메뉴 건너뛰기




Volumn 19, Issue 12, 2015, Pages 1651-1663

Therapeutic targeting of Toll-like receptors in cutaneous disorders

Author keywords

cutaneous; pattern recognition receptors; skin; therapeutics; Toll like receptors

Indexed keywords

BROPIRIMINE; CPG OLIGODEOXYNUCLEOTIDE; IMIQUIMOD; LOXORIBINE; NICOTINAMIDE; PATTERN RECOGNITION RECEPTOR; PIMECROLIMUS; POLYINOSINIC POLYCYTIDYLIC ACID; RAPAMYCIN; RESIQUIMOD; RETINOIC ACID; TACROLIMUS; TOLL LIKE RECEPTOR; TOSYLCHLORAMIDE SODIUM; ZINC DERIVATIVE; DERMATOLOGICAL AGENT;

EID: 84951798567     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2015.1069275     Document Type: Review
Times cited : (6)

References (110)
  • 1
    • 36149001699 scopus 로고    scopus 로고
    • Toll-like receptors are key participants in innate immune responses
    • Arancibia SA, Beltrán CJ, Aguirre IM, et al. Toll-like receptors are key participants in innate immune responses. Biol Res 2007;40(2):97-112
    • (2007) Biol Res , vol.40 , Issue.2 , pp. 97-112
    • Arancibia, S.A.1    Beltrán, C.J.2    Aguirre, I.M.3
  • 2
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of toll-like receptors
    • Tsan M-F, Gao B. Endogenous ligands of Toll-like receptors. J Leuk Biol 2004;76(3):514-19
    • (2004) J Leuk Biol , vol.76 , Issue.3 , pp. 514-519
    • Tsan, M.-F.1    Gao, B.2
  • 3
    • 84866953674 scopus 로고    scopus 로고
    • Adaptors in toll-like receptor signaling and their potential as therapeutic targets
    • Ve T, J Gay N, Mansell A, et al. Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Curr Drug Targets 2012;13(11):1360-74
    • (2012) Curr Drug Targets , vol.13 , Issue.11 , pp. 1360-1374
    • Ve, T.1    Gay, N.J.2    Mansell, A.3
  • 4
    • 33846240438 scopus 로고    scopus 로고
    • Human keratinocytes express functional toll-like receptor 3, 4, 5, and 9
    • Lebre MC, van der Aar AM, van Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2006;127(2):331-41
    • (2006) J Invest Dermatol , vol.127 , Issue.2 , pp. 331-341
    • Lebre, M.C.1    Van Der-Aar, A.M.2    Van Baarsen, L.3
  • 5
    • 0038579508 scopus 로고    scopus 로고
    • Normal keratinocytes express toll-like receptors (TLRs) 1, 2 and 5: Modulation of TLR expression in chronic plaque psoriasis
    • Baker B, Ovigne JM, Powles A, et al. Normal keratinocytes express toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 2003;148(4):670-9
    • (2003) Br J Dermatol , vol.148 , Issue.4 , pp. 670-679
    • Baker, B.1    Ovigne, J.M.2    Powles, A.3
  • 6
    • 33745324477 scopus 로고    scopus 로고
    • TLR activation of langerhans celllike dendritic cells triggers an antiviral immune response
    • Renn CN, Sanchez DJ, Ochoa MT, et al. TLR activation of Langerhans celllike dendritic cells triggers an antiviral immune response. J Immunol 2006;177(1):298-305
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 298-305
    • Renn, C.N.1    Sanchez, D.J.2    Ochoa, M.T.3
  • 7
    • 70349838270 scopus 로고    scopus 로고
    • Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9
    • Yu N, Zhang S, Zuo F, et al. Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J Dermatol Sci 2009;56(2):113-20
    • (2009) J Dermatol Sci , vol.56 , Issue.2 , pp. 113-120
    • Yu, N.1    Zhang, S.2    Zuo, F.3
  • 8
    • 79955586582 scopus 로고    scopus 로고
    • Activation of toll-like receptors 1, 2, 4, 5, and 7 on human melanocytes modulate pigmentation
    • Jin SH, Kang HY. Activation of Toll-like receptors 1, 2, 4, 5, and 7 on human melanocytes modulate pigmentation. Ann Dermatol 2010;22(4):486-9
    • (2010) Ann Dermatol , vol.22 , Issue.4 , pp. 486-489
    • Jin, S.H.1    Kang, H.Y.2
  • 9
    • 84894494873 scopus 로고    scopus 로고
    • Propionibacterium acnes: An update on its role in the pathogenesis of acne
    • Beylot C, Auffret N, Poli F, et al. Propionibacterium acnes: an update on its role in the pathogenesis of acne. J Eur Acad Dermatol Venereol 2014;28(3):271-8
    • (2014) J Eur Acad Dermatol Venereol , vol.28 , Issue.3 , pp. 271-278
    • Beylot, C.1    Auffret, N.2    Poli, F.3
  • 10
    • 0036681834 scopus 로고    scopus 로고
    • Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    • Kim J, Ochoa M-T, Krutzik SR, et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002;169(3):1535-41
    • (2002) J Immunol , vol.169 , Issue.3 , pp. 1535-1541
    • Kim, J.1    Ochoa, M.-T.2    Krutzik, S.R.3
  • 11
    • 84903756814 scopus 로고    scopus 로고
    • Toll-like receptor 2 and P. Acnes: Do they trigger initial acne vulgaris lesions?
    • Bakry OA, Samaka RM, Sebika H, et al. Toll-like receptor 2 and P. acnes: do they trigger initial acne vulgaris lesions? Anal Quant Cytop Histopathol 2014;36(2):100-10
    • (2014) Anal Quant Cytop Histopathol , vol.36 , Issue.2 , pp. 100-110
    • Bakry, O.A.1    Samaka, R.M.2    Sebika, H.3
  • 12
    • 14044257262 scopus 로고    scopus 로고
    • Cutting edge: All-trans retinoic acid down-regulates TLR2 expression and function
    • Liu PT, Krutzik SR, Kim J, et al. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol 2005;174(5):2467-70
    • (2005) J Immunol , vol.174 , Issue.5 , pp. 2467-2470
    • Liu, P.T.1    Krutzik, S.R.2    Kim, J.3
  • 13
    • 84865313629 scopus 로고    scopus 로고
    • Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients
    • Dispenza MC, Wolpert EB, Gilliland KL, et al. Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients. J Invest Dermatol 2012;132(9):2198-205
    • (2012) J Invest Dermatol , vol.132 , Issue.9 , pp. 2198-2205
    • Dispenza, M.C.1    Wolpert, E.B.2    Gilliland, K.L.3
  • 14
    • 84896792478 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin
    • Bergler-Czop B, Brzezińska-Wcisło L. Pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin. Postepy Dermatol Alergol 2014;31(1):21-8
    • (2014) Postepy Dermatol Alergol , vol.31 , Issue.1 , pp. 21-28
    • Bergler-Czop, B.1    Brzezińska-Wcisło, L.2
  • 15
    • 34249802075 scopus 로고    scopus 로고
    • In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions
    • Tenaud I, Khammari A, Dreno B. In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions. Exp Dermatol 2007;16(6):500-6
    • (2007) Exp Dermatol , vol.16 , Issue.6 , pp. 500-506
    • Tenaud, I.1    Khammari, A.2    Dreno, B.3
  • 16
    • 50249109962 scopus 로고    scopus 로고
    • CBT-SL5, a bacteriocin from enterococcus faecalis, suppresses the expression of interleukin-8 induced by propionibacterium acnes in cultured human keratinocytes
    • Lee YJ, Choi HJ, Kang TW, et al. CBT-SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin-8 induced by Propionibacterium acnes in cultured human keratinocytes. J Microbiol Biotechnol 2008;18(7):1308-16
    • (2008) J Microbiol Biotechnol , vol.18 , Issue.7 , pp. 1308-1316
    • Lee, Y.J.1    Choi, H.J.2    Kang, T.W.3
  • 17
    • 80052969838 scopus 로고    scopus 로고
    • Ex vivo demonstration of a synergistic effect of adapalene and benzoyl peroxide on inflammatory acne lesions
    • Zuliani T, Khammari A, Chaussy H, et al. Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions. Exp Dermatol 2011;20(10):850-3
    • (2011) Exp Dermatol , vol.20 , Issue.10 , pp. 850-853
    • Zuliani, T.1    Khammari, A.2    Chaussy, H.3
  • 18
    • 36749006632 scopus 로고    scopus 로고
    • Zinc salts inhibit in vitro toll-like receptor 2 surface expression by keratinocytes
    • Jarrousse V, Castex-Rizzi N, Khammari A, et al. Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol 2007;17(6):492-6
    • (2007) Eur J Dermatol , vol.17 , Issue.6 , pp. 492-496
    • Jarrousse, V.1    Castex-Rizzi, N.2    Khammari, A.3
  • 19
    • 70349987611 scopus 로고    scopus 로고
    • Nicotinamide inhibits propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kB and MAPK pathways
    • Grange PA, Raingeaud J, Calvez V, et al. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kB and MAPK pathways. J Dermatol Sci 2009;56(2):106-12
    • (2009) J Dermatol Sci , vol.56 , Issue.2 , pp. 106-112
    • Grange, P.A.1    Raingeaud, J.2    Calvez, V.3
  • 20
    • 37349015349 scopus 로고    scopus 로고
    • An integrated model of the recognition of candida albicans by the innate immune system
    • Netea MG, Brown GD, Kullberg BJ, et al. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008;6(1):67-78
    • (2008) Nat Rev Microbiol , vol.6 , Issue.1 , pp. 67-78
    • Netea, M.G.1    Brown, G.D.2    Kullberg, B.J.3
  • 22
    • 84855754509 scopus 로고    scopus 로고
    • Toll-like receptor 9 modulates macrophage antifungal effector function during innate recognition of candida albicans and saccharomyces cerevisiae
    • Kasperkovitz PV, Khan NS, Tam JM, et al. Toll-like receptor 9 modulates macrophage antifungal effector function during innate recognition of Candida albicans and Saccharomyces cerevisiae. Infec Imm 2011;79(12):4858-67
    • (2011) Infec Imm , vol.79 , Issue.12 , pp. 4858-4867
    • Kasperkovitz, P.V.1    Khan, N.S.2    Tam, J.M.3
  • 23
    • 78650638271 scopus 로고    scopus 로고
    • TLR9 is actively recruited to aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking
    • Kasperkovitz PV, Cardenas ML, Vyas JM. TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking. J Immunol 2010;185(12):7614-22
    • (2010) J Immunol , vol.185 , Issue.12 , pp. 7614-7622
    • Kasperkovitz, P.V.1    Cardenas, M.L.2    Vyas, J.M.3
  • 24
    • 16244421044 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2
    • Razonable RR, Henault M, Lee LN, et al. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2. Antim Agents Chemother 2005;49(4):1617-21
    • (2005) Antim Agents Chemother , vol.49 , Issue.4 , pp. 1617-1621
    • Razonable, R.R.1    Henault, M.2    Lee, L.N.3
  • 25
    • 0141844541 scopus 로고    scopus 로고
    • The antifungal drug amphotericin B promotes inflammatory cytokine release by a tolllike receptor- and CD14-dependent mechanism
    • Sau K, Mambula SS, Latz E, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Tolllike receptor- and CD14-dependent mechanism. J Biol Chem 2003;278(39):37561-8
    • (2003) J Biol Chem , vol.278 , Issue.39 , pp. 37561-37568
    • Sau, K.1    Mambula, S.S.2    Latz, E.3
  • 26
    • 84896478014 scopus 로고    scopus 로고
    • An immunomodulatory activity of micafungin in preclinical aspergillosis
    • Moretti S, Bozza S, Massi-Benedetti C, et al. An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicro Chemother 2014;69(4):1065-74
    • (2014) J Antimicro Chemother , vol.69 , Issue.4 , pp. 1065-1074
    • Moretti, S.1    Bozza, S.2    Massi-Benedetti, C.3
  • 27
    • 77956545733 scopus 로고    scopus 로고
    • Effects of caspofungin, candida albicans and aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs
    • Salvenmoser S, Seidler MJ, Dalpke A, et al. Effects of caspofungin, Candida albicans and Aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs. FEMS Immu Med Microbiol 2010;60(1):74-7
    • (2010) FEMS Immu Med Microbiol , vol.60 , Issue.1 , pp. 74-77
    • Salvenmoser, S.1    Seidler, M.J.2    Dalpke, A.3
  • 29
    • 84886536182 scopus 로고    scopus 로고
    • Lactobacillus crispatus modulates epithelial cell defense against candida albicans through toll-like receptors 2 and 4, interleukin 8 and human bdefensins 2 and 3
    • Rizzo A, Losacco A, Carratelli CR. Lactobacillus crispatus modulates epithelial cell defense against Candida albicans through Toll-like receptors 2 and 4, interleukin 8 and human bdefensins 2 and 3. Immunol Lett 2013;156(1):102-9
    • (2013) Immunol Lett , vol.156 , Issue.1 , pp. 102-109
    • Rizzo, A.1    Losacco, A.2    Carratelli, C.R.3
  • 30
    • 59449104320 scopus 로고    scopus 로고
    • Farnesol promotes epithelial cell defense against candida albicans through toll-like receptor 2 expression, interleukin-6 and human β-defensin 2 production
    • Décanis N, Savignac K, Rouabhia M. Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human β-defensin 2 production. Cytokine 2009;45(2):132-40
    • (2009) Cytokine , vol.45 , Issue.2 , pp. 132-140
    • Décanis, N.1    Savignac, K.2    Rouabhia, M.3
  • 31
    • 84894550575 scopus 로고    scopus 로고
    • Recognition of herpes simplex viruses: Toll-like receptors and beyond
    • Ma Y, He B. Recognition of herpes simplex viruses: toll-like receptors and Beyond. J Mol Biol 2014;426(6):1133-47
    • (2014) J Mol Biol , vol.426 , Issue.6 , pp. 1133-1147
    • Ma, Y.1    He, B.2
  • 32
    • 75849117856 scopus 로고    scopus 로고
    • Mucosal treatments for herpes simplex virus: Insights on targeted immunoprophylaxis and therapy
    • McGowin CL, Pyles RB. Mucosal treatments for herpes simplex virus: insights on targeted immunoprophylaxis and therapy. Fut Microbiol 2010;5(1):15-22
    • (2010) Fut Microbiol , vol.5 , Issue.1 , pp. 15-22
    • McGowin, C.L.1    Pyles, R.B.2
  • 33
    • 77953613673 scopus 로고    scopus 로고
    • The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis
    • Tuon FF, Fernandes ER, Duarte MI, et al. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. J Dermatol Sci 2010;59(1):55-7
    • (2010) J Dermatol Sci , vol.59 , Issue.1 , pp. 55-57
    • Tuon, F.F.1    Fernandes, E.R.2    Duarte, M.I.3
  • 34
    • 84857660166 scopus 로고    scopus 로고
    • Miltefosine triggers a strong proinflammatory cytokine response during visceral leishmaniasis: Role of TLR4 and TLR9
    • Mukherjee AK, Gupta G, Adhikari A, et al. Miltefosine triggers a strong proinflammatory cytokine response during visceral leishmaniasis: Role of TLR4 and TLR9. Int Immunopharmacol 2012;12(4):565-72
    • (2012) Int Immunopharmacol , vol.12 , Issue.4 , pp. 565-572
    • Mukherjee, A.K.1    Gupta, G.2    Adhikari, A.3
  • 35
    • 77954185428 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide augments the antileishmanial activity of miltefosine against experimental visceral leishmaniasis
    • Sane SA, Shakya N, Haq W, et al. CpG oligodeoxynucleotide augments the antileishmanial activity of miltefosine against experimental visceral leishmaniasis. J Antimicro Chemother 2010;65(7):1448-54
    • (2010) J Antimicro Chemother , vol.65 , Issue.7 , pp. 1448-1454
    • Sane, S.A.1    Shakya, N.2    Haq, W.3
  • 36
    • 79959280243 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide 2006 and miltefosine, a potential combination for treatment of experimental visceral leishmaniasis
    • Gupta S, Sane SA, Shakya N, et al. CpG oligodeoxynucleotide 2006 and miltefosine, a potential combination for treatment of experimental visceral leishmaniasis. Antim Agents Chemother 2011;55(7):3461-4
    • (2011) Antim Agents Chemother , vol.55 , Issue.7 , pp. 3461-3464
    • Gupta, S.1    Sane, S.A.2    Shakya, N.3
  • 37
    • 33845578705 scopus 로고    scopus 로고
    • Immunomodulatory effects associated with a live vaccine against leishmania major containing CpG oligodeoxynucleotides
    • Wu W, Weigand L, Belkaid Y, et al. Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur J Immunol 2006;36(12):3238-47
    • (2006) Eur J Immunol , vol.36 , Issue.12 , pp. 3238-3247
    • Wu, W.1    Weigand, L.2    Belkaid, Y.3
  • 38
    • 84928788105 scopus 로고    scopus 로고
    • Coinjection with TLR2 agonist pam3csk4 reduces the pathology of leishmanization in mice
    • Huang L, Hinchman M, Mendez S. Coinjection with TLR2 Agonist Pam3CSK4 Reduces the Pathology of Leishmanization in Mice. PLoS Neg Trop Dis 2015;9(3):e0003546-e46
    • (2015) PLoS Neg Trop Dis , vol.9 , Issue.3 , pp. e46-e0003546
    • Huang, L.1    Hinchman, M.2    Mendez, S.3
  • 39
    • 77957654090 scopus 로고    scopus 로고
    • Leprosy and the adaptation of human toll-like receptor 1
    • Wong SH, Gochhait S, Malhotra D, et al. Leprosy and the adaptation of human toll-like receptor 1. PLoS Path 2010;6(7):e1000979
    • (2010) PLoS Path , vol.6 , Issue.7 , pp. e1000979
    • Wong, S.H.1    Gochhait, S.2    Malhotra, D.3
  • 40
    • 70349658386 scopus 로고    scopus 로고
    • Polymorphisms in toll-like receptor 4 (TLR4) are associated with protection against leprosy
    • Bochud PY, Sinsimer D, Aderem A, et al. Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. Eur J Clin Microbiol Infect Dis 2009;28(9):1055-65
    • (2009) Eur J Clin Microbiol Infect Dis , vol.28 , Issue.9 , pp. 1055-1065
    • Bochud, P.Y.1    Sinsimer, D.2    Aderem, A.3
  • 41
    • 0038578610 scopus 로고    scopus 로고
    • Activation and regulation of tolllike receptors 2 and 1 in human leprosy
    • Krutzik SR, Ochoa MT, Sieling PA, et al. Activation and regulation of Tolllike receptors 2 and 1 in human leprosy. Nat Med 2003;9(5):525-32
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 525-532
    • Krutzik, S.R.1    Ochoa, M.T.2    Sieling, P.A.3
  • 42
    • 84901479786 scopus 로고    scopus 로고
    • Heterogeneity of host TLR2 stimulation by staphylocoocus aureus isolates
    • Hilmi D, Parcina M, Stollewerk D, et al. Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. PLoS One 2014;9(5):e96416
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e96416
    • Hilmi, D.1    Parcina, M.2    Stollewerk, D.3
  • 43
    • 84903899737 scopus 로고    scopus 로고
    • Possible role of toll-like receptor-2 in the intracellular survival of staphylococcus aureus in murine peritoneal macrophages: Involvement of cytokines and anti-oxidant enzymes
    • Bishayi B, Bandyopadhyay D, Majhi A, et al. Possible role of toll-like receptor-2 in the intracellular survival of Staphylococcus aureus in murine peritoneal macrophages: involvement of cytokines and anti-oxidant enzymes. Scand J Immunol 2014;80(2):127-43
    • (2014) Scand J Immunol , vol.80 , Issue.2 , pp. 127-143
    • Bishayi, B.1    Bandyopadhyay, D.2    Majhi, A.3
  • 44
    • 79951516747 scopus 로고    scopus 로고
    • TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    • Yamasaki K, Kanada K, Macleod DT, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 2010;131(3):688-97
    • (2010) J Invest Dermatol , vol.131 , Issue.3 , pp. 688-697
    • Yamasaki, K.1    Kanada, K.2    Macleod, D.T.3
  • 45
    • 84884353255 scopus 로고    scopus 로고
    • Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel
    • Coda AB, Hata T, Miller J, et al. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol 2013;69(4):570-7
    • (2013) J Am Acad Dermatol , vol.69 , Issue.4 , pp. 570-577
    • Coda, A.B.1    Hata, T.2    Miller, J.3
  • 46
    • 79955910090 scopus 로고    scopus 로고
    • An association of TLR2-16934A> T polymorphism and severity/phenotype of atopic dermatitis
    • Potaczek D, Nastalek M, Okumura K, et al. An association of TLR2-16934A> T polymorphism and severity/phenotype of atopic dermatitis. J Eur Acad Dermatol Venereol 2011;25(6):715-21
    • (2011) J Eur Acad Dermatol Venereol , vol.25 , Issue.6 , pp. 715-721
    • Potaczek, D.1    Nastalek, M.2    Okumura, K.3
  • 47
    • 84903712422 scopus 로고    scopus 로고
    • Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10
    • Kaesler S, Volz T, Skabytska Y, et al. Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10. J All Clin Immunol 2014;134(1):92-9
    • (2014) J All Clin Immunol , vol.134 , Issue.1 , pp. 92-99
    • Kaesler, S.1    Volz, T.2    Skabytska, Y.3
  • 48
    • 84866279011 scopus 로고    scopus 로고
    • The role of T-regulatory cells and toll-like receptors 2 and 4 in atopic dermatitis
    • Lesiak A, Smolewski P, Sobolewska-Sztychny D, et al. The role of T-regulatory cells and toll-like receptors 2 and 4 in atopic dermatitis. Scand J Immunol 2012;76(4):405-10
    • (2012) Scand J Immunol , vol.76 , Issue.4 , pp. 405-410
    • Lesiak, A.1    Smolewski, P.2    Sobolewska-Sztychny, D.3
  • 49
    • 84875220580 scopus 로고    scopus 로고
    • Activation of epidermal toll-like receptor 2 enhances tight junction function: Implications for atopic dermatitis and skin barrier repair
    • Kuo I-H, Carpenter-Mendini A, Yoshida T, et al. Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol 2012;133(4):988-98
    • (2012) J Invest Dermatol , vol.133 , Issue.4 , pp. 988-998
    • Kuo, I.-H.1    Carpenter-Mendini, A.2    Yoshida, T.3
  • 50
    • 79952805993 scopus 로고    scopus 로고
    • Effects of tacrolimus ointment on tolllike receptors in atopic dermatitis
    • Antiga E, Volpi W, Torchia D, et al. Effects of tacrolimus ointment on Tolllike receptors in atopic dermatitis. Clin Exper Dermatol 2011;36(3):235-41
    • (2011) Clin Exper Dermatol , vol.36 , Issue.3 , pp. 235-241
    • Antiga, E.1    Volpi, W.2    Torchia, D.3
  • 51
    • 36749027632 scopus 로고    scopus 로고
    • Expression, subcellular localization and cytokinic modulation of toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin
    • Begon É, Michel L, Flageul B, et al. Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin. Eur J Dermatol 2007;17(6):497-506
    • (2007) Eur J Dermatol , vol.17 , Issue.6 , pp. 497-506
    • Begon, É.1    Michel, L.2    Flageul, B.3
  • 52
    • 84896320691 scopus 로고    scopus 로고
    • TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis
    • Flutter B, Nestle FO. TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol 2013;43(12):3138-46
    • (2013) Eur J Immunol , vol.43 , Issue.12 , pp. 3138-3146
    • Flutter, B.1    Nestle, F.O.2
  • 53
    • 79952383537 scopus 로고    scopus 로고
    • Imiquimod 5% cream induced psoriasis: A case report, summary of the literature and mechanism
    • Patel U, Mark N, Machler B, et al. Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism. Br J Dermatol 2011;164(3):670-2
    • (2011) Br J Dermatol , vol.164 , Issue.3 , pp. 670-672
    • Patel, U.1    Mark, N.2    Machler, B.3
  • 54
    • 84879410185 scopus 로고    scopus 로고
    • A toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis
    • Jiang W, Zhu F-G, Bhagat L, et al. A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis. J Invest Dermatol 2013;133(7):1777-84
    • (2013) J Invest Dermatol , vol.133 , Issue.7 , pp. 1777-1784
    • Jiang, W.1    Zhu, F.-G.2    Bhagat, L.3
  • 56
    • 84860219697 scopus 로고    scopus 로고
    • Differential expression of TLR-2 and TLR-4 in the epithelial cells in oral lichen planus
    • Janardhanam SB, Prakasam S, Swaminathan VT, et al. Differential expression of TLR-2 and TLR-4 in the epithelial cells in oral lichen planus. Arch Oral Biol 2012;57(5):495-502
    • (2012) Arch Oral Biol , vol.57 , Issue.5 , pp. 495-502
    • Janardhanam, S.B.1    Prakasam, S.2    Swaminathan, V.T.3
  • 57
    • 84868371037 scopus 로고    scopus 로고
    • TLR4 and TLR9 are induced in oral lichen planus
    • Siponen M, Kauppila JH, Soini Y, et al. TLR4 and TLR9 are induced in oral lichen planus. J Oral Pathol Med 2012;41(10):741-7
    • (2012) J Oral Pathol Med , vol.41 , Issue.10 , pp. 741-747
    • Siponen, M.1    Kauppila, J.H.2    Soini, Y.3
  • 58
    • 84878857650 scopus 로고    scopus 로고
    • Immunohistochemical study of toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions
    • Salem SAM, Abu-Zeid RM, Nada OH. Immunohistochemical study of toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions. Arch Dermatol Res 2013;305(2):125-31
    • (2013) Arch Dermatol Res , vol.305 , Issue.2 , pp. 125-131
    • Salem, S.A.M.1    Abu-Zeid, R.M.2    Nada, O.H.3
  • 59
    • 84920713537 scopus 로고    scopus 로고
    • The dysfunctional innate immune response triggered by toll-like receptor activation is restored by TLR7/TLR8 and TLR9 ligands in cutaneous lichen planus
    • Domingues R, Carvalho GC, Silva Oliveira L, et al. The dysfunctional innate immune response triggered by Toll-like receptor activation is restored by TLR7/TLR8 and TLR9 ligands in cutaneous lichen planus. Br J Dermatol 2015;172(1):48-55
    • (2015) Br J Dermatol , vol.172 , Issue.1 , pp. 48-55
    • Domingues, R.1    Carvalho, G.C.2    Silva Oliveira, L.3
  • 60
    • 84951858099 scopus 로고    scopus 로고
    • Potential role of TLR ligand in aethiopathogenesis of tunisian endemic pemphigus foliaceus
    • Abida O, Krichen-Makni S, Kharrat N, et al. Potential Role of TLR ligand in aethiopathogenesis of Tunisian endemic pemphigus foliaceus. Biochem Physiol 2013;2(3):117
    • (2013) Biochem Physiol , vol.2 , Issue.3 , pp. 117
    • Abida, O.1    Krichen-Makni, S.2    Kharrat, N.3
  • 61
    • 78650160681 scopus 로고    scopus 로고
    • Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests that toll-like receptor 7 inhibitors may be useful treatments for pemphigus
    • Sebaratnam D, Martin L, Rubin A, et al. Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests that Toll-like receptor 7 inhibitors may be useful treatments for pemphigus. Clin Exp Dermatol 2011;36(1):91-3
    • (2011) Clin Exp Dermatol , vol.36 , Issue.1 , pp. 91-93
    • Sebaratnam, D.1    Martin, L.2    Rubin, A.3
  • 62
    • 84866735326 scopus 로고    scopus 로고
    • TLR7 and TLR9 in SLE: When sensing self goes wrong
    • Celhar T, Magalhaes R, Fairhurst AM. TLR7 and TLR9 in SLE: when sensing self goes wrong. Immunol Res 2012;53(1-3):58-77
    • (2012) Immunol Res , vol.53 , Issue.1-3 , pp. 58-77
    • Celhar, T.1    Magalhaes, R.2    Fairhurst, A.M.3
  • 63
    • 84896264633 scopus 로고    scopus 로고
    • Epicutaneous application of tolllike receptor 7 agonists leads to systemic autoimmunity in wild-type mice: A new model of systemic lupus erythematosus
    • Yokogawa M, Takaishi M, Nakajima K, et al. Epicutaneous application of tolllike receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic lupus erythematosus. Arth Rheumatol 2014;66(3):694-706
    • (2014) Arth Rheumatol , vol.66 , Issue.3 , pp. 694-706
    • Yokogawa, M.1    Takaishi, M.2    Nakajima, K.3
  • 64
    • 84928152372 scopus 로고    scopus 로고
    • Identifying toll-like receptor expression in cutaneous sarcoidosis
    • Huizenga T, Kado J, Mehregan DR, et al. Identifying Toll-like Receptor Expression in Cutaneous Sarcoidosis. Am J Dermatopathol 2015;37(1):67-72
    • (2015) Am J Dermatopathol , vol.37 , Issue.1 , pp. 67-72
    • Huizenga, T.1    Kado, J.2    Mehregan, D.R.3
  • 65
    • 78651068822 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
    • Agarwal SK, Wu M, Livingston CK, et al. Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arth Res Ther 2011;13(1):R3
    • (2011) Arth Res Ther , vol.13 , Issue.1 , pp. R3
    • Agarwal, S.K.1    Wu, M.2    Livingston, C.K.3
  • 66
    • 77957940944 scopus 로고    scopus 로고
    • Poly (I: C) drives type I IFN- and TGFb-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis
    • Farina GA, York MR, Di Marzio M, et al. Poly (I: C) drives type I IFN- and TGFb-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol 2010;130(11):2583-93
    • (2010) J Invest Dermatol , vol.130 , Issue.11 , pp. 2583-2593
    • Farina, G.A.1    York, M.R.2    Di Marzio, M.3
  • 67
    • 84899555500 scopus 로고    scopus 로고
    • Toll-like receptors as therapeutic targets for cancer
    • Holldack J. Toll-like receptors as therapeutic targets for cancer. Drug Discov Today 2014;19(4):379-82
    • (2014) Drug Discov Today , vol.19 , Issue.4 , pp. 379-382
    • Holldack, J.1
  • 68
    • 84879440776 scopus 로고    scopus 로고
    • Expression and significance of HMGB1, TLR4 and NF-kappaB p65 in human epidermal tumors
    • Weng H, Deng Y, Xie Y, et al. Expression and significance of HMGB1, TLR4 and NF-kappaB p65 in human epidermal tumors. BMC Cancer 2013;13(1):311
    • (2013) BMC Cancer , vol.13 , Issue.1 , pp. 311
    • Weng, H.1    Deng, Y.2    Xie, Y.3
  • 69
    • 84863763258 scopus 로고    scopus 로고
    • Distinct innate immune gene expression profiles in non-melanoma skin cancer of immunocompetent and immunosuppressed patients
    • Muehleisen B, Jiang SB, Gladsjo JA, et al. Distinct innate immune gene expression profiles in non-melanoma skin cancer of immunocompetent and immunosuppressed patients. PLoS One 2012;7(7):e40754
    • (2012) PLoS One , vol.7 , Issue.7 , pp. e40754
    • Muehleisen, B.1    Jiang, S.B.2    Gladsjo, J.A.3
  • 70
    • 4644228445 scopus 로고    scopus 로고
    • Open study of the efficacy and mechanism of action of topical imiquimod in basal cell carcinoma
    • Vidal D, Matías-Guiu X, Alomar A. Open study of the efficacy and mechanism of action of topical imiquimod in basal cell carcinoma. Clin Exp Dermatol 2004;29(5):518-25
    • (2004) Clin Exp Dermatol , vol.29 , Issue.5 , pp. 518-525
    • Vidal, D.1    Matías-Guiu, X.2    Alomar, A.3
  • 71
    • 33645802442 scopus 로고    scopus 로고
    • Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma
    • Spencer JM. Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma. Dermatol Sur 2006;32(1):63-9
    • (2006) Dermatol sur , vol.32 , Issue.1 , pp. 63-69
    • Spencer, J.M.1
  • 72
    • 40349084067 scopus 로고    scopus 로고
    • Imiquimod 5% cream following curettage without electrodesiccation for basal cell carcinoma: Preliminary report
    • Rigel DS, Torres AM, Ely H. Imiquimod 5% cream following curettage without electrodesiccation for basal cell carcinoma: preliminary report. J Drugs Dermatol 2008;7(1 Suppl 1):s15-16
    • (2008) J Drugs Dermatol , vol.7 , Issue.1 , pp. s15-16
    • Rigel, D.S.1    Torres, A.M.2    Ely, H.3
  • 73
    • 40349098161 scopus 로고    scopus 로고
    • A 36-month clinical experience of the effectiveness of curettage and imiquimod 5% cream in the treatment of basal cell carcinoma
    • Tillman D Jr, Carroll M. A 36-month clinical experience of the effectiveness of curettage and imiquimod 5% cream in the treatment of basal cell carcinoma. J Drugs Dermatol 2008;7(1 Suppl 1):s7-14
    • (2008) J Drugs Dermatol , vol.7 , Issue.1 , pp. s7-14
    • Tillman, D.1    Carroll, M.2
  • 74
    • 45849122874 scopus 로고    scopus 로고
    • Confirmation of histological clearance of superficial basal cell carcinoma with multiple serial sectioning and mohs' micrographic surgery following treatment with imiquimod 5% cream
    • Ezughah FI, Affleck AG, Evans A, et al. Confirmation of histological clearance of superficial basal cell carcinoma with multiple serial sectioning and Mohs' micrographic surgery following treatment with imiquimod 5% cream. J Dermatol Treat 2008;19(3):156-8
    • (2008) J Dermatol Treat , vol.19 , Issue.3 , pp. 156-158
    • Ezughah, F.I.1    Affleck, A.G.2    Evans, A.3
  • 75
    • 57749201993 scopus 로고    scopus 로고
    • Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream: Conclusion of a 5-year long-term follow-up study in Europe
    • Gollnick H, Barona CG, Frank RG, et al. Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream: conclusion of a 5-year long-term follow-up study in Europe. Eur J Dermatol 2008;18(6):677-82
    • (2008) Eur J Dermatol , vol.18 , Issue.6 , pp. 677-682
    • Gollnick, H.1    Barona, C.G.2    Frank, R.G.3
  • 76
    • 80054042870 scopus 로고    scopus 로고
    • Effectiveness and satisfaction with imiquimod for the treatment of superficial basal cell carcinoma in daily dermatological practice
    • Daudén E. Effectiveness and satisfaction with imiquimod for the treatment of superficial basal cell carcinoma in daily dermatological practice. J Eur Acad Dermatol Venereol 2011;25(11):1304-10
    • (2011) J Eur Acad Dermatol Venereol , vol.25 , Issue.11 , pp. 1304-1310
    • Daudén, E.1
  • 77
    • 77953669704 scopus 로고    scopus 로고
    • Study protocol the SINS trial: A randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma
    • Ozolins M, Williams HC, Armstrong SJ, Bath-Hextall FJ. Study protocol The SINS trial: A randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma. Trials 2010;11:42
    • (2010) Trials , vol.11 , pp. 42
    • Ozolins, M.1    Williams, H.C.2    Armstrong, S.J.3    Bath-Hextall, F.J.4
  • 78
    • 84891372701 scopus 로고    scopus 로고
    • Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): A multicentre, non-inferiority, randomised controlled trial
    • Bath-Hextall F, Ozolins M, Armstrong SJ, et al. Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncol 2014;15(1):96-105
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 96-105
    • Bath-Hextall, F.1    Ozolins, M.2    Armstrong, S.J.3
  • 79
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, doubleblind, parallel group, vehicle-controlled trials
    • Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, doubleblind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004;50(5):714-21
    • (2004) J Am Acad Dermatol , vol.50 , Issue.5 , pp. 714-721
    • Lebwohl, M.1    Dinehart, S.2    Whiting, D.3
  • 80
    • 33846982896 scopus 로고    scopus 로고
    • Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream
    • Torres A, Storey L, Anders M, et al. Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream. J Transl Med 2007;5(1):7
    • (2007) J Transl Med , vol.5 , Issue.1 , pp. 7
    • Torres, A.1    Storey, L.2    Anders, M.3
  • 81
    • 45749148641 scopus 로고    scopus 로고
    • A phase II dose-ranging study of topical resiquimod to treat actinic keratosis
    • Szeimies RM, Bichel J, Ortonne JP, et al. A phase II dose-ranging study of topical resiquimod to treat actinic keratosis. Br J Dermatol 2008;159(1):205-10
    • (2008) Br J Dermatol , vol.159 , Issue.1 , pp. 205-210
    • Szeimies, R.M.1    Bichel, J.2    Ortonne, J.P.3
  • 82
    • 84897949357 scopus 로고    scopus 로고
    • Toll-like receptors and skin cancer
    • Burns EM, Yusuf N. Toll-like receptors and skin cancer. Front Immunol 2014;5
    • (2014) Front Immunol , pp. 5
    • Burns, E.M.1    Yusuf, N.2
  • 83
    • 84855996465 scopus 로고    scopus 로고
    • TLR expression in human melanoma cells
    • Saint-Jean M, Knol AC, Nguyen JM, et al. TLR expression in human melanoma cells. Eur J Dermatol 2012;21(6):899-905
    • (2012) Eur J Dermatol , vol.21 , Issue.6 , pp. 899-905
    • Saint-Jean, M.1    Knol, A.C.2    Nguyen, J.M.3
  • 84
    • 77954951851 scopus 로고    scopus 로고
    • TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    • Mittal D, Saccheri F, Vénéreau E, et al. TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J 2010;29(13):2242-52
    • (2010) EMBO J , vol.29 , Issue.13 , pp. 2242-2252
    • Mittal, D.1    Saccheri, F.2    Vénéreau, E.3
  • 85
    • 84908147322 scopus 로고    scopus 로고
    • Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation
    • Singh M, Khong H, Dai Z, et al. Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation. J Immunol 2014;193(9):4722-31
    • (2014) J Immunol , vol.193 , Issue.9 , pp. 4722-4731
    • Singh, M.1    Khong, H.2    Dai, Z.3
  • 86
    • 84878570297 scopus 로고    scopus 로고
    • Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours
    • Millward M, Underhill C, Lobb S, et al. Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours. Br J Cancer 2013;108(10):1998-2004
    • (2013) Br J Cancer , vol.108 , Issue.10 , pp. 1998-2004
    • Millward, M.1    Underhill, C.2    Lobb, S.3
  • 87
    • 49749143414 scopus 로고    scopus 로고
    • Topical imiquimod and intralesional interleukin-2 increase activated lymphocytes and restore the Th1/Th2 balance in patients with metastatic melanoma
    • Green D, Dalgleish A, Belonwu N, et al. Topical imiquimod and intralesional interleukin-2 increase activated lymphocytes and restore the Th1/Th2 balance in patients with metastatic melanoma. Br J Dermatol 2008;159(3):606-14
    • (2008) Br J Dermatol , vol.159 , Issue.3 , pp. 606-614
    • Green, D.1    Dalgleish, A.2    Belonwu, N.3
  • 88
    • 47849128971 scopus 로고    scopus 로고
    • Imiquimod treatment of lentigo maligna: An open-label study of 34 primary lesions in 32 patients
    • Buettiker UV, Yawalkar NY, Braathen LR, et al. Imiquimod treatment of lentigo maligna: an open-label study of 34 primary lesions in 32 patients. Arch Dermatol 2008;144(7):943-5
    • (2008) Arch Dermatol , vol.144 , Issue.7 , pp. 943-945
    • Buettiker, U.V.1    Yawalkar, N.Y.2    Braathen, L.R.3
  • 89
    • 0038783532 scopus 로고    scopus 로고
    • The imidazoquinolines and their place in the therapy of cutaneous disease
    • Smith KJ, Hamza S, Skelton H. The imidazoquinolines and their place in the therapy of cutaneous disease. Expert Opin Pharmacother 2003;4(7):1105-19
    • (2003) Expert Opin Pharmacother , vol.4 , Issue.7 , pp. 1105-1119
    • Smith, K.J.1    Hamza, S.2    Skelton, H.3
  • 90
    • 80655128209 scopus 로고    scopus 로고
    • Imiquimod: A review of off-label clinical applications
    • David CV, Nguyen H, Goldenberg G. Imiquimod: a review of off-label clinical applications. J Drugs Dermatol 2011;10(11):1300-6
    • (2011) J Drugs Dermatol , vol.10 , Issue.11 , pp. 1300-1306
    • David, C.V.1    Nguyen, H.2    Goldenberg, G.3
  • 91
    • 44049089154 scopus 로고    scopus 로고
    • Cutaneous pharmacodynamics of a toll-like receptor 7 agonist, 852A, in humans
    • Astry C, Birmachu W, Harrison LI, et al. Cutaneous Pharmacodynamics of a Toll-Like Receptor 7 Agonist, 852A, in Humans. J Clin Pharmacol 2008;48(6):755-62
    • (2008) J Clin Pharmacol , vol.48 , Issue.6 , pp. 755-762
    • Astry, C.1    Birmachu, W.2    Harrison, L.I.3
  • 92
    • 77957676318 scopus 로고    scopus 로고
    • The expression of toll-like receptors in dermatological diseases and the therapeutic effect of current and newer topical toll-like receptor modulators
    • Valins W, Amini S, Berman B. The expression of toll-like receptors in dermatological diseases and the therapeutic effect of current and newer topical toll-like receptor modulators. J Clin Aesth Dermatol 2010;3(9):20
    • (2010) J Clin Aesth Dermatol , vol.3 , Issue.9 , pp. 20
    • Valins, W.1    Amini, S.2    Berman, B.3
  • 93
    • 33646518605 scopus 로고    scopus 로고
    • Toll-like receptors: Applications to dermatologic disease
    • Kang SS, Kauls LS, Gaspari AA. Toll-like receptors: applications to dermatologic disease. J Am Acad Dermatol 2006;54(6):951-83
    • (2006) J Am Acad Dermatol , vol.54 , Issue.6 , pp. 951-983
    • Kang, S.S.1    Kauls, L.S.2    Gaspari, A.A.3
  • 95
    • 53949084448 scopus 로고    scopus 로고
    • Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes
    • Büchau AS, Schauber J, Hultsch T, et al. Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. J Invest Dermatol 2008;128(11):2646-54
    • (2008) J Invest Dermatol , vol.128 , Issue.11 , pp. 2646-2654
    • Büchau, A.S.1    Schauber, J.2    Hultsch, T.3
  • 96
    • 77952940222 scopus 로고    scopus 로고
    • Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: Reduced rate of (pre-) malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial
    • Salgo R, Gossmann J, Schöfer H, et al. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-) malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transpl 2010;10(6):1385-93
    • (2010) Am J Transpl , vol.10 , Issue.6 , pp. 1385-1393
    • Salgo, R.1    Gossmann, J.2    Schöfer, H.3
  • 97
    • 79955079914 scopus 로고    scopus 로고
    • The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides
    • Yamamoto M, Sato T, Beren J, et al. The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides. Biomaterials 2011;32(18):4238-42
    • (2011) Biomaterials , vol.32 , Issue.18 , pp. 4238-4242
    • Yamamoto, M.1    Sato, T.2    Beren, J.3
  • 98
    • 51649116214 scopus 로고    scopus 로고
    • Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients
    • Molenkamp BG, Sluijter BJ, van Leeuwen PA, et al. Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients. Clin Cancer Res 2008;14(14):4532-42
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4532-4542
    • Molenkamp, B.G.1    Sluijter, B.J.2    Van Leeuwen, P.A.3
  • 99
    • 84930180929 scopus 로고    scopus 로고
    • Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage
    • Borkowski AW, Kuo I-H, Bernard JJ, et al. Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 2015;135(2):569-78
    • (2015) J Invest Dermatol , vol.135 , Issue.2 , pp. 569-578
    • Borkowski, A.W.1    Kuo, I.-H.2    Bernard, J.J.3
  • 100
    • 84862810103 scopus 로고    scopus 로고
    • Administration of poly (I: C) improved dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance
    • Kim CH, Do Park C, Lee AY. Administration of poly (I: C) improved dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance. Vaccine 2012;30(14):2405-10
    • (2012) Vaccine , vol.30 , Issue.14 , pp. 2405-2410
    • Kim, C.H.1    Do Park, C.2    Lee, A.Y.3
  • 101
    • 34547665101 scopus 로고    scopus 로고
    • Toll-like receptor 3 expressed by melanoma cells as a target for therapy?
    • Salaun B, Lebecque S, Matikainen S, et al. Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res 2007;13(15):4565-74
    • (2007) Clin Cancer Res , vol.13 , Issue.15 , pp. 4565-4574
    • Salaun, B.1    Lebecque, S.2    Matikainen, S.3
  • 103
    • 84866242485 scopus 로고    scopus 로고
    • Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNb secretion controlled differently by TLR3 and MDA5
    • Szabo A, Osman RM, Bacskai I, et al. Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNb secretion controlled differently by TLR3 and MDA5. Melan Res 2012;22(5):351-61
    • (2012) Melan Res , vol.22 , Issue.5 , pp. 351-361
    • Szabo, A.1    Osman, R.M.2    Bacskai, I.3
  • 104
    • 36448961257 scopus 로고    scopus 로고
    • Disifin (sodium tosylchloramide) and toll-like receptors (TLRs): Evolving importance in health and diseases
    • Ofodile ON. Disifin (sodium tosylchloramide) and Toll-like receptors (TLRs): evolving importance in health and diseases. J Indust Micro Biotechnol 2007;34(12):751-62
    • (2007) J Indust Micro Biotechnol , vol.34 , Issue.12 , pp. 751-762
    • Ofodile, O.N.1
  • 105
    • 84902115681 scopus 로고    scopus 로고
    • Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer
    • Hernández-Sancén P, Maldonado-Bernal C. Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer. Genes Immun 2014;15(4):199-209
    • (2014) Genes Immun , vol.15 , Issue.4 , pp. 199-209
    • Hernández-Sancén, P.1    Maldonado-Bernal, C.2
  • 107
    • 77949349601 scopus 로고    scopus 로고
    • The role of toll-like receptors in host defenses and their relevance to dermatologic diseases
    • Terhorst D, Kalali BN, Ollert M, et al. The role of toll-like receptors in host defenses and their relevance to dermatologic diseases. Am J Clin Dermatol 2010;11(1):1-10
    • (2010) Am J Clin Dermatol , vol.11 , Issue.1 , pp. 1-10
    • Terhorst, D.1    Kalali, B.N.2    Ollert, M.3
  • 108
    • 79955832940 scopus 로고    scopus 로고
    • Toll-like receptors as potential therapeutic targets in cardiac dysfunction
    • Hofmann U, Ertl G, Frantz S. Toll-like receptors as potential therapeutic targets in cardiac dysfunction. Expert Opin Therap Targets 2011;15(6):753-65
    • (2011) Expert Opin Therap Targets , vol.15 , Issue.6 , pp. 753-765
    • Hofmann, U.1    Ertl, G.2    Frantz, S.3
  • 109
    • 84884545858 scopus 로고    scopus 로고
    • Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance
    • Watanabe Y, Nagai Y, Takatsu K. Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients 2013;5(9):3757-78
    • (2013) Nutrients , vol.5 , Issue.9 , pp. 3757-3778
    • Watanabe, Y.1    Nagai, Y.2    Takatsu, K.3
  • 110
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
    • Dummer R, Hauschild A, Becker JC, et al. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008;14(3):856-64
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 856-864
    • Dummer, R.1    Hauschild, A.2    Becker, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.