An association of TLR2-16934A>T polymorphism and severity/phenotype of atopic dermatitis

Journal of the European Academy of Dermatology and Venereology

Volumn 25, Issue 6, 2011, Pages 715-721

  Potaczek, D P ^a   Nastalek, M ^b   Okumura, K ^a   Wojas Pelc, A ^b   Undas, A ^b   Nishiyama, C ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

atopic dermatitis; IgE; polymorphism; SCORAD; TLR2; tryptase

Indexed keywords

C REACTIVE PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 6; LUCIFERASE; TOLL LIKE RECEPTOR 2; TRYPTASE;

ADULT; ALLERGIC CONJUNCTIVITIS; ARTICLE; ASTHMA; ATOPIC DERMATITIS; DISEASE SEVERITY; ENZYME ACTIVITY; FAMILY HISTORY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; ALLELES; ASTHMA; C-REACTIVE PROTEIN; DERMATITIS, ATOPIC; FEMALE; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-6; MALE; PHENOTYPE; POLYMORPHISM, GENETIC; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC; TRYPTASES;

EID: 79955910090     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03812.x     Document Type: Article

References (17)

1. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186: 23-31.
2. Ott H, Wilke J, Baron JM, et al. Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or disease severity in childhood atopic dermatitis. J Eur Acad Dermatol Venereol 2010; 24: 395-402.
3. Oh DY, Schumann RR, Hamann L, et al. Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis. Allergy 2009; 64: 1608-1615.
4. Gerdes S, Kurrat W, Mrowietz U,. Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis. Br J Dermatol 2009; 160: 736-740.
5. Lyakhovitsky A, Barzilai A, Heyman R, et al. Low-dose methotrexate treatment for moderate-to-severe atopic dermatitis in adults. J Eur Acad Dermatol Venereol 2010; 24: 43-49.
6. Eder W, Klimecki W, Yu L, et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004; 113: 482-488. (Pubitemid 38338954)
7. Payne V, Kam PC,. Mast cell tryptase: a review of its physiology and clinical significance. Anaesthesia 2004; 59: 695-703. (Pubitemid 38997011)
8. Bender BG, Ballard R, Canono B, et al. Disease severity, scratching, and sleep quality in patients with atopic dermatitis. J Am Acad Dermatol 2008; 58: 415-420. (Pubitemid 351226301)
9. Haniïn JM, Rajka G,. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92 (Suppl.): 44-47.
10. Kanada S, Nakano N, Potaczek DP, et al. Two different transcription factors discriminate the -315C>T-polymorphism of the FcÎμRI α-chain gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T. J Immunol 2008; 180: 8204-8210.
11. Kormann MS, Ferstl R, Depner M, et al. Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk. Allergy 2009; 64: 636-642.
12. Niebuhr M, Langnickel J, Draing C, et al. Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism. Allergy 2008; 63: 728-734. (Pubitemid 351591862)
13. Ahmad-Nejad P, Mrabet-Dahbi S, Breuer K, et al. The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol 2004; 113: 565-567. (Pubitemid 38338967)
14. Weidinger S, Novak N, Klopp N, et al. Lack of association between Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and atopic eczema. J Allergy Clin Immunol 2006; 118: 277-279. (Pubitemid 43946482)
15. Smit LA, Bongers SI, Ruven HJ, et al. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy 2007; 37: 1602-1608. (Pubitemid 47609856)
16. Ott H, Stanzel S, Ocklenburg C, et al. Total serum IgE as a parameter to differentiate between intrinsic and extrinsic atopic dermatitis in children. Acta Derm Venereol 2009; 89: 257-261.
17. Veltkamp M, Wijnen PA, van Moorsel CH, et al. Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. Clin Exp Immunol 2007; 149: 453-462. (Pubitemid 47256146)