Miltefosine triggers a strong proinflammatory cytokine response during visceral leishmaniasis: Role of TLR4 and TLR9

International Immunopharmacology

Volumn 12, Issue 4, 2012, Pages 565-572

  Mukherjee, Asok Kumar ^a,b   Gupta, Gaurav ^a   Adhikari, Anupam ^a   Majumder, Saikat ^a   Kar Mahapatra, Santanu ^a   Bhattacharyya Majumdar, Suchandra ^a   Majumdar, Subrata ^a  

^a BOSE INSTITUTE   (India)

^b Maniktala   (India)

Author keywords

Miltefosine; PBMC; THP1; Toll like receptors; Visceral leishmaniasis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; MILTEFOSINE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LEISHMANIA DONOVANI; MALE; NONHUMAN; PARASITE LOAD; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; VISCERAL LEISHMANIASIS;

ADULT; ANTIPROTOZOAL AGENTS; CELL LINE; CYTOKINES; FEMALE; HUMANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LEUKOCYTES, MONONUCLEAR; MALE; PHOSPHORYLCHOLINE; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; YOUNG ADULT;

EID: 84857660166     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.02.002     Document Type: Article

References (45)

1. F. Chappuis, S. Sundar, A. Hailu, H. Ghalib, S. Rijal, and R.W. Peeling Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 5 2007 873 882 (Pubitemid 47578388)
2. R.N. Coler, and S.G. Reed Second-generation vaccines against leishmaniasis Trends Parasitol 21 2005 244 249 (Pubitemid 40544642)
3. P. Desjeux Global control and Leishmania HIV co-infection Clin Dermatol 17 1999 317 325 (Pubitemid 29497896)
4. A. Bryceson A policy for leishmaniasis with respect to the prevention and control of drug resistance Trop Med Int Health 6 2001 928 934 (Pubitemid 33010880)
5. S. Sundar Drug resistance in Indian visceral leishmaniasis Trop Med Int Health 6 2001 849 854 (Pubitemid 33010870)
6. L. Gradoni, M. Gramiccia, and A. Scalone Visceral leishmaniasis treatment Emerg Infect Dis 9 2003 1617 1620
7. C. Bern, J. Adler-Moore, J. Berenguer, M. Boelaert, M. den Boer, and R.N. Davidson Liposomal amphotericin B for the treatment of visceral leishmaniasis Clin Infect Dis 43 2006 917 924 (Pubitemid 44435523)
8. P. Hilgard, T. Klenner, J. Stekar, and C. Unger Alkylphosphocholines: a new class of membrane-active anticancer agents Cancer Chemother Pharmacol 32 1993 90 95 (Pubitemid 23131925)
9. R. Leonard, J. Hardy, G. van Tienhoven, S. Houston, P. Simmonds, and M. David Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer J Clin Oncol 19 2001 4150 4159 (Pubitemid 33049533)
10. T.K. Jha, S. Sundar, C.P. Thakur, P. Bachmann, J. Karbwang, and C. Fischer Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis N Engl J Med 341 1999 1795 1800
11. R.D. Pearson Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis Curr Infect Dis Rep 5 2003 41 42
12. S. Sundar, A. Makharia, D.K. More, G. Agrawal, A. Voss, and C. Fischer Short-course of oral miltefosine for treatment of visceral leishmaniasis Clin Infect Dis 31 2000 1110 1113 (Pubitemid 32299377)
13. S. Sundar, F. Rosenkaimer, M.K. Makharia, A.K. Goyal, A.K. Mandal, and A. Voss Trial of oral miltefosine for visceral leishmaniasis Lancet 352 1998 1821 1823 (Pubitemid 28550072)
14. G. Arthur, and R. Bittman The inhibition of cell signaling pathways by antitumor ether lipids Biochim Biophys Acta 1390 1998 85 102 (Pubitemid 28122329)
15. P. Escobar, V. Yardley, and S.L. Croft Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice Antimicrob Agents Chemother 45 2001 1872 1875 (Pubitemid 32466363)
16. P. Wadhone, M. Maiti, R. Agarwal, V. Kamat, S. Martin, and B. Saha Miltefosine promotes IFN-gamma-dominated anti-leishmanial immune response J Immunol 182 2009 7146 7154
17. G. Gupta, S. Bhattacharjee, S. Bhattacharyya, P. Bhattacharya, A. Adhikari, and A. Mukherjee CXC chemokine-mediated protection against visceral leishmaniasis: involvement of the proinflammatory response J Infect Dis 200 2009 1300 1310
18. C. Gallego, D. Golenbock, M.A. Gomez, and N.G. Saravia Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis Infect Immun 79 2011 2871 2879
19. R. Medzhitov, and C.A. Janeway Innate immunity: impact on the adaptive immune response Curr Opin Immunol 9 1997 4 9 (Pubitemid 27095892)
20. M.G. Netea, C. van der Graaf, J.W. Van der Meer, and B.J. Kullberg Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system J Leukoc Biol 75 2004 749 755 (Pubitemid 38580054)
21. F.F. Tuon, E.R. Fernandes, C. Pagliari, M.I. Duarte, and V.S. Amato The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma Parasite Immunol 32 2010 769 772
22. P. Kropf, M.A. Freudenberg, M. Modolell, H.P. Price, S. Herath, and S. Antoniazi Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major Infect Immun 72 2004 1920 1928 (Pubitemid 38419902)
23. P. Bhattacharya, S. Bhattacharjee, G. Gupta, S. Majumder, A. Adhikari, and A. Mukherjee Arabinosylated lipoarabinomannan-mediated protection in visceral leishmaniasis through up-regulation of toll-like receptor 2 signaling: an immunoprophylactic approach J Infect Dis 202 2010 145 155
24. D.T. Hart, K. Vickerman, and G.H. Coombs A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers Parasitology 82 1981 345 355 (Pubitemid 11084017)
25. A.K. Mukherjee, G. Gupta, S. Bhattacharjee, S.K. Guha, S. Majumder, and A. Adhikari Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms J Infect 61 2010 173 184
26. S. Bhattacharyya, S. Ghosh, B. Dasgupta, D. Mazumder, S. Roy, and S. Majumdar Chemokine-induced leishmanicidal activity in murine macrophages via the generation of nitric oxide J Infect Dis 185 2002 1704 1708 (Pubitemid 34615462)
27. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids Anal Biochem 126 1982 131 138 (Pubitemid 13203451)
28. P. Hilgard, E. Kampherm, L. Nolan, J. Pohl, and T. Reissmann Investigation into the immunological effects of miltefosine, a new anticancer agent under development J Cancer Res Clin Oncol 117 1991 403 408
29. C.H. Hochhuth, K. Vehmeyer, H. Eibl, and C. Unger Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells Cell Immunol 141 1992 161 168
30. I. Eue Hexadecylphosphocholine selectively upregulates expression of intracellular adhesion molecule-1 and class I major histocompatibility complex antigen in human monocytes J Exp Ther Oncol 2 2002 333 336 (Pubitemid 35265982)
31. F.F. Tuon, V.S. Amato, H.A. Bacha, T. Almusawi, M.I. Duarte, and V. Amato Neto Toll-like receptors and leishmaniasis Infect Immun 76 2008 866 872 (Pubitemid 351428044)
32. M. Barral-Netto, A. Barral, C.E. Brownell, Y.A. Skeiky, L.R. Ellingsworth, and D.R. Twardzik Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism Science 257 1992 545 548
33. D. Chandra, and S. Naik Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism Clin Exp Immunol 154 2008 224 234
34. F.F. Tuon, E.R. Fernandes, M.I. Duarte, and V.S. Amato The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis J Dermatol Sci 59 2010 55 57
35. C. Bogdan Mechanisms and consequences of persistence of intracellular pathogens: leishmaniasis as an example Cell Microbiol 10 2008 1221 1234 (Pubitemid 351663916)
36. Z.K. Pan Toll-like receptors and TLR-mediated signaling: more questions than answers Am J Physiol Lung Cell Mol Physiol 286 2004 L918 L920
37. V.S. Raman, A. Bhatia, A. Picone, J. Whittle, H.R. Bailor, and J. O'Donnell Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis J Immunol 185 2010 1701 1710
38. M.S. Faria, F.C. Reis, R.L. Azevedo-Pereira, L.S. Morrison, J.C. Mottram, and A.P. Lima Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages J Immunol 186 2011 411 422
39. C.S. Guerra, R.M. Silva, L.O. Carvalho, K.S. Calabrese, P.T. Bozza, and S. Corte-Real Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis Int J Exp Pathol 91 2010 451 459
40. F.H. Abou Fakher, N. Rachinel, M. Klimczak, J. Louis, and N. Doyen TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions J Immunol 182 2009 1386 1396
41. G. Theiner, S. Rössner, A. Dalpke, K. Bode, T. Berger, and A. Gessner TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells Mol Immunol 45 2008 244 252 (Pubitemid 47331637)
42. A. Sarkar, P. Saha, G. Mandal, D. Mukhopadhyay, S. Roy, and S.K. Singh Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis Cytometry A 79 2011 35 45
43. L. Manna, S. Reale, E. Picillo, F. Vitale, and A.E. Gravino Interferon-gamma (INF-gamma), IL4 expression levels and Leishmania DNA load as prognostic markers for monitoring response to treatment of leishmaniotic dogs with miltefosine and allopurinol Cytokine 44 2008 288 292
44. S.A. Sane, N. Shakya, W. Haq, and S. Gupta CpG oligodeoxynucleotide augments the antileishmanial activity of miltefosine against experimental visceral leishmaniasis J Antimicrob Chemother 65 2010 1448 1454
45. - Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis J Exp Med 204 2 2007 285 297 (Pubitemid 46294545)