Loss of STAG2 causes aneuploidy in normal human bladder cells

Genetics and Molecular Research

Volumn 14, Issue 1, 2015, Pages 2638-2646

  Li, X ^a,b   Zhang, T W ^a   Tang, J L ^b   Fa, P P ^c   Lu, J X ^b   Qi, F M ^b   Cai, Z M ^b   Liu, C X ^a   Sun, X J ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^c PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

Author keywords

Aneuploidy; Bladder cancer; Cohesin complex; Stromal antigen 2; Urologic neoplasms

Indexed keywords

CELL ANTIGEN; COHESIN; COMPLEMENT; MESSENGER RNA; PROTEIN RAD21; PROTEIN SMC1; PROTEIN SMC3; STROMAL ANTIGEN 2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CELL NUCLEUS ANTIGEN; NONHISTONE PROTEIN; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEOCHONDROITIN SULFATE; RAD21 PROTEIN, HUMAN; SMC3 PROTEIN, HUMAN; STAG2 PROTEIN, HUMAN; STRUCTURAL MAINTENANCE OF CHROMOSOME PROTEIN 1;

ANEUPLOIDY; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; BLADDER TUMOR; CELL ASSAY; CELL PROLIFERATION; CHROMOSOME SEGREGATION; CHROMOSOME SEPARATION; CONTROLLED STUDY; GENE; GENE FUNCTION; GENE LOSS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; KARYOTYPE; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAG2 GENE; TUMOR CELL; WESTERN BLOTTING; BLADDER; CELL LINE; CYTOLOGY; GENE EXPRESSION; GENETICS; KARYOTYPING; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE;

ANEUPLOIDY; ANTIGENS, NUCLEAR; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CHONDROITIN SULFATE PROTEOGLYCANS; CHROMOSOMAL PROTEINS, NON-HISTONE; GENE EXPRESSION; HUMANS; KARYOTYPING; NUCLEAR PROTEINS; PHOSPHOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 84926347122     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.March.30.24     Document Type: Article

References (25)

1. Balbás-Martínez C, Sagrera A, Carrillo-de-Santa-Pau E, Earl J, et al. (2013). Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat. Genet. 45: 1464-1469.
2. Canudas S and Smith S (2009). Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J. Cell Biol. 187: 165-173.
3. Chung NG, Kim MS, Yoo NJ and Lee SH (2012). Somatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias. Leuk. Lymphoma 53: 1234-1235.
4. Darwiche N, Freeman LA and Strunnikov A (1999). Characterization of the components of the putative mammalian sister chromatid cohesion complex. Gene 233: 39-47.
5. Deardorff MA, Wilde JJ, Albrecht M, Dickinson E, et al. (2012). RAD21 mutations cause a human cohesinopathy. Am. J. Hum. Genet. 90: 1014-1027.
6. Djos A, Fransson S, Kogner P and Martinsson T (2013). Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene. BMC Med. Genet. 14: 102.
7. Gruber S, Haering CH and Nasmyth K (2003). Chromosomal cohesin forms a ring. Cell 112: 765-777.
8. Guacci V, Koshland D and Strunnikov A (1997). A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S, cerevisiae. Cell 91: 47-57.
9. Guo G, Sun X, Chen C, Wu S, et al. (2013). Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat. Genet. 45: 1459-1463.
10. Iwaizumi M, Shinmura K, Mori H, Yamada H, et al. (2009). Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut 58: 249-260.
11. Kim MS, Kim SS, Je EM, Yoo NJ, et al. (2012). Mutational and expressional analyses of STAG2 gene in solid cancers. Neoplasma 59: 524-529.
12. Kitajima TS, Kawashima SA and Watanabe Y (2004). The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 427: 510-517.
13. Kon A, Shih LY, Minamino M, Sanada M, et al. (2013). Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat. Genet. 45: 1232-1237.
14. Losada A, Yokochi T, Kobayashi R and Hirano T (2000). Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. J. Cell Biol. 150: 405-416.
15. Michaelis C, Ciosk R and Nasmyth K (1997). Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91: 35-45.
16. Prieto I, Pezzi N, Buesa JM, Kremer L, et al. (2002). STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. EMBO Rep. 3: 543-550.
17. Salic A, Waters JC and Mitchison TJ (2004). Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell 118: 567-578.
18. Solomon DA, Kim T, Diaz-Martinez LA, Fair J, et al. (2011). Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 333: 1039-1043.
19. Solomon DA, Kim JS, Bondaruk J, Shariat SF, et al. (2013). Frequent truncating mutations of STAG2 in bladder cancer. Nat. Genet. 45: 1428-1430.
20. Sumara I, Vorlaufer E, Gieffers C, Peters BH, et al. (2000). Characterization of vertebrate cohesin complexes and their regulation in prophase. J. Cell Biol. 151: 749-762.
21. Taylor CF, Platt FM, Hurst CD, Thygesen HH, et al. (2013). Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumor grade and stage and inversely related to chromosomal copy number changes. Hum. Mol. Genet. [Epub ahead of print]
22. Wong RW (2010). An update on cohesin function as a ‘molecular glue’ on chromosomes and spindles. Cell Cycle 9: 1754-1758.
23. Xiao T, Wallace J and Felsenfeld G (2011). Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol. Cell. Biol. 31: 2174-2183.
24. Zhang N and Pati D (2009). Handcuff for sisters: a new model for sister chromatid cohesion. Cell Cycle 8: 399-402.
25. Zhang N, Kuznetsov SG, Sharan SK, Li K, et al. (2008). A handcuff model for the cohesin complex. J. Cell Biol.183: 1019-1031.