Perspective: Ambient air pollution: Inflammatory response and effects on the lung’s vasculature

Pulmonary Circulation

Volumn 4, Issue 1, 2014, Pages 25-35

  Grunig, Gabriele ^a   Marsh, Leigh M ^b   Esmaeil, Nafiseh ^a,c   Jackson, Katelin ^a   Gordon, Terry ^a   Reibman, Joan ^a   Kwapiszewska, Grazyna ^b   Park, Sung Hyun ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Airways; Cardiovascular; Particulate matter; Pulmonary circulation; Pulmonary hypertension; Pulmonary immune responses

Indexed keywords

EID: 85026336577     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/674902     Document Type: Review

References (109)

1. Bell ML, Davis DL, Fletcher T. A retrospective assessment of mortality from the London smog episode of 1952: the role of influenza and pollution. Environ Health Perspect 2004;112:6-8.
2. Nemery B, Hoet PH, Nemmar A. The Meuse Valley fog of 1930: an air pollution disaster. Lancet 2001;357:704-708.
3. Helfand WH, Lazarus J, Theerman P. Donora, Pennsylvania: an environmental disaster of the 20th century. Am J Public Health 2001;91:553.
4. Hunt A, Abraham JL, Judson B, Berry CL. Toxicologic and epidemiologic clues from the characterization of the 1952 London smog fine particulate matter in archival autopsy lung tissues. Environ Health Perspect 2003;111:1209-1214.
5. Lippmann M, Yeates DB, Albert RE. Deposition, retention, and clearance of inhaled particles. Br J Ind Med 1980; 37:337-362.
6. Pinkerton KE, Green FH, Saiki C, Vallyathan V, Plopper CG, Gopal V, Hung D, et al. Distribution of particulate matter and tissue remodeling in the human lung. Environ Health Perspect 2000;108:1063-1069.
7. Brauer M, Avila-Casado C, Fortoul TI, Vedal S, Stevens B, Churg A. Air pollution and retained particles in the lung. Environ Health Perspect 2001;109:1039-1043.
8. Churg A, Brauer M. Human lung parenchyma retains PM2.5. AmJ Respir Crit Care Med 1997;155:2109-2111.
9. Stein R. China’s air pollution linked to millions of early deaths. National Public Radio online 2013. http://www.npr.org/blogs/health/2013/04/02/176017887/chinas-air-pollution -linked-to-millions-of-early-deaths. Published April 2, 2013.
10. Mouawad J. Shell settles air pollution accusations. New York Times. April 24, 2009, page B9.
11. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa MA, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224-2260.
12. World Health Organization. Tackling the global clean air challenge. http://www.who.int/mediacentre/news/releases/2011/air_pollution_20110926/en/. Published September 26, 2011.
13. Allen RW, Gombojav E, Barkhasragchaa B, Byambaa T, Lkhasuren O, Amram O, Takaro TK, Janes CR. An assessment of air pollution and its attributable mortality in Ulaanbaatar, Mongolia. Air Qual Atmos Health 2013;6:137-150.
14. Naddafi K, Sowlat M, Safari M. Integrated assessment of air pollution in Tehran, over the period fromSeptember 2008 to September 2009. Iran J Public Health 2012;41:77-86.
15. Rizwan S, Nongkynrih B, Gupta SK. Air pollution in Delhi: its magnitude and effects on health. Indian J Comm Med 2013;38:4-8.
16. Almbauer R, Pucher K, Sturm PJ. Air quality modeling for the city of Graz. Meteorol Atmos Phys 1995;57:31-42.
17. Anderson HR, Brunekreef B, Cohen A, Katsouyanni K, Krewski D, Kreyling WG, Künzli N, et al. Review of evidence on health aspects of air pollution—REVIHAAP: first results. Copenhagen: World Health Organization, 2013.
18. Brook RD, Rajagopalan S, Pope CA, III, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 2010;121:2331-2378.
19. Pope CA III, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 2004;109:71-77.
20. Jerrett M, Burnett RT, Beckerman BS, Turner MC, Krewski D, Thurston G, Martin RV, et al. Spatial analysis of air pollution and mortality in California. Am J Respir Crit Care Med 2013;188:593-599.
21. Hao M, Comier S, Wang M, Lee JJ, Nel A. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. J Allergy Clin Immunol 2003;112:905-914.
22. Jin C, Shelburne CP, Li G, Potts EN, Riebe KJ, Sempowski GD, Foster WM, Abraham SN. Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J Clin Invest 2011;121:941-955.
23. Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin GR, Ning Z, Kleinman MT, Sioutas C, Nel AE. Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for trafficrelated asthma flares. Am J Physiol Lung Cell Mol Physiol 2010;299:L374-L383.
24. van Eeden SF, Hogg JC. Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation. J Toxicol Environ Health A 2002; 65:1597-1613.
25. Fujii T, Hayashi S, Hogg JC, Mukae H, Suwa T, Goto Y, Vincent R, van Eeden SF. Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. Am J Respir Cell Mol Biol 2002;27:34-41.
26. Zhao J, Gao Z, Tian Z, Xie Y, Xin F, Jiang R, Kan H, Song W. The biological effects of individual-level PM2.5 exposure on systemic immunity and inflammatory response in traffic policemen. Occup Environ Med 2013;70:426-431.
27. Zhao C, Liao J, Chu W, Wang S, Yang T, Tao Y, Wang G. Involvement of TLR2 and TLR4 and Th1/Th2 shift in inflammatory responses induced by fine ambient particulate matter in mice. Inhal Toxicol 2012;24:918-927.
28. Walters DM, Breysse PN, Schofield B, Wills-Karp M. Complement factor 3 mediates particulate matter-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol 2002; 27:413-418.
29. Saunders V, Breysse P, Clark J, Sproles A, Davila M, Wills-Karp M. Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent. Environ Health Perspect 2010;118:640-646.
30. McCormack MC, Breysse PN, Matsui EC, Hansel NN, Peng RD, Curtin-Brosnan J, Williams DL, Wills-Karp M, Diette GB. Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Ann Allergy Asthma Immunol 2011; 106:308-315.
31. Spira-Cohen A, Chen LC, Kendall M, Sheesley R, Thurston GD. Personal exposures to traffic-related particle pollution among children with asthma in the South Bronx, NY. J Exposure Sci Environ Epidemiol 2010;20:446-456.
32. Gasana J, Dillikar D, Mendy A, Forno E, Ramos Vieira E. Motor vehicle air pollution and asthma in children: a metaanalysis. Environ Res 2012;117:36-45.
33. Brandt SJ, Perez L, Künzli N, Lurmann F, McConnell R. Costs of childhood asthma due to traffic-related pollution in two California communities. Eur Respir J 2012;40:363-370.
34. Nishimura KK, Galanter JM, Roth LA, Oh SS, Thakur N, Nguyen EA, Thyne S, et al. Early-life air pollution and asthma risk in minority children: the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013;188:309-318.
35. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, ThiemannHH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994; 149:358-364.
36. Anderson HR, Butland BK, van Donkelaar A, Brauer M, Strachan DP, Clayton T, van Dingenen R, et al. Satellitebased estimates of ambient air pollution and global variations in childhood asthma prevalence. Environ Health Perspect 2012;120:1333-1339.
37. Hiura TS, Kaszubowski MP, Li N, Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 1999;163: 5582-5591.
38. Suwa T, Hogg JC, Vincent R, Mukae H, Fujii T, van Eeden SF. Ambient air particulates stimulate alveolar macrophages of smokers to promote differentiation of myeloid precursor cells. Exp Lung Res 2002;28:1-18.
39. Van den Broeck W, Derore A, Simoens P. Anatomy and nomenclature of murine lymph nodes: descriptive study and nomenclatory standardization in BALB/cAnNCrl mice. J Immunol Methods 2006;312:12-19.
40. Rani R, Smulian AG, Greaves DR, Hogan SP, Herbert DR. TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. Eur J Immunol 2011;41:2000-2009.
41. Hoffman C, Park SH, Daley E, Emson C, Louten J, Sisco M, de Waal Malefyt R, Grunig G. Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products. PLOS ONE 2011;6:e27629.
42. Peden D, Reed CE. Environmental and occupational allergies. J Allergy Clin Immunol 2010;125:S150-S160.
43. Loh MM, Levy JI, Spengler JD, Houseman EA, Bennett DH. Ranking cancer risks of organic hazardous air pollutants in the United States. Environ Health Perspect 2007; 115:1160-1168.
44. Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, Chen L, Mille RL. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci 2008;102:76-81.
45. Niedzwiecki M, Zhu H, Corson L, Grunig G, Factor PH, Chu S, Jiang H, Miller RL. Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice. Allergy 2012;67:904-910.
46. Ng S, Yoshida K, Zelikoff JT. Tumor challenges in immunotoxicity testing. Methods Mol Biol 2010;598:143-155.
47. Ng SP, Zelikoff JT. The effects of prenatal exposure of mice to cigarette smoke on offspring immune parameters. J Toxicol Environ Health A 2008;71:445-453.
48. Bleck B, Grunig G, Chiu A, Liu M, Gordon T, Kazeros A, Reibman J. MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells. J Immunol 2013;190:3757-3763.
49. Johansson MW, Kruger SJ, Schiebler ML, Evans MD, Sorkness RL, Denlinger LC, Busse WW, et al. Markers of vascular perturbation correlate with airway structural change in asthma. AmJ Respir Crit CareMed 2013;188:167-178.
50. Salvato G. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001;56:902-906.
51. Green FH, Butt JC, James AL, Carroll NG. Abnormalities of the bronchial arteries in asthma. Chest 2006;130:1025-1033.
52. Said SI, Hamidi SA, Dickman KG, Szema AM, Lyubsky S, Lin RZ, Jiang Y, Chen JJ, Waschek JA, Kort S. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation 2007; 115:1260-1268.
53. Said SI, Hamidi SA, Gonzalez Bosc L. Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis? Eur Respir J 2010;35:730-734.
54. Johnson RL Jr. Relative effects of air pollution on lungs and heart. Circulation 2004;109:5-7.
55. Nadziejko C, Fang K, Narciso S, Zhong M, Su WC, Gordon T, Nádas A, Chen LC. Effect of particulate and gaseous pollutants on spontaneous arrhythmias in aged rats. Inhal Toxicol 2004;16:373-380.
56. Kreyling WG, Semmler-Behnke M, Takenaka S, Moller W. Differences in the biokinetics of inhaled nano-versus micrometer-sized particles. Acc Chem Res 2012.
57. Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005;113:1555-1560.
58. Muhlfeld C, Geiser M, Kapp N, Gehr P, Rothen-Rutishauser B. Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": evidence for clearance through microvasculature. Part Fibre Toxicol 2007;4:7.
59. Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B. Passage of inhaled particles into the blood circulation in humans. Circulation 2002;105:411-414.
60. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 2010;28:1300-1303.
61. Cao C, Lawrence DA, Strickland DK, Zhang L. A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood 2005;106:3234-3241.
62. Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 2009;54:S10-S19.
63. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, et al. Strategic plan for lung vascular research: an NHLBI-ORDR workshop report. Am J Respir Crit Care Med 2010;182:1554-1562.
64. Pryor WA, Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann NY Acad Sci 1993;686:12-28.
65. Domagala-Kulawik J. Effects of cigarette smoke on the lung and systemic immunity. J Physiol Pharmacol 2008;59 (suppl 6):19-34.
66. Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009;9:375-383.
67. Taylor JD. COPD and the response of the lung to tobacco smoke exposure. Pulm Pharmacol Ther 2010;23:376-383.
68. Schiess R, Senn O, Fischler M, Huber LC, Vatandaslar S, Speich R, Ulrich S. Tobacco smoke: a risk factor for pulmonary arterial hypertension? a case-control study. Chest 2010;138:1086-1092.
69. Nadziejko C, Fang K, Bravo A, Gordon T. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke. J Appl Physiol 2007;102:1780-1785.
70. Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel FC, Milger K, et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell 2011;147:293-305.
71. Santos S, Peinado VI, Ramírez J, Melgosa T, Roca J, Rodriguez-Roisin R, Barbera JA. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 2002;19:632-638.
72. Weissmann N, Grimminger F, Seeger W. Smoking: is it a risk factor for pulmonary vascular diseases? Pulm Circ 2012;2:395-396.
73. Grau M, Barr RG, Lima JA, Hoffman EA, Bluemke DA, Carr JJ, Chahal, H, et al. Percent emphysema and right ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis-Lung and Multi-Ethnic Study of Atherosclerosis-Right Ventricle studies. Chest 2013;144: 136-144.
74. Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 2005; 111:2684-2698.
75. Curtis JL, Warnock ML, Arraj SM, Kaltreider HB. Histo-logic analysis of an immune response in the lung parenchyma of mice: angiopathy accompanies inflammatory cell influx. Am J Pathol 1990;137:689-699.
76. Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, et al. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 2008;205:361-372.
77. Tormanen KR, Uller L, Persson CG, Erjefalt JS. Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels. Am J Respir Crit Care Med 2005;171:19-25.
78. Tigani B, Cannet C, Karmouty-Quintana H, Ble F-X, Zurbruegg S, Schaeublin E, Fozard JR, Beckmann N. Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI. Am J Physiol Lung Cell Mol Physiol 2007;292:L644-L653.
79. Rydell-Tormanen K, Uller L, Erjefalt JS. Allergic airway inflammation initiates long-term vascular remodeling of the pulmonary circulation. Int Arch Allergy Immunol 2009; 149:251-258.
80. Grunig G, Corry DB, Reibman J, Wills-Karp M. Interleukin 13 and the evolution of asthma therapy. Am J Clin Exp Immunol 2012;1:20-27.
81. Cho W, Chen N, Tang C, Elias JA, Lee C. IL-13-induces vascular remodeling and pulmonary arterial hypertension via arginase 2-dependent pathway. Am J Respir Crit Care Med 2010; 181(conf abstr):A6323.
82. Kawashima S, Hirose K, Takahashi K, Tamachi T, Ikeda K, Tokoyoda K, Nakayama T, Nakajima H. Interleukin-25 induces pulmonary arterial remodeling via natural killer T cell-dependent mechanisms. Int Arch Allergy Immunol 2013;161(suppl 2):118-124.
83. Mushaben EM, Hershey GK, Pauciulo MW, Nichols WC, Le Cras TD. Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypo- morph and wild-type mice. PLOS ONE 2012;7:e32468.
84. Park SH, Chen WC, Hoffman C, Marsh LM, West J, Grunig G. Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypo-morphic BMPR2 gene. PLOS ONE 2013;8:e55180.
85. Gilmour MI, McGee J, Duvall RM, Dailey L, Daniels M, Boykin E, Cho S-H, Doerfler D, Gordon T, Devlin RB. Comparative toxicity of size-fractionated airborne particu-late matter obtained from different cities in the United States. Inhalation Toxicol 2007;19(suppl 1):7-16.
86. Walters DM, Breysse PN, Wills-Karp M. Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice. Am J Respir Crit Care Med 2001;164:1438-1443.
87. Padilla J, Daley E, Chow A, Robinson K, Parthasarathi K, McKenzie ANJ, Tschernig T, Kurup VP, Donaldson DD, Grunig G. IL-13 regulates the immune response to inhaled antigens. J Immunol 2005;174:8097-8105.
88. Chen WC, Park SH, Hoffman C, Philip C, Robinson L, West J, Grunig G. Right ventricular systolic pressure measurements in combination with harvest of lung and immune tissue samples in mice. J Vis Exp 2013;71:e50023. doi:10.3791/50023.
89. Leary PJ, Barr RG, Bluemke DA, Hough CL, Kaufman JD, Szpiro AA, Kawut SM, Van Hee VC. The relationship of road-way proximity and NOx with right ventricular structure and function: the MESA-Right Ventricle and MESA-Air studies. Am J Respir Crit Care Med 2013;187(conf abstr):A3976.
90. Bloomfield GS, Lagat DK, Akwanalo OC, Carter EJ, Lugogo N, Vedanthan R, Velazquez EJ, Kimaiyo S, Sherman CB. Conditions that predispose to pulmonary hypertension and right heart failure in persons exposed to household air pollution in LMIC. Global Heart 2012;7:249-259.
91. Calderon-Garciduenas L, Vincent R, Mora-Tiscareño A, Franco-Lira M, Henríquez-Roldan C, Barragán-Mejía G, Garrido-García L, et al. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Environ Health Perspect 2007;115:1248-1253.
92. Thomson EM, Williams A, Yauk CL, Vincent R. Toxico-genomic analysis of susceptibility to inhaled urban particu-late matter in mice with chronic lung inflammation. Part Fibre Toxicol 2009;6:6.
93. Courtois A, Andujar P, Ladeiro Y, Baudrimont I, Delannoy E, Leblais V, Begueret H, et al. Impairment of NO-dependent relaxation in intralobar pulmonary arteries: comparison of urban particulate matter and manufactured nanoparticles. Environ Health Perspect 2008;116:1294-1299.
94. Batalha JR, Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Krishna Murthy GG, Koutrakis P, Godleski JJ. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ Health Perspect 2002;110:1191-1197.
95. Rubin LJ. Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci 2012;91:517-521.
96. Barst RJ, Gibbs JS, Ghofrani HA, Hoeper MM, McLaughlin VV, Rubin LJ, Sitbon O, Tapson VF, Galie N. Updated evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 2009;54(suppl):S78-S84.
97. Makellar A. An investigation into the nature of black phthisis; or ulceration induced by carbonaceous accumulation in lungs of coal miners and other operatives. Scottish Mining Website. http://www.scottishmining.co.uk/500.html. Originally published in 1846.
98. Samuelson S. Chronic cor pulmonale in silicosis. Acta Med Scand Suppl 1952;266:875-885.
99. Rosenman KD, Zhu Z. Pneumoconiosis and associated medical conditions. Am J Ind Med 1995;27:107-113.
100. Murray J, Reid G, Kielkowski D, de Beer M. Cor pul-monale and silicosis: a necropsy based case-control study. Br J Ind Med 1993;50:544-548.
101. Herget J, Kuncova M, Havrankova J, Palecek F. Pulmonary hypertension in silicotic rats. Arch Environ Health 1979;34:320-324.
102. Leung CC, Yu IT, Chen W. Silicosis. Lancet 2012;379: 2008-2018.
103. World Health Organization. Silicosis. Fact sheet 238. http://www.who.int/inf-fs/en/fact238.html. Published May 2000.
104. Lioy PJ, Weisel CP, Millette JR, Eisenreich S, Vallero D, Offenberg J, Buckley B, et al. Characterization of the dust/ smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC11 September 2001. Environ Health Perspect 2002; 110:703-714.
105. Yiin LM, Millette JR, Vette A, Ilacqua V, Quan C, Gorczynski J, Kendall M, et al. Comparisons of the dust/smoke particulate that settled inside the surrounding buildings and outside on the streets of southern New York City after the collapse of the World Trade Center, September 11, 2001. J Air Waste Manag Assoc 2004;54:515-528.
106. Caplan-Shaw CE, Yee H, Rogers L, Abraham JL, Parsia SS, Naidich DP, Borczuk A, et al. Lung pathologic findings in a local residential and working community exposed to World Trade Center dust, gas, and fumes. J Occup Environ Med 2011;53:981-991.
107. Beaudry C, Lavoueí J, Sauveí JF, Beígin D, Senhaji Rhazi M, Perrault G, Dion C, Geírin M. Occupational exposure to silica in construction workers: a literature-based exposure database. J Occup Environ Hyg 2013;10:71-77.
108. Cook AG, Weinstein P, Centeno JA. Health effects of natural dust: role of trace elements and compounds. Biol Trace Elem Res 2005;103:1-15.
109. Chalupka S. Occupational silica exposure in hydraulic fracturing. Workplace Health Safe 2012;60:460.