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Volumn 4, Issue 11, 2014, Pages 1326-1341

The genomic landscape of pediatric Ewing sarcoma

(34)  Crompton, Brian D a   Stewart, Chip b   Taylor Weiner, Amaro b   Alexe, Gabriela a,b,c   Kurek, Kyle C d   Calicchio, Monica L d   Kiezun, Adam b   Carter, Scott L b   Shukla, Sachet A a   Mehta, Swapnil S a   Thorner, Aaron R a   de Torres, Carmen e   Lavarino, Cinzia e   Suñol, Mariona e   McKenna, Aaron b   Sivachenko, Andrey b   Cibulskis, Kristian b   Lawrence, Michael S b   Stojanov, Petar a,b   Rosenberg, Mara b   more..


Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR A7; PROTEIN; PROTEIN P53; STROMAL ANTIGEN 2; TRANSCRIPTION FACTOR ETS; UNCLASSIFIED DRUG; CELL NUCLEUS ANTIGEN; DNA; STAG2 PROTEIN, HUMAN;

EID: 84908447818     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-13-1037     Document Type: Article
Times cited : (379)

References (73)
  • 3
    • 84896691170 scopus 로고    scopus 로고
    • Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusionpositive and fusion-negative tumors
    • Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusionpositive and fusion-negative tumors. Cancer Discov 2014; 4: 216-31.
    • (2014) Cancer Discov , vol.4 , pp. 216-231
    • Shern, J.F.1    Chen, L.2    Chmielecki, J.3    Wei, J.S.4    Patidar, R.5    Rosenberg, M.6
  • 4
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research N. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-74.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 5
    • 0026686674 scopus 로고
    • Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
    • Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-5.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3    Desmaze, C.4    Melot, T.5    Peter, M.6
  • 6
    • 0028307384 scopus 로고
    • A second Ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
    • Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. A second Ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 1994; 6: 146-51.
    • (1994) Nat Genet , vol.6 , pp. 146-151
    • Sorensen, P.H.1    Lessnick, S.L.2    Lopez-Terrada, D.3    Liu, X.F.4    Triche, T.J.5    Denny, C.T.6
  • 7
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing’s sarcoma
    • Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, et al. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing’s sarcoma. Cancer Cell 2006; 9: 405-16.
    • (2006) Cancer Cell , vol.9 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3    Wong, J.S.4    Whangbo, J.S.5    Golub, T.R.6
  • 8
    • 0037456435 scopus 로고    scopus 로고
    • Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone
    • Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348: 694-701.
    • (2003) N Engl J Med , vol.348 , pp. 694-701
    • Grier, H.E.1    Krailo, M.D.2    Tarbell, N.J.3    Link, M.P.4    Fryer, C.J.5    Pritchard, D.J.6
  • 11
    • 84891590949 scopus 로고    scopus 로고
    • Biomarkers in Ewing sarcoma: The promise and challenge of personalized medicine. A report from the Children’s Oncology Group
    • Shukla N, Schiffman J, Reed D, Davis IJ, Womer RB, Lessnick SL, et al. Biomarkers in Ewing sarcoma: the promise and challenge of personalized medicine. A report from the Children’s Oncology Group. Front Oncol 2013; 3: 141.
    • (2013) Front Oncol , vol.3 , pp. 141
    • Shukla, N.1    Schiffman, J.2    Reed, D.3    Davis, I.J.4    Womer, R.B.5    Lessnick, S.L.6
  • 12
    • 0030783770 scopus 로고    scopus 로고
    • Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors
    • Kovar H, Jug G, Aryee DN, Zoubek A, Ambros P, Gruber B, et al. Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. Oncogene 1997; 15: 2225-32.
    • (1997) Oncogene , vol.15 , pp. 2225-2232
    • Kovar, H.1    Jug, G.2    Aryee, D.N.3    Zoubek, A.4    Ambros, P.5    Gruber, B.6
  • 13
    • 20044367805 scopus 로고    scopus 로고
    • Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: A highly lethal subset associated with poor chemoresponse
    • Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos AG, Healey JH, et al. Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. J Clin Oncol 2005; 23: 548-58.
    • (2005) J Clin Oncol , vol.23 , pp. 548-558
    • Huang, H.Y.1    Illei, P.B.2    Zhao, Z.3    Mazumdar, M.4    Huvos, A.G.5    Healey, J.H.6
  • 14
    • 0027281872 scopus 로고
    • Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours
    • Kovar H, Auinger A, Jug G, Aryee D, Zoubek A, Salzer-Kuntschik M, et al. Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours. Oncogene 1993; 8: 2683-90.
    • (1993) Oncogene , vol.8 , pp. 2683-2690
    • Kovar, H.1    Auinger, A.2    Jug, G.3    Aryee, D.4    Zoubek, A.5    Salzer-Kuntschik, M.6
  • 16
    • 84905457348 scopus 로고    scopus 로고
    • The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation
    • Brohl AS, Solomon DA, Chang W, Wang J, Song Y, Sindiri S, et al. The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet 2014; 10: e1004475.
    • (2014) PLoS Genet , vol.10 , pp. 1004475
    • Brohl, A.S.1    Solomon, D.A.2    Chang, W.3    Wang, J.4    Song, Y.5    Sindiri, S.6
  • 17
    • 68149164796 scopus 로고    scopus 로고
    • Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: An analysis of 1631 cases from the SEER database, 1973-2005
    • Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973-2005. Cancer 2009; 115: 3526-36.
    • (2009) Cancer , vol.115 , pp. 3526-3536
    • Jawad, M.U.1    Cheung, M.C.2    Min, E.S.3    Schneiderbauer, M.M.4    Koniaris, L.G.5    Scully, S.P.6
  • 18
    • 3843084078 scopus 로고    scopus 로고
    • The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
    • Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer 2004; 91: 355-8.
    • (2004) Br J Cancer , vol.91 , pp. 355-358
    • Bamford, S.1    Dawson, E.2    Forbes, S.3    Clements, J.4    Pettett, R.5    Dogan, A.6
  • 20
    • 85081844368 scopus 로고    scopus 로고
    • Seattle, WA, Available from, Data retrieved April 2014
    • Exome Variant Server NGESPE. Seattle, WA.2014. Available from: http://evs.gs.washington.edu/EVS/. Data retrieved April 2014.
    • (2014)
  • 21
    • 84975795680 scopus 로고    scopus 로고
    • An integrated map of genetic variation from 1,092 human genomes
    • Genomes Project C
    • Genomes Project C Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, et al. An integrated map of genetic variation from 1,092 human genomes. Nature 2012; 491: 56-65.
    • (2012) Nature , vol.491 , pp. 56-65
    • Abecasis, G.R.1    Auton, A.2    Brooks, L.D.3    Depristo, M.A.4    Durbin, R.M.5
  • 22
    • 18244401894 scopus 로고    scopus 로고
    • Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex
    • Huber M, Siegenthaler G, Mirancea N, Marenholz I, Nizetic D, Breitkreutz D, et al. Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. J Invest Dermatol 2005; 124: 998-1007.
    • (2005) J Invest Dermatol , vol.124 , pp. 998-1007
    • Huber, M.1    Siegenthaler, G.2    Mirancea, N.3    Marenholz, I.4    Nizetic, D.5    Breitkreutz, D.6
  • 23
    • 0022837415 scopus 로고
    • Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family
    • Kim HS, Maeda N. Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family. J Biol Chem 1986; 261: 6712-8.
    • (1986) J Biol Chem , vol.261 , pp. 6712-6718
    • Kim, H.S.1    Maeda, N.2
  • 24
    • 0347626094 scopus 로고    scopus 로고
    • Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing’s sarcoma cells: Therapeutic prospects
    • Benini S, Manara MC, Cerisano V, Perdichizzi S, Strammiello R, S erra M, et al. Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing’s sarcoma cells: therapeutic prospects. Int J Cancer 2004; 108: 358-66.
    • (2004) Int J Cancer , vol.108 , pp. 358-366
    • Benini, S.1    Manara, M.C.2    Cerisano, V.3    Perdichizzi, S.4    Strammiello, R.5    S Erra, M.6
  • 25
    • 0034648695 scopus 로고    scopus 로고
    • Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation
    • Silvany RE, Eliazer S, Wolff NC, Ilaria RL. Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation. Oncogene 2000; 19: 4523-30.
    • (2000) Oncogene , vol.19 , pp. 4523-4530
    • Silvany, R.E.1    Eliazer, S.2    Wolff, N.C.3    Ilaria, R.L.4
  • 28
  • 29
    • 66349134225 scopus 로고    scopus 로고
    • Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors
    • Zenali MJ, Zhang PL, Bendel AE, Brown RE. Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors. Ann Clin Lab Sci 2009; 39: 160-6.
    • (2009) Ann Clin Lab Sci , vol.39 , pp. 160-166
    • Zenali, M.J.1    Zhang, P.L.2    Bendel, A.E.3    Brown, R.E.4
  • 30
    • 1642540093 scopus 로고    scopus 로고
    • Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation
    • Mateo-Lozano S, Tirado OM, Notario V. Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation. Oncogene 2003; 22: 9282-7.
    • (2003) Oncogene , vol.22 , pp. 9282-9287
    • Mateo-Lozano, S.1    Tirado, O.M.2    Notario, V.3
  • 31
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins AS, Mackintosh C, Martin DH, Campos M, Hernandez T, Ordonez JL, et al. Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 2006; 12: 3532-40.
    • (2006) Clin Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    Mackintosh, C.2    Martin, D.H.3    Campos, M.4    Hernandez, T.5    Ordonez, J.L.6
  • 32
    • 84877726490 scopus 로고    scopus 로고
    • High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma
    • Crompton BD, Carlton AL, Thorner AR, Christie AL, Du J, Calicchio ML, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res 2013; 73: 2873-83.
    • (2013) Cancer Res , vol.73 , pp. 2873-2883
    • Crompton, B.D.1    Carlton, A.L.2    Thorner, A.R.3    Christie, A.L.4    Du, J.5    Calicchio, M.L.6
  • 33
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R, Getz G. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol 2011; 12: R41.
    • (2011) Genome Biol , vol.12 , pp. R41
    • Mermel, C.H.1    Schumacher, S.E.2    Hill, B.3    Meyerson, M.L.4    Beroukhim, R.5    Getz, G.6
  • 38
    • 84897865695 scopus 로고    scopus 로고
    • Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes
    • Taylor CF, Platt FM, Hurst CD, Thygesen HH, Knowles MA. Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes. Hum Mol Genet 2014; 23: 1964-74.
    • (2014) Hum Mol Genet , vol.23 , pp. 1964-1974
    • Taylor, C.F.1    Platt, F.M.2    Hurst, C.D.3    Thygesen, H.H.4    Knowles, M.A.5
  • 39
    • 0027230568 scopus 로고
    • Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
    • May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, et al. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A 1993; 90: 5752-6.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3    Lunsford, L.B.4    Lewis, B.C.5    Delattre, O.6
  • 40
    • 0027438827 scopus 로고
    • Combinatorial generation of variable fusion proteins in the Ewing family of tumours
    • Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, et al. Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J 1993; 12: 4481-7.
    • (1993) EMBO J , vol.12 , pp. 4481-4487
    • Zucman, J.1    Melot, T.2    Desmaze, C.3    Ghysdael, J.4    Plougastel, B.5    Peter, M.6
  • 41
    • 84878575138 scopus 로고    scopus 로고
    • Multiple splice variants of EWSR1-ETS fusion transcripts co-existing in the Ewing sarcoma family of tumors
    • Patocs B, Nemeth K, Garami M, Arato G, Kovalszky I, Szendroi M, et al. Multiple splice variants of EWSR1-ETS fusion transcripts co-existing in the Ewing sarcoma family of tumors. Cell Oncol 2013; 36: 191-200.
    • (2013) Cell Oncol , vol.36 , pp. 191-200
    • Patocs, B.1    Nemeth, K.2    Garami, M.3    Arato, G.4    Kovalszky, I.5    Szendroi, M.6
  • 42
    • 0029095176 scopus 로고
    • ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
    • Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ. ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J 1995; 14: 4781-93.
    • (1995) EMBO J , vol.14 , pp. 4781-4793
    • Sgouras, D.N.1    Athanasiou, M.A.2    Beal, G.J.3    Fisher, R.J.4    Blair, D.G.5    Mavrothalassitis, G.J.6
  • 48
    • 84875135862 scopus 로고    scopus 로고
    • Criteria for inference of chromothripsis in cancer genomes
    • Korbel JO, Campbell PJ. Criteria for inference of chromothripsis in cancer genomes. Cell 2013; 152: 1226-36.
    • (2013) Cell , vol.152 , pp. 1226-1236
    • Korbel, J.O.1    Campbell, P.J.2
  • 54
    • 84888380730 scopus 로고    scopus 로고
    • Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
    • Guo G, Sun X, Chen C, Wu S, Huang P, Li Z, et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet 2013; 45: 1459-63.
    • (2013) Nat Genet , vol.45 , pp. 1459-1463
    • Guo, G.1    Sun, X.2    Chen, C.3    Wu, S.4    Huang, P.5    Li, Z.6
  • 55
    • 84885021313 scopus 로고    scopus 로고
    • Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
    • Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet 2013; 45: 1232-7.
    • (2013) Nat Genet , vol.45 , pp. 1232-1237
    • Kon, A.1    Shih, L.Y.2    Minamino, M.3    Sanada, M.4    Shiraishi, Y.5    Nagata, Y.6
  • 58
    • 84882738244 scopus 로고    scopus 로고
    • Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites
    • Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, et al. Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 2013; 154: 801-13.
    • (2013) Cell , vol.154 , pp. 801-813
    • Yan, J.1    Enge, M.2    Whitington, T.3    Dave, K.4    Liu, J.5    Sur, I.6
  • 59
    • 20944444999 scopus 로고    scopus 로고
    • Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion
    • Vega H, Waisfisz Q, Gordillo M, Sakai N, Yanagihara I, Yamada M, et al. Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 2005; 37: 468-70.
    • (2005) Nat Genet , vol.37 , pp. 468-470
    • Vega, H.1    Waisfisz, Q.2    Gordillo, M.3    Sakai, N.4    Yanagihara, I.5    Yamada, M.6
  • 60
    • 59849113821 scopus 로고    scopus 로고
    • Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing
    • Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, et al. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol 2009; 27: 182-9.
    • (2009) Nat Biotechnol , vol.27 , pp. 182-189
    • Gnirke, A.1    Melnikov, A.2    Maguire, J.3    Rogov, P.4    Leproust, E.M.5    Brockman, W.6
  • 62
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455: 1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 63
    • 80052707308 scopus 로고    scopus 로고
    • ContEst: Estimating cross-contamination of human samples in nextgeneration sequencing data
    • Cibulskis K, McKenna A, Fennell T, Banks E, DePristo M, Getz G. ContEst: estimating cross-contamination of human samples in nextgeneration sequencing data. Bioinformatics 2011; 27: 2601-2.
    • (2011) Bioinformatics , vol.27 , pp. 2601-2602
    • Cibulskis, K.1    McKenna, A.2    Fennell, T.3    Banks, E.4    Depristo, M.5    Getz, G.6
  • 64
    • 77956295988 scopus 로고    scopus 로고
    • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
    • McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 2010; 20: 1297-303.
    • (2010) Genome Res , vol.20 , pp. 1297-1303
    • McKenna, A.1    Hanna, M.2    Banks, E.3    Sivachenko, A.4    Cibulskis, K.5    Kernytsky, A.6
  • 66
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012; 150: 1107-20.
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1    Berger, A.H.2    Hammerman, P.S.3    Hernandez, B.4    Pugh, T.J.5    Hodis, E.6
  • 70
    • 84876020288 scopus 로고    scopus 로고
    • Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation
    • Costello M, Pugh TJ, Fennell TJ, Stewart C, Lichtenstein L, Meldrim JC, et al. Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation. Nucleic Acids Res 2013; 41: e67.
    • (2013) Nucleic Acids Res , vol.41 , pp. 67
    • Costello, M.1    Pugh, T.J.2    Fennell, T.J.3    Stewart, C.4    Lichtenstein, L.5    Meldrim, J.C.6
  • 73
    • 77956400377 scopus 로고    scopus 로고
    • The tumor suppressor p53: From structures to drug discovery
    • Joerger AC, Fersht AR. The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol 2010; 2: a000919.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. 000919
    • Joerger, A.C.1    Fersht, A.R.2


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