Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis

Circulation

Volumn 112, Issue 25, 2005, Pages 3930-3936

  Mills, Nicholas L ^a   Törnqvist, Håkan ^b   Robinson, Simon D ^a   Gonzalez, Manuel ^b   Darnley, Kareen ^c   MacNee, William ^c   Boon, Nicholas A ^a   Donaldson, Ken ^c   Blomberg, Anders ^b   Sandstrom, Thomas ^b   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Air pollution; Blood flow; Endothelium; Fibrinolysis

Indexed keywords

ACETYLCHOLINE; BRADYKININ; NITROPRUSSIDE SODIUM; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENT; VERAPAMIL;

ACUTE HEART INFARCTION; ADULT; AIR POLLUTION; ARTICLE; BLOOD VESSEL TONE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE MARKER; DOUBLE BLIND PROCEDURE; EXHAUST GAS; EXPOSURE; FIBRINOLYSIS; FOREARM BLOOD FLOW; HUMAN; INFLAMMATION; INHALATION; MALE; PATHOGENESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOSIS; URBAN AREA; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; BLOOD; BLOOD FLOW; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; EXERCISE TEST; FOREARM; PATHOPHYSIOLOGY; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ADULT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENVIRONMENTAL EXPOSURE; EXERCISE TEST; FIBRINOLYSIS; FOREARM; HUMANS; INFLAMMATION; INHALATION; MALE; MUSCLE, SMOOTH, VASCULAR; REGIONAL BLOOD FLOW; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENTS; VEHICLE EMISSIONS;

EID: 33644875170     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.588962     Document Type: Article

References (33)

1. Peters A, Dockery DW, Muller JE, Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation. 2001;103:2810-2815.
2. Dockery DW, Pope CA, Xu XP, Spengler JD, Ware JH, Fay ME, Ferris BG, Speizer FE. An association between air-pollution and mortality in 6 United States cities. N Engl J Med. 1993;329:1753-1759.
3. Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000;343:1742-1749.
4. Laden F, Neas LM, Dockery DW, Schwartz J. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect. 2000;108:941-947.
5. Ware JH. Particulate air pollution and mortality - clearing the air. N Engl J Med. 2000;343:1798-1799.
6. Pope CA III, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 2004;109:71-77.
7. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R, Mittleman M, Samet J, Smith SC, Tager I. Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation. 2004;109:2655-2671.
8. Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H. Exposure to traffic and the onset of myocardial infarction. N Engl J Med. 2004;351:1721-1730.
9. Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet. 2002;360:1203-1209.
10. Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, Webb DJ. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation. 1999;99:1411-1415.
11. Newby DE, McLeod AL, Uren NG, Flint L, Ludlam CA, Webb DJ, Fox KA, Boon NA. Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis. Circulation. 2001;103:1936-1941.
12. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104:2673-2678.
13. Halcox JPJ, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KRA, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-658.
14. Rudell B, Sandstrom T, Hammarstrom U, Ledin ML, Horstedt P, Stjemberg N. Evaluation of an exposure setup for studying effects of diesel exhaust in humans. Int Arch Occup Environ Health. 1994;66:77-83.
15. Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate S, Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 1999;159:702-709.
16. Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M, Donald AE, Palacios M, Griffin GE, Deanfield JE, MacAllister RJ, Vallance P. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation. 2000;102:994-999.
17. Robinson SD, Ludlam CA, Boon NA, Newby DE. Phosphodiesterase type 5 inhibition does not reverse endothelial dysfunction in patients with coronary heart disease. Heart. Published online April 29, 2005.
18. Newby DE, Wright RA, Ludlam CA, Fox KA, Boon NA, Webb DJ. An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium. Thromb Haemost. 1997;78:1242-1248.
19. Adam DJ, Evans SM, Webb DJ, Bradbury AW. Plasma endothelin levels and outcome in patients undergoing repair of ruptured infrarenal abdominal aortic aneurysm. J Vasc Surg. 2001;33:1242-1246.
20. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001;280:C719-C741.
21. Mulsch A, Bauersachs J, Schafer A, Stasch JP, Kast R, Busse R. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol. 1997;120:681-689.
22. Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolensld A, Walter U, Skatchkov M, Meinertz T, Munzel T. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res. 2000;87:999-1005.
23. Ikeda M, Suzuki M, Watarai K, Sagai M, Tomita T. Impairment of endothelium-dependent relaxation by diesel exhaust particles in rat thoracic aorta. Jpn J Pharmacol. 1995;68:183-189.
24. Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation. 2002;105:1534-1536.
25. 10). Occup Environ Med. 2005;62:164-171.
26. 10). Free Radic Biol Med. 2003;34:1369-1382.
27. Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001;7:20-26.
28. Baeza-Squiban A, Bonvallot V, Boland S, Marano F. Airborne particles evoke an inflammatory response in human airway epithelium: activation of transcription factors. Cell Biol Toxicol. 1999;15:375-380.
29. Brunekreef B, Holgate ST. Air pollution and health. Lancet. 2002;360:1233-1242.
30. Pope CA III, Hill RW, Villegas GM. Particulate air pollution and daily mortality on Utah's Wasatch Front. Environ Health Perspect. 1999;107:567-573.
31. UN Environment Program and WHO Report. Air Pollution in the World's Megacities. 1994;36:5-37.
32. Schwartz J. What are people dying of on high air-pollution days. Environ Res. 1994;64:26-35.
33. Ayres JG. Heath effects of gaseous air pollutants. In: Hester RE, Harrison RM, eds. Issues in Environmental Science and Technology: Air Pollution and Health. Cambridge: Royal Society of Chemistry; 1998:1-20.