No significant translocation of inhaled 35-nm carbon particles to the circulation in humans

Inhalation Toxicology

Volumn 18, Issue 10, 2006, Pages 741-747

  Wiebert, Pernilla ^a,b,c   Sanchez Crespo, Alejandro ^c   Falk, Rolf ^d   Philipson, Klas ^a   Lundin, Anders ^b   Larsson, Stig ^c   Möller, Winfried ^e   Kreyling, Wolfgang ^e   Svartengren, Magnus ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM COUNTY COUNCIL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d Swedish Radiation Protection Authority   (Sweden)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; NANOPARTICLE; TECHNEGAS; TECHNETIUM 99M;

ADULT; ASTHMA; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; CONFERENCE PAPER; CONTROLLED STUDY; EXPOSURE; FEMALE; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IMAGING; IN VITRO STUDY; IN VIVO STUDY; INHALATION; INHALATION TEST; ISOTOPE LABELING; LEACHING; LUNG; MALE; MEDICAL PARAMETERS; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCINTILLATION CAMERA; SYSTEMIC CIRCULATION; THYROID GLAND; TOXICOKINETICS; TRANSPORT KINETICS; URINALYSIS; URINARY EXCRETION; URINE LEVEL;

AEROSOLS; ASTHMA; BIOLOGICAL TRANSPORT; CARBON; FEMALE; GAMMA CAMERAS; HUMANS; INHALATION EXPOSURE; LUNG; MALE; MIDDLE AGED; PARTICLE SIZE; RADIOACTIVE TRACERS; TECHNETIUM;

EID: 33745238113     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370600748455     Document Type: Conference Paper

References (23)

1. Areskoug, H., Camner, P., Dahlén, S. E., Lastbom, L., Nyberg, F., Pershagen, G., and Sydbom, A. 2000. Particles in ambient air - A health risk assessment. Scand. J. Work Environ. Health 26(Suppl. 1):90-94.
2. Atkinson, R. W., Anderson, H. R., Sunyer, J., Ayres, J., Baccini, M., Vonk, J. M., Boumghar, A., Forastiere, F., Forsberg, B., Touloumi, G., Schwartz, J., and Katsouyanni, K. 2001. Acute effects of particulate air pollution on respiratory admissions: Results from APHEA 2 project. Air pollution and health: A European Approach. Am. J. Respir. Crit. Care Med. 15(164):1860-1866.
3. Beasley, T. M., Palmer, H. E., and Nelp, W. B. 1966. Distribution and excretion of technetium in humans. Health Phys. 12(10):1425-1435.
4. Brown, J. S., Zeman, K. L., and Bennett, W. D. 2002. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am. J. Respir. Crit. Care Med. 166(9):1240-1247.
5. Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E. 1993. An association between air pollution and mortality in six U.S. Cities. N. Engl. J. Med. 329:1753-1759.
6. Donaldson, K., Stone, V., Clouter, A., Renwick, L., and MacNee, W. 2001. Ultrafine particles. Occup. Environ. Med. 58(3):211-216, 199.
7. Gerber, G. B., van Hees, M., Garten, C. T., Jr., Vandecasteele, C. M., Vankerkom, J., van Bruwaene, R., Kirchmann, R., Colard, J., and Cogneau, M. 1989. Technetium absorption and turnover in monogastric and polygastric animals. Health Phys. 57(2):315-319.
8. Goodman, P. G., Dockery, D. W., and Clancy, L. 2004. Cause-specific mortality and the extended effects of particulate pollution and temperature exposure. Environ. Health Perspect. 112(2):179-185.
9. Isawa, T., Teshima, T., Anazawa, Y., Miki, M., and Mahmud, A. M. 1995. Inhalation of pertechnegas: Similar clearance from the lungs to that of inhaled pertechnetate aerosol. Nucl. Med. Commun. 16(9):741-746.
10. Kim, C. S., and Kang, T. C. 1997. Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease. Am. J. Respir. Crit. Care Med. 155(3):899-905.
11. Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., and Schulz., H. 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J. Toxicol. Environ. Health A 65(20):1513-1530.
12. Murr, L. E., Esquivel, E. V., and Bang. J. J. 2004. Characterization of nanostructure phenomena in airborne particulate aggregates and their potential for respiratory health effects. J. Mater. Sci. Mater. Med. 15(3):237-247.
13. Möller, W., Felten, K., Seitz, J., Sommerer, K., Takenaka, S., Wiebert, P., Philipson, K., Svartengren, S., and Kreyling, W. G. 2006. A generator for the production of radiolabelled ultrafine carbonaceous particles for deposition and clearance studies in the respiratory tract. J. Aerosol Sci. 37:631-644.
14. Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411-414.
15. Oberdorster, G., Ferin, J., Gelein, R., Soderholm, S. C., and Finkelstein, J. 1992. Role of the alveolar macrophage in lung injury: Studies with ultrafine particles. Environ. Health Perspect. 97:193-199.
16. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., and Cox. C. 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health. A 65(20):1531-1543.
17. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., and Cox, C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 16(6-7):437-445.
18. Peters, A., Dockery, D. W., Muller, J. E., and Mittleman, M. A. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103(23):2810-2815.
19. Scalzetti, E. M., and Gagne, G. M. 1995. The Transition from Technegas to Pertechnegas. J. Nucl. Med. 36:267-269.
20. Svartengren, M., Strand, V., Bylin, G., Järup, L., and Pershagen, G. 2000. Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen. Eur. Respir. J. 15:716-724.
21. Takenaka, S., Karg, E., Roth, C., Schulz, H., Ziesenis, A., Heinzmann, U., Schramel, P., and Heyder, J. 2001. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ. Health Perspect. 109(Suppl. 4):547-551.
22. Wiebert, P., Sanchez-Crespo, A., Seitz, J., Falk, R., Philipson, K., Kreyling, W. G., Möller, W., Sommerer, K., Larsson, S., and Svartengren, M. 2006. Negligible clearance of ultrafine particles retained in healthy and affected human lungs. Eur. Respir. J. In press.
23. Xu, J. H., Moonen, M., Johansson, Å., and Bake, B. 2001. Dynamics of "Technegas" deposited in the lung. Nucl. Med. Commun. 22:383-387.