Impact of rapamycin on liver regeneration

Virchows Archiv

Volumn 452, Issue 5, 2008, Pages 545-557

  Palmes, Daniel ^a   Zibert, Andree ^a   Budny, Tymotheus ^a   Bahde, Ralf ^a   Minin, Evgeny ^a   Kebschull, Linus ^a   Hölzen, Jens ^a   Schmidt, Hartmut ^a   Spiegel, Hans Ullrich ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Antineoplastic; Fibrosis; Immunosuppression; Small for size; Transplantation

Indexed keywords

ANGIOPOIETIN 1; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RAPAMYCIN; SCATTER FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; TRANSGELIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; LIVER SINUSOID; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL;

ACTINS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; HEPATECTOMY; HEPATOCYTES; IMMUNOSUPPRESSIVE AGENTS; LIVER; LIVER REGENERATION; MALE; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, INBRED LEW; SIROLIMUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 42549128274     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-008-0604-y     Document Type: Article

References (45)

1. Abraham RT, Gibbons JJ (2007) The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res 13:3109-3114
2. Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442:779-785
3. Biecker E, De Gottardi A, Neef M, Unternährer M, Schneider V, Ledermann M, Sägesser H, Shaw S, Reichen J (2005) Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms. J Pharmacol Exp Ther 313:952-961
4. Boylan JM, Anand P, Gruppuso PA (2001) Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat. J Biol Chem 276:44457-44463
5. Budny T, Palmes D, Stratmann U, Minin E, Herbst H, Spiegel HU (2007) Morphologic features in the regenerating liver-a comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells. Virchows Arch 451:781-791
6. Butzal M, Loges S, Schweizer M, Fischer U, Gehling UM, Hossfeld DK, Fiedler W (2004) Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro. Exp Cell Res 300:65-71
7. Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G, Milella M (2006) Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 66:5549-5554
8. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-584
9. Dharancy S, Catteau B, Mortier L, Boleslawski E, Declerck N, Canva V, Piette F, Mathurin P, Pruvot FR (2006) Conversion to sirolimus: a useful strategy for recalcitrant cutaneous viral warts in liver transplant recipient. Liver Transpl 12:1883-1887
10. Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA (1999) Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology 30:761-769
11. Fausto N (2004) Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39:1477-1487
12. Gabele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA (2005) The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280:13374-13382
13. Goggin MM, Nelsen CJ, Kimball SR, Jefferson LS, Morley SJ, Albrecht JH (2004) Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Hepatology 40:537-544
14. Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK (2002) Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8:128-135
15. Guba M, Yezhelyev M, Eichhorn ME, Schmid G, Ischenko I, Papyan A, Graeb C, Seeliger H, Geissler EK, Jauch KW, Bruns CJ (2005) Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF. Blood 105:4463-4469
16. Hellerbrand C, Wang SC, Tsukamoto H, Brenner DA, Rippe RA (1996) Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 24:670-676
17. Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM, Shibuya M (2002) MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2:289-300
18. Ilyin GP, Glaise D, Gilot D, Baffet G, Guguen-Guillouzo C (2003) Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. Am J Physiol Gastrointest Liver Physiol 285:G115-G127
19. Jiang F, Parsons CJ, Stefanovic B (2006) Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45:401-409
20. Jiang YP, Ballou LM, Lin RZ (2001) Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. J Biol Chem 276:10943-10951
21. Kneteman NM, Oberholzer J, Al Saghier M, Meeberg GA, Blitz M, Ma MM, Wong WW, Gutfreund K, Mason AL, Jewell LD, Shapiro AM, Bain VG, Bigam DL (2004) Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Liver Transpl 10:1301-1311
22. Le Pabic H, L'Helgoualc'h A, Coutant A, Wewer UM, Baffet G, Clément B, Théret N (2005) Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol 43:1038-1044
23. Mabuchi A, Mullaney I, Sheard PW, Hessian PA, Mallard BL, Tawadrous MN, Zimmermann A, Senoo H, Wheatley AM (2004) Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. J Hepatol 40:910-916
24. Macias-Silva M, Li W, Leu JI, Crissey MA, Taub R (2002) Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J Biol Chem 277:28483-28490
25. Man K, Su M, Ng KT, Lo CM, Zhao Y, Ho JW, Sun CK, Lee TK, Fan ST (2006) Rapamycin attenuates liver graft injury in cirrhotic recipient-the significance of down-regulation of Rho-ROCK-VEGF pathway. Am J Transplant 6:697-704
26. Mayerhofer M, Aichberger KJ, Florian S, Valent P (2005) Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. FASEB J 19:960-962
27. Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C (2002) BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 100:3767-3775
28. Neef M, Ledermann M, Saegesser H, Schneider V, Reichen J (2006) Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term. J Hepatol 44:167-175
29. Nelsen CJ, Rickheim DG, Tucker MM, Hansen LK, Albrecht JH (2003) Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes. J Biol Chem 278:3656-3663
30. Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F (2004) Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 10:1013-1023
31. Palmes D, Spiegel HU (2004) Animal models of liver regeneration. Biomaterials 25:1601-1611
32. Park J, Ha H, Ahn HJ, Kang SW, Kim YS, Seo JY, Kim MS (2005) Sirolimus inhibits platelet-derived growth factor-induced collagen synthesis in rat vascular smooth muscle cells. Transplant Proc 37:3459-3462
33. Pinzani M, Knauss TC, Pierce GF, Hsieh P, Kenney W, Dubyak GR, Abboud HE (1991) Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells. Am J Physiol 260:C485-C491
34. Reynaert H, Chavez M, Geerts A (2001) Vascular endothelial growth factor and liver regeneration. J Hepatol 34:759-761
35. Rickheim DG, Nelsen CJ, Fassett JT, Timchenko NA, Hansen LK, Albrecht JH (2002) Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology 36:30-38
36. Sato T, El-Assal ON, Ono T, Yamanoi A, Dhar DK, Nagasue N (2001) Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol 34:690-698
37. Schumacher G, Oidtmann M, Rosewicz S, Langrehr J, Jonas S, Mueller AR, Rueggeberg A, Neuhaus R, Bahra M, Jacob D, Gerlach H, Neuhaus P (2002) Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth. Transplant Proc 34:1392-1393
38. Shegogue D, Trojanowska M (2004) Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem 279:23166-23175
39. Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 312:549-560
40. Smolewski P (2006) Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 17:487-494
41. Soejima Y, Shimada M, Suehiro T, Hiroshige S, Ninomiya M, Shiotani S, Harada N, Hideki I, Yonemura Y, Maehara Y (2003) Outcome analysis in adult-to-adult living donor liver transplantation using the left lobe. Liver Transpl 9:581-586
42. Taub R (2004) Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 5:836-847
43. Webber EM, Bruix J, Pierce RH, Fausto N (1998) Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 28:1226-1234
44. Zhou J, Fan J, Wang Z, Wu ZQ, Qiu SJ, Huang XW, Yu Y, Sun J, Xiao YS, He YF, Wang YQ, Tang ZY (2006) Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: report of an initial experience. World J Gastroenterol 12:3114-3118
45. Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, Norton P, Zern MA (1999) Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 117:1198-1204