Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets

Lipids

Volumn 45, Issue 12, 2010, Pages 1101-1108

  García Arcos, Itsaso ^a,b   González Kother, Paola ^a,c   Aspichueta, Patricia ^a   Rueda, Yuri ^a   Ochoa, Begona ^a   Fresnedo, Olatz ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b Columbia University School of Medicine ^*  (United States)

^c UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN   (Chile)

Author keywords

Lipid composition; Lipid droplets; Liver regeneration

Indexed keywords

CHOLESTEROL ESTER; FAT DROPLET; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; LIPID ANALYSIS; LIPID COMPOSITION; LIPID STORAGE; LIVER REGENERATION; NONHUMAN; PARTIAL HEPATECTOMY; PHENOTYPE; RAT; STEROIDOGENESIS;

ANIMALS; FEMALE; HEPATECTOMY; LIPID METABOLISM; LIPIDS; LIVER REGENERATION; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

MAMMALIA; RATTUS;

EID: 78651107338     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-010-3492-2     Document Type: Article

References (44)

1. Fausto N (2000) Liver regeneration. J Hepatol 32:19-31
2. Michalopoulos GK (2007) Liver regeneration. J Cell Physiol 213:286-300
3. Michalopoulos GK (2009) Liver regeneration: Alternative epithelial pathways. Int J Biochem Cell Biol. doi:10.1016/j. biolcel.209.09.014
4. Taub R (2004) Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 5:836-847
5. Newberry EP, Kennedy SM, Xie Y, Luo J, Stanley SE, Semenkovich CF, Crooke RM, Graham MJ, Davidson NO (2008) Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology 48:1097-1105
6. Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA (2004) Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology 40:1322-1332
7. DeAngelis RA, Markiewski MM, Taub R, Lambris JD (2005) A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42:1148-1157
8. Fernandez MA, Albor C, Ingelmo-Torres M, Nixon SJ, Ferguson C, Kurzchalia T, Tebar F, Enrich C, Parton RG, Pol A (2006) Caveolin-1 is essential for liver regeneration. Science 313:1628-1632
9. Leclercq IA, Field J, Farrell GC (2003) Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Gastroenterology 124:1451-1464
10. Yamauchi H, Uetsuka K, Okada T, Nakayama H, Doi K (2003) Impaired liver regeneration after partial hepatectomy in db/db mice. Exp Toxicol Pathol 54:281-286
11. Rinia HA, Burger KN, Bonn M, Muller M (2008) Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopy. Biophys J 95:4908-4914
12. Bartz R, Li WH, Venables B, Zehmer JK, Roth MR, Welti R, Anderson RG, Liu P, Chapman KD (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48:837-847
13. Hodges BD, Wu CC (2010) Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets. J Lipid Res 51:262-273
14. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette- Mackie EJ, Londos C (1997) Adipose differentiation-related protein is a ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38:2249-2263
15. Brasaemle DL, Dolios G, Shapiro L, Wang R (2004) Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem 279:46835-46842
16. Cermelli S, Guo Y, Gross SP, Welte MA (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol 16:1783-1795
17. Dugail I, Hajduch E (2007) A new look at adipocyte lipid droplets: Towards a role in the sensing of triacylglycerol stores? Cell Mol Life Sci 64:2452-2458
18. Fujimoto Y, Itabe H, Kinoshita T, Homma KJ, Onoduka J, Mori M, Yamaguchi S, Makita M, Higashi Y, Yamashita A, Takano T (2007) Involvement of long chain acyl-CoA synthetase in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7. J Lipid Res 48:1280-1292
19. Umlauf E, Csaszar E, Moertelmaier M, Schuetz GJ, Parton RG, Prohaska R (2004) Association of stomatin with lipid bodies. J Biol Chem 279:23699-23709
20. Welte MA (2007) Proteins under new management: lipid droplets deliver. Trends Cell Biol 17:363-369
21. Murphy DJ, Vance J (1999) Mechanisms of lipid-body formation. Trends Biochem Sci 24:109-115
22. Mendis-Handagama SM, Aten RF, Watkins PA, Scallen TJ, Berhman HR (1995) Peroxisomes and sterol carrier protein-2 in luteal cell steroidogenesis: A possible role in cholesterol transport from lipid droplets to mitochondria. Tissue Cell 27:483-490
23. Igal RA, Coleman RA (1998) Neutral lipid storage disease: A genetic disorder with abnormalities in the regulation of phospholipid metabolism. J Lipid Res 39:31-43
24. Waynforth HB, Flecknell PA (1992) Experimental and surgical technique in the rat. Academic Press, London, pp 241-245
25. Palacios L, Ochoa B, Jose Gomez-Lechon M, Vicente CJ, Fresnedo O (2006) Overexpression of SND p102, a rat homologue of p100 coactivator, promotes the secretion of lipoprotein phospholipids in primary hepatocytes. Biochim Biophys Acta 1761:698-708
26. García-Arcos I, Rueda Y, González-Kother P, Palacios L, Ochoa B, Fresnedo O (2010) Association of SND1 protein with low density lipid droplets in hepatic steatosis. J Physiol Biochem 66:73-83
27. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
28. Ruiz JI, Ochoa B (1997) Quantification in the subnanomolar range of phospholipids and neutral lipids by monodimensional thin-layer chromatography and image analysis. J Lipid Res 38:1482-1489
29. Brasaemle DL (2006) A metabolic push to proliferate. Science 313:1581-1582
30. Grisham JW (1962) A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res 22:842-849
31. Farrell GC (2004) Probing Prometheus: fat fueling the fire? Hepatology 40:1252-1255
32. Ontko JA, Perrin LW, Horne LS (1986) Isolation of hepatocellular lipid droplets: The separation of distinct subpopulations. J Lipid Res 27:1097-1103
33. Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, Schwabe RF, Hillman EM, Piantedosi R, Libien J (2008) Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage. Biochim Biophys Acta 1791:408-418
34. Murphy DJ (2001) The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 40:325-438
35. Jump DB, Clarke SD (1999) Regulation of gene expression by dietary fat. Annu Rev Nutr 19:63-90
36. Fuki IV, Preobrazhensky SN, Misharin AY, Bushmakina NG, Menschikov GB, Repin VS, Karpov RS (1989) Effect of cell cholesterol content on apolipoprotein B secretion and LDL receptor activity in the human hepatoma cell line, HepG2. Biochim Biophys Acta 1001:235-238
37. Isusi E, Aspichueta P, Liza M, Hernandez ML, Diaz C, Hernandez G, Martinez MJ, Ochoa B (2000) Short- and long-term effects of atorvastatin, lovastatin and simvastatin on the cellular metabolism of cholesteryl esters and VLDL secretion in rat hepatocytes. Atherosclerosis 153:283-294
38. Temel RE, Hou L, Rudel LL, Shelness GS (2007) ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins. J Lipid Res 48:1618-1627
39. Field FJ, Mathur SN, LaBrecque DR (1985) Cholesterol metabolism in regenerating liver of the rat. Am J Physiol 249:G679-G684
40. Lo SassoG, Celli N, Caboni M, Murzilli S, Salvatore L, Morgano A, Vacca M, Pagliani T, Parini P, Moschetta A (2010) Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes. Hepatology 51:1334-1344
41. Delahunty TJ, Rubinstein D (1970) Accumulation and release of triglycerides by rat liver following partial hepatectomy. J Lipid Res 11:536-543
42. Houweling M, Tijburg LB, Vaartjes WJ, Van Golde LM (1992) Phosphatidylethanolamine metabolism in rat liver after partial hepatectomy. Control of biosynthesis of phosphatidylethanolamine by the availability of ethanolamine. Biochem J 283(Pt 1):55-61
43. Tijburg LB, Nyathi CB, Meijer GW, Geelen MJ (1991) Biosynthesis and secretion of triacylglycerol in rat liver after partial hepatectomy. Biochem J 277(Pt 3):723-728
44. Vance DE, Vance JE (2008) Biochemistry of lipids, lipoproteins and membranes. Elsevier, Amsterdam