Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

Cell Reports

Volumn 8, Issue 6, 2014, Pages 1919-1929

  Bolden, Jessica E ^a   Tasdemir, Nilgun ^a,b,c   Dow, Lukas E ^a   van Es, Johan H ^d   Wilkinson, John E ^e   Zhao, Zhen ^a   Clevers, Hans ^d,f   Lowe, Scott W ^a,g  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Cold Spring Harbor ^*  (United States)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d HUBRECHT INSTITUTE   (Netherlands)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; BROMODOMAIN INHIBITOR; MEMBRANE PROTEIN; PROTEIN BRD4; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, MOUSE; DOXORUBICIN; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, MOUSE; MICRORNA; NUCLEAR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ADULT; ALOPECIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPLETION; DRUG MECHANISM; DRUG SAFETY; EPIDERMIS HYPERPLASIA; GENE SILENCING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINAL STEM CELL; METABOLIC STRESS; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RADIATION ENTEROPATHY; RNA INTERFERENCE; SMALL INTESTINE; TISSUE REGENERATION; TRANSGENIC MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; CELL LINE; CYTOLOGY; DRUG EFFECTS; GAMMA RADIATION; GENETICS; HYPERPLASIA; INTESTINE; METABOLISM; PATHOLOGY; RADIATION RESPONSE; SKIN; STEM CELL; THYMUS;

ANIMALS; AZEPINES; BONE MARROW CELLS; CELL LINE; DOXORUBICIN; GAMMA RAYS; HYPERPLASIA; INTESTINES; MICE; MICE, TRANSGENIC; MICRORNAS; NUCLEAR PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; RNA, SMALL INTERFERING; SKIN; STEM CELLS; THYMUS GLAND; TRANSCRIPTION FACTORS; TRIAZOLES;

EID: 84907419946     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.08.025     Document Type: Article

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