Effects of caspofungin, Candida albicans and Aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs

FEMS Immunology and Medical Microbiology

Volumn 60, Issue 1, 2010, Pages 74-77

  Salvenmoser, Stefanie ^a   Seidler, Marc J ^a   Dalpke, Alexander ^a   Müller, Frank Michael C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

echinocandins; FACS; LightCycler; TLR manipulation

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; CD11B ANTIGEN; FLUCONAZOLE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; VORICONAZOLE;

ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONTROLLED STUDY; CPG ISLAND; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; ANTIGENS, CD11B; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CELLS, CULTURED; ECHINOCANDINS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-8; NEUTROPHILS; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTORS; TRIAZOLES; UP-REGULATION;

EID: 77956545733     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2010.00720.x     Document Type: Article

References (10)

1. Alvarez ME, Fuxman Bass JI, Geffner JR et al 2006) Neutrophil signaling pathways activated by bacterial DNA stimulation. J Immunol 177 : 4037 4046.
2. Akira S (2003) Mammalian toll-like receptors. Curr Opin Immunol 15 : 5 11.
3. Bellocchio S, Montagnoli C, Bozza S, Gaziano R, Rossi G, Mambula SS, Vecchi A, Mantovani A, Levitz SM Romani L (2004a) The contribution of the toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172 : 3059 3069.
4. Bellocchio S, Moretti S, Perruccio K, Fallarino F, Bozza S, Montagnoli C, Mosci P, Lipford GB, Pitzurra L Romani L (2004b) TLRs govern neutrophil activity in aspergillosis. J Immunol 173 : 7406 7415.
5. Gil-Lamaignere C, Roilides E, Lyman CA, Simitsopoulou M, Stergiopoulou T, Maloukou A Walsh TJ (2003) Human phagocytic cell responses to Scedosporium apiospermum (Pseudallescheria boydii): variable susceptibility to oxidative injury. Infect Immun 71 : 6472 6478.
6. Kurt-Jones EA, Mandell L, Whitney C, Padgett A, Gosselin K, Newburger PE Finberg RW (2002) Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood 100 : 1860 1868.
7. Lucarelli M, Gatti AM, Savarino G, Quattroni P, Martinelli L, Monari E Boraschi D (2004) Innate defence functions of macrophages can be biased by nano-sized ceramic and metallic particles. Eur Cytokine Netw 15 : 339 346.
8. Muzio M, Bosisio D, Polentarutti N et al 2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 164 : 5998 6004.
9. Ramirez-Ortiz ZG, Specht CA, Wang JP, Lee CK, Bartholomeu DC, Gazzinelli RT Levitz SM (2008) Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect Immun 76 : 2123 2129.
10. Visintin A, Mazzoni A, Spitzer JH, Wyllie DH, Dower SK Segal DM (2001) Regulation of toll-like receptors in human monocytes and dendritic cells. J Immunol 166 : 249 255.