Controlled exposure of humans with metabolic syndrome to concentrated ultrafine ambient particulate matter causes cardiovascular effects

Toxicological Sciences

Volumn 140, Issue 1, 2014, Pages 61-72

  Devlin, Robert B ^a   Smith, Candice B ^a,c   Schmitt, Michael T ^a   Rappold, Ana G ^a   Hinderliter, Alan ^b   Graff, Don ^a,d   Carraway, Martha Sue ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d CELERION   (United States)

Author keywords

Clinical study; Heart rate variability; Human; Particulate matter

Indexed keywords

ANTIHYPERTENSIVE AGENT; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; GLUTATHIONE TRANSFERASE M1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PADGEM PROTEIN; PLASMINOGEN; THROMBOMODULIN; TRIACYLGLYCEROL; AIR POLLUTANT; GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE TRANSFERASE; PARTICULATE MATTER;

ABDOMINAL OBESITY; ACUTE PHASE RESPONSE; ADULT; AGED; AIR; AIR POLLUTANT; ANTIHYPERTENSIVE THERAPY; ARTERY DIAMETER; ARTICLE; BLOOD CELL; BLOOD PRESSURE; BRACHIAL ARTERY; CARDIOVASCULAR EFFECT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; ENVIRONMENTAL EXPOSURE; FEMALE; FIBRIN FORMATION; FIBRINOLYSIS; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HEART DEPOLARIZATION; HEART RATE; HEART RATE VARIABILITY; HEART REPOLARIZATION; HOLTER MONITORING; HUMAN; HYPEREMIA; HYPERTENSION; INFLAMMATION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NULL ALLELE; PARTICLE SIZE; PARTICULATE MATTER; PHYSICIAN; PROTEIN BLOOD LEVEL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; REST; RISK ASSESSMENT; TRIACYLGLYCEROL BLOOD LEVEL; VASCULITIS; WAIST CIRCUMFERENCE; ANALYSIS; BLOOD; CARDIOVASCULAR DISEASES; COMPLICATION; DRUG EFFECTS; ELECTROCARDIOGRAPHY; EXPOSURE; GENETICS; RISK;

ADULT; AGED; AIR POLLUTANTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CROSS-OVER STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HEART RATE; HUMANS; INHALATION EXPOSURE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PARTICLE SIZE; PARTICULATE MATTER; RISK;

EID: 84903837550     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu063     Document Type: Article

References (58)

1. Alexis, N. E., Zhou, H., Lay, J. C., Harris, B., Hernandez, M. L., Lu, T. S., Bromberg, P. A., Diaz-Sanchez, D., Devlin, R. B., Kleeberger, S. R., et al. (2009). The glutathione-s-transferase mu 1 null genotype modulates ozone-induced airway inflammation in human subjects. J. Allergy Clin. Immunol. 124, 1222-1228, e1225.
2. Araujo, J. A. (2010). Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual. Atmos. Health 4, 79-93.
3. Bellavia, A., Urch, B., Speck,M., Brook, R. D., Scott, J. A., Albetti, B., Behbod, B., North, M., Valeri, L., Bertazzi, P. A., et al. (2013). DNA hypomethylation, ambient particulate matter, and increased blood pressure: Findings from controlled human exposure experiments. J. Am. Heart Assoc. 2, e000212.
4. Carlsten, C., Kaufman, J. D., Trenga, C. A., Allen, J., Peretz, A., and Sullivan, J. H. (2008). Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust. Inhal. Toxicol. 20, 917-921.
5. Chahine, T., Baccarelli, A., Litonjua, A., Wright, R. O., Suh, H., Gold, D. R., Sparrow, D., Vokonas, P., and Schwartz, J. (2007). Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ. Health Perspect. 115, 1617-1622.
6. Chan, C. C., Chuang, K. J., Shiao, G. M., and Lin, L, Y. (2004). Personal exposure to submicrometer particles and heart rate variability in human subjects. Environ. Health Perspect. 112, 1063-1067.
7. Chen, J. C., and Schwartz, J. (2008). Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environ. Health Perspect. 116, 612-617.
8. Choi, J. I., and Kim, C. S. (2007). Mathematical analysis of particle deposition in human lungs: An improved single path transport model. Inhal. Toxicol. 19, 925-939.
9. Cosselman, K. E., Krishnan, R. M., Oron, A. P., Jansen, K., Peretz, A., Sullivan, J. H., Larson, T. V., and Kaufman, J. D. (2012). Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 59, 943-948.
10. Delfino, R. J., Gillen, D. L., Tjoa, T., Staimer, N., Polidori, A., Arhami, M., Sioutas, C., and Longhurst, J. (2011). Electrocardiographic st-segment depression and exposure to traffic-related aerosols in elderly subjects with coronary artery disease. Environ. Health Perspect. 119, 196-202.
11. Delfino, R. J., Staimer, N., Tjoa, T., Polidori, A., Arhami, M., Gillen, D. L., Kleinman, M. T., Vaziri, N. D., Longhurst, J., Zaldivar, F., et al. (2008). Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environ. Health Perspect. 116, 898-906.
12. Delfino, R. J., Tjoa, T., Gillen, D. L., Staimer, N., Polidori, A., Arhami, M., Jamner, L., Sioutas, C., and Longhurst, J. (2010). Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease. Epidemiology 21, 396-404.
13. Devlin, R. B., Cascio,W. E., Kehrl, H., and Ghio, A. J. (2000). Changes in heart rate variability in young and elderly humans exposed to concentrated ambient air pollution. Toxicologist 54, 316-317.
14. Devlin, R. B., Duncan, K. E., Jardim, M., Schmitt, M. T., Rappold, A. G., and Diaz-Sanchez, D. (2012). Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation 126, 104-111.
15. Dillon, M. A., Harris, B.,Hernandez, M. L., Zou, B., Reed,W., Bromberg, P. A., Devlin, R. B., Diaz-Sanchez, D., Kleeberger, S., Zhou, H., et al. (2011). Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the gstm1 null genotype. Occup. Environ. Med. 68, 783-785.
16. EPA US. (2009). Integrated science assessment for particulate matter (final report). Washington, DC, EPa/600/R-08/139F.
17. FDA. (2005). Guidance for industry: E14 clnical evaluation of qt/qtc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs.
18. Ford, E. S., Giles, W. H., and Mokdad, A. H. (2004). Increasing prevalence of the metabolic syndrome among us adults. Diabetes Carre 27, 2444-2449.
19. Ghio, A. J., Hall, A., Bassett, M. A., Cascio, W. E., and Devlin, R. B. (2003). Exposure to concentrated ambient air particles alters hematologic indices in humans. Inhal. Toxicol. 15, 1465-1478.
20. Ghio, A. J., Sobus, J. R., Pleil, J. F., and Madden, M. C. (2012). Controlled human exposures to diesel exhaust. Swiss Med. Wkly. 142, w13597.
21. Gong, H., Jr, Linn, W. S., Clark, K. W., Anderson, K. R., Sioutas, C., Alexis, N. E., Cascio, W. E., and Devlin, R. B. (2008). Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in los angeles. Inhal. Toxicol. 20, 533-545.
22. Graff, D. W., Cascio,W. E., Rappold, A., Zhou, H., Huang, Y. C., and Devlin, R. B. (2009). Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environ. Health Perspect. 117, 1089-1094.
23. Grundy, SM. (2008). Metabolic syndrome pandemic. Arterioscler. Thromb. Vasc. Biol. 28, 629-636.
24. Gupta, T., Demokritou, P., and Koutrakis, P. (2004). Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhal. Toxicol. 16, 851-862.
25. Holguin, F., Tellez-Rojo,M.M., Hernandez, M., Cortez, M., Chow, J. C., Watson, J. G., Mannino, D., and Romieu, l. (2003). Air pollution and heart rate variability among the elderly in mexico city. Epidemiology 14, 521-527.
26. Kim, J. H., and Hong, Y. C. (2012). Gstm1, gstt1, and gstp1 polymorphisms and associations between air pollutants and markers of insulin resistance in elderly koreans. Environ. Health Perspect. 120, 1378-1384.
27. Kim, C. S., and Jaques, P. A. (2000). Respiratory dose of inhaled ultrafine particles in healthy adults. Philos. Trans. R. Soc. Lond. A 358, 2693-2705.
28. Kim, S. C., Kim, D., and Sioutas, C. (2000). A new generation of portable coarse, fine, and ultrafine particle concentrators for use in inhalation toxicology. Inhal. Toxicol. 12, 121-137.
29. Krishnan, R. M., Sullivan, J. H., Carlsten, C., Wilkerson, H. W., Beyer, R. P., Bammler, T., Farin, F., Peretz, A., and Kaufman, J. D. (2013). A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Part Fibre Toxicol. 10, 7.
30. Langrish, J. P., Lundback, M., Mills, N. L., Johnston, N. R.,Webb, D. J., Sandstrom, T., Blomberg, A., andNewby, D. E. (2009). Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans. Hypertension 54, 910-915.
31. Leitte, A. M., Schlink, U., Herbarth, O., Wiedensohler, A., Pan, X. C., Hu, M., Wehner, B., Breitner, S., Peters, A., Wichmann, H. E., et al. (2012). Associations between size-segregated particle number concentrations and respiratory mortality in beijing, china. Int. J. Environ. Health Res. 22, 119-133.
32. Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M., Oberley, T., Froines, J., and Nel, A. (2003). Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect. 111, 455-460.
33. Liao, D., Creason, J., Shy, C., Williams, R., Watts, R., and Zweidinger, R. (1999).Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ. Health Perspect. 107, 521-525.
34. Lundback, M., Mills, N. L., Lucking, A., Barath, S., Donaldson, K., Newby, D. E., Sandström, T., and Blomberg, A. (2009). Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol. 6, 7.
35. Madrigano, J., Baccarelli, A., Wright, R. O., Suh, H., Sparrow, D., Vokonas, P. S., and Schwartz, J. (2010).Air pollution, obesity, genes and cellular adhesion molecules. Occup. Environ. Med. 67, 312-317.
36. Mahmoudi,M., Curzen, N., and Gallagher, P. J. (2007). Atherogenesis: The role of inflammation and infection. Histopathology 50, 535-546.
37. Mills, N. L., Tornqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., Mac-Nee, W., Boon, N. A., Donaldson, K., Blomberg, A., Sandstrom, T., et al. (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112, 3930-3936.
38. Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B. (2002). Passage of inhaled particles into the blood ciruclation in humans. Circulation 105, 411-414.
39. O'Neill, M. S., Veves, A., Zanobetti, A., Sarnat, J. A., Gold, D. R., Economides, P. A., Horton, E. S., and Schwartz, J. (2005). Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 111, 2913-2920.
40. Park, S. K., Auchincloss, A. H., O'Neill, M. S., Prineas, R., Correa, J. C.,Keeler, J., Barr, R. G., Kaufman, J. D., and Diez Roux, A. V. (2010). Particulate air pollution, metabolic syndrome, and heart rate variability: The multi-ethnic study of atherosclerosis (mesa). Environ. Health Perspect. 118, 1406-1411.
41. Peretz, A., Sullivan, J. H., Leotta, D. F., Trenga, C. A., Sands, F. N., Allen, J., Carlsten, C., Wilkinson, C. W., Gill, E. A., and Kaufman, J. D. (2008). Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ. Health Perspect. 116, 937-942.
42. Peters, A., von Klot, S., Heier, M., Trentinaglia, I., Hormann, A., Wichmann, H. E., and Löwel, H. (2004). Exposure to traffic and the onset of myocardial infarction. N. Engl. J. Med. 351, 1721-1730.
43. Pope, C. A., III, Verrier, R. L., Lovett, E. G., Larson, A. C., Raizenne, M. E., Kanner, R. E., Schwartz, J., Villegas, G. M., Gold, D. R., and Dockery, D. W. (1999). Heart rate variability associated with particulate air pollution. Am. Heart J. 138, 890-899.
44. Pope, C. A., 3rd, and Dockery, D. W. (2006). Health effects of fine particulate air pollution: Lines that connect. J. Air Waste Manag. Assoc. 56, 709-742.
45. Rajagopalan, S., and Brook, R. D. (2012). Air pollution and type 2 diabetes:Mechanistic insights. Diabetes 61, 3037-3045.
46. Ruckerl, R., Ibald-Mulli, A., Koenig, W., Schneider, A., Woelke, G., Cyrys, J., Heinrich, J., Marder, V., Frampton, M., Wichmann, H. E., et al. (2006). Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am. J. Respir. Crit. Care Med. 173, 432-441.
47. Samet, J. M., Rappold, A., Graff, D., Cascio, W. E., Berntsen, J. H., Huang, Y. C., Herbst, M., Bassett, M., Montilla, T., Hazucha, M. J., et al. (2009). Concentrated ambient ultrafine particle exposure induces cardiac Changes in young healthy volunteers. Am. J. Respir. Crit. Care Med. 179, 1034-1042.
48. Schneider, A., Neas, L., Herbst, M. C., Case, M., Williams, R. W., Cascio, W., Schmitt, M. T., Buse, J. B., Peters, A., and Devlin, R. B. (2008). Endothelial dysfunction: Associations with exposure to ambient fine particles in diabetic individuals. Environ. Health Perspect. 116, 1666-1674.
49. Schwartz, J., Park, S. K., O'Neill, M. S., Vokonas, P. S., Sparrow, D., Weiss, S., and Kelsey, K. (2005). Glutathione-s-transferase m1, obesity, statins, and autonomic effects of particles: Gene-by-drug-by-environment interaction. Am. J. Respir. Crit. Care Med. 172, 1529-1533.
50. Shah, A. P., Pietropaoli, A. P., Frasier, L. M., Speers, D. M., Chalupa, D. C., Delehanty, J.M., Huang, L. S., Utell, M. J., and Frampton, M. W. (2008). Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environ. Health Perspect. 116, 375-380.
51. Stolzel, M., Breitner, S., Cyrys, J., Pitz, M.,Wolke, G., Kreyling, W., Heinrich, J., Wichmann, H. E., and Peters, A. (2007). Daily mortality and particulate matter in different size classes in erfurt, germany. J. Expo. Sci. Environ. Epidemiol. 17, 458-467.
52. Suzuki, T., Hirata, K., Elkind, M. S., Jin, Z., Rundek, T., Miyake, Y., Boden-Albala, B., Di Tullio, M. R., Sacco, R., and Homma, S. (2008). Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: The northern manhattan study (nomas). Am. Heart J. 156, 405-410.
53. Timonen, K. L., Vanninen, E., de Hartog, J., Ibald-Mulli, A., Brunekreef, B., Gold, D. R., Heinrich, J., Hoek, G., Lanki, T., Peters, A., et al. (2005). Effects of ultrafine and fine particulate and gaseous air pollution on cardiac au tonomic control in subjects with coronary artery disease: The ultra study. J. Expo. Anal. Environ. Epidemiol. 16, 332-341.
54. Tong, H., Rappold, A. G., Diaz-Sanchez, D., Steck, S. E., Berntsen, J., Cascio, W. E., Devlin, R. B., and Samet, J. M. (2012). Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults. Environ. Health Perspect. 120, 952-957.
55. Tornqvist, H., Mills, N. L., Gonzalez, M., Miller, M. R., Robinson, S. D., Megson, I. L., Macnee, W., Donaldson, K., Söderberg, S., Newby, D. E., et al. (2007). Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am. J. Respir. Crit. Care Med. 176, 395-400.
56. Urch, B., Silverman, F., Corey, P., Brook, J. R., Lukic, K. Z., Rajagopalan, S., and Brook, R. D. (2005). Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ. Health Perspect. 113, 1052-1055.
57. Weiss, R. (2005). Predictors of changes in glucose tolerance status in obese youth. Diabetes Care 28, 902-909.
58. Zanobetti, A., and Schwartz, J. (2001). Are diabetics more susceptible to the health effects of airborne particles? Am. J. Respir. Crit. Care Med. 164, 831-833.