Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 6, Issue 6, 2014, Pages 517-531

  Saber, Anne T ^a   Jacobsen, Nicklas R ^a   Jackson, Petra ^a   Poulsen, Sarah Søs ^a   Kyjovska, Zdenka O ^a   Halappanavar, Sabina ^b   Yauk, Carole L ^b   Wallin, Håkan ^a,c   Vogel, Ulla ^a,d  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b HEALTH CANADA   (Canada)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CARDIOLOGY; DIESEL ENGINES; NANOPARTICLES; PATHOLOGY; PROTEINS;

ACUTE-PHASE RESPONSE; BRONCHOALVEOLAR LAVAGE FLUID; CARDIO-VASCULAR DISEASE; DIESEL EXHAUST PARTICLES; EPIDEMIOLOGICAL STUDIES; INDEPENDENT PREDICTORS; OCCUPATIONAL EXPOSURE; PARTICULATE AIR POLLUTION;

DISEASES;

CARBON NANOTUBE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MICRORNA; NANOPARTICLE; SERUM AMYLOID A;

ACUTE PHASE RESPONSE; AIR POLLUTANT; AIR POLLUTION; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; HUMAN; INHALATION; LIFESTYLE; LUNG FUNCTION; LUNG LAVAGE; LUNG PARENCHYMA; NEUTROPHIL; NONHUMAN; PARTICULATE MATTER; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ACUTE PHASE RESPONSE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ANIMAL; EXPOSURE; MOUSE; OCCUPATIONAL EXPOSURE;

ACUTE-PHASE REACTION; ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; INHALATION EXPOSURE; MICE; NANOPARTICLES; OCCUPATIONAL EXPOSURE;

EID: 84907888107     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1279     Document Type: Review

References (93)

1. Pope CA III, Thun MJ, Namboodiri MM, Dockery DW, Evans JS, Speizer FE, Heath CW Jr. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med 1995, 151:669-674. PM:7881654.
2. Dockery DW, Pope CA III, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993, 329:1753-1759. PM:8179653.
3. Clancy L, Goodman P, Sinclair H, Dockery DW. Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 2002, 360:1210-1214. PM:12401247.
4. Hertel S, Viehmann A, Moebus S, Mann K, Brocker-Preuss M, Mohlenkamp S, Nonnemacher M, Erbel R, Jakobs H, Memmesheimer M, et al. Influence of short-term exposure to ultrafine and fine particles on systemic inflammation. Eur J Epidemiol 2010, 25:581-592. PM:20559688.
5. Li Z, Hulderman T, Salmen R, Chapman R, Leonard SS, Young SH, Shvedova A, Luster MI, Simeonova PP. Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes. Environ Health Perspect 2007, 115:377-382. ISI:000244651500029.
6. Chen LC, Nadziejko C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 2005, 17:217-224. ISI:000227779500005.
7. Mikkelsen L, Sheykhzade M, Jensen KA, Saber AT, Jacobsen NR, Vogel U, Wallin H, Loft S, Moller P. Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2). Part Fibre Toxicol 2011, 8:32. PM:22074227.
8. Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP. Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. Toxicol Lett 2011, 204:12-16. PM:21513782.
9. Donaldson K, Stone V, Seaton A, MacNee W. Ambient particle inhalation and the cardiovascular system: potential mechanisms. Environ Health Perspect 2001, 109(Suppl 4):523-527. PM:11544157.
10. Gabay C, Kushner I. Mechanisms of disease: acute-phase proteins and other systemic responses to inflammation. New Engl J Med 1999, 340:448-454. ISI:000078571000007.
11. Saber AT, Lamson JS, Jacobsen NR, Ravn-Haren G, Hougaard KS, Nyendi AN, Wahlberg P, Madsen AM, Jackson P, Wallin H, et al. Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk. PLoS One 2013, 8:e69020. PM:23894396.
12. Kaptoge S, Di AE, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, et al. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012, 367:1310-1320. PM:23034020.
13. Taubes G. Cardiovascular disease. Does inflammation cut to the heart of the matter? Science 2002, 296:242-245. PM:11951014.
14. Lowe GD. The relationship between infection, inflammation, and cardiovascular disease: an overview. Ann Periodontol 2001, 6:1-8.
15. Mezaki T, Matsubara T, Hori T, Higuchi K, Nakamura A, Nakagawa I, Imai S, Ozaki K, Tsuchida K, Nasuno A, et al. Plasma levels of soluble thrombomodulin, C-reactive protein, and serum amyloid A protein in the atherosclerotic coronary circulation. Jpn Heart J 2003, 44:601-612.
16. Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J 2010, 74:213-220. ISI:000274099300001.
17. Pussinen PJ, Tuomisto K, Jousilahti P, Havulinna AS, Sundvall J, Salomaa V. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007, 27:1433-1439. ISI:000246714600030.
18. Estabragh ZR, Mamas MA. The cardiovascular manifestations of influenza: a systematic review. Int J Cardiol 2013, 167:2397-2403. PM:23474244.
19. Rivera MF, Lee JY, Aneja M, Goswami V, Liu L, Velsko IM, Chukkapalli SS, Bhattacharyya I, Chen H, Lucas AR, et al. Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One 2013, 8:e57178. PM:23451182.
20. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000, 342:836-843. PM:10733371.
21. Johnson BD, Kip KE, Marroquin OC, Ridker PM, Kelsey SF, Shaw LJ, Pepine CJ, Sharaf B, Bairey Merz CN, Sopko G, et al. Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation 2004, 109:726-732. PM:14970107.
22. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004, 351:2599-2610. PM:15602020.
23. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005, 113:823-839.
24. Fang SC, Cassidy A, Christiani DC. A systematic review of occupational exposure to particulate matter and cardiovascular disease. Int J Environ Res Public Health 2010, 7:1773-1806. ISI:000277119600030.
25. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem 2008, 54:24-38. PM:18160725.
26. Jacobsen NR, Moller P, Jensen KA, Vogel U, Ladefoged O, Loft S, Wallin H. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice. Part Fibre Toxicol 2009, 6:2. PM:19138394.
27. Bourdon JA, Saber AT, Jacobsen NR, Jensen KA, Madsen AM, Lamson JS, Wallin H, Moller P, Loft S, Yauk CL, et al. Carbon Black Nanoparticle Instillation Induces Sustained Inflammation and Genotoxicity in Mouse Lung and Liver. Part Fibre Toxicol 2012, 9:5. PM:22300514.
28. Husain M, Saber AT, Guo C, Jacobsen NR, Jensen KA, Yauk CL, Williams A, Vogel U, Wallin H, Halappanavar S. Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation. Toxicol Appl Pharmacol 2013, 269:250-262. PM:23557971.
29. Jackson P, Hougaard KS, Boisen AM, Jacobsen NR, Jensen KA, Moller P, Brunborg G, Gutzkow KB, Andersen O, Loft S, et al. Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver DNA strand breaks in dams and offspring. Nanotoxicology 2012, 6:486-500. PM:21649560.
30. Saber AT, Jacobsen NR, Bornholdt J, Kjaer SL, Dybdahl M, Risom L, Loft S, Vogel U, Wallin H. Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor. Part Fibre Toxicol 2006, 3:4.
31. Saber AT, Bornholdt J, Dybdahl M, Sharma AK, Loft S, Vogel U, Wallin H. Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation. Arch Toxicol 2005, 79:177-182.
32. Boisen AM, Shipley T, Jackson P, Hougaard KS, Wallin H, Yauk CL, Vogel U. NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice. Part Fibre Toxicol 2012, 9:19. PM:22656316.
33. Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, Wallin H. Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity, and inflammation in mice. Part Fibre Toxicol 2008, 5:3. PM:18331653.
34. Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Loschner K, Larsen EH, Birkedal RK, Vibenholt A, Boisen AM, Wallin H, et al. Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 2010, 7:16. PM:20546558.
35. Sos PS, Jacobsen NR, Labib S, Wu D, Husain M, Williams A, Bogelund JP, Andersen O, Kobler C, Molhave K, et al. Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells. PLoS One 2013, 8:e80452. PM:24260392.
36. Bornholdt J, Dybdahl M, Vogel U, Hansen M, Loft S, Wallin H. Inhalation of ozone induces DNA strand breaks and inflammation in mice. Mutat Res 2002, 520:63.
37. Dybdahl M, Risom L, Bornholdt J, Autrup H, Loft S, Wallin H. Inflammatory and genotoxic effects of diesel particles in vitro and in vivo. Mutat Res 2004, 562:119-131.
38. Risom L, Dybdahl M, Bornholdt J, Vogel U, Wallin H, Moller P, Loft S. Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation. Carcinogenesis 2003, 24:1847-1852.
39. Halappanavar S, Jackson P, Williams A, Jensen KA, Hougaard KS, Vogel U, Yauk CL, Wallin H. Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study. Environ Mol Mutagen 2011, 52:425-439. PM:21259345.
40. Jackson P, Halappanavar S, Hougaard KS, Williams A, Madsen AM, Lamson JS, Andersen O, Yauk C, Wallin H, Vogel U. Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression. Nanotoxicology 2013, 7:85-96. PM:22117692.
41. Bourdon JA, Saber AT, Halappanavar S, Jackson PA, Wu D, Hougaard KS, Jacobsen NR, Williams A, Vogel U, Wallin H, et al. Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung. Environ Mol Mutagen 2012, 53:462-468. PM:22753103.
42. Bourdon JA, Halappanavar S, Saber AT, Jacobsen NR, Williams A, Wallin H, Vogel U, Yauk CL. Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis. Toxicol Sci 2012, 127:474-484. PM:22461453.
43. Saber AT, Halappanavar S, Folkmann JK, Bornholdt J, Boisen AM, Moller P, Williams A, Yauk C, Vogel U, Loft S, et al. Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation. Part Fibre Toxicol 2009, 6:12. PM:19374780.
44. Uhlar CM, Whitehead AS. Serum amyloid A, the major vertebrate acute-phase reactant. Eur J Biochem 1999, 265:501-523. ISI:000083077100001.
45. Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, Wang S, McDonald TO, O'Brien KD, Heinecke JW, et al. Serum amyloid A3 does not contribute to circulating SAA levels. J Lipid Res 2009, 50:1353-1362. ISI:000266912200010.
46. Meek RL, Urielishoval S, Benditt EP. Expression of apolipoprotein serum amyloid-A messenger-Rna in human atherosclerotic lesions and cultured vascular cells - implications for serum amyloid-A Function. Proc Natl Acad Sci USA 1994, 91:3186-3190. ISI:A1994NF96800067.
47. Whitehead AS, Zahedi K, Rits M, Mortensen RF, Lelias JM. Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation. Biochem J 1990, 266:283-290. PM:2310378.
48. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-1812. PM:12813013.
49. Jackson P, Hougaard KS, Vogel U, Wu D, Casavant L, Williams A, Wade M, Yauk CL, Wallin H, Halappanavar S. Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomic effects in dams and offspring. Mutat Res 2012, 745:73-83.
50. Teeguarden JG, Webb-Robertson BJ, Waters KM, Murray AR, Kisin ER, Varnum SM, Jacobs JM, Pounds JG, Zanger RC, Shvedova AA. Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice. Toxicol Sci 2011, 120:123-135. PM:21135415.
51. Chang CC, Chen SH, Ho SH, Yang CY, Wang HD, Tsai ML. Proteomic analysis of proteins from bronchoalveolar lavage fluid reveals the action mechanism of ultrafine carbon black-induced lung injury in mice. Proteomics 2007, 7:4388-4397. PM:17963277.
52. Liang TS, Wang JM, Murphy PM, Gao JL. Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils. Biochem Biophys Res Commun 2000, 270:331-335. PM:10753626.
53. Badolato R, Wang JM, Murphy WJ, Lloyd AR, Michiel DF, Bausserman LL, Kelvin DJ, Oppenheim JJ. Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J Exp Med 1994, 180:203-209. PM:7516407.
54. Duffin R, Tran L, Brown D, Stone V, Donaldson K. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 2007, 19:849-856. PM:17687716.
55. Saber AT, Jensen KA, Jacobsen NR, Birkedal R, Mikkelsen L, Moller P, Loft S, Wallin H, Vogel U. Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology 2012, 6:453-471. PM:21649461.
56. Simeonova PP, Erdely A. Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers. Inhal Toxicol 2009, 21(Suppl 1):68-73. PM:19558236.
57. Skovgaard K, Cirera S, Vasby D, Podolska A, Breum SO, Durrwald R, Schlegel M, Heegaard PM. Expression of innate immune genes, proteins and microRNAs in lung tissue of pigs infected experimentally with influenza virus (H1N2). Innate Immun 2013, 19:531-544. PM:23405029.
58. Halappanavar S, Nikota J, Wu D, Williams A, Yauk CL, Stampfli M. IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol 2013, 190:3679-3686. PM:23440414.
59. Lindhorst E, Young D, Bagshaw W, Hyland M, Kisilevsky R. Acute inflammation, acute phase serum amyloid A and cholesterol metabolism in the mouse. Biochim Biophys Acta 1997, 1339:143-154. PM:9165109.
60. Balci B. The modification of serum lipids after acute coronary syndrome and importance in clinical practice. Curr Cardiol Rev 2011, 7:272-276. PM:22758629.
61. Pfohl M, Schreiber I, Liebich HM, Haring HU, Hoffmeister HM. Upregulation of cholesterol synthesis after acute myocardial infarction-is cholesterol a positive acute phase reactant? Atherosclerosis 1999, 142:389-393. PM:10030390.
62. Jeyaseelan S, Chu HW, Young SK, Worthen GS. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun 2004, 72:7247-7256. ISI:000225453900056.
63. Meek RL, Eriksen N, Benditt EP. Murine serum amyloid A3 is a high density apolipoprotein and is secreted by macrophages. Proc Natl Acad Sci USA 1992, 89:7949-7952. PM:1518819.
64. Tomita T, Sakurai Y, Ishibashi S, Maru Y. Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis. Oncogene 2011, 30:3429-3439. PM:21399660.
65. Cabana VG, Reardon CA, Wei B, Lukens JR, Getz GS. SAA-only HDL formed during the acute phase response in apoA-I+/+and apoA-I-/- mice. J Lipid Res 1999, 40:1090-1103. ISI:000080853900013.
66. Cabana VG, Lukens JR, Rice KS, Hawkins TJ, Getz GS. HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its decrease. J Lipid Res 1996, 37:2662-2674. ISI:A1996WD85500017.
67. Steinmetz A, Hocke G, Saile R, Puchois P, Fruchart JC. Influence of serum amyloid A on cholesterol esterification in human plasma. Biochim Biophys Acta 1989, 1006:173-178. PM:2512983.
68. Hafiane A, Jabor B, Ruel I, Ling J, Genest J. High-density lipoprotein mediated cellular cholesterol efflux in acute coronary syndromes. Am J Cardiol 2014, 113:249-255. PM:24210679.
69. Lee HY, Kim SD, Baek SH, Choi JH, Cho KH, Zabel BA, Bae YS. Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation. Biochem Biophys Res Commun 2013, 433:18-23. PM:23454129.
70. Artl A, Marsche G, Lestavel S, Sattler W, Malle E. Role of serum amyloid A during metabolism of acute-phase HDL by macrophages. Arterioscler Thromb Vasc Biol 2000, 20:763-772. ISI:000085834100023.
71. Dong Z, Wu T, Qin W, An C, Wang Z, Zhang M, Zhang Y, Zhang C, An F. Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Mol Med 2011, 17:1357-1364. PM:21953420.
72. Hiratsuka S, Watanabe A, Sakurai Y, Kashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Baitarani H, Maru Y. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 2008, 10:1349-1355. ISI:000260586700018.
73. Song C, Shen Y, Yamen E, Hsu K, Yan W, Witting PK, Geczy CL, Freedman SB. Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes. Atherosclerosis 2009, 202:596-604. PM:18571179.
74. Saber AT, Jacobsen NR, Mortensen A, Szarek J, Jackson P, Madsen AM, Jensen KA, Koponen IK, Brunborg G, Gutzkow KB, et al. Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint. Part Fibre Toxicol 2012, 9:4. PM:22300483.
75. Poitou C, Viguerie N, Cancello R, De MR, Cinti S, Stich V, Coussieu C, Gauthier E, Courtine M, Zucker JD, et al. Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia 2005, 48:519-528. PM:15729583.
76. Pruett BS, Pruett SB. An explanation for the paradoxical induction and suppression of an acute phase response by ethanol. Alcohol 2006, 39:105-110. PM:17134663.
77. Nurmi K, Virkanen J, Rajamaki K, Niemi K, Kovanen PT, Eklund KK. Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages-a novel anti-inflammatory action of alcohol. PLoS One 2013, 8:e78537. PM:24244322.
78. Tolstrup J, Gronbaek M. Alcohol and atherosclerosis: recent insights. Curr Atheroscler Rep 2007, 9:116-124. PM:17877920.
79. Barboriak JJ, Anderson AJ, Hoffmann RG. Smoking, alcohol and coronary artery occlusion. Atherosclerosis 1982, 43:277-282. PM:7115464.
80. Whicher J, Biasucci L, Rifai N. Inflammation, the acute phase response and atherosclerosis. Clin Chem Lab Med 1999, 37:495-503. PM:10418738.
81. Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. Ibuprofen suppresses interleukin-1β induction of pro-amyloidogenic α1-antichymotrypsin to ameliorate β-amyloid (Abeta) pathology in Alzheimer's models. Neuropsychopharmacology 2005, 30:1111-1120. PM:15688088.
82. Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P, Engert JC, Bennett D, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009, 302:37-48. PM:19567438.
83. Vogel U. Commentary. Atherosclerosis 2013, 228:324. PM:23219221.
84. Barregard L, Sallsten G, Gustafson P, Andersson L, Johansson L, Basu S, Stigendal L. Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation. Inhal Toxicol 2006, 18:845-853. PM:16864402.
85. Allen RW, Carlsten C, Karlen B, Leckie S, van ES, Vedal S, Wong I, Brauer M. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med 2011, 183:1222-1230. PM:21257787.
86. Brauner EV, Forchhammer L, Moller P, Barregard L, Gunnarsen L, Afshari A, Wahlin P, Glasius M, Dragsted LO, Basu S, et al. Indoor particles affect vascular function in the aged: an air filtration-based intervention study. Am J Respir Crit Care Med 2008, 177:419-425. PM:17932377.
87. Ohlson CG, Berg P, Bryngelsson IL, Elihn K, Ngo Y, Westberg H, Sjogren B. Inflammatory markers and exposure to occupational air pollutants. Inhal Toxicol 2010, 22:1083-1090. PM:21029032.
88. Huttunen K, Siponen T, Salonen I, Yli-Tuomi T, Aurela M, Dufva H, Hillamo R, Linkola E, Pekkanen J, Pennanen A, et al. Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients. Environ Res 2012, 116:44-51. PM:22541720.
89. Mills NL, Robinson SD, Fokkens PH, Leseman DL, Miller MR, Anderson D, Freney EJ, Heal MR, Donovan RJ, Blomberg A, et al. Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect 2008, 116:709-715. PM:18560524.
90. Channell MM, Paffett ML, Devlin RB, Madden MC, Campen MJ. Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model. Toxicol Sci 2012, 127:179-186. PM:22331494.
91. Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicol Sci 2013, 134:304-311. PM:23650127.
92. Baranova IN, Bocharov AV, Vishnyakova TG, Kurlander R, Chen Z, Fu D, Arias IM, Csako G, Patterson AP, Eggerman TL. CD36 is a novel serum amyloid A (SAA) receptor mediating SAA binding and SAA-induced signaling in human and rodent cells. J Biol Chem 2010, 285:8492-8506. PM:20075072.
93. Wang X, Chai H, Wang Z, Lin PH, Yao Q, Chen C. Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 2008, 295:H2399-H2408. PM:18931033.