-
1
-
-
0034624828
-
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
-
Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
-
(2000)
Nature
, vol.404
, pp. 193-197
-
-
Akashi, K.1
Traver, D.2
Miyamoto, T.3
Weissman, I.L.4
-
2
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperley J.F., Gardembas M., Melo J.V., Russell-Jones R., Bain B.J., Baxter E.J., Chase A., Chessells J.M., Colombat M., Dearden C.E., et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N. Engl. J. Med. 347 (2002) 481-487
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
Russell-Jones, R.4
Bain, B.J.5
Baxter, E.J.6
Chase, A.7
Chessells, J.M.8
Colombat, M.9
Dearden, C.E.10
-
3
-
-
0013312329
-
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
-
Armstrong S.A., Kung A.L., Mabon M.E., Silverman L.B., Stam R.W., Den Boer M.L., Pieters R., Kersey J.H., Sallan S.E., Fletcher J.A., et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 3 (2003) 173-183
-
(2003)
Cancer Cell
, vol.3
, pp. 173-183
-
-
Armstrong, S.A.1
Kung, A.L.2
Mabon, M.E.3
Silverman, L.B.4
Stam, R.W.5
Den Boer, M.L.6
Pieters, R.7
Kersey, J.H.8
Sallan, S.E.9
Fletcher, J.A.10
-
4
-
-
18544375333
-
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
-
Armstrong S.A., Staunton J.E., Silverman L.B., Pieters R., den Boer M.L., Minden M.D., Sallan S.E., Lander E.S., Golub T.R., and Korsmeyer S.J. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat. Genet. 30 (2002) 41-47
-
(2002)
Nat. Genet.
, vol.30
, pp. 41-47
-
-
Armstrong, S.A.1
Staunton, J.E.2
Silverman, L.B.3
Pieters, R.4
den Boer, M.L.5
Minden, M.D.6
Sallan, S.E.7
Lander, E.S.8
Golub, T.R.9
Korsmeyer, S.J.10
-
5
-
-
33947388857
-
Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease
-
Baldwin B.R., Li L., Tse K.F., Small S., Collector M., Whartenby K.A., Sharkis S.J., Racke F., Huso D., and Small D. Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease. Leukemia 21 (2007) 764-771
-
(2007)
Leukemia
, vol.21
, pp. 764-771
-
-
Baldwin, B.R.1
Li, L.2
Tse, K.F.3
Small, S.4
Collector, M.5
Whartenby, K.A.6
Sharkis, S.J.7
Racke, F.8
Huso, D.9
Small, D.10
-
6
-
-
34347346041
-
Prognostic factors and risk assessment in chronic myelomonocytic leukemia: Validation study of the M.D. Anderson Prognostic Scoring System
-
Beran M., Wen S., Shen Y., Onida F., Jelinek J., Cortes J., Giles F., and Kantarjian H. Prognostic factors and risk assessment in chronic myelomonocytic leukemia: Validation study of the M.D. Anderson Prognostic Scoring System. Leuk. Lymphoma 48 (2007) 1150-1160
-
(2007)
Leuk. Lymphoma
, vol.48
, pp. 1150-1160
-
-
Beran, M.1
Wen, S.2
Shen, Y.3
Onida, F.4
Jelinek, J.5
Cortes, J.6
Giles, F.7
Kantarjian, H.8
-
7
-
-
27544450742
-
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation
-
Brandts C.H., Sargin B., Rode M., Biermann C., Lindtner B., Schwable J., Buerger H., Muller-Tidow C., Choudhary C., McMahon M., et al. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res. 65 (2005) 9643-9650
-
(2005)
Cancer Res.
, vol.65
, pp. 9643-9650
-
-
Brandts, C.H.1
Sargin, B.2
Rode, M.3
Biermann, C.4
Lindtner, B.5
Schwable, J.6
Buerger, H.7
Muller-Tidow, C.8
Choudhary, C.9
McMahon, M.10
-
8
-
-
13344282746
-
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias
-
Carow C.E., Levenstein M., Kaufmann S.H., Chen J., Amin S., Rockwell P., Witte L., Borowitz M.J., Civin C.I., and Small D. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood 87 (1996) 1089-1096
-
(1996)
Blood
, vol.87
, pp. 1089-1096
-
-
Carow, C.E.1
Levenstein, M.2
Kaufmann, S.H.3
Chen, J.4
Amin, S.5
Rockwell, P.6
Witte, L.7
Borowitz, M.J.8
Civin, C.I.9
Small, D.10
-
9
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng T., Rodrigues N., Shen H., Yang Y., Dombkowski D., Sykes M., and Scadden D.T. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (2000) 1804-1808
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
10
-
-
22044448746
-
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
-
Choudhary C., Schwable J., Brandts C., Tickenbrock L., Sargin B., Kindler T., Fischer T., Berdel W.E., Muller-Tidow C., and Serve H. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 106 (2005) 265-273
-
(2005)
Blood
, vol.106
, pp. 265-273
-
-
Choudhary, C.1
Schwable, J.2
Brandts, C.3
Tickenbrock, L.4
Sargin, B.5
Kindler, T.6
Fischer, T.7
Berdel, W.E.8
Muller-Tidow, C.9
Serve, H.10
-
11
-
-
0028222367
-
Expression of the FLT3 gene in human leukemia-lymphoma cell lines
-
DaSilva N., Hu Z.B., Ma W., Rosnet O., Birnbaum D., and Drexler H.G. Expression of the FLT3 gene in human leukemia-lymphoma cell lines. Leukemia 8 (1994) 885-888
-
(1994)
Leukemia
, vol.8
, pp. 885-888
-
-
DaSilva, N.1
Hu, Z.B.2
Ma, W.3
Rosnet, O.4
Birnbaum, D.5
Drexler, H.G.6
-
12
-
-
33845991464
-
Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders
-
David M., Cross N.C., Burgstaller S., Chase A., Curtis C., Dang R., Gardembas M., Goldman J.M., Grand F., Hughes G., et al. Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders. Blood 109 (2007) 61-64
-
(2007)
Blood
, vol.109
, pp. 61-64
-
-
David, M.1
Cross, N.C.2
Burgstaller, S.3
Chase, A.4
Curtis, C.5
Dang, R.6
Gardembas, M.7
Goldman, J.M.8
Grand, F.9
Hughes, G.10
-
13
-
-
0041785491
-
MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP
-
Deguchi K., Ayton P.M., Carapeti M., Kutok J.L., Snyder C.S., Williams I.R., Cross N.C., Glass C.K., Cleary M.L., and Gilliland D.G. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 3 (2003) 259-271
-
(2003)
Cancer Cell
, vol.3
, pp. 259-271
-
-
Deguchi, K.1
Ayton, P.M.2
Carapeti, M.3
Kutok, J.L.4
Snyder, C.S.5
Williams, I.R.6
Cross, N.C.7
Glass, C.K.8
Cleary, M.L.9
Gilliland, D.G.10
-
14
-
-
0030002950
-
Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
-
Drexler H.G. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia 10 (1996) 588-599
-
(1996)
Leukemia
, vol.10
, pp. 588-599
-
-
Drexler, H.G.1
-
15
-
-
0024273333
-
Prognostic factors in adult chronic myelomonocytic leukemia: An analysis of 107 cases
-
Fenaux P., Beuscart R., Lai J.L., Jouet J.P., and Bauters F. Prognostic factors in adult chronic myelomonocytic leukemia: An analysis of 107 cases. J. Clin. Oncol. 6 (1988) 1417-1424
-
(1988)
J. Clin. Oncol.
, vol.6
, pp. 1417-1424
-
-
Fenaux, P.1
Beuscart, R.2
Lai, J.L.3
Jouet, J.P.4
Bauters, F.5
-
16
-
-
0037114829
-
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
-
Frohling S., Schlenk R.F., Breitruck J., Benner A., Kreitmeier S., Tobis K., Dohner H., and Dohner K. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 100 (2002) 4372-4380
-
(2002)
Blood
, vol.100
, pp. 4372-4380
-
-
Frohling, S.1
Schlenk, R.F.2
Breitruck, J.3
Benner, A.4
Kreitmeier, S.5
Tobis, K.6
Dohner, H.7
Dohner, K.8
-
17
-
-
0029134556
-
Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors
-
Gabbianelli M., Pelosi E., Montesoro E., Valtieri M., Luchetti L., Samoggia P., Vitelli L., Barberi T., Testa U., Lyman S., et al. Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 86 (1995) 1661-1670
-
(1995)
Blood
, vol.86
, pp. 1661-1670
-
-
Gabbianelli, M.1
Pelosi, E.2
Montesoro, E.3
Valtieri, M.4
Luchetti, L.5
Samoggia, P.6
Vitelli, L.7
Barberi, T.8
Testa, U.9
Lyman, S.10
-
18
-
-
0036720398
-
The roles of FLT3 in hematopoiesis and leukemia
-
Gilliland D.G., and Griffin J.D. The roles of FLT3 in hematopoiesis and leukemia. Blood 100 (2002) 1532-1542
-
(2002)
Blood
, vol.100
, pp. 1532-1542
-
-
Gilliland, D.G.1
Griffin, J.D.2
-
19
-
-
20444402664
-
FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
-
Grundler R., Miething C., Thiede C., Peschel C., and Duyster J. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Blood 105 (2005) 4792-4799
-
(2005)
Blood
, vol.105
, pp. 4792-4799
-
-
Grundler, R.1
Miething, C.2
Thiede, C.3
Peschel, C.4
Duyster, J.5
-
20
-
-
0034598830
-
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
-
Hayakawa F., Towatari M., Kiyoi H., Tanimoto M., Kitamura T., Saito H., and Naoe T. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19 (2000) 624-631
-
(2000)
Oncogene
, vol.19
, pp. 624-631
-
-
Hayakawa, F.1
Towatari, M.2
Kiyoi, H.3
Tanimoto, M.4
Kitamura, T.5
Saito, H.6
Naoe, T.7
-
21
-
-
0029984081
-
Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells
-
Hjertson M., Sundstrom C., Lyman S.D., Nilsson K., and Nilsson G. Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells. Exp. Hematol. 24 (1996) 748-754
-
(1996)
Exp. Hematol.
, vol.24
, pp. 748-754
-
-
Hjertson, M.1
Sundstrom, C.2
Lyman, S.D.3
Nilsson, K.4
Nilsson, G.5
-
22
-
-
16944366584
-
Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
-
Horiike S., Yokota S., Nakao M., Iwai T., Sasai Y., Kaneko H., Taniwaki M., Kashima K., Fujii H., Abe T., and Misawa S. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia 11 (1997) 1442-1446
-
(1997)
Leukemia
, vol.11
, pp. 1442-1446
-
-
Horiike, S.1
Yokota, S.2
Nakao, M.3
Iwai, T.4
Sasai, Y.5
Kaneko, H.6
Taniwaki, M.7
Kashima, K.8
Fujii, H.9
Abe, T.10
Misawa, S.11
-
23
-
-
0032843305
-
High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells
-
Ishii E., Zaitsu M., Ihara K., Hara T., and Miyazaki S. High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells. Pediatr. Hematol. Oncol. 16 (1999) 437-441
-
(1999)
Pediatr. Hematol. Oncol.
, vol.16
, pp. 437-441
-
-
Ishii, E.1
Zaitsu, M.2
Ihara, K.3
Hara, T.4
Miyazaki, S.5
-
24
-
-
0037062350
-
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
-
Kelly L.M., Kutok J.L., Williams I.R., Boulton C.L., Amaral S.M., Curley D.P., Ley T.J., and Gilliland D.G. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc. Natl. Acad. Sci. USA 99 (2002) 8283-8288
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8283-8288
-
-
Kelly, L.M.1
Kutok, J.L.2
Williams, I.R.3
Boulton, C.L.4
Amaral, S.M.5
Curley, D.P.6
Ley, T.J.7
Gilliland, D.G.8
-
25
-
-
0036093475
-
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
-
Kelly L.M., Liu Q., Kutok J.L., Williams I.R., Boulton C.L., and Gilliland D.G. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood 99 (2002) 310-318
-
(2002)
Blood
, vol.99
, pp. 310-318
-
-
Kelly, L.M.1
Liu, Q.2
Kutok, J.L.3
Williams, I.R.4
Boulton, C.L.5
Gilliland, D.G.6
-
26
-
-
0033134792
-
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
-
Kiyoi H., Naoe T., Nakano Y., Yokota S., Minami S., Miyawaki S., Asou N., Kuriyama K., Jinnai I., Shimazaki C., et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 93 (1999) 3074-3080
-
(1999)
Blood
, vol.93
, pp. 3074-3080
-
-
Kiyoi, H.1
Naoe, T.2
Nakano, Y.3
Yokota, S.4
Minami, S.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Jinnai, I.9
Shimazaki, C.10
-
27
-
-
0031686409
-
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
-
Kiyoi H., Towatari M., Yokota S., Hamaguchi M., Ohno R., Saito H., and Naoe T. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 12 (1998) 1333-1337
-
(1998)
Leukemia
, vol.12
, pp. 1333-1337
-
-
Kiyoi, H.1
Towatari, M.2
Yokota, S.3
Hamaguchi, M.4
Ohno, R.5
Saito, H.6
Naoe, T.7
-
28
-
-
0030831130
-
Identification of clonogenic common lymphoid progenitors in mouse bone marrow
-
Kondo M., Weissman I.L., and Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91 (1997) 661-672
-
(1997)
Cell
, vol.91
, pp. 661-672
-
-
Kondo, M.1
Weissman, I.L.2
Akashi, K.3
-
29
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis P.D., Gale R.E., Frew M.E., Harrison G., Langabeer S.E., Belton A.A., Walker H., Wheatley K., Bowen D.T., Burnett A.K., et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98 (2001) 1752-1759
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
Harrison, G.4
Langabeer, S.E.5
Belton, A.A.6
Walker, H.7
Wheatley, K.8
Bowen, D.T.9
Burnett, A.K.10
-
30
-
-
28344449144
-
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model
-
Lee B.H., Williams I.R., Anastasiadou E., Boulton C.L., Joseph S.W., Amaral S.M., Curley D.P., Duclos N., Huntly B.J., Fabbro D., et al. FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model. Oncogene 24 (2005) 7882-7892
-
(2005)
Oncogene
, vol.24
, pp. 7882-7892
-
-
Lee, B.H.1
Williams, I.R.2
Anastasiadou, E.3
Boulton, C.L.4
Joseph, S.W.5
Amaral, S.M.6
Curley, D.P.7
Duclos, N.8
Huntly, B.J.9
Fabbro, D.10
-
31
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine R.L., Wadleigh M., Cools J., Ebert B.L., Wernig G., Huntly B.J., Boggon T.J., Wlodarska I., Clark J.J., Moore S., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7 (2005) 387-397
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
-
32
-
-
33947220301
-
FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
-
Li L., Piloto O., Kim K.T., Ye Z., Nguyen H.B., Yu X., Levis M., Cheng L., and Small D. FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Br. J. Haematol. 137 (2007) 64-75
-
(2007)
Br. J. Haematol.
, vol.137
, pp. 64-75
-
-
Li, L.1
Piloto, O.2
Kim, K.T.3
Ye, Z.4
Nguyen, H.B.5
Yu, X.6
Levis, M.7
Cheng, L.8
Small, D.9
-
33
-
-
33749364564
-
Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia
-
Lin P., Jones D., Medeiros L.J., Chen W., Vega-Vazquez F., and Luthra R. Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia. Am. J. Clin. Pathol. 126 (2006) 530-533
-
(2006)
Am. J. Clin. Pathol.
, vol.126
, pp. 530-533
-
-
Lin, P.1
Jones, D.2
Medeiros, L.J.3
Chen, W.4
Vega-Vazquez, F.5
Luthra, R.6
-
34
-
-
0029097145
-
Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
-
Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., and Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3 (1995) 147-161
-
(1995)
Immunity
, vol.3
, pp. 147-161
-
-
Mackarehtschian, K.1
Hardin, J.D.2
Moore, K.A.3
Boast, S.4
Goff, S.P.5
Lemischka, I.R.6
-
35
-
-
0029145627
-
Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines
-
Meierhoff G., Dehmel U., Gruss H.J., Rosnet O., Birnbaum D., Quentmeier H., Dirks W., and Drexler H.G. Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines. Leukemia 9 (1995) 1368-1372
-
(1995)
Leukemia
, vol.9
, pp. 1368-1372
-
-
Meierhoff, G.1
Dehmel, U.2
Gruss, H.J.3
Rosnet, O.4
Birnbaum, D.5
Quentmeier, H.6
Dirks, W.7
Drexler, H.G.8
-
36
-
-
0034554796
-
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
-
Mizuki M., Fenski R., Halfter H., Matsumura I., Schmidt R., Muller C., Gruning W., Kratz-Albers K., Serve S., Steur C., et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 96 (2000) 3907-3914
-
(2000)
Blood
, vol.96
, pp. 3907-3914
-
-
Mizuki, M.1
Fenski, R.2
Halfter, H.3
Matsumura, I.4
Schmidt, R.5
Muller, C.6
Gruning, W.7
Kratz-Albers, K.8
Serve, S.9
Steur, C.10
-
37
-
-
0028534860
-
The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
-
Morrison S.J., and Weissman I.L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1 (1994) 661-673
-
(1994)
Immunity
, vol.1
, pp. 661-673
-
-
Morrison, S.J.1
Weissman, I.L.2
-
38
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao M., Yokota S., Iwai T., Kaneko H., Horiike S., Kashima K., Sonoda Y., Fujimoto T., and Misawa S. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 10 (1996) 1911-1918
-
(1996)
Leukemia
, vol.10
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
Kaneko, H.4
Horiike, S.5
Kashima, K.6
Sonoda, Y.7
Fujimoto, T.8
Misawa, S.9
-
39
-
-
0036464647
-
Prognostic factors and scoring systems in chronic myelomonocytic leukemia: A retrospective analysis of 213 patients
-
Onida F., Kantarjian H.M., Smith T.L., Ball G., Keating M.J., Estey E.H., Glassman A.B., Albitar M., Kwari M.I., and Beran M. Prognostic factors and scoring systems in chronic myelomonocytic leukemia: A retrospective analysis of 213 patients. Blood 99 (2002) 840-849
-
(2002)
Blood
, vol.99
, pp. 840-849
-
-
Onida, F.1
Kantarjian, H.M.2
Smith, T.L.3
Ball, G.4
Keating, M.J.5
Estey, E.H.6
Glassman, A.B.7
Albitar, M.8
Kwari, M.I.9
Beran, M.10
-
40
-
-
3142512347
-
Activating FLT3 mutations in CD117/KIT positive T-Cell acute lymphoblastic leukemias
-
Paietta E., Ferrando A.A., Neuberg D., Bennett J.M., Racevskis J., Lazarus H., Dewald G., Rowe J.M., Wiernik P.H., Tallman M.S., and Look A.T. Activating FLT3 mutations in CD117/KIT positive T-Cell acute lymphoblastic leukemias. Blood 104 (2004) 558-560
-
(2004)
Blood
, vol.104
, pp. 558-560
-
-
Paietta, E.1
Ferrando, A.A.2
Neuberg, D.3
Bennett, J.M.4
Racevskis, J.5
Lazarus, H.6
Dewald, G.7
Rowe, J.M.8
Wiernik, P.H.9
Tallman, M.S.10
Look, A.T.11
-
41
-
-
0038204191
-
Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease
-
Pardanani A., Reeder T.L., Kimlinger T.K., Baek J.Y., Li C.Y., Butterfield J.H., and Tefferi A. Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease. Leuk. Res. 27 (2003) 739-742
-
(2003)
Leuk. Res.
, vol.27
, pp. 739-742
-
-
Pardanani, A.1
Reeder, T.L.2
Kimlinger, T.K.3
Baek, J.Y.4
Li, C.Y.5
Butterfield, J.H.6
Tefferi, A.7
-
42
-
-
0029587212
-
The flt3/flk-2 ligand: Receptor distribution and action on murine haemopoietic cell survival and proliferation
-
Rasko J.E., Metcalf D., Rossner M.T., Begley C.G., and Nicola N.A. The flt3/flk-2 ligand: Receptor distribution and action on murine haemopoietic cell survival and proliferation. Leukemia 9 (1995) 2058-2066
-
(1995)
Leukemia
, vol.9
, pp. 2058-2066
-
-
Rasko, J.E.1
Metcalf, D.2
Rossner, M.T.3
Begley, C.G.4
Nicola, N.A.5
-
43
-
-
0030034761
-
FLT3/FLK-2 (STK-1) Ligand does not stimulate human megakaryopoiesis in vitro
-
Ratajczak M.Z., Ratajczak J., Ford J., Kregenow R., Marlicz W., and Gewirtz A.M. FLT3/FLK-2 (STK-1) Ligand does not stimulate human megakaryopoiesis in vitro. Stem Cells 14 (1996) 146-150
-
(1996)
Stem Cells
, vol.14
, pp. 146-150
-
-
Ratajczak, M.Z.1
Ratajczak, J.2
Ford, J.3
Kregenow, R.4
Marlicz, W.5
Gewirtz, A.M.6
-
44
-
-
33645312560
-
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML
-
Reindl C., Bagrintseva K., Vempati S., Schnittger S., Ellwart J.W., Wenig K., Hopfner K.P., Hiddemann W., and Spiekermann K. Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood 107 (2006) 3700-3707
-
(2006)
Blood
, vol.107
, pp. 3700-3707
-
-
Reindl, C.1
Bagrintseva, K.2
Vempati, S.3
Schnittger, S.4
Ellwart, J.W.5
Wenig, K.6
Hopfner, K.P.7
Hiddemann, W.8
Spiekermann, K.9
-
45
-
-
0348140592
-
Modeling the dosage effect of oncogenes in leukemogenesis
-
Ren R. Modeling the dosage effect of oncogenes in leukemogenesis. Curr. Opin. Hematol. 11 (2004) 25-34
-
(2004)
Curr. Opin. Hematol.
, vol.11
, pp. 25-34
-
-
Ren, R.1
-
46
-
-
33747189188
-
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
-
Rocnik J.L., Okabe R., Yu J.C., Lee B.H., Giese N., Schenkein D.P., and Gilliland D.G. Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood 108 (2006) 1339-1345
-
(2006)
Blood
, vol.108
, pp. 1339-1345
-
-
Rocnik, J.L.1
Okabe, R.2
Yu, J.C.3
Lee, B.H.4
Giese, N.5
Schenkein, D.P.6
Gilliland, D.G.7
-
47
-
-
0027130517
-
Hematopoietic receptors of class III receptor-type tyrosine kinases
-
Rosnet O., and Birnbaum D. Hematopoietic receptors of class III receptor-type tyrosine kinases. Crit. Rev. Oncog. 4 (1993) 595-613
-
(1993)
Crit. Rev. Oncog.
, vol.4
, pp. 595-613
-
-
Rosnet, O.1
Birnbaum, D.2
-
48
-
-
9244260192
-
Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
-
Rosnet O., Buhring H.J., Marchetto S., Rappold I., Lavagna C., Sainty D., Arnoulet C., Chabannon C., Kanz L., Hannum C., and Birnbaum D. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia 10 (1996) 238-248
-
(1996)
Leukemia
, vol.10
, pp. 238-248
-
-
Rosnet, O.1
Buhring, H.J.2
Marchetto, S.3
Rappold, I.4
Lavagna, C.5
Sainty, D.6
Arnoulet, C.7
Chabannon, C.8
Kanz, L.9
Hannum, C.10
Birnbaum, D.11
-
49
-
-
2442676466
-
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins
-
Scheijen B., Ngo H.T., Kang H., and Griffin J.D. FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins. Oncogene 23 (2004) 3338-3349
-
(2004)
Oncogene
, vol.23
, pp. 3338-3349
-
-
Scheijen, B.1
Ngo, H.T.2
Kang, H.3
Griffin, J.D.4
-
50
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
Schnittger S., Schoch C., Dugas M., Kern W., Staib P., Wuchter C., Loffler H., Sauerland C.M., Serve H., Buchner T., et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 100 (2002) 59-66
-
(2002)
Blood
, vol.100
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
Kern, W.4
Staib, P.5
Wuchter, C.6
Loffler, H.7
Sauerland, C.M.8
Serve, H.9
Buchner, T.10
-
51
-
-
1842420032
-
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
-
Smith B.D., Levis M., Beran M., Giles F., Kantarjian H., Berg K., Murphy K.M., Dauses T., Allebach J., and Small D. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 103 (2004) 3669-3676
-
(2004)
Blood
, vol.103
, pp. 3669-3676
-
-
Smith, B.D.1
Levis, M.2
Beran, M.3
Giles, F.4
Kantarjian, H.5
Berg, K.6
Murphy, K.M.7
Dauses, T.8
Allebach, J.9
Small, D.10
-
52
-
-
1242315428
-
Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia
-
Stirewalt D.L., Meshinchi S., Kussick S.J., Sheets K.M., Pogosova-Agadjanyan E., Willman C.L., and Radich J.P. Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br. J. Haematol. 124 (2004) 481-484
-
(2004)
Br. J. Haematol.
, vol.124
, pp. 481-484
-
-
Stirewalt, D.L.1
Meshinchi, S.2
Kussick, S.J.3
Sheets, K.M.4
Pogosova-Agadjanyan, E.5
Willman, C.L.6
Radich, J.P.7
-
53
-
-
0141465061
-
The role of FLT3 in haematopoietic malignancies
-
Stirewalt D.L., and Radich J.P. The role of FLT3 in haematopoietic malignancies. Nat. Rev. Cancer 3 (2003) 650-665
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 650-665
-
-
Stirewalt, D.L.1
Radich, J.P.2
-
54
-
-
19944427559
-
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
-
Stone R.M., DeAngelo D.J., Klimek V., Galinsky I., Estey E., Nimer S.D., Grandin W., Lebwohl D., Wang Y., Cohen P., et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 105 (2005) 54-60
-
(2005)
Blood
, vol.105
, pp. 54-60
-
-
Stone, R.M.1
DeAngelo, D.J.2
Klimek, V.3
Galinsky, I.4
Estey, E.5
Nimer, S.D.6
Grandin, W.7
Lebwohl, D.8
Wang, Y.9
Cohen, P.10
-
55
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C., Steudel C., Mohr B., Schaich M., Schakel U., Platzbecker U., Wermke M., Bornhauser M., Ritter M., Neubauer A., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99 (2002) 4326-4335
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
Schaich, M.4
Schakel, U.5
Platzbecker, U.6
Wermke, M.7
Bornhauser, M.8
Ritter, M.9
Neubauer, A.10
-
56
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., McDowell E.P., Lazo-Kallanian S., Williams I.R., Sears C., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128 (2007) 325-339
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
-
57
-
-
11144235822
-
After chronic myelogenous leukemia: Tyrosine kinase inhibitors in other hematologic malignancies
-
Wadleigh M., DeAngelo D.J., Griffin J.D., and Stone R.M. After chronic myelogenous leukemia: Tyrosine kinase inhibitors in other hematologic malignancies. Blood 105 (2005) 22-30
-
(2005)
Blood
, vol.105
, pp. 22-30
-
-
Wadleigh, M.1
DeAngelo, D.J.2
Griffin, J.D.3
Stone, R.M.4
-
58
-
-
33744490974
-
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G., Mercher T., Okabe R., Levine R.L., Lee B.H., and Gilliland D.G. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 107 (2006) 4274-4281
-
(2006)
Blood
, vol.107
, pp. 4274-4281
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
Levine, R.L.4
Lee, B.H.5
Gilliland, D.G.6
-
59
-
-
0035476264
-
Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
-
Whitman S.P., Archer K.J., Feng L., Baldus C., Becknell B., Carlson B.D., Carroll A.J., Mrozek K., Vardiman J.W., George S.L., et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study. Cancer Res. 61 (2001) 7233-7239
-
(2001)
Cancer Res.
, vol.61
, pp. 7233-7239
-
-
Whitman, S.P.1
Archer, K.J.2
Feng, L.3
Baldus, C.4
Becknell, B.5
Carlson, B.D.6
Carroll, A.J.7
Mrozek, K.8
Vardiman, J.W.9
George, S.L.10
-
60
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
-
Yamamoto Y., Kiyoi H., Nakano Y., Suzuki R., Kodera Y., Miyawaki S., Asou N., Kuriyama K., Yagasaki F., Shimazaki C., et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 97 (2001) 2434-2439
-
(2001)
Blood
, vol.97
, pp. 2434-2439
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
Suzuki, R.4
Kodera, Y.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Yagasaki, F.9
Shimazaki, C.10
|