메뉴 건너뛰기




Volumn 8, Issue 6, 2013, Pages

PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; TRANSCRIPTION FACTOR E2F; TRANSCRIPTOME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; TRANSCRIPTION FACTOR E2F2;

EID: 84879146244     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065644     Document Type: Article
Times cited : (32)

References (42)
  • 1
    • 76149101639 scopus 로고    scopus 로고
    • Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRα-deficient mouse livers
    • Yang X, Guo M, Wan YJ, (2010) Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRα-deficient mouse livers. Am J Pathol 176: 733-743.
    • (2010) Am J Pathol , vol.176 , pp. 733-743
    • Yang, X.1    Guo, M.2    Wan, Y.J.3
  • 2
    • 77956975444 scopus 로고    scopus 로고
    • Cycling through metabolism
    • Aguilar V, Fajas L, (2010) Cycling through metabolism. EMBO Mol Med 2: 338-348.
    • (2010) EMBO Mol Med , vol.2 , pp. 338-348
    • Aguilar, V.1    Fajas, L.2
  • 3
    • 76449100708 scopus 로고    scopus 로고
    • PPARs: diverse regulators in energy metabolism and metabolic diseases
    • Wang YX, (2010) PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 20: 124-137.
    • (2010) Cell Res , vol.20 , pp. 124-137
    • Wang, Y.X.1
  • 4
    • 76749137586 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions
    • Wagner KD, Wagner N, (2010) Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol Ther 125: 423-435.
    • (2010) Pharmacol Ther , vol.125 , pp. 423-435
    • Wagner, K.D.1    Wagner, N.2
  • 6
    • 0036730442 scopus 로고    scopus 로고
    • Delayed liver regeneration in peroxisome proliferator-activated receptor-α-null mice
    • Anderson SP, Yoon L, Richard EB, Dunn CS, Cattley RC, et al. (2002) Delayed liver regeneration in peroxisome proliferator-activated receptor-α-null mice. Hepatology 36: 544-554.
    • (2002) Hepatology , vol.36 , pp. 544-554
    • Anderson, S.P.1    Yoon, L.2    Richard, E.B.3    Dunn, C.S.4    Cattley, R.C.5
  • 7
    • 0036120125 scopus 로고    scopus 로고
    • Hepatic regeneration in peroxisome proliferator-activated receptor α-null mice after partial hepatectomy
    • Rao M, Peters JM, Gonzalez FJ, Reddy JK, (2002) Hepatic regeneration in peroxisome proliferator-activated receptor α-null mice after partial hepatectomy. Hepatol Res 22: 52-57.
    • (2002) Hepatol Res , vol.22 , pp. 52-57
    • Rao, M.1    Peters, J.M.2    Gonzalez, F.J.3    Reddy, J.K.4
  • 8
    • 0037305697 scopus 로고    scopus 로고
    • Impaired Ras membrane association and activation in PPAR α knockout mice after partial hepatectomy
    • Wheeler MD, Smutney OM, Check JF, Rusyn I, Schulte-Hermann R, et al. (2003) Impaired Ras membrane association and activation in PPAR α knockout mice after partial hepatectomy. Am J Physiol-Gastr L 284: G302-G312.
    • (2003) Am J Physiol-Gastr L , vol.284
    • Wheeler, M.D.1    Smutney, O.M.2    Check, J.F.3    Rusyn, I.4    Schulte-Hermann, R.5
  • 9
    • 14544276802 scopus 로고    scopus 로고
    • Decreased expression of peroxisome proliferator-activated receptor α and liver fatty acid binding protein after partial hepatectomy of rats and mice
    • Skrtic S, Carlsson L, Ljungberg A, Linden D, Michalik L, et al. (2005) Decreased expression of peroxisome proliferator-activated receptor α and liver fatty acid binding protein after partial hepatectomy of rats and mice. Liver Int 25: 33-40.
    • (2005) Liver Int , vol.25 , pp. 33-40
    • Skrtic, S.1    Carlsson, L.2    Ljungberg, A.3    Linden, D.4    Michalik, L.5
  • 10
    • 84867179312 scopus 로고    scopus 로고
    • Analysis of the role of hepatic PPARγ expression during mouse liver regeneration
    • Gazit V, Huang J, Weymann A, Rudnick DA, (2012) Analysis of the role of hepatic PPARγ expression during mouse liver regeneration. Hepatology 56: 1489-1498.
    • (2012) Hepatology , vol.56 , pp. 1489-1498
    • Gazit, V.1    Huang, J.2    Weymann, A.3    Rudnick, D.A.4
  • 11
    • 79952415541 scopus 로고    scopus 로고
    • Lipid Metabolism and Peroxisome Proliferator-Activated Receptor Signaling Pathways Participate in Late-Phase Liver Regeneration
    • Yuan X, Yan SK, Zhao J, Shi D, Yuan B, et al. (2011) Lipid Metabolism and Peroxisome Proliferator-Activated Receptor Signaling Pathways Participate in Late-Phase Liver Regeneration. J Proteome Res 10: 1179-1190.
    • (2011) J Proteome Res , vol.10 , pp. 1179-1190
    • Yuan, X.1    Yan, S.K.2    Zhao, J.3    Shi, D.4    Yuan, B.5
  • 12
    • 78549248181 scopus 로고    scopus 로고
    • PPARα-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells
    • Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ, (2010) PPARα-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. Toxicol Sci 118: 404-410.
    • (2010) Toxicol Sci , vol.118 , pp. 404-410
    • Qu, A.1    Shah, Y.M.2    Matsubara, T.3    Yang, Q.4    Gonzalez, F.J.5
  • 13
    • 44949102554 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-gamma (PPARγ) during liver regeneration in rats
    • Yamamoto Y, Ono T, Dhar DK, Yamanoi A, Tachibana M, et al. (2008) Role of peroxisome proliferator-activated receptor-gamma (PPARγ) during liver regeneration in rats. J Gastroen Hepatol 23: 930-937.
    • (2008) J Gastroen Hepatol , vol.23 , pp. 930-937
    • Yamamoto, Y.1    Ono, T.2    Dhar, D.K.3    Yamanoi, A.4    Tachibana, M.5
  • 14
    • 77957348621 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    • Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, et al. (2010) Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol 177: 1834-1847.
    • (2010) Am J Pathol , vol.177 , pp. 1834-1847
    • Zingarelli, B.1    Piraino, G.2    Hake, P.W.3    O'Connor, M.4    Denenberg, A.5
  • 15
    • 51849123779 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression
    • Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, et al. (2008) Ligand activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci 105: 418-428.
    • (2008) Toxicol Sci , vol.105 , pp. 418-428
    • Shan, W.1    Palkar, P.S.2    Murray, I.A.3    McDevitt, E.I.4    Kennett, M.J.5
  • 16
    • 84870946722 scopus 로고    scopus 로고
    • GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
    • Kostadinova R, Montagner A, Gouranton E, Fleury S, Guillou H, et al. (2012) GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell and Bioscience 2: 34.
    • (2012) Cell and Bioscience , vol.2 , pp. 34
    • Kostadinova, R.1    Montagner, A.2    Gouranton, E.3    Fleury, S.4    Guillou, H.5
  • 17
    • 0036771764 scopus 로고    scopus 로고
    • Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway
    • Di-Poï N, Tan NS, Michalik L, Wahli W, Desvergne B, (2002) Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 10: 721-733.
    • (2002) Mol Cell , vol.10 , pp. 721-733
    • Di-Poï, N.1    Tan, N.S.2    Michalik, L.3    Wahli, W.4    Desvergne, B.5
  • 18
    • 47249099486 scopus 로고    scopus 로고
    • Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes
    • Tsuji K, Mitsutake S, Yokose U, Sugiura M, Kohama T, et al. (2008) Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes. FEBS J 275: 3815-3826.
    • (2008) FEBS J , vol.275 , pp. 3815-3826
    • Tsuji, K.1    Mitsutake, S.2    Yokose, U.3    Sugiura, M.4    Kohama, T.5
  • 19
    • 54349120502 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor-β/δ inhibits cell proliferation in human HaCaT keratinocytes
    • Borland MG, Foreman JE, Girroir EE, Zolfaghari R, Sharma AK, et al. (2008) Ligand activation of peroxisome proliferator-activated receptor-β/δ inhibits cell proliferation in human HaCaT keratinocytes. Mol Pharmacol 74: 1429-1442.
    • (2008) Mol Pharmacol , vol.74 , pp. 1429-1442
    • Borland, M.G.1    Foreman, J.E.2    Girroir, E.E.3    Zolfaghari, R.4    Sharma, A.K.5
  • 20
    • 2342640982 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor δ stimulates the proliferation of human breast and prostate cancer cell lines
    • Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, et al. (2004) Activation of peroxisome proliferator-activated receptor δ stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Res 64: 3162-3170.
    • (2004) Cancer Res , vol.64 , pp. 3162-3170
    • Stephen, R.L.1    Gustafsson, M.C.2    Jarvis, M.3    Tatoud, R.4    Marshall, B.R.5
  • 21
    • 56049100021 scopus 로고    scopus 로고
    • Effect of ligand activation of peroxisome proliferator-activated receptor- β/δ (PPARβ/δ) in human lung cancer cell lines
    • He PF, Borland MG, Zhu BA, Sharma AK, Amin S, et al. (2008) Effect of ligand activation of peroxisome proliferator-activated receptor- β/δ (PPARβ/δ) in human lung cancer cell lines. Toxicology 254: 112-117.
    • (2008) Toxicology , vol.254 , pp. 112-117
    • He, P.F.1    Borland, M.G.2    Zhu, B.A.3    Sharma, A.K.4    Amin, S.5
  • 22
    • 84859885816 scopus 로고    scopus 로고
    • Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
    • Trapnell C, Roberts A, Goff L, Pertea G, Kim D, et al. (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nature Protocols 7: 562-578.
    • (2012) Nature Protocols , vol.7 , pp. 562-578
    • Trapnell, C.1    Roberts, A.2    Goff, L.3    Pertea, G.4    Kim, D.5
  • 23
    • 34147146967 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor- β/δ (PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes
    • Burdick AD, Bility MT, Girroir EE, Billin AN, Willson TM, et al. (2007) Ligand activation of peroxisome proliferator-activated receptor- β/δ (PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes. Cell Signal 19: 1163-1171.
    • (2007) Cell Signal , vol.19 , pp. 1163-1171
    • Burdick, A.D.1    Bility, M.T.2    Girroir, E.E.3    Billin, A.N.4    Willson, T.M.5
  • 24
    • 0033618410 scopus 로고    scopus 로고
    • Multiple ras effector pathways contribute to G(1) cell cycle progression
    • Gille H, Downward J, (1999) Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem 274: 22033-22040.
    • (1999) J Biol Chem , vol.274 , pp. 22033-22040
    • Gille, H.1    Downward, J.2
  • 25
    • 84861759663 scopus 로고    scopus 로고
    • Healing the diabetic heart: modulation of cardiometabolic syndrome through peroxisome proliferator activated receptors (PPARs)
    • Huang TH, Roufogalis BD, (2012) Healing the diabetic heart: modulation of cardiometabolic syndrome through peroxisome proliferator activated receptors (PPARs). Curr Mol Pharmacol 5: 241-247.
    • (2012) Curr Mol Pharmacol , vol.5 , pp. 241-247
    • Huang, T.H.1    Roufogalis, B.D.2
  • 26
    • 0035941270 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor δ promotes lipid accumulation in human macrophages
    • Vosper H, Patel L, Graham TL, Khoudoli GA, Hill A, et al. (2001) The peroxisome proliferator-activated receptor δ promotes lipid accumulation in human macrophages. J Biol Chem 276: 44258-44265.
    • (2001) J Biol Chem , vol.276 , pp. 44258-44265
    • Vosper, H.1    Patel, L.2    Graham, T.L.3    Khoudoli, G.A.4    Hill, A.5
  • 27
    • 0037039374 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer
    • Barak Y, Liao D, He WM, Ong ES, Nelson MC, et al. (2002) Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer. P Natl Acad Sci USA 99: 303-308.
    • (2002) P Natl Acad Sci USA , vol.99 , pp. 303-308
    • Barak, Y.1    Liao, D.2    He, W.M.3    Ong, E.S.4    Nelson, M.C.5
  • 28
    • 37049018807 scopus 로고    scopus 로고
    • PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor
    • Romanowska M, Al Yacoub N, Seidel H, Donandt S, Gerken H, et al. (2008) PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor. J Invest Dermatol 128: 110-124.
    • (2008) J Invest Dermatol , vol.128 , pp. 110-124
    • Romanowska, M.1    Al Yacoub, N.2    Seidel, H.3    Donandt, S.4    Gerken, H.5
  • 29
    • 54349120502 scopus 로고    scopus 로고
    • Ligand Activation of Peroxisome Proliferator-Activated Receptor-beta/delta Inhibits Cell Proliferation in Human HaCaT Keratinocytes
    • Borland MG, Foreman JE, Girroir EE, Zolfaghari R, Sharma AK, et al. (2008) Ligand Activation of Peroxisome Proliferator-Activated Receptor-beta/delta Inhibits Cell Proliferation in Human HaCaT Keratinocytes. Molecular Pharmacology 74: 1429-1442.
    • (2008) Molecular Pharmacology , vol.74 , pp. 1429-1442
    • Borland, M.G.1    Foreman, J.E.2    Girroir, E.E.3    Zolfaghari, R.4    Sharma, A.K.5
  • 30
    • 85047690318 scopus 로고    scopus 로고
    • Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1(-/-) mice
    • Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, et al. (2004) Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1(-/-) mice. J Clin Invest 113: 1288-1295.
    • (2004) J Clin Invest , vol.113 , pp. 1288-1295
    • Fajas, L.1    Annicotte, J.S.2    Miard, S.3    Sarruf, D.4    Watanabe, M.5
  • 31
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T, Griffiths B, Chung YL, Delpuech O, Jr G, et al. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.L.3    Delpuech Jr., O.G.4
  • 32
    • 77955470822 scopus 로고    scopus 로고
    • Metabolism and proliferation share common regulatory pathways in cancer cells
    • Fritz V, Fajas L, (2010) Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29: 4369-4377.
    • (2010) Oncogene , vol.29 , pp. 4369-4377
    • Fritz, V.1    Fajas, L.2
  • 33
    • 20544449673 scopus 로고    scopus 로고
    • The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation
    • Buzzai M, Bauer DE, Jones RG, DeBerardinis RJ, Hatzivassiliou G, et al. (2005) The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24: 4165-4173.
    • (2005) Oncogene , vol.24 , pp. 4165-4173
    • Buzzai, M.1    Bauer, D.E.2    Jones, R.G.3    DeBerardinis, R.J.4    Hatzivassiliou, G.5
  • 34
    • 54449087638 scopus 로고    scopus 로고
    • Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats
    • Zhou Y, Zhang X, Chen L, Wu J, Dang H, et al. (2008) Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am J Physiol-Renal 295: F662-F671.
    • (2008) Am J Physiol-Renal , vol.295
    • Zhou, Y.1    Zhang, X.2    Chen, L.3    Wu, J.4    Dang, H.5
  • 36
    • 37349070024 scopus 로고    scopus 로고
    • An E2F1-dependent gene expression program that determines the balance between proliferation and cell death
    • Hallstrom TC, Mori S, Nevins JR, (2008) An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13: 11-22.
    • (2008) Cancer Cell , vol.13 , pp. 11-22
    • Hallstrom, T.C.1    Mori, S.2    Nevins, J.R.3
  • 37
    • 0032774295 scopus 로고    scopus 로고
    • No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice
    • Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, et al. (1999) No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog 25: 295-303.
    • (1999) Mol Carcinog , vol.25 , pp. 295-303
    • Lukas, E.R.1    Bartley, S.M.2    Graveel, C.R.3    Diaz, Z.M.4    Dyson, N.5
  • 39
    • 33644797510 scopus 로고    scopus 로고
    • Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2
    • Cicenas J, Urban P, Vuaroqueaux V, Labuhn M, Kung W, et al. (2005) Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. Breast Cancer Research 7: R394-R401.
    • (2005) Breast Cancer Research , vol.7
    • Cicenas, J.1    Urban, P.2    Vuaroqueaux, V.3    Labuhn, M.4    Kung, W.5
  • 40
    • 79954992662 scopus 로고    scopus 로고
    • Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis
    • Siersbaek R, Nielsen R, John S, Sung MH, Baek S, et al. (2011) Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J 30: 1459-1472.
    • (2011) EMBO J , vol.30 , pp. 1459-1472
    • Siersbaek, R.1    Nielsen, R.2    John, S.3    Sung, M.H.4    Baek, S.5
  • 42
    • 0037621952 scopus 로고    scopus 로고
    • Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury
    • Leclercq IA, Field J, Farrell GC, (2003) Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Gastroenterology 124: 1451-1464.
    • (2003) Gastroenterology , vol.124 , pp. 1451-1464
    • Leclercq, I.A.1    Field, J.2    Farrell, G.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.