Cutting edge: All-trans retinoic acid down-regulates TLR2 expression and function

Journal of Immunology

Volumn 174, Issue 5, 2005, Pages 2467-2470

  Liu, Philip T ^a   Krutzik, Stephan R ^a   Kim, Jenny ^a   Modlin, Robert L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYTOKINE; LIGAND; RETINOIC ACID; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ACNE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; RECEPTOR DOWN REGULATION;

EID: 14044257262     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2467     Document Type: Article

References (21)

1. Netea, M. G., C. van der Graaf, J. W. Van der Meer, and B. J. Kullberg. 2004. Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. J. Leukocyte Biol. 75-749.
2. Kim, J., M. T. Ochoa, S. R. Krutzik, O. Takeuchi, S. Uematsu, A. J. Legaspi, H. D. Brightbill, D. Holland, W. J. Cuhliffe, S. Akira, et al. 2002. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J. Immunol. 169:1535.
3. Krutzik, S. R., P. A. Sieling, and R. L. Modlin. 2001. The role of Toll-like receptors in host defense against microbial infection. Curr. Opin. Immunol. 13:104.
4. Oliveira, R. B., M. T. Ochoa, P. A. Sieling, T. H. Rea, A. Rambukkana, E. N. Sarno, and R. L. Modlin. 2003. Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect. Immun. 71:1427.
5. Chong, A. J., A. Shimamoto, C. R. Hampton, H. Takayama, D. J. Spring, C. L. Rothnie, M. Yada, T. H. Pohlman, and E. D. Verrier. 2004. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J. Thorac. Cardiovasc. Surg. 128:170.
6. Vowels, B. R., S. Yang, and J. J. Leyden. 1995. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect. Immun. 63:3158.
7. Niemeier, V., J. Kupfer, M. Demmelbauer-Ebner, U. Stangier, I. Effendy, and U. Gieler. 1998. Coping with acne vulgaris: evaluation of the chronic skin disorder questionnaire in patients with acne. Dermatology 196:108.
8. Leyden, J. J. 2003. A review of the use of combination therapies for the treatment of acne vulgaris. J. Am. Acad. Dermatol. 49:S200.
9. Okuno, M., S. Kojima, R. Matsushima-Nishiwaki, H. Tsurumi, Y. Muto, S. L. Friedman, and H. Moriwaki. 2004. Retinoids in cancer chemoprevention. Curr. Cancer Drug Targets 4:285.
10. Chalker, D. K., J. L. Lesher, Jr., J. G. Smith, Jr., H. C. Klauda, P. E. Pochi, W. S. Jacoby, D. M. Yonkosky, J. J. Voorhees, C. N. Ellis, and S. Matsuda-John. 1987. Efficacy of topical isotretinoin 0.05% gel in acne vulgaris: results of a multicenter, double-blind investigation. J. Am. Acad. Dermatol. 17:251.
11. Weiss, J. S. 1997. Current options for the topical treatment of acne vulgaris. Pediatr. Dermatol. 14:480.
12. Gibbs, S., C. Backendorf, and M. Ponec. 1996. Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3. Arch. Dermatol. Res. 288:729.
13. Krutzik, S. R., M. T. Ochoa, P. A. Sieling, S. Uematsu, Y. W. Ng, A. Legaspi, P. T. Liu, S. T. Cole, P. J. Godowski, Y. Maeda, et al. 2003. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat. Med. 9:525.
14. Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their produces, and cytokines. J. Immunol. 168:554.
15. Monney, L., C. A. Sabaros, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415:536.
16. Costet, P., F. Lalanne, M. C. Gerbod-Giannone, J. R. Molina, X. Fu, E. G. Lund, L. J. Gudas, and A. R. Tall. 2003. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol. Cell. Biol. 23:7756.
17. Mukaida, N., Y. Mahe, and K. Matsushima. 1990. Cooperative interaction of nuclear factor-κB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem. 265:21128.
18. Na, S. Y., B. Y. Kang, S. W. Chung, S. J. Han, X. Ma, G. Trinchieri, S. Y. Im, J. W. Lee, and T. S. Kim. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 274:7674.
19. Motomura, K., M. Ohata, M. Satre, and H. Tsukamoto. 2001. Destabilization of TNF-α mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease. Am. J. Physiol. 281:E420.
20. Means, T. K., B. W. Jones, A. B. Schromm, B. A. Shurtleff, J. A. Smith, J. Keane, D. T. Golenbock, S. N. Vogel, and M. J. Fenton. 2001. Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses. J. Immunol. 166:4074.
21. Savedra, R., Jr., R. L. Delude, R. R. Ingalls, M. J. Fenton, and D. T. Golenbock. 1996. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endocoxin signaling system. J. Immunol. 157:2549.