메뉴 건너뛰기




Volumn 63, Issue 5, 2016, Pages 1660-1674

Akt-mediated foxo1 inhibition is required for liver regeneration

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FAT DROPLET; GROWTH FACTOR; PROTEIN KINASE B; PROTEIN KINASE B BETA; TRANSCRIPTION FACTOR FKHR; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; AKT1 PROTEIN, MOUSE; AKT2 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; PDPK1 PROTEIN, MOUSE;

EID: 84951765778     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28286     Document Type: Article
Times cited : (53)

References (59)
  • 3
    • 0001276586 scopus 로고
    • Experimental pathology of liver resection
    • Higgins GM, Anderson RM. Experimental pathology of liver resection. Arch Pathol 1931;12:186-197.
    • (1931) Arch Pathol , vol.12 , pp. 186-197
    • Higgins, G.M.1    Anderson, R.M.2
  • 4
    • 0022650663 scopus 로고
    • Liver resections in cirrhotic patients: a Western experience
    • Bismuth H, Houssin D, Ornowski J, Meriggi F. Liver resections in cirrhotic patients: a Western experience. World J Surg 1986;10:311-317.
    • (1986) World J Surg , vol.10 , pp. 311-317
    • Bismuth, H.1    Houssin, D.2    Ornowski, J.3    Meriggi, F.4
  • 5
    • 84919629977 scopus 로고    scopus 로고
    • Liver regeneration after living donor transplantation: adult-to-adult living donor liver transplantation cohort study
    • Olthoff KM, Emond JC, Shearon TH, Everson G, Baker TB, Fisher RA, et al. Liver regeneration after living donor transplantation: adult-to-adult living donor liver transplantation cohort study. Liver Transpl 2015;21:79-88.
    • (2015) Liver Transpl , vol.21 , pp. 79-88
    • Olthoff, K.M.1    Emond, J.C.2    Shearon, T.H.3    Everson, G.4    Baker, T.B.5    Fisher, R.A.6
  • 6
    • 84922455894 scopus 로고    scopus 로고
    • Authors' response to the letter: Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours or portal hypertension by Zhong et al. Gut 2015;64:522.
    • Bruix J, Gores G, Mazzaferro V. Authors' response to the letter: Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours or portal hypertension by Zhong et al. Gut 2015;64:522.
    • (2015) Gut , vol.64 , pp. 522
    • Bruix, J.1    Gores, G.2    Mazzaferro, V.3
  • 7
    • 84882341576 scopus 로고    scopus 로고
    • Resection strategies for hepatocellular carcinoma
    • Wong TC, Lo CM. Resection strategies for hepatocellular carcinoma. Semin Liver Dis 2013;33:273-281.
    • (2013) Semin Liver Dis , vol.33 , pp. 273-281
    • Wong, T.C.1    Lo, C.M.2
  • 8
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: from myth to mechanism
    • Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004;5:836-847.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 836-847
    • Taub, R.1
  • 10
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 14
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001;292:1728-1731.
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3    Thorvaldsen, J.L.4    Chu, Q.5    Crenshaw, E.B.6
  • 16
    • 0034731449 scopus 로고    scopus 로고
    • Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration
    • Hong F, Nguyen VA, Shen X, Kunos G, Gao B. Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. Biochem Biophys Res Commun 2000;279:974-979.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 974-979
    • Hong, F.1    Nguyen, V.A.2    Shen, X.3    Kunos, G.4    Gao, B.5
  • 17
    • 84879146244 scopus 로고    scopus 로고
    • PPARbeta regulates liver regeneration by modulating Akt and E2f signaling
    • Liu HX, Fang Y, Hu Y, Gonzalez FJ, Fang J, Wan YJ. PPARbeta regulates liver regeneration by modulating Akt and E2f signaling. PLoS One 2013;8:e65644.
    • (2013) PLoS One , vol.8
    • Liu, H.X.1    Fang, Y.2    Hu, Y.3    Gonzalez, F.J.4    Fang, J.5    Wan, Y.J.6
  • 18
    • 84906545577 scopus 로고    scopus 로고
    • Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy
    • Marshall KM, He S, Zhong Z, Atkinson C, Tomlinson S. Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. J Exp Med 2014;211:1793-1805.
    • (2014) J Exp Med , vol.211 , pp. 1793-1805
    • Marshall, K.M.1    He, S.2    Zhong, Z.3    Atkinson, C.4    Tomlinson, S.5
  • 19
    • 58949092180 scopus 로고    scopus 로고
    • The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation
    • Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, et al. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 2009;49:204-214.
    • (2009) Hepatology , vol.49 , pp. 204-214
    • Haga, S.1    Ozaki, M.2    Inoue, H.3    Okamoto, Y.4    Ogawa, W.5    Takeda, K.6
  • 21
    • 34547101027 scopus 로고    scopus 로고
    • Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest
    • Mullany LK, Nelsen CJ, Hanse EA, Goggin MM, Anttila CK, Peterson M, et al. Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest. J Biol Chem 2007;282:21244-21252.
    • (2007) J Biol Chem , vol.282 , pp. 21244-21252
    • Mullany, L.K.1    Nelsen, C.J.2    Hanse, E.A.3    Goggin, M.M.4    Anttila, C.K.5    Peterson, M.6
  • 22
    • 84856788284 scopus 로고    scopus 로고
    • Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity
    • Wan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, et al. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol 2012;32:96-106.
    • (2012) Mol Cell Biol , vol.32 , pp. 96-106
    • Wan, M.1    Easton, R.M.2    Gleason, C.E.3    Monks, B.R.4    Ueki, K.5    Kahn, C.R.6
  • 23
  • 24
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 2007;6:208-216.
    • (2007) Cell Metab , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 25
    • 84857934301 scopus 로고    scopus 로고
    • Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
    • Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 2012;18:388-395.
    • (2012) Nat Med , vol.18 , pp. 388-395
    • Lu, M.1    Wan, M.2    Leavens, K.F.3    Chu, Q.4    Monks, B.R.5    Fernandez, S.6
  • 26
    • 66149102890 scopus 로고    scopus 로고
    • The role of FOXO in the regulation of metabolism
    • Gross DN, Wan M, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Curr Diab Rep 2009;9:208-214.
    • (2009) Curr Diab Rep , vol.9 , pp. 208-214
    • Gross, D.N.1    Wan, M.2    Birnbaum, M.J.3
  • 28
    • 33646168160 scopus 로고    scopus 로고
    • Lipid droplets: a unified view of a dynamic organelle
    • Martin S, Parton RG. Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006;7:373-378.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 373-378
    • Martin, S.1    Parton, R.G.2
  • 29
    • 78651107338 scopus 로고    scopus 로고
    • Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets
    • Garcia-Arcos I, Gonzalez-Kother P, Aspichueta P, Rueda Y, Ochoa B, Fresnedo O. Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets. Lipids 2010;45:1101-1108.
    • (2010) Lipids , vol.45 , pp. 1101-1108
    • Garcia-Arcos, I.1    Gonzalez-Kother, P.2    Aspichueta, P.3    Rueda, Y.4    Ochoa, B.5    Fresnedo, O.6
  • 30
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 31
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
    • Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, et al. Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B. Science 1998;279:710-714.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3    Erdjument-Bromage, H.4    Painter, G.F.5    Holmes, A.B.6
  • 32
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601.
    • (1999) Nature , vol.399 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3    Fontana, J.4    Fujio, Y.5    Walsh, K.6
  • 33
    • 17944363486 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
    • Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell 2001;8:693-704.
    • (2001) Mol Cell , vol.8 , pp. 693-704
    • Lee, M.J.1    Thangada, S.2    Paik, J.H.3    Sapkota, G.P.4    Ancellin, N.5    Chae, S.S.6
  • 36
  • 37
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 2005;11:952-958.
    • (2005) Nat Med , vol.11 , pp. 952-958
    • Liu, S.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.4    Rockey, D.C.5
  • 38
    • 33644615458 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase/Akt-signal pathway mediates proliferation and secretory function of hepatic sinusoidal endothelial cells in rats after partial hepatectomy
    • Ping C, Lin Z, Jiming D, Jin Z, Ying L, Shigang D, et al. The phosphoinositide 3-kinase/Akt-signal pathway mediates proliferation and secretory function of hepatic sinusoidal endothelial cells in rats after partial hepatectomy. Biochem Biophys Res Commun 2006;342:887-893.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 887-893
    • Ping, C.1    Lin, Z.2    Jiming, D.3    Jin, Z.4    Ying, L.5    Shigang, D.6
  • 40
    • 84893702351 scopus 로고    scopus 로고
    • MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN
    • Yan-nan B, Zhao-yan Y, Li-xi L, Jiang Y, Qing-jie X, Yong Z. MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN. Biochem Biophys Res Commun 2014;443:802-807.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 802-807
    • Yan-nan, B.1    Zhao-yan, Y.2    Li-xi, L.3    Jiang, Y.4    Qing-jie, X.5    Yong, Z.6
  • 41
    • 34250902930 scopus 로고    scopus 로고
    • Targeting the protein kinase C family: are we there yet?
    • Mackay HJ, Twelves CJ. Targeting the protein kinase C family: are we there yet? Nat Rev Cancer 2007;7:554-562.
    • (2007) Nat Rev Cancer , vol.7 , pp. 554-562
    • Mackay, H.J.1    Twelves, C.J.2
  • 43
    • 23044467856 scopus 로고    scopus 로고
    • PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle
    • Dong LQ, Liu F. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am J Physiol Endocrinol Metab 2005;289:E187-E196.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , pp. E187-E196
    • Dong, L.Q.1    Liu, F.2
  • 44
    • 84899484738 scopus 로고    scopus 로고
    • Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
    • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature 2014;508:541-545.
    • (2014) Nature , vol.508 , pp. 541-545
    • Liu, P.1    Begley, M.2    Michowski, W.3    Inuzuka, H.4    Ginzberg, M.5    Gao, D.6
  • 46
    • 77954607192 scopus 로고    scopus 로고
    • Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
    • Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, et al. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One 2010;5:e9646.
    • (2010) PLoS One , vol.5
    • Mahajan, K.1    Coppola, D.2    Challa, S.3    Fang, B.4    Chen, Y.A.5    Zhu, W.6
  • 47
    • 0035448879 scopus 로고    scopus 로고
    • Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
    • Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001;15:2203-2208.
    • (2001) Genes Dev , vol.15 , pp. 2203-2208
    • Chen, W.S.1    Xu, P.Z.2    Gottlob, K.3    Chen, M.L.4    Sokol, K.5    Shiyanova, T.6
  • 48
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001;276:38349-38352.
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 49
    • 0042591476 scopus 로고    scopus 로고
    • FOXO transcription factors as regulators of immune homeostasis: molecules to die for?
    • Birkenkamp KU, Coffer PJ. FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol 2003;171:1623-1629.
    • (2003) J Immunol , vol.171 , pp. 1623-1629
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 50
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 52
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004;117:421-426.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 53
    • 0033711708 scopus 로고    scopus 로고
    • 1 cyclin-dependent kinases in the mammalian cell cycle
    • 1 cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 2000;12:676-684.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 676-684
    • Ekholm, S.V.1    Reed, S.I.2
  • 55
    • 56249100986 scopus 로고    scopus 로고
    • A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
    • Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 2008;456:269-273.
    • (2008) Nature , vol.456 , pp. 269-273
    • Liu, Y.1    Dentin, R.2    Chen, D.3    Hedrick, S.4    Ravnskjaer, K.5    Schenk, S.6
  • 56
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003;423:550-555.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 57
    • 80053927531 scopus 로고    scopus 로고
    • Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c
    • Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, et al. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab 2011;14:516-527.
    • (2011) Cell Metab , vol.14 , pp. 516-527
    • Wan, M.1    Leavens, K.F.2    Saleh, D.3    Easton, R.M.4    Guertin, D.A.5    Peterson, T.R.6
  • 58
    • 0037244002 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    • Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res 2003;44:22-32.
    • (2003) J Lipid Res , vol.44 , pp. 22-32
    • Hussain, M.M.1    Shi, J.2    Dreizen, P.3
  • 59
    • 45749133797 scopus 로고    scopus 로고
    • FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
    • Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, et al. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest 2008;118:2347-2364.
    • (2008) J Clin Invest , vol.118 , pp. 2347-2364
    • Kamagate, A.1    Qu, S.2    Perdomo, G.3    Su, D.4    Kim, D.H.5    Slusher, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.