1983) 755-761
43. Sousa Cardoso R., Magalhaes D.A., Baiao A.M., Junta C.M., Macedo C., Marques M.M., Sakamoto-Hojo E.T., Donadi E.A., and Passos G.A. Onset of promiscuous gene expression in murine fetal thymus organ culture. Immunology 119 (2006) 369-375
44. Van Ewijk W., Shores E.W., and Singer A. Crosstalk in the mouse thymus. Immunol. Today 15 (1994) 214-217
45. Zhang B., Wang Z., Ding J., Peterson P., Gunning W.T., and Ding H.F. NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. J. Biol. Chem. 281 (2006) 38617-38624
46. Zuklys S., Balciunaite G., Agarwal A., Fasler-Kan E., Palmer E., and Hollander G.A. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Immunol. 165 (2000) 1976-1983