A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Particle and Fibre Toxicology

Volumn 10, Issue 1, 2013, Pages

  Krishnan, Ranjini M ^a   Sullivan, Jeffrey H ^a   Carlsten, Chris ^a   Wilkerson, Hui Wen ^a   Beyer, Richard P ^a   Bammler, Theo ^a   Farin, Fred ^a   Peretz, Alon ^a   Kaufman, Joel D ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; DIESEL FUEL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; HEMOGLOBIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ADULT; AIR POLLUTION; ARTICLE; BLOOD ANALYSIS; BLOOD CELL COUNT; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; ERYTHROCYTE; EXHAUST GAS; FEMALE; GENOTYPE; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HUMAN; LYMPHOCYTE; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; THROMBOCYTOSIS;

ADULT; BIOLOGICAL MARKERS; BLOOD CELL COUNT; CELL ADHESION MOLECULES; CROSS-OVER STUDIES; CYTOKINES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HEMATOCRIT; HEMOGLOBINS; HUMANS; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; MALE; METABOLIC SYNDROME X; THROMBOCYTOSIS; TIME FACTORS; VEHICLE EMISSIONS; WASHINGTON; YOUNG ADULT;

EID: 84877029023     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-10-7     Document Type: Article

References (51)

1. Peters A, Dockery DW, Muller JE, Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 2001, 103:2810-2815. 10.1161/01.CIR.103.23.2810, 11401937.
2. Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004, 351:1721-1730. 10.1056/NEJMoa040203, 15496621.
3. Nawrot TS, Perez L, Kunzli N, Munters E, Nemery B. Public health importance of triggers of myocardial infarction: a comparative risk assessment. Lancet 2011, 377:732-740. 10.1016/S0140-6736(10)62296-9, 21353301.
4. Mustafic H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, Perier MC, Marijon E, Vernerey D, Empana JP, Jouven X. Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA 2012, 307:713-721. 10.1001/jama.2012.126, 22337682.
5. Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the american heart association. Circulation 2010, 121:2331-2378. 10.1161/CIR.0b013e3181dbece1, 20458016.
6. Charron A, Harrison RM. Fine (PM2.5) and coarse (PM2.5-10) particulate matter on a heavily trafficked London highway: sources and processes. Environ Sci Technol 2005, 39:7768-7776. 10.1021/es050462i, 16295835.
7. Mills NL, Tornqvist H, Robinson SD, Gonzalez MC, Soderberg S, Sandstrom T, Blomberg A, Newby DE, Donaldson K. Air pollution and atherothrombosis. Inhal Toxicol 2007, 19(Suppl 1):81-89.
8. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R, Mittleman M, Samet J, Smith SC, Tager I. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 2004, 109:2655-2671. 10.1161/01.CIR.0000128587.30041.C8, 15173049.
9. Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 2008, 116:937-942. 10.1289/ehp.11027, 2453163, 18629317.
10. Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, Newby DE. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007, 357:1075-1082. 10.1056/NEJMoa066314, 17855668.
11. Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A, Arhami M, Kleinman MT, Vaziri ND, Longhurst J, Sioutas C. Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms. Environ Health Perspect 2009, 117:1232-1238. 10.1289/journla.ehp.0800194, 2721866, 19672402.
12. van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, Qui D, Vincent R, Hogg JC. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 2001, 164:826-830. 10.1164/ajrccm.164.5.2010160, 11549540.
13. Nemmar A, Al-Maskari S, Ali BH, Al-Amri IS. Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. Am J Physiol Lung Cell Mol Physiol 2007, 292:L664-L670.
14. Carlsten C, Kaufman JD, Trenga CA, Allen J, Peretz A, Sullivan JH. Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust. Inhal Toxicol 2008, 20:917-921. 10.1080/08958370802074908, 3603854, 18668408.
15. Carlsten C, Kaufman JD, Peretz A, Trenga CA, Sheppard L, Sullivan JH. Coagulation markers in healthy human subjects exposed to diesel exhaust. Thromb Res 2007, 120:849-855. 10.1016/j.thromres.2007.01.005, 2288659, 17321570.
16. Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet 1995, 345:176-178. 10.1016/S0140-6736(95)90173-6, 7741860.
17. Seaton A, Soutar A, Crawford V, Elton R, McNerlan S, Cherrie J, Watt M, Agius R, Stout R. Particulate air pollution and the blood. Thorax 1999, 54:1027-1032. 10.1136/thx.54.11.1027, 1745387, 10525563.
18. Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005, 112:3930-3936. 10.1161/CIRCULATIONAHA.105.588962, 16365212.
19. Barath S, Mills NL, Lundback M, Tornqvist H, Lucking AJ, Langrish JP, Soderberg S, Boman C, Westerholm R, Londahl J. Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol 2010, 7:19. 10.1186/1743-8977-7-19, 2918524, 20653945.
20. Austin AW, Patterson SM, von Kanel R. Hemoconcentration and hemostasis during acute stress: interacting and independent effects. Ann Behav Med 2011, 42:153-173. 10.1007/s12160-011-9274-0, 21562905.
21. Jern C, Wadenvik H, Mark H, Hallgren J, Jern S. Haematological changes during acute mental stress. Br J Haematol 1989, 71:153-156. 10.1111/j.1365-2141.1989.tb06290.x, 2917123.
22. de Boer D, Ring C, Carroll D. Time course and mechanisms of hemoconcentration in response to mental stress. Biol Psychol 2006, 72:318-324. 10.1016/j.biopsycho.2005.12.004, 16448738.
23. Cosselman KE RMK, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD. Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 2012, 59:943-948. 10.1161/HYPERTENSIONAHA.111.186593, 22431582.
24. Lucking AJ, Lundback M, Mills NL, Faratian D, Barath SL, Pourazar J, Cassee FR, Donaldson K, Boon NA, Badimon JJ. Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J 2008, 29:3043-3051. 10.1093/eurheartj/ehn464, 18952612.
25. Wilson DW, Aung HH, Lame MW, Plummer L, Pinkerton KE, Ham W, Kleeman M, Norris JW, Tablin F. Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation. Inhal Toxicol 2010, 22:267-276. 10.3109/08958370903278069, 20064101.
26. Nemmar A, Hoet PH, Dinsdale D, Vermylen J, Hoylaerts MF, Nemery B. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 2003, 107:1202-1208. 10.1161/01.CIR.0000053568.13058.67, 12615802.
27. Calderon-Garciduenas L, Villarreal-Calderon R, Valencia-Salazar G, Henriquez-Roldan C, Gutierrez-Castrellon P, Torres-Jardon R, Osnaya-Brizuela N, Romero L, Solt A, Reed W. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal Toxicol 2008, 20:499-506. 10.1080/08958370701864797, 18368620.
28. Shaw CA, Robertson S, Miller MR, Duffin R, Tabor CM, Donaldson K, Newby DE, Hadoke PW. Diesel particulate-exposed macrophages cause marked endothelial cell activation. Am J Respir Cell Mol Biol 2010, : .
29. Yang HM, Ma JY, Castranova V, Ma JK. Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor-alpha from rat alveolar macrophages. Exp Lung Res 1997, 23:269-284. 10.3109/01902149709087372, 9184793.
30. Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF. Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol 2002, 39:935-942. 10.1016/S0735-1097(02)01715-1, 11897432.
31. Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 2005, 294:3003-3010. 10.1001/jama.294.23.3003, 16414948.
32. Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 2005, 113:201-206. 1277865, 15687058.
33. Fuster V, Moreno PR. Atherothrombosis as a systemic, often silent, disease. Nat Clin Pract Cardiovasc Med 2005, 2:431. 10.1038/ncpcardio0310, 16265564.
34. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol 2005, 46:937-954. 10.1016/j.jacc.2005.03.074, 16168274.
35. Zanobetti A, Schwartz J. Air pollution and emergency admissions in Boston, MA. J Epidemiol Community Health 2006, 60:890-895. 10.1136/jech.2005.039834, 2566060, 16973538.
36. Baccarelli A, Martinelli I, Zanobetti A, Grillo P, Hou LF, Bertazzi PA, Mannucci PM, Schwartz J. Exposure to particulate air pollution and risk of deep vein thrombosis. Arch Intern Med 2008, 168:920-927. 10.1001/archinte.168.9.920, 3093962, 18474755.
37. Brown DW, Giles WH, Croft JB. Hematocrit and the risk of coronary heart disease mortality. Am Heart J 2001, 142:657-663. 10.1067/mhj.2001.118467, 11579356.
38. Sorlie PD, Garcia-Palmieri MR, Costas R, Havlik RJ. Hematocrit and risk of coronary heart disease: the Puerto Rico Health Program. Am Heart J 1981, 101:456-461. 10.1016/0002-8703(81)90136-8, 7211675.
39. Gagnon DR, Zhang TJ, Brand FN, Kannel WB. Hematocrit and the risk of cardiovascular disease-the Framingham study: a 34-year follow-up. Am Heart J 1994, 127:674-682. 10.1016/0002-8703(94)90679-3, 8122618.
40. Delfino RJ, Staimer N, Tjoa T, Polidori A, Arhami M, Gillen DL, Kleinman MT, Vaziri ND, Longhurst J, Zaldivar F, Sioutas C. Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environ Health Perspect 2008, 116:898-906. 10.1289/ehp.11189, 2453158, 18629312.
41. Lupattelli G, Lombardini R, Schillaci G, Ciuffetti G, Marchesi S, Siepi D, Mannarino E. Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: association with small, dense LDL cholesterol particles. Am Heart J 2000, 140:521-526. 10.1067/mhj.2000.108508, 10966556.
42. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, Rimm EB. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004, 351:2599-2610. 10.1056/NEJMoa040967, 15602020.
43. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999, 138:S419-S420. 10.1016/S0002-8703(99)70266-8, 10539839.
44. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005, 115:3378-3384. 10.1172/JCI27196, 1297269, 16322783.
45. Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G. An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS One 2008, 3:e2535. 10.1371/journal.pone.0002535, 2432042, 18596971.
46. dupont NC, Wang K, Wadhwa PD, Culhane JF, Nelson EL. Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol 2005, 66:175-191. 10.1016/j.jri.2005.03.005, 16029895.
47. Prabhakar U, Eirikis E, Reddy M, Silvestro E, Spitz S, Pendley C, Davis HM, Miller BE. Validation and comparative analysis of a multiplexed assay for the simultaneous quantitative measurement of Th1/Th2 cytokines in human serum and human peripheral blood mononuclear cell culture supernatants. J Immunol Methods 2004, 291:27-38. 10.1016/j.jim.2004.04.018, 15345302.
48. Leng SX, McElhaney JE, Walston JD, Xie D, Fedarko NS, Kuchel GA. ELISA and multiplex technologies for cytokine measurement in inflammation and aging research. J Gerontol Biol Med Sci 2008, 63:879-884.
49. Dossus L, Becker S, Achaintre D, Kaaks R, Rinaldi S. Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA. J Immunol Methods 2009, 350:125-132. 10.1016/j.jim.2009.09.001, 19748508.
50. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735-2752. 10.1161/CIRCULATIONAHA.105.169404, 16157765.
51. Gould T, Larson T, Stewart J, Kaufman JD, Slater D, McEwen N. A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration. Inhal Toxicol 2008, 20:49-52. 10.1080/08958370701758478, 18236222.