Respiratory filter reduces the cardiovascular effects associated with diesel exhaust exposure. A randomized, prospective, double-blind, controlled study of heart failure: The FILTER-HF Trial

JACC: Heart Failure

Volumn 4, Issue 1, 2016, Pages 55-64

  Vieira, Jefferson L ^a   Guimaraes, Guilherme V ^a   de Andre, Paulo A ^a   Cruz, Fátima D ^a   Saldiva, Paulo H Nascimento ^a   Bocchi, Edimar A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Air pollution; Endothelium; Heart failure

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; EXHAUST GAS;

ADULT; AIR FILTER; AIR POLLUTION; ARTERIAL STIFFNESS; ARTICLE; BLOOD VESSEL PARAMETERS; CARDIOVASCULAR EFFECT; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENDOTHELIAL DYSFUNCTION; EXHAUST GAS; FEMALE; FILTRATION; HEART FAILURE; HEART RATE VARIABILITY; HUMAN; MALE; MIDDLE AGED; PARTICULATE MATTER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REACTIVE HYPEREMIA INDEX; RESPIRATORY FILTER; ADVERSE EFFECTS; ENVIRONMENTAL EXPOSURE; EXERCISE TEST; GAS MASK; HEART RATE; HYPEREMIA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; TOXICITY; VASCULAR ENDOTHELIUM; WALKING;

BIOMARKERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL EXPOSURE; EXERCISE TEST; FEMALE; HEART FAILURE; HEART RATE; HUMANS; HYPEREMIA; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PROSPECTIVE STUDIES; RESPIRATORY PROTECTIVE DEVICES; VASCULAR STIFFNESS; VEHICLE EMISSIONS; WALKING;

EID: 84951831742     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2015.07.018     Document Type: Article

References (61)

1. World Health Organization. Ambient (outdoor) air quality and health. Media centre_Fact sheets [serial online]. Available at: . Accessed June 30, 2015. http://www.who.int/mediacentre/factsheets/fs313/en/.
2. Morishita M., Thompson K.C., Brook R.D. Understanding air pollution and cardiovascular diseases: is it preventable?. Curr Cardiovasc Risk Rep 2015, 9. pii: 30.
3. Cassee F.R., Héroux M.E., Gerlofs-Nijland M.E., Kelly F.J. Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituents and sources of emission. Inhal Toxicol 2013, 25:802-812.
4. Pope C.A., Dockery D.W. Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc 2006, 56:709-742.
5. Neophytou A.M., Hart J.E., Cavallari J.M., et al. Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry. Environ Health 2013, 12:105.
6. Hoek G., Krishnan R.M., Beelen R., et al. Long-term air pollution exposure and cardiorespiratory mortality: a review. Environ Health 2013, 12:43.
7. Chen J., Normand S.L., Wang Y., Krumholz H.M. National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA 2011, 306:1669-1678.
8. Storrow A.B., Jenkins C.A., Self W.H., et al. The burden of acute heart failure on U.S. emergency departments. J Am Coll Cardiol HF 2014, 2:269-277.
9. Chaudhry S.I., McAvay G., Chen S., et al. Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the Cardiovascular Health Study. J Am Coll Cardiol 2013, 61:635-642.
10. Shah A.S., Langrish J.P., Nair H., et al. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet 2013, 382:1039-1048.
11. Martinelli N., Olivieri O., Girelli D. Air particulate matter and cardiovascular disease: a narrative review. Eur J Intern Med 2013, 24:295-302.
12. Ghio A.J., Sobus J.R., Pleil J.D., Madden M.C. Controlled human exposures to diesel exhaust. Swiss Med Wkly 2012, 142:w13597.
13. Peretz A., Sullivan J.H., Leotta D.F., et al. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 2008, 116:937-942.
14. Mills N.L., Törnqvist H., Robinson S.D., et al. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005, 112:3930-3936.
15. Marti C.N., Gheorghiade M., Kalogeropoulos A.P., Georgiopoulou V.V., Quyyumi A.A., Butler J. Endothelial dysfunction, arterial stiffness, and heart failure. J Am Coll Cardiol 2012, 60:1455-1469.
16. Langrish J.P., Mills N.L., Chan J.K., et al. Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol 2009, 6:8.
17. Saldiva P, de André PA, Santos UP, Vormittag E, Fajersztajn L. Cidades e Soluções: Roteiro Globo News [serial online]. Available at: . Accessed October 15, 2013. http://g1.globo.com/platb/files/336/theme/Relat%a3rio%20Cidades%20e%20Solu%b7%a5es.pdf.
18. Kuvin J.T., Patel A.R., Sliney K.A., et al. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 2003, 146:168-174.
19. Bocchi E.A., Guimarães G., Mocelin A., Bacal F., Bellotti G., Ramires J.F. Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 2002, 106:1097-1103.
20. Affinity Plus: Respirador de Peça Semifacial Filtrante [Online media]. Available at: . Accessed June 30, 2015. http://media.msanet.com/International/Brazil/Catalogos/affinity_vo_ga.pdf.
21. Matsuzawa Y., Sugiyama S., Sugamura K., et al. Digital assessment of endothelial function and ischemic heart disease in women. J Am Coll Cardiol 2010, 55:1688-1696.
22. Moerland M., Kales A.J., Schrier L., van Dongen M.G., Bradnock D., Burggraaf J. Evaluation of the EndoPAT as a tool to assess endothelial function. Int J Vasc Med 2012, 2012:904141.
23. Wallén M.B., Hasson D., Theorell T., Canlon B., Osika W. Possibilities and limitations of the Polar RS800 in measuring heart rate variability at rest. Eur J Appl Physiol 2012, 112:1153-1165.
24. Allen R.W., Carlsten C., Karlen B., et al. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med 2011, 183:1222-1230.
25. Bräuner E.V., Forchhammer L., Møller P., et al. Indoor particles affect vascular function in the aged: an air filtration-based intervention study. Am J Respir Crit Care Med 2008, 177:419-425.
26. Hwang S.J., Lee K.H., Kim C.S., et al. Endothelial dysfunction in heart failure rats exposed to real urban air pollution. Int J Cardiol 2014, 176:494-496.
27. Brook R.D., Brook J.R., Urch B., Vincent R., Rajagopalan S., Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002, 105:1534-1536.
28. Mills N.L., Miller M.R., Lucking A.J., et al. Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation. Eur Heart J 2011, 32:2660-2671.
29. O'Neill M.S., Veves A., Zanobetti A., et al. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 2005, 111:2913-2920.
30. Saber A.T., Jacobsen N.R., Jackson P., et al. Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014, 6:517-531.
31. Brook R.D. Cardiovascular effects of air pollution. Clin Sci (Lond) 2008, 115:175-187.
32. Rückerl R., Ibald-Mulli A., Koenig W., et al. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 2006, 173:432-441.
33. Ostro B., Malig B., Broadwin R., et al. Chronic PM2.5 exposure and inflammation: determining sensitive subgroups in mid-life women. Environ Res 2014, 132:168-175.
34. Devlin R.B., Smith C.B., Schmitt M.T., et al. Controlled exposure of humans with metabolic syndrome to concentrated ultrafine ambient particulate matter causes cardiovascular effects. Toxicol Sci 2014, 140:61-72.
35. Krishnan R.M., Sullivan J.H., Carlsten C., et al. A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Part Fibre Toxicol 2013, 10:7.
36. Barath S., Mills N.L., Lundbäck M., et al. Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol 2010, 7:19.
37. Lucking A.J., Lundback M., Mills N.L., et al. Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J 2008, 29:3043-3051.
38. Mills N.L., Donaldson K., Hadoke P.W., et al. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 2009, 6:36-44.
39. Fröhlich E., Salar-Behzadi S. Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies. Int J Mol Sci 2014, 15:4795-4822.
40. Nakane H. Translocation of particles deposited in the respiratory system: a systematic review and statistical analysis. Environ Health Prev Med 2012, 17:263-274.
41. Kreyling W.G., Semmler M., Erbe F., et al. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health A 2002, 65:1513-1530.
42. Nemmar A., Holme J.A., Rosas I., Schwarze P.E., Alfaro-Moreno E. Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies. Biomed Res Int 2013, 2013:279371.
43. Mills N.L., Amin N., Robinson S.D., et al. Do inhaled carbon nanoparticles translocate directly into the circulation in humans?. Am J Respir Crit Care Med 2006, 173:426-431.
44. Nemmar A., Hoet P.H., Vanquickenborne B., et al. Passage of inhaled particles into the blood circulation in humans. Circulation 2002, 105:411-414.
45. Simkhovich B.Z., Marjoram P., Kleinman M.T., Kloner R.A. Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. Basic Res Cardiol 2007, 102:467-475.
46. Geiser M., Rothen-Rutishauser B., Kapp N., et al. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005, 113:1555-1560.
47. Wiebert P., Sanchez-Crespo A., Falk R., et al. No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal Toxicol 2006, 18:741-747.
48. Péry A.R., Brochot C., Hoet P.H., Nemmar A., Bois F.Y. Development of a physiologically based kinetic model for 99m-technetium-labelled carbon nanoparticles inhaled by humans. Inhal Toxicol 2009, 21:1099-1107.
49. Wellenius G.A., Yeh G.Y., Coull B.A., Suh H.H., Phillips R.S., Mittleman M.A. Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study. Environ Health 2007, 6:26.
50. Dominici F., Peng R.D., Bell M.L., et al. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 2006, 295:1127-1134.
51. Oremus M., Don-Wauchope A., McKelvie R., et al. BNP and NT-proBNP as prognostic markers in persons with chronic stable heart failure. Heart Fail Rev 2014, 19:471-505.
52. Wellenius G.A., Bateson T.F., Mittleman M.A., Schwartz J. Particulate air pollution and the rate of hospitalization for congestive heart failure among Medicare beneficiaries in Pittsburgh, Pennsylvania. Am J Epidemiol 2005, 161:1030-1036.
53. Wellenius G.A., Schwartz J., Mittleman M.A. Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities. Am J Cardiol 2006, 97:404-408.
54. Grunig G., Marsh L.M., Esmaeil N., et al. Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature. Pulm Circ 2014, 4:25-35.
55. Simkhovich B.Z., Kleinman M.T., Kloner R.A. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms. J Am Coll Cardiol 2008, 52:719-726.
56. Lundbäck M., Mills N.L., Lucking A., et al. Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol 2009, 6:7.
57. Mills N.L., Törnqvist H., Gonzalez M.C., et al. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007, 357:1075-1082.
58. Rundell K.W. Effect of air pollution on athlete health and performance. Br J Sports Med 2012, 46:407-412.
59. Cutrufello P.T., Rundell K.W., Smoliga J.M., Stylianides G.A. Inhaled whole exhaust and its effect on exercise performance and vascular function. Inhal Toxicol 2011, 23:658-667.
60. Peretz A., Kaufman J.D., Trenga C.A., et al. Effects of diesel exhaust inhalation on heart rate variability in human volunteers. Environ Res 2008, 107:178-184.
61. Mills N.L., Finlayson A.E., Gonzalez M.C., et al. Diesel exhaust inhalation does not affect heart rhythm or heart rate variability. Heart 2011, 97:544-550.