Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease

New England Journal of Medicine

Volumn 357, Issue 11, 2007, Pages 1075-1082

  Mills, Nicholas L ^a   Törnqvist, Håkan ^c   Gonzalez, Manuel C ^c   Vink, Elen ^a   Robinson, Simon D ^a   Söderberg, Stefan ^c   Boon, Nicholas A ^a   Donaldson, Ken ^b   Sandström, Thomas ^c   Blomberg, Anders ^c   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITROPRUSSIDE SODIUM; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENT;

ADULT; AIR POLLUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXHAUST GAS; FIBRINOLYSIS; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART RATE; HUMAN; INHALATION; MALE; PRIORITY JOURNAL; ST SEGMENT DEPRESSION; THROMBOSIS; VASOMOTOR REFLEX; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; EXERCISE; MIDDLE AGED; PARTICULATE MATTER; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

AIR POLLUTION; CARDIOVASCULAR SYSTEM; CORONARY DISEASE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENVIRONMENTAL EXPOSURE; EXERCISE; FIBRINOLYSIS; HUMANS; INHALATION; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; PARTICULATE MATTER; THROMBOSIS; VASODILATOR AGENTS; VEHICLE EMISSIONS;

EID: 34548779665     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa066314     Document Type: Article

References (34)

1. The world health report 2002 - reducing risks, promoting healthy life. Geneva: World Health Organization. (Accessed August 17, 2007, at http://www.who.int/whr/2002/en/.)
2. Brook RD, Franklin B, Cascio W, et al. Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 2004;109:2655-71.
3. Miller KA, Siscovick DS, Sheppard L, et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 2007;356:447-58.
4. Laden F, Neas LM, Dockery DW, Schwartz J. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect 2000;108:941-7.
5. Ware JH. Particulate air pollution and mortality - clearing the air. N Engl J Med 2000;343:1798-9.
6. Sun Q, Wang A, Jin X, et al. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 2005;294:3003-10.
7. Radomski A, Jurasz P, Alonso-Escolano D, et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 2005;146:882-93.
8. Nemmar A, Hoylaerts MF, Hoet PH, Nemery B. Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects. Toxicol Lett 2004;149:243-53.
9. von Klot S, Peters A, Aalto P, et al. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 2005;112:3073-9. [Erratum, Circulation 2006;113:e71.]
10. Pekkanen J, Peters A, Hoek G, et al. Particulate air pollution and risk of STsegment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 2002;106:933-8.
11. Gold DR, Litonjua AA, Zanobetti A, et al. Air pollution and ST-segment depression in elderly subjects. Environ Health Perspect 2005;113:883-7.
12. Peters A, Dockery DW, Muller JE, Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 2001;103:2810-5.
13. Peters A, von Klot S, Heier M, et al. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004;351:1721-30.
14. Stone PH. Triggering myocardial infarction. N Engl J Med 2004;351:1716-8.
15. Salvi S, Blomberg A, Rudell B, et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999;159:702-9.
16. Behndig AF, Mudway IS, Brown JL, et al. Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J 2006;27:359-65.
17. Mills NL, Tornqvist H, Robinson SD, et al. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005;112:3930-6.
18. Air quality guidelines for Europe. 2nd ed. No. 91. Copenhagen: World Health Organization Regional Office for Europe, 2000:173-98.
19. Witherow FN, Dawson P, Ludlam CA, Fox KA, Newby DE. Marked bradykinin-induced tissue plasminogen activator release in patients with heart failure maintained on chronic ACE inhibitor therapy. J Am Coll Cardiol 2002;40:961-6.
20. Newby DE, Wright RA, Labinjoh C, et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation 1999;99:1411-5.
21. Newby DE, Wright RA, Ludlam CA, Fox KA, Boon NA, Webb DJ. An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium. Thromb Haemost 1997;78:1242-8.
22. Urban air pollution in megacities of the world: a report from the United Nations Environment Programme and the World Health Organization. Report no. 36. London: Blackwell, 1992.
23. Lanki T, de Hartog JJ, Heinrich J, et al. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ Health Perspect 2006;114:655-60.
24. Geller MD, Sardar SB, Phuleria H, Fine PM, Sioutas C. Measurements of particle number and mass concentrations and size distributions in a tunnel environment. Environ Sci Technol 2005;39:8653-63.
25. Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med 2000;343:1742-9.
26. Rosenberg RD, Aird WC. Vascularbed-specific hemostasis and hypercoagulable states. N Engl J Med 1999;340:1555-64.
27. Nemmar A, Hoet PH, Dinsdale D, Vermylen J, Hoylaerts MF, Nemery B. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 2003;107:1202-8.
28. Zeiher AM, Drexler H, Wollschläger H, Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
29. Treasure CB, Klein JL, Weintraub WS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995;332:481-7.
30. Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002;105:1534-6.
31. 10). Free Radic Biol Med 2003;34:1369-82.
32. Brunekreef B, Holgate ST. Air pollution and health. Lancet 2002;360:1233-42.
33. Schwartz J. What are people dying of on high air-pollution days? Environ Res 1994;64:26-35.
34. 2 on the airways of healthy subjects. Am J Respir Crit Care Med 1997;156:418-24. [Erratum, Am J Respir Crit Care Med 1997;156:2028.]