Activation of toll-like receptors 1, 2, 4, 5, and 7 on human melanocytes modulate pigmentation

Annals of Dermatology

Volumn 22, Issue 4, 2010, Pages 486-489

  Jin, Sun Hee ^a   Kang, Hee Young ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Melanocytes; Pigmentation; Toll like receptors

Indexed keywords

EID: 79955586582     PISSN: 10139087     EISSN: None     Source Type: Journal    
DOI: 10.5021/ad.2010.22.4.486     Document Type: Article

References (7)

1. Plonka PM, Passeron T, Brenner M, Tobin DJ, Shibahara S, Thomas A, et al. What are melanocytes really doing all day long...? Exp Dermatol 2009;18:799-819.
2. Terhorst D, Kalali BN, Ollert M, Ring J, Mempel M. The role of toll-like receptors in host defenses and their relevance to dermatologie diseases. Am J Clin Dermatol 2010;11:1 -10.
3. Mackintosh JA. The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J Theor Biol 2001;211:101-113. (Pubitemid 32664863)
4. Yu N, Zhang S, Zuo F, Kang K, Guan M, Xiang L. Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J Dermatol Sci 2009;56:113-120.
5. Ahn JH, Park TJ, Jin SH, Kang HY. Human melanocytes express functional Toll-like receptor 4. Exp Dermatol 2008; 17:412-417.
6. Kang HY, Park TJ, Jin SH. Imiquimod, a Toll-like receptor 7 agonist, inhibits melanogenesis and proliferation of human melanocytes. J Invest Dermatol 2009;129:243-246.
7. Choi TY, Kim JH, Ko DH, Kim CH, Hwang JS, Ahn S, et al. Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds. Pigment Cell Res 2007;20:120-127.