Identifying toll-like receptor expression in cutaneous sarcoidosis

American Journal of Dermatopathology

Volumn 37, Issue 1, 2015, Pages 67-72

  Huizenga, Taryn ^a   Kado, Jessica ^a   Mehregan, Darius R ^a   Diamond, Stephanie ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cutaneous sarcoidosis; Sarcoid; Sarcoidosis; TLR; Toll like receptor

Indexed keywords

BACTERIAL ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR RELA; RELA PROTEIN, HUMAN;

ANTIGENICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; EPIDERMIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOIDOSIS; SIGNAL TRANSDUCTION; SKIN BIOPSY; SKIN GRANULOMA; TRANSCRIPTION INITIATION; BIOPSY; CASE CONTROL STUDY; IMMUNOLOGY; PATHOLOGY; SKIN; SKIN DISEASE; UPREGULATION;

BIOPSY; CASE-CONTROL STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; SARCOIDOSIS; SKIN; SKIN DISEASES; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 84928152372     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0000000000000199     Document Type: Article

References (38)

1. Mana J, Marcoval J. Skin manifestations of sarcoidosis. Presse Med. 2012;41:e355-e374.
2. Eishi Y. Etiologic link between sarcoidosis and propionibacterium acnes. Respir Investig. 2013;51:56-68.
3. Eishi Y. Etiologic aspect of sarcoidosis as an allergic endogenous infection caused by propionibacterium acnes. Biomed Res Int. 2013;2013:18.
4. Moller DR. Potential etiologic agents in sarcoidosis. Proc Am Thorac Soc. 2007;4:3.
5. Abe C, Iwai L, Mikami R, et al. Frequent isolation of propionibacterium acnes from sarcoidosis lymph nodes. Zentralbl Bakteriol Mikrobiol Hyg A. 1984;256:541-547.
6. Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996;86:973-983.
7. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997;388:394-397.
8. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-680.
9. Takeuchi O, Sato S, Horiuchi T, et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002;169:10-14.
10. Takeuchi O, Kawai T, Muhlradt PF, et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 2001;13:933-940.
11. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TLR4 gene. Science. 1998;282: 2085-2088.
12. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of doublestranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732-738.
13. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410: 1099-1103.
14. Hari A, Flach TL, Shi Y, et al. Toll-like receptors: role in dermatological disease. Mediators Inflamm. 2010;2010:437246.
15. Miller LS. Toll-like receptors in skin. Adv Dermatol. 2008;24:71-87.
16. Kado JA, Shango M, Mehregan C, et al. Mapping Toll-like receptor activity in different stages of cutaneous T-cell lymphoma. Am J Dermatopathol. 2012;34:691-698.
17. Pivarcsi A, Bodai L, Rethi B, et al. Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol. 2003;15:721-730.
18. Lebre MC, van der Aar, AM, van Baarsen, L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol. 2007;127:331-341.
19. Kawai K, Shimura H, Minagawa M, et al. Expression of functional Tolllike receptor 2 on human epidermal keratinocytes. J Dermatol Sci. 2002; 30:185-194.
20. Curry JL, Qin JZ, Bonish B, et al. Innate immune-related receptors in normal and psoriatic skin. Arch Pathol Lab Med. 2003;127:178-186.
21. Ku JK, Kwon HJ, Kim MY, et al. Expression of Toll-like receptors in verruca and molluscum contagiosum. J Korean Med Sci. 2008;23:307-314.
22. Baker BS, Ovigne JM, Powles AV, et al. Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: Modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol. 2003;148:670-679.
23. Schurmann M, Kwiatkowski R, Albrecht M, et al. Study of Toll-like receptor gene loci in sarcoidosis. Clin Exp Immunol. 2008;152:423-431.
24. Veltkamp M, Van Moorsel CH, Rijkers GT. Toll-like receptor (TLR)-9 genetics and function in sarcoidosis. Clin Exp Immunol. 2010;162:7.
25. Gabrilovich MI, et al. Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis. Clin Exp Immunol. 2013;173:512-522.
26. Pabst S, et al. Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis. Clin Exp Immunol. 2006;143:420-426.
27. Veltkamp M, van Moorsel CH, Rijkers GT, et al. Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. Tissue Antigens. 2012;79:25-32.
28. Wahlstrom J, Katchar K, Wigzell H, et al. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med. 2001;163:115-121.
29. Kang SS, Kauls LS, Gaspari AA. Toll-like receptors: Applications to dermatologic disease. J Am Acad Dermatol. 2006;54:951-983; quiz 983-986.
30. Sieling PA, Chung W, Duong BT, et al. Toll-like receptor 2 ligands as adjuvants for human Th1 responses. J Immunol. 2003;170:194-200.
31. Bouis DA, Popova TG, Takashima A, et al. Dendritic cells phagocytose and are activated by Treponema pallidum. Infect Immun. 2001;69: 518-528.
32. Gazouli M, Ikonomopoulos J, Trigidou R, et al. Assessment of mycobacterial, propionibacterial, and human herpesvirus 8 DNA in tissues of greek patients with sarcoidosis. J Clin Microbiol. 2002;40:3060-3063.
33. Yamada T, Eishi Y, Ikeda S, et al. In situ localization of Propionibacterium acnes DNA in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter deposition. J Pathol. 2002;198:541-547.
34. Ishige I, Usui Y, Takemura T, et al. Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis. Lancet. 1999;354:120-123.
35. Nishiwaki T, Yoneyama H, Eishi Y, et al. Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. Am J Pathol. 2004;165:631-639.
36. Vowels BR, Yang S, Leyden JJ, Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: Implications for chronic inflammatory acne. Infect Immun. 1995;63:3158-3165.
37. Kim J, Ochoa MT, Krutzik SR, et al. Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002;169: 1535-1541.
38. Steen T, English JC. Oral minocycline in treatment of cutaneous sarcoidosis. JAMA Dermatol. 2013;149:758-760.