Particulate matter beyond mass: Recent health evidence on the role of fractions, chemical constituents and sources of emission

Inhalation Toxicology

Volumn 25, Issue 14, 2013, Pages 802-812

  Cassee, Flemming R ^a,b   Héroux, Marie Eve ^c   Gerlofs Nijland, Miriam E ^a   Kelly, Frank J ^d  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c WHO European Centre for Environment and Health   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Air pollution adverse effects; Particulate matter; Toxicology

Indexed keywords

1,3 BUTADIENE; BIODIESEL; BLACK CARBON; COAL; COPPER; DIESEL FUEL; GASOLINE; METAL; METAL OXIDE; NICKEL; NITROGEN DIOXIDE; OIL; ORGANIC CARBON; OZONE; POLYCYCLIC AROMATIC HYDROCARBON; RAPESEED OIL; RUBBER; STYRENE; TRANSITION ELEMENT; VANADIUM; ZINC; ZINC OXIDE;

AEROSOL; AIR POLLUTANT; AIR POLLUTION; AIR QUALITY; AIR QUALITY STANDARD; ASTHMA; BIOASSAY; BIOMASS; COMBUSTION; CYTOTOXICITY; DESERT; DNA DAMAGE; DUST; ELECTRIC POWER PLANT; ELECTROCARDIOGRAM; ENVIRONMENTAL EXPOSURE; EUROPEAN UNION; EXHAUST GAS; HEALTH HAZARD; HEART FUNCTION; HOST RESISTANCE; HUMAN; INFLAMMATION; INHALATION; ISCHEMIC HEART DISEASE; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG COMPLIANCE; MUTAGENICITY; NONHUMAN; OCEANIC REGIONS; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; POLLUTION CONTROL; PRIORITY JOURNAL; REVIEW; SEA; SHORT TERM EXPOSURE; SMOKE; SPERMATOZOON ABNORMALITY; ST SEGMENT DEPRESSION; TRAFFIC; URBAN AREA; WOOD; WORLD HEALTH ORGANIZATION;

AIR POLLUTANTS; ANIMALS; BIOMASS; DUST; HUMANS; INDUSTRY; METALS; PARTICULATE MATTER; POWER PLANTS; VEHICLE EMISSIONS;

EID: 84890354548     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2013.850127     Document Type: Review

References (94)

1. Akinaga LM, Lichtenfels AJ, Carvalho-Oliveira R, et al. (2009). Effects of chronic exposure to air pollution from Sao Paulo city on coronary of Swiss mice, from birth to adulthood. Toxicol Pathol 37:306-14.
2. Araujo JA. (2010). Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual Atmos Health 4:79-93.
3. Bakand S, Hayes A, Dechsakulthorn F. (2012). Nanoparticles: a review of particle toxicology following inhalation exposure. Inhal Toxicol 24: 125-35.
4. Barbato DL, Tomei G, Tomei F, Sancini A. (2010). Traffic air pollution and oxidatively generated DNA damage: can urinary 8-oxo-7,8- dihydro-2-deoxiguanosine be considered a good biomarker? A metaanalysis. Biomarkers 15:538-45.
5. Barmpadimos I, Keller J, Oderbolz D, et al. (2012). One decade of parallel fine (PM2.5) and coarse (PM10-PM2.5) particulate matter measurements in Europe: trends and variability. Atmos Chem Phys 12:3189-203.
6. Barrett EG, Day KC, Gigliotti AP, et al. (2011). Effects of simulated downwind coal combustion emissions on pre-existing allergic airway responses in mice. Inhal Toxicol 23:792-804.
7. Behndig AF, Mudway IS, Brown JL, et al. (2006). Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Resp J 27:359-65.
8. Biswas S, Verma V, Schauer JJ, et al. (2009). Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavyduty vehicles retrofitted with emission control technologies. Environ Sci Technol 43:3905-12.
9. Bølling AK, Totlandsdal AI, Sallsten G, et al. (2012). Wood smoke particles from different combustion phases induce similar proinflammatory effects in a co-culture of monocyte and pneumocyte cell lines. Part Fibre Toxicol 9:45.
10. Brauner EV, Møller P, Barregard L, et al. (2008). Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals. Part Fibre Toxicol 5:13.
11. Bunger J, Krahl J, Baum K, et al. (2000). Cytotoxic and mutagenic effects, particle size and concentration analysis of diesel engine emissions using biodiesel and petrol diesel as fuel. Arch Toxicol 74: 490-8.
12. Bunger J, Krahl J, Munack A, et al. (2007). Strong mutagenic effects of diesel engine emissions using vegetable oil as fuel. Arch Toxicol 81: 599-603.
13. Calogero AE, La Vignera S, Condorelli RA, et al. (2011). Environmental car exhaust pollution damages human sperm chromatin and DNA. J Endocrinol Invest 34:e139-43.
14. Charrier JG, Anastasio C. (2011). Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid. Atmos Environ 45:7555-62.
15. Ciarrocca M, Caciari T, Ponticiello BG, et al. (2011). Folliclestimulating hormone levels in female workers exposed to urban pollutants. Int J Environ Health Res 21:391-401.
16. Duffin R, Mills NL, Donaldson K. (2007). Nanoparticles - a thoracic toxicology perspective. Yonsei Med J 48:561-72.
17. Elder A, Gelein R, Finkelstein J, et al. (2004). On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol 16:41-53.
18. Elder A, Couderc JP, Gelein R, et al. (2007). Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol 19:1-12.
19. EPA. (2009). Integrated science assessment for particulate matter (final report). Washington, DC: United States Environmental Protection Agency. Available from: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid= 216546#Download. [Last accessed: 5 April 2013].
20. European Commission Cafe Working Group on Particulate Matter (EC). (2004). Second position paper on particulate matter. Available from: http://ec.europa.eu/environment/archives/cafe/pdf/working-groups/ 2nd-position-paper-pm.pdf. [Last accessed: 28 June 2013].
21. EU. (2008). Directive 2008/50/EC of the European Parliament and of the Council of 21 May 2008 on ambient air quality and cleaner air for Europe. Official J EU 152:1-44.
22. Frampton MW. (2001). Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environ Health Perspect 109:529-32.
23. Frampton MW, Utell MJ, Zareba W, et al. (2004). Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst 126:1-47; discussion 49-63.
24. Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, et al. (2007). Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol 19:1055-69.
25. Gilmour MI, McGee J, Duvall RM, et al. (2007). Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States. Inhal Toxicol 19:7-16.
26. Gilmour PS, Schladweiler MC, Nyska A, et al. (2006). Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposure. J Toxicol Environ Health A 69:2011-32.
27. Godleski JJ, Rohr AC, Coull BA, et al. (2011). Toxicological evaluation of realistic emission source aerosols (TERESA): summary and conclusions. Inhal Toxicol 23:95-103.
28. Gottipolu RR, Landa ER, Schladweiler MC, et al. (2008). Cardiopulmonary responses of intratracheally instilled tire particles and constituent metal components. Inhal Toxicol 20:473-84.
29. Graff DW, Cascio WE, Rappold A, et al. (2009). Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environ Health Perspect 117: 1089-94.
30. Guven A, Kayikci A, Cam K, et al. (2008). Alterations in semen parameters of toll collectors working at motorways: does diesel exposure induce detrimental effects on semen? Andrologia 40: 346-51.
31. Halatek T, Stepnik M, Stetkiewicz J, et al. (2011). The inflammatory response in lungs of rats exposed on the airborne particles collected during different seasons in four European cities. J Toxicol Environ Health A 46:1469-81.
32. Happo MS, Salonen RO, Halinen AI, et al. (2010). Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities. Inhal Toxicol 22:402-16.
33. Harder V, Gilmour P, Lentner B, et al. (2005). Cardiovascular responses in unrestrained WKY rats to inhaled ultrafine carbon particles. Inhal Toxicol 17:29-42.
34. HEI Panel on the Health Effects of Traffic-Related Air Pollution. (2010). Traffic-related air pollution: a critical review of the literature on emissions, exposure, and health effects. Boston: Health Effects Institute. Special Report 17. Available from: http://pubs.healtheffects.org/getfile.php?u= 553. [Last accessed: 14 March 2013].
35. HEI Review Panel on Ultrafine Particles. (2013). Understanding the health effects of ultrafine ambient particles. Boston: Health Effects Institute. Available from: http://pubs.healtheffects.org/getfile.php?u=893. [Last accessed: 28 June 2013].
36. Hesterberg TW, Long CM, Sax SN, et al. (2011). Particulate matter in new technology diesel exhaust (NTDE) is quantitatively and qualitatively very different from that found in traditional diesel exhaust (TDE). J Air Waste Manag Assoc 61:894-913.
37. Jacobs L, Nawrot TS, de Geus B, et al. (2010). Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study. Environ Health 9:64.
38. Jalava PI, Salonen RO, Pennanen AS, et al. (2008). Effects of solubility of urban air fine and coarse particles on cytotoxic and inflammatory responses in RAW 264.7 macrophage cell line. Toxicol Appl Pharmacol 229:146-60.
39. Jalava PI, Tapanainen M, Kuuspalo K, et al. (2010). Toxicological effects of emission particles from fossil- and biodiesel-fueled diesel engine with and without DOC/POC catalytic converter. Inhal Toxicol 22:48-58.
40. Kelly FJ. (2003). Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med 60:612-16.
41. Kelly F, Anderson HR, Armstrong B, et al.; HEI Health Review Committee. (2011). The impact of the congestion charging scheme on air quality in London. Part 1. Emissions modeling and analysis of air pollution measurements. Res Rep Health Eff Inst (155):5-71.
42. Kelly FJ, Fussell JC. (2012). Size, source and chemical composition as determinants of toxicity attributable to smbient particulate matter. Atmos Environ 60:504-26.
43. Kleinman MT, Araujo JA, Nel A, et al. (2008). Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicol Lett 178:127-30.
44. Kreyling WG, Hirn S, Schleh C. (2010). Nanoparticles in the lung. Nat Biotechnol 28:1275-6.
45. Kreyling WG, Semmler-Behnke M, Takenaka S, Moller W. (2013). Differences in the biokinetics of inhaled nano- versus micrometersized particles. Acc Chem Res 46:714-22.
46. Kurmi OP, Dunster C, Ayres JG, Kelly FJ. (2013). Oxidative potential of smoke from burning wood and mixed biomass fuels. Free Radic Res 47:829-35.
47. Langrish JP, Mills NL, Chan JK, et al. (2009). Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol 6:8.
48. Langrish JP, Li X, Wang S, et al. (2012). Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect 120:367-72.
49. Larsson BM, Grunewald J, Skold CM, et al. (2010). Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel. Respir Med 104:1912-18.
50. Laumbach RJ, Rich DQ, Gandhi S, et al. (2010). Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure. J Occup Environ Med 52:324-31.
51. Lippmann M, Chen LC. (2009). Health effects of concentrated ambient air particulate matter (CAPs) and its components. Crit Rev Toxicol 39:865-913.
52. Lippmann M, Ito K, Hwang JS, et al. (2006). Cardiovascular effects of nickel in ambient air. Environ Health Perspect 114:1662-9.
53. Lucking AJ, Lundback M, Barath SL, et al. (2011). Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation 123:1721-8.
54. Lund AK, Knuckles TL, Obot Akata C, et al. (2007). Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci 95:485-94.
55. Mauad T, Rivero DH, de Oliveira RC, et al. (2008). Chronic exposure to ambient levels of urban particles affects mouse lung development. Am J Respir Crit Care Med 178:721-8.
56. McCreanor J, Cullinan P, Nieuwenhuijsen MJ, et al. (2007). Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med 357:2348-58.
57. Mills NL, Tornqvist H, Robinson SD, et al. (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930-6.
58. Mills NL, Tornqvist H, Gonzalez MC, et al. (2007). Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 357:1075-82.
59. Mills NL, Robinson SD, Fokkens PH, et al. (2008). Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect 116: 709-15.
60. Mills NL, Miller MR, Lucking AJ, et al. (2011). Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation. Eur Heart J 32:2660-71.
61. Palli D, Saieva C, Munnia A, et al. (2008). DNA adducts and PM(10) exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study. Sci Total Environ 403:105-12.
62. Pedersen M, Wichmann J, Autrup H, et al. (2009). Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res 109:1012-20.
63. Peters A, Ruckerl R, Cyrys J. (2011). Lessons from air pollution epidemiology for studies of engineered nanomaterials. J Occup Environ Med 53:S8-13.
64. Polymenakou PN, Mandalakis M, Stephanou EG, Tselepides A. (2008). Particle size distribution of airborne microorganisms and pathogens during an intense African dust event in the eastern Mediterranean. Environ Health Perspect 116:292-6.
65. Quan C, Sun Q, Lippmann M, Chen LC. (2010). Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction. Inhal Toxicol 22:738-53.
66. Reiss R, Anderson EL, Cross CE, et al. (2007). Evidence of health impacts of sulfate- and nitrate-containing particles in ambient air. Inhal Toxicol 19:419-49.
67. Rundell KW, Hoffman JR, Caviston R, et al. (2007). Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function. Inhal Toxicol 19:133-40.
68. Sancini A, Tomei F, Tomei G, et al. (2011). Exposure to urban stressors and free testosterone plasma values. Int Arch Occup Environ Health 84:609-16.
69. Schauer JJ, Lough GC, Shafer MM, et al. (2006). Characterization of metals emitted from motor vehicles. Res Rep Health Eff Inst 1-76; discussion (133):77-88.
70. Schlesinger RB, Cassee FR. (2003). Atmospheric secondary inorganic particulate matter: the toxicological perspective as a basis for health effects risk assessment. Inhal Toxicol 15:197-235.
71. Seilkop SK, Campen MJ, Lund AK, et al. (2012). Identification of chemical components of combustion emissions that affect proatherosclerotic vascular responses in mice. Inhal Toxicol 24:270-87.
72. Soares SR, Carvalho-Oliveira R, Ramos-Sanchez E, et al. (2009). Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice. Atherosclerosis 207:368-73.
73. Steerenberg PA, van Amelsvoort L, Lovik M, et al. (2006). Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: an exploratory study. Inhal Toxicol 18:333-46.
74. Stockfelt L, Sallsten G, Almerud P, et al. (2013). Short-term chamber exposure to low doses of two kinds of wood smoke does not induce systemic inflammation, coagulation or oxidative stress in healthy humans. Inhal Toxicol 25:417-25.
75. Strak M, Janssen NA, Godri KJ, et al. (2012). Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential - the RAPTES Project. Environ Health Perspect 120:1183-9.
76. Svartengren M, Strand V, Bylin G, et al. (2000). Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen. Eur Respir J 15:716-24.
77. Swanson KJ, Madden MC, Ghio AJ. (2007). Biodiesel exhaust: the need for health effects research. Environ Health Perspect 115:496-9.
78. Taylor K, Foster ML, Law JM, et al. (2013). Assessment of geographical variation in the respiratory toxicity of desert dust particles. Inhal Toxicol 25:405-16.
79. Thorpe A, Harrison RM. (2008). Sources and properties of non-exhaust particulate matter from road traffic: a review. Sci Total Environ 400: 270-82.
80. Tomao E, Tomei G, Rosati MV, et al. (2009). Luteinizing hormone (LH) levels in male workers exposed to urban stressors. Sci Total Environ 407:4591-5.
81. Tomei G, Tomao E, Ciarrocca M, et al. (2009). Follicle-stimulating hormone levels in male workers exposed to urban chemical, physical, and psychosocial stressors. Toxicol Ind Health 25: 395-402.
82. Tomei G, Ciarrocca M, Fiore P, et al. (2008). Exposure to urban stressor and effects on free testosterone in female workers. Sci Total Environ 392:198-202.
83. Upadhyay S, Stoeger T, Harder V, et al. (2008). Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats. Part Fibre Toxicol 5:19.
84. Urch B, Brook JR, Wasserstein D, et al. (2004). Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans. Inhal Toxicol 16:345-52.
85. Urch B, Silverman F, Corey P, et al. (2005). Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ Health Perspect 113:1052-5.
86. Verma V, Polidori A, Schauer JJ, et al. (2009). Physicochemical and toxicological profiles of particulate matter in Los Angeles during the October 2007 Southern California wildfires. Environ Sci Technol 43: 954-60.
87. Wegesser TC, Last JA. (2008). Lung response to coarse PM: bioassay in mice. Toxicol Appl Pharmacol 230:159-66.
88. Wegesser TC, Pinkerton KE, Last JA. (2009). California wildfires of 2008: coarse and fine particulate matter toxicity. Environ Health Perspect 117:893-7.
89. Wilfong ER, Lyles M, Rietcheck RL, et al. (2011). The acute and longterm effects of Middle East sand particles on the rat airway following a single intratracheal instillation. J Toxicol Environ Health A 74: 1351-65.
90. WHO Regional Office for Europe. (2006). Air quality guidelines global update 2005: particulate matter, ozone, nitrogen dioxide and sulfur dioxide. Copenhagen: WHO Regional Office for Europe. Available from: http://www.euro.who. int/-data/assets/pdf-file/0005/78638/E90038.pdf. [Last accessed: 6 April 2013].
91. WHO Regional Office for Europe. (2012). Health Effects of Black Carbon. Copenhagen: WHO Regional Office for Europe. Available from: http://www.euro.who. int/-data/assets/pdf-file/0004/162535/e96541.pdf. [Last accessed: 28 June 2013].
92. WHO Regional Office for Europe. (2013). Review of evidence on health aspects of air pollution - REVIHAAP Project, Technical Report. Copenhagen: WHO Regional Office for Europe. Available from: http://www.euro.who.int/-data/ assets/pdf-file/0004/193108/REVIHAAP-Final-technical-report.pdf [Last accessed: 28 Oct 2013].
93. Zuurbier M, Hoek G, Oldenwening M, et al. (2011a). Respiratory effects of commuters' exposure to air pollution in traffic. Epidemiology 22: 219-27.
94. Zuurbier M, Hoek G, Oldenwening M, et al. (2011b). In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults. Environ Health Perspect 119:1384-9.