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Volumn 74, Issue 2, 2015, Pages 247-258

The βc receptor family - Structural insights and their functional implications

Author keywords

Beta common receptor; Granulocyte macrophage colony stimulating factor; Inflammation; Interleukin 3; Interleukin 5

Indexed keywords

CD123 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR ALPHA; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR ALPHA; INTERLEUKIN 6; JANUS KINASE 2; STAT5 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CD131 ANTIGEN; CYTOKINE;

EID: 84949626705     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.02.005     Document Type: Review
Times cited : (67)

References (105)
  • 1
    • 84867421584 scopus 로고    scopus 로고
    • The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
    • Broughton S.E., et al. The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev 2012, 250(1):277-302.
    • (2012) Immunol Rev , vol.250 , Issue.1 , pp. 277-302
    • Broughton, S.E.1
  • 2
    • 84881254509 scopus 로고    scopus 로고
    • Signalling by the betac family of cytokines
    • Hercus T.R., et al. Signalling by the betac family of cytokines. Cytokine Growth Factor Rev 2013, 24(3):189-201.
    • (2013) Cytokine Growth Factor Rev , vol.24 , Issue.3 , pp. 189-201
    • Hercus, T.R.1
  • 3
    • 70349336496 scopus 로고    scopus 로고
    • The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
    • Hercus T.R., et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 2009, 114(7):1289-1298.
    • (2009) Blood , vol.114 , Issue.7 , pp. 1289-1298
    • Hercus, T.R.1
  • 4
    • 84893837713 scopus 로고    scopus 로고
    • Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF
    • Wang Y., et al. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res 2014, 74(3):716-726.
    • (2014) Cancer Res , vol.74 , Issue.3 , pp. 716-726
    • Wang, Y.1
  • 5
    • 0346996709 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway
    • Gomez-Cambronero J., Horn J., Paul C.C., Baumann M.A. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol 2003, 171(12):6846-6855.
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6846-6855
    • Gomez-Cambronero, J.1    Horn, J.2    Paul, C.C.3    Baumann, M.A.4
  • 6
    • 38849141667 scopus 로고    scopus 로고
    • Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking
    • Xu Y., Zhan Y., Lew A.M., Naik S.H., Kershaw M.H. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol 2007, 179(11):7577-7584.
    • (2007) J Immunol , vol.179 , Issue.11 , pp. 7577-7584
    • Xu, Y.1    Zhan, Y.2    Lew, A.M.3    Naik, S.H.4    Kershaw, M.H.5
  • 7
    • 4644220029 scopus 로고    scopus 로고
    • Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro
    • Dahl C., Hoffmann H.J., Saito H., Schiotz P.O. Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro. Allergy 2004, 59(10):1087-1096.
    • (2004) Allergy , vol.59 , Issue.10 , pp. 1087-1096
    • Dahl, C.1    Hoffmann, H.J.2    Saito, H.3    Schiotz, P.O.4
  • 8
    • 0023879839 scopus 로고
    • Recombinant human interleukin 5 is a selective activator of human eosinophil function
    • Lopez A.F., et al. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 1988, 167(1):219-224.
    • (1988) J Exp Med , vol.167 , Issue.1 , pp. 219-224
    • Lopez, A.F.1
  • 9
    • 79951814186 scopus 로고    scopus 로고
    • Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB
    • Tanaka T., et al. Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB. J Med Genet 2011, 48(3):205-209.
    • (2011) J Med Genet , vol.48 , Issue.3 , pp. 205-209
    • Tanaka, T.1
  • 10
    • 41749118531 scopus 로고    scopus 로고
    • Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
    • Inoue Y., et al. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med 2008, 177(7):752-762.
    • (2008) Am J Respir Crit Care Med , vol.177 , Issue.7 , pp. 752-762
    • Inoue, Y.1
  • 11
    • 0344655326 scopus 로고    scopus 로고
    • Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions
    • Nishinakamura R., Miyajima A., Mee P.J., Tybulewicz V.L., Murray R. Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Blood 1996, 88(7):2458-2464.
    • (1996) Blood , vol.88 , Issue.7 , pp. 2458-2464
    • Nishinakamura, R.1    Miyajima, A.2    Mee, P.J.3    Tybulewicz, V.L.4    Murray, R.5
  • 12
    • 0028328236 scopus 로고
    • Evidence for GM-CSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies
    • Berenbaum F., Rajzbaum G., Amor B., Toubert A. Evidence for GM-CSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies. Eur Cytokine Netw 1994, 5(1):43-46.
    • (1994) Eur Cytokine Netw , vol.5 , Issue.1 , pp. 43-46
    • Berenbaum, F.1    Rajzbaum, G.2    Amor, B.3    Toubert, A.4
  • 13
    • 84895153556 scopus 로고    scopus 로고
    • Emerging cell and cytokine targets in rheumatoid arthritis
    • Burmester G.R., Feist E., Dorner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol 2014, 10(2):77-88.
    • (2014) Nat Rev Rheumatol , vol.10 , Issue.2 , pp. 77-88
    • Burmester, G.R.1    Feist, E.2    Dorner, T.3
  • 14
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • Pavord I.D., et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012, 380(9842):651-659.
    • (2012) Lancet , vol.380 , Issue.9842 , pp. 651-659
    • Pavord, I.D.1
  • 15
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan C.T., et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia 2000, 14(10):1777-1784.
    • (2000) Leukemia , vol.14 , Issue.10 , pp. 1777-1784
    • Jordan, C.T.1
  • 16
    • 0037108559 scopus 로고    scopus 로고
    • Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis
    • Testa U., et al. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis. Blood 2002, 100(8):2980-2988.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2980-2988
    • Testa, U.1
  • 17
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L., et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell 2009, 5(1):31-42.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 31-42
    • Jin, L.1
  • 18
    • 84922283792 scopus 로고    scopus 로고
    • Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC
    • Busfield S.J., et al. Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC. Leukemia 2014, 28(11):2213-2221.
    • (2014) Leukemia , vol.28 , Issue.11 , pp. 2213-2221
    • Busfield, S.J.1
  • 19
    • 84899137486 scopus 로고    scopus 로고
    • Monoclonal antibody targeting of IL-3 receptor alpha with CSL362 effectively depletes CML progenitor and stem cells
    • Nievergall E., et al. Monoclonal antibody targeting of IL-3 receptor alpha with CSL362 effectively depletes CML progenitor and stem cells. Blood 2014, 123(8):1218-1228.
    • (2014) Blood , vol.123 , Issue.8 , pp. 1218-1228
    • Nievergall, E.1
  • 20
    • 84890259150 scopus 로고    scopus 로고
    • GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression
    • Gutschalk C.M., et al. GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression. Cancer Med 2013, 2(2):117-129.
    • (2013) Cancer Med , vol.2 , Issue.2 , pp. 117-129
    • Gutschalk, C.M.1
  • 21
    • 84900335537 scopus 로고    scopus 로고
    • A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
    • Su S., et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer cell 2014, 25(5):605-620.
    • (2014) Cancer cell , vol.25 , Issue.5 , pp. 605-620
    • Su, S.1
  • 22
    • 84902687656 scopus 로고    scopus 로고
    • GM-CSF production by tumor cells is associated with improved survival in colorectal cancer
    • Nebiker C.A., et al. GM-CSF production by tumor cells is associated with improved survival in colorectal cancer. Clin Cancer Res 2014, 20(12):3094-3106.
    • (2014) Clin Cancer Res , vol.20 , Issue.12 , pp. 3094-3106
    • Nebiker, C.A.1
  • 23
    • 84871960166 scopus 로고    scopus 로고
    • Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors
    • Urdinguio R.G., et al. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res 2013, 73(1):395-405.
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 395-405
    • Urdinguio, R.G.1
  • 24
    • 0027366330 scopus 로고
    • The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration
    • Korpelainen E.I., et al. The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration. Proc Natl Acad Sci U S A 1993, 90(23):11137-11141.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.23 , pp. 11137-11141
    • Korpelainen, E.I.1
  • 25
    • 0029876233 scopus 로고    scopus 로고
    • IL-3 receptor expression, regulation and function in cells of the vasculature
    • Korpelainen E.I., Gamble J.R., Vadas M.A., Lopez A.F. IL-3 receptor expression, regulation and function in cells of the vasculature. Immunol Cell Biol 1996, 74(1):1-7.
    • (1996) Immunol Cell Biol , vol.74 , Issue.1 , pp. 1-7
    • Korpelainen, E.I.1    Gamble, J.R.2    Vadas, M.A.3    Lopez, A.F.4
  • 26
    • 84870600462 scopus 로고    scopus 로고
    • The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors
    • Luo X.J., et al. The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors. PLoS One 2012, 7(11):e50375.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50375
    • Luo, X.J.1
  • 27
    • 84867020238 scopus 로고    scopus 로고
    • The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
    • Krieger M., et al. The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions. Sci Rep 2012, 2:697.
    • (2012) Sci Rep , vol.2 , pp. 697
    • Krieger, M.1
  • 28
    • 0035692476 scopus 로고    scopus 로고
    • Interleukin-5 receptor alpha chain expression and splicing during brain development in mice
    • Lins C., Borojevic R. Interleukin-5 receptor alpha chain expression and splicing during brain development in mice. Growth Factors 2001, 19(3):145-152.
    • (2001) Growth Factors , vol.19 , Issue.3 , pp. 145-152
    • Lins, C.1    Borojevic, R.2
  • 29
    • 0027419895 scopus 로고
    • Interleukin-4 and -5 as modulators of nerve growth factor synthesis/secretion in astrocytes
    • Awatsuji H., et al. Interleukin-4 and -5 as modulators of nerve growth factor synthesis/secretion in astrocytes. J Neurosci Res 1993, 34(5):539-545.
    • (1993) J Neurosci Res , vol.34 , Issue.5 , pp. 539-545
    • Awatsuji, H.1
  • 30
    • 0141705330 scopus 로고    scopus 로고
    • GABAergic control of neuropeptide gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus
    • Bali B., Kovacs K.J. GABAergic control of neuropeptide gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus. Eur J Neurosci 2003, 18(6):1518-1526.
    • (2003) Eur J Neurosci , vol.18 , Issue.6 , pp. 1518-1526
    • Bali, B.1    Kovacs, K.J.2
  • 31
    • 48449102092 scopus 로고    scopus 로고
    • The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
    • Hansen G., et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 2008, 134(3):496-507.
    • (2008) Cell , vol.134 , Issue.3 , pp. 496-507
    • Hansen, G.1
  • 32
    • 0024846310 scopus 로고
    • Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
    • Gearing D.P., King J.A., Gough N.M., Nicola N.A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 1989, 8(12):3667-3676.
    • (1989) EMBO J , vol.8 , Issue.12 , pp. 3667-3676
    • Gearing, D.P.1    King, J.A.2    Gough, N.M.3    Nicola, N.A.4
  • 33
    • 0025637605 scopus 로고
    • Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor
    • Hayashida K., et al. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A 1990, 87(24):9655-9659.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.24 , pp. 9655-9659
    • Hayashida, K.1
  • 34
    • 82955193831 scopus 로고    scopus 로고
    • Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha
    • Patino E., et al. Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha. Structure 2011, 19(12):1864-1875.
    • (2011) Structure , vol.19 , Issue.12 , pp. 1864-1875
    • Patino, E.1
  • 35
    • 84861425858 scopus 로고    scopus 로고
    • Structural basis of interleukin-5 dimer recognition by its alpha receptor
    • Kusano S., et al. Structural basis of interleukin-5 dimer recognition by its alpha receptor. Protein Sci 2012, 21(6):850-864.
    • (2012) Protein Sci , vol.21 , Issue.6 , pp. 850-864
    • Kusano, S.1
  • 36
    • 0024558339 scopus 로고
    • Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines
    • Mita S., et al. Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines. Proc Natl Acad Sci U S A 1989, 86(7):2311-2315.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.7 , pp. 2311-2315
    • Mita, S.1
  • 37
    • 33745152640 scopus 로고    scopus 로고
    • An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope
    • Carr P.D., Conlan F., Ford S., Ollis D.L., Young I.G. An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006, 62(Pt 6):509-513.
    • (2006) Acta Crystallogr Sect F Struct Biol Cryst Commun , vol.62 , pp. 509-513
    • Carr, P.D.1    Conlan, F.2    Ford, S.3    Ollis, D.L.4    Young, I.G.5
  • 38
    • 0034655647 scopus 로고    scopus 로고
    • Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist
    • Rossjohn J., et al. Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Blood 2000, 95(8):2491-2498.
    • (2000) Blood , vol.95 , Issue.8 , pp. 2491-2498
    • Rossjohn, J.1
  • 39
    • 84907843570 scopus 로고    scopus 로고
    • Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin-3 binding and receptor activation
    • Carr P.D., et al. Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin-3 binding and receptor activation. Biochem J 2014, 463(3):393-403.
    • (2014) Biochem J , vol.463 , Issue.3 , pp. 393-403
    • Carr, P.D.1
  • 40
    • 0026520373 scopus 로고
    • Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor
    • Walter M.R., et al. Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. J Mol Biol 1992, 224(4):1075-1085.
    • (1992) J Mol Biol , vol.224 , Issue.4 , pp. 1075-1085
    • Walter, M.R.1
  • 41
    • 84904796836 scopus 로고    scopus 로고
    • Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
    • Broughton S.E., et al. Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody. Cell Rep 2014, 8(2):410-419.
    • (2014) Cell Rep , vol.8 , Issue.2 , pp. 410-419
    • Broughton, S.E.1
  • 42
    • 0038532303 scopus 로고    scopus 로고
    • A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5
    • Murphy J.M., et al. A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5. J Biol Chem 2003, 278(12):10572-10577.
    • (2003) J Biol Chem , vol.278 , Issue.12 , pp. 10572-10577
    • Murphy, J.M.1
  • 43
    • 0033607540 scopus 로고    scopus 로고
    • Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly
    • Haman A., et al. Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. J Biol Chem 1999, 274(48):34155-34163.
    • (1999) J Biol Chem , vol.274 , Issue.48 , pp. 34155-34163
    • Haman, A.1
  • 44
    • 0028233122 scopus 로고
    • Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor
    • Hercus T.R., et al. Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor. Blood 1994, 83(12):3500-3508.
    • (1994) Blood , vol.83 , Issue.12 , pp. 3500-3508
    • Hercus, T.R.1
  • 45
    • 0030960120 scopus 로고    scopus 로고
    • Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition
    • Rajotte D., et al. Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition. J Exp Med 1997, 185(11):1939-1950.
    • (1997) J Exp Med , vol.185 , Issue.11 , pp. 1939-1950
    • Rajotte, D.1
  • 46
    • 0029982521 scopus 로고    scopus 로고
    • Hematopoietic receptor complexes
    • Wells J.A., de Vos A.M. Hematopoietic receptor complexes. Annu Rev Biochem 1996, 65:609-634.
    • (1996) Annu Rev Biochem , vol.65 , pp. 609-634
    • Wells, J.A.1    de Vos, A.M.2
  • 47
    • 77951908853 scopus 로고    scopus 로고
    • The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation
    • Mirza S., Walker A., Chen J., Murphy J.M., Young I.G. The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation. Biochem J 2010, 426(3):307-317.
    • (2010) Biochem J , vol.426 , Issue.3 , pp. 307-317
    • Mirza, S.1    Walker, A.2    Chen, J.3    Murphy, J.M.4    Young, I.G.5
  • 48
    • 0028013295 scopus 로고
    • Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor
    • Lock P., Metcalf D., Nicola N.A. Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A 1994, 91(1):252-256.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.1 , pp. 252-256
    • Lock, P.1    Metcalf, D.2    Nicola, N.A.3
  • 49
    • 0344089342 scopus 로고    scopus 로고
    • Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex
    • McClure B.J., et al. Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. Blood 2003, 101(4):1308-1315.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1308-1315
    • McClure, B.J.1
  • 50
    • 0029860206 scopus 로고    scopus 로고
    • A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all three ligands
    • Woodcock J.M., Bagley C.J., Zacharakis B., Lopez A.F. A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. J Biol Chem 1996, 271(42):25999-26006.
    • (1996) J Biol Chem , vol.271 , Issue.42 , pp. 25999-26006
    • Woodcock, J.M.1    Bagley, C.J.2    Zacharakis, B.3    Lopez, A.F.4
  • 51
    • 0028005446 scopus 로고
    • Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF
    • Woodcock J.M., et al. Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J 1994, 13(21):5176-5185.
    • (1994) EMBO J , vol.13 , Issue.21 , pp. 5176-5185
    • Woodcock, J.M.1
  • 52
    • 0028245262 scopus 로고
    • Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function
    • Barry S.C., et al. Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function. J Biol Chem 1994, 269(11):8488-8492.
    • (1994) J Biol Chem , vol.269 , Issue.11 , pp. 8488-8492
    • Barry, S.C.1
  • 53
    • 0028962672 scopus 로고
    • Structure/function analysis of human interleukin 5 and its receptor
    • Tavernier J., et al. Structure/function analysis of human interleukin 5 and its receptor. Agents Actions Suppl 1995, 46:23-34.
    • (1995) Agents Actions Suppl , vol.46 , pp. 23-34
    • Tavernier, J.1
  • 54
    • 36348943571 scopus 로고    scopus 로고
    • The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
    • Ramshaw H.S., et al. The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood 2007, 110(10):3582-3590.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3582-3590
    • Ramshaw, H.S.1
  • 55
    • 84870923584 scopus 로고    scopus 로고
    • Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis
    • Broxmeyer H.E., et al. Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis. Nat Med 2012, 18(12):1786-1796.
    • (2012) Nat Med , vol.18 , Issue.12 , pp. 1786-1796
    • Broxmeyer, H.E.1
  • 56
    • 0029938639 scopus 로고    scopus 로고
    • Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3
    • Feng Y., Klein B.K., McWherter C.A. Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. J Mol Biol 1996, 259(3):524-541.
    • (1996) J Mol Biol , vol.259 , Issue.3 , pp. 524-541
    • Feng, Y.1    Klein, B.K.2    McWherter, C.A.3
  • 57
    • 64549151389 scopus 로고    scopus 로고
    • A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex
    • Dey R., Ji K., Liu Z., Chen L. A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex. PLoS One 2009, 4(4):e5188.
    • (2009) PLoS One , vol.4 , Issue.4 , pp. e5188
    • Dey, R.1    Ji, K.2    Liu, Z.3    Chen, L.4
  • 58
    • 0030900022 scopus 로고    scopus 로고
    • Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function
    • Barry S.C., et al. Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function. Blood 1997, 89(3):842-852.
    • (1997) Blood , vol.89 , Issue.3 , pp. 842-852
    • Barry, S.C.1
  • 59
    • 65549106958 scopus 로고    scopus 로고
    • A new isoform of interleukin-3 receptor alpha with novel differentiation activity and high affinity binding mode
    • Chen J., et al. A new isoform of interleukin-3 receptor alpha with novel differentiation activity and high affinity binding mode. J Biol Chem 2009, 284(9):5763-5773.
    • (2009) J Biol Chem , vol.284 , Issue.9 , pp. 5763-5773
    • Chen, J.1
  • 60
    • 0027155448 scopus 로고
    • A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5
    • Milburn M.V., et al. A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature 1993, 363(6425):172-176.
    • (1993) Nature , vol.363 , Issue.6425 , pp. 172-176
    • Milburn, M.V.1
  • 61
    • 2242432815 scopus 로고
    • Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins
    • Johanson K., et al. Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. J Biol Chem 1995, 270(16):9459-9471.
    • (1995) J Biol Chem , vol.270 , Issue.16 , pp. 9459-9471
    • Johanson, K.1
  • 62
    • 0028388743 scopus 로고
    • Analysis of the interaction between human interleukin-5 and the soluble domain of its receptor using a surface plasmon resonance biosensor
    • Morton T.A., et al. Analysis of the interaction between human interleukin-5 and the soluble domain of its receptor using a surface plasmon resonance biosensor. J Mol Recognit 1994, 7(1):47-55.
    • (1994) J Mol Recognit , vol.7 , Issue.1 , pp. 47-55
    • Morton, T.A.1
  • 63
    • 38649137731 scopus 로고    scopus 로고
    • Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
    • LaPorte S.L., et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell 2008, 132(2):259-272.
    • (2008) Cell , vol.132 , Issue.2 , pp. 259-272
    • LaPorte, S.L.1
  • 64
    • 77649146245 scopus 로고    scopus 로고
    • Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2
    • Lupardus P.J., Birnbaum M.E., Garcia K.C. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure 2010, 18(3):332-342.
    • (2010) Structure , vol.18 , Issue.3 , pp. 332-342
    • Lupardus, P.J.1    Birnbaum, M.E.2    Garcia, K.C.3
  • 65
    • 43149117024 scopus 로고    scopus 로고
    • Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly
    • Ishino T., Harrington A.E., Zaks-Zilberman M., Scibek J.J., Chaiken I. Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly. Cytokine 2008, 42(2):179-190.
    • (2008) Cytokine , vol.42 , Issue.2 , pp. 179-190
    • Ishino, T.1    Harrington, A.E.2    Zaks-Zilberman, M.3    Scibek, J.J.4    Chaiken, I.5
  • 66
    • 0023800021 scopus 로고
    • Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA
    • Kunimoto D.Y., Harriman G.R., Strober W. Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA. J Immunol 1988, 141(3):713-720.
    • (1988) J Immunol , vol.141 , Issue.3 , pp. 713-720
    • Kunimoto, D.Y.1    Harriman, G.R.2    Strober, W.3
  • 67
    • 0029969736 scopus 로고    scopus 로고
    • Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits
    • Li J., Cook R., Chaiken I. Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits. J Biol Chem 1996, 271(49):31729-31734.
    • (1996) J Biol Chem , vol.271 , Issue.49 , pp. 31729-31734
    • Li, J.1    Cook, R.2    Chaiken, I.3
  • 68
    • 0037102095 scopus 로고    scopus 로고
    • Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes
    • Scibek J.J., et al. Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes. Anal Biochem 2002, 307(2):258-265.
    • (2002) Anal Biochem , vol.307 , Issue.2 , pp. 258-265
    • Scibek, J.J.1
  • 69
    • 45149114572 scopus 로고    scopus 로고
    • Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging
    • Zaks-Zilberman M., Harrington A.E., Ishino T., Chaiken I.M. Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging. J Biol Chem 2008, 283(19):13398-13406.
    • (2008) J Biol Chem , vol.283 , Issue.19 , pp. 13398-13406
    • Zaks-Zilberman, M.1    Harrington, A.E.2    Ishino, T.3    Chaiken, I.M.4
  • 70
    • 47149112955 scopus 로고    scopus 로고
    • Structure-based rationale for interleukin 5 receptor antagonism
    • Ishino T., Harrington A.E., Gopi H., Chaiken I. Structure-based rationale for interleukin 5 receptor antagonism. Curr Pharm Des 2008, 14(12):1231-1239.
    • (2008) Curr Pharm Des , vol.14 , Issue.12 , pp. 1231-1239
    • Ishino, T.1    Harrington, A.E.2    Gopi, H.3    Chaiken, I.4
  • 71
    • 1542304706 scopus 로고    scopus 로고
    • Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition
    • Ishino T., Pasut G., Scibek J., Chaiken I. Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition. J Biol Chem 2004, 279(10):9547-9556.
    • (2004) J Biol Chem , vol.279 , Issue.10 , pp. 9547-9556
    • Ishino, T.1    Pasut, G.2    Scibek, J.3    Chaiken, I.4
  • 72
    • 0141527338 scopus 로고    scopus 로고
    • Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
    • Boulanger M.J., Bankovich A.J., Kortemme T., Baker D., Garcia K.C. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell 2003, 12(3):577-589.
    • (2003) Mol Cell , vol.12 , Issue.3 , pp. 577-589
    • Boulanger, M.J.1    Bankovich, A.J.2    Kortemme, T.3    Baker, D.4    Garcia, K.C.5
  • 73
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger M.J., Chow D.C., Brevnova E.E., Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 2003, 300(5628):2101-2104.
    • (2003) Science , vol.300 , Issue.5628 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 74
    • 84897993623 scopus 로고    scopus 로고
    • Structural basis of the proinflammatory signaling complex mediated by TSLP
    • Verstraete K., et al. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol 2014, 21(4):375-382.
    • (2014) Nat Struct Mol Biol , vol.21 , Issue.4 , pp. 375-382
    • Verstraete, K.1
  • 75
    • 84869410452 scopus 로고    scopus 로고
    • Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
    • Ring A.M., et al. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol 2012, 13(12):1187-1195.
    • (2012) Nat Immunol , vol.13 , Issue.12 , pp. 1187-1195
    • Ring, A.M.1
  • 76
    • 27944505913 scopus 로고    scopus 로고
    • Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    • Wang X., Rickert M., Garcia K.C. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science 2005, 310(5751):1159-1163.
    • (2005) Science , vol.310 , Issue.5751 , pp. 1159-1163
    • Wang, X.1    Rickert, M.2    Garcia, K.C.3
  • 77
    • 0029657911 scopus 로고    scopus 로고
    • A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor
    • Bagley C.J., Phillips J., Cambareri B., Vadas M.A., Lopez A.F. A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor. J Biol Chem 1996, 271(50):31922-31928.
    • (1996) J Biol Chem , vol.271 , Issue.50 , pp. 31922-31928
    • Bagley, C.J.1    Phillips, J.2    Cambareri, B.3    Vadas, M.A.4    Lopez, A.F.5
  • 78
    • 33745227715 scopus 로고    scopus 로고
    • A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
    • Kraich M., et al. A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. BMC Biol 2006, 4:13.
    • (2006) BMC Biol , vol.4 , pp. 13
    • Kraich, M.1
  • 79
    • 0033580831 scopus 로고    scopus 로고
    • Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor
    • Layton J.E., et al. Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor. J Biol Chem 1999, 274(25):17445-17451.
    • (1999) J Biol Chem , vol.274 , Issue.25 , pp. 17445-17451
    • Layton, J.E.1
  • 80
    • 0036300916 scopus 로고    scopus 로고
    • The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    • Zhang J.L., Simeonowa I., Wang Y., Sebald W. The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters. J Mol Biol 2002, 315(3):399-407.
    • (2002) J Mol Biol , vol.315 , Issue.3 , pp. 399-407
    • Zhang, J.L.1    Simeonowa, I.2    Wang, Y.3    Sebald, W.4
  • 81
    • 0028590077 scopus 로고
    • Rational design of a receptor super-antagonist of human interleukin-6
    • Savino R., et al. Rational design of a receptor super-antagonist of human interleukin-6. EMBO J 1994, 13(24):5863-5870.
    • (1994) EMBO J , vol.13 , Issue.24 , pp. 5863-5870
    • Savino, R.1
  • 82
    • 0032188942 scopus 로고    scopus 로고
    • Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    • Syed R.S., et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature 1998, 395(6701):511-516.
    • (1998) Nature , vol.395 , Issue.6701 , pp. 511-516
    • Syed, R.S.1
  • 83
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: crystal structure of the complex
    • de Vos A.M., Ultsch M., Kossiakoff A.A. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992, 255(5042):306-312.
    • (1992) Science , vol.255 , Issue.5042 , pp. 306-312
    • de Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 84
    • 0028226252 scopus 로고
    • Specific human granulocyte-macrophage colony-stimulating factor antagonists
    • Hercus T.R., et al. Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc Natl Acad Sci U S A 1994, 91(13):5838-5842.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.13 , pp. 5838-5842
    • Hercus, T.R.1
  • 85
    • 0029000927 scopus 로고
    • Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist
    • Tavernier J., et al. Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. Proc Natl Acad Sci U S A 1995, 92(11):5194-5198.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.11 , pp. 5194-5198
    • Tavernier, J.1
  • 86
    • 0025861759 scopus 로고
    • Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors
    • Kitamura T., Sato N., Arai K., Miyajima A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell 1991, 66(6):1165-1174.
    • (1991) Cell , vol.66 , Issue.6 , pp. 1165-1174
    • Kitamura, T.1    Sato, N.2    Arai, K.3    Miyajima, A.4
  • 87
    • 0025770219 scopus 로고
    • A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
    • Tavernier J., et al. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 1991, 66(6):1175-1184.
    • (1991) Cell , vol.66 , Issue.6 , pp. 1175-1184
    • Tavernier, J.1
  • 88
    • 0026736730 scopus 로고
    • Common subunits of cytokine receptors and the functional redundancy of cytokines
    • Miyajima A., Hara T., Kitamura T. Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem Sci 1992, 17(10):378-382.
    • (1992) Trends Biochem Sci , vol.17 , Issue.10 , pp. 378-382
    • Miyajima, A.1    Hara, T.2    Kitamura, T.3
  • 89
    • 0028052289 scopus 로고
    • The role of the WSXWS equivalent motif in growth hormone receptor function
    • Baumgartner J.W., Wells C.A., Chen C.M., Waters M.J. The role of the WSXWS equivalent motif in growth hormone receptor function. J Biol Chem 1994, 269(46):29094-29101.
    • (1994) J Biol Chem , vol.269 , Issue.46 , pp. 29094-29101
    • Baumgartner, J.W.1    Wells, C.A.2    Chen, C.M.3    Waters, M.J.4
  • 90
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci U S A 1990, 87(18):6934-6938.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.18 , pp. 6934-6938
    • Bazan, J.F.1
  • 91
    • 0032946324 scopus 로고    scopus 로고
    • The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region
    • Kernebeck T., et al. The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region. Protein Sci 1999, 8(1):5-12.
    • (1999) Protein Sci , vol.8 , Issue.1 , pp. 5-12
    • Kernebeck, T.1
  • 92
    • 0025942918 scopus 로고
    • The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
    • Miyazaki T., Maruyama M., Yamada G., Hatakeyama M., Taniguchi T. The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction. EMBO J 1991, 10(11):3191-3197.
    • (1991) EMBO J , vol.10 , Issue.11 , pp. 3191-3197
    • Miyazaki, T.1    Maruyama, M.2    Yamada, G.3    Hatakeyama, M.4    Taniguchi, T.5
  • 93
    • 0026765013 scopus 로고
    • Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization
    • Quelle D.E., Quelle F.W., Wojchowski D.M. Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization. Mol Cell Biol 1992, 12(10):4553-4561.
    • (1992) Mol Cell Biol , vol.12 , Issue.10 , pp. 4553-4561
    • Quelle, D.E.1    Quelle, F.W.2    Wojchowski, D.M.3
  • 94
    • 0026705352 scopus 로고
    • Identification of ligand binding determinants of the prolactin receptor
    • Rozakis-Adcock M., Kelly P.A. Identification of ligand binding determinants of the prolactin receptor. J Biol Chem 1992, 267(11):7428-7433.
    • (1992) J Biol Chem , vol.267 , Issue.11 , pp. 7428-7433
    • Rozakis-Adcock, M.1    Kelly, P.A.2
  • 95
    • 84856720066 scopus 로고    scopus 로고
    • The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor
    • Dagil R., et al. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor. Structure 2012, 20(2):270-282.
    • (2012) Structure , vol.20 , Issue.2 , pp. 270-282
    • Dagil, R.1
  • 96
    • 0029151003 scopus 로고
    • Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling
    • Jenkins B.J., D'Andrea R., Gonda T.J. Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling. EMBO J 1995, 14(17):4276-4287.
    • (1995) EMBO J , vol.14 , Issue.17 , pp. 4276-4287
    • Jenkins, B.J.1    D'Andrea, R.2    Gonda, T.J.3
  • 97
    • 0029910703 scopus 로고    scopus 로고
    • Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation
    • Jenkins B.J., Bagley C.J., Woodcock J., Lopez A.F., Gonda T.J. Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation. J Biol Chem 1996, 271(47):29707-29714.
    • (1996) J Biol Chem , vol.271 , Issue.47 , pp. 29707-29714
    • Jenkins, B.J.1    Bagley, C.J.2    Woodcock, J.3    Lopez, A.F.4    Gonda, T.J.5
  • 98
    • 0026764441 scopus 로고
    • Rational design of potent antagonists to the human growth hormone receptor
    • Fuh G., et al. Rational design of potent antagonists to the human growth hormone receptor. Science 1992, 256(5064):1677-1680.
    • (1992) Science , vol.256 , Issue.5064 , pp. 1677-1680
    • Fuh, G.1
  • 99
    • 0032570710 scopus 로고    scopus 로고
    • Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling
    • Rowlinson S.W., et al. Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling. J Biol Chem 1998, 273(9):5307-5314.
    • (1998) J Biol Chem , vol.273 , Issue.9 , pp. 5307-5314
    • Rowlinson, S.W.1
  • 100
    • 26944493862 scopus 로고    scopus 로고
    • Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    • Brown R.J., et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005, 12(9):814-821.
    • (2005) Nat Struct Mol Biol , vol.12 , Issue.9 , pp. 814-821
    • Brown, R.J.1
  • 101
    • 84900432315 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase JAK2 by the growth hormone receptor
    • Brooks A.J., et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science 2014, 344(6185):1249783.
    • (2014) Science , vol.344 , Issue.6185 , pp. 1249783
    • Brooks, A.J.1
  • 102
    • 0017332040 scopus 로고
    • Purification and properties of colony-stimulating factor from mouse lung-conditioned medium
    • Burgess A.W., Camakaris J., Metcalf D. Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem 1977, 252(6):1998-2003.
    • (1977) J Biol Chem , vol.252 , Issue.6 , pp. 1998-2003
    • Burgess, A.W.1    Camakaris, J.2    Metcalf, D.3
  • 103
    • 0019402068 scopus 로고
    • Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine
    • Ihle J.N., Pepersack L., Rebar L. Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine. J Immunol 1981, 126(6):2184-2189.
    • (1981) J Immunol , vol.126 , Issue.6 , pp. 2184-2189
    • Ihle, J.N.1    Pepersack, L.2    Rebar, L.3
  • 104
    • 0018837746 scopus 로고
    • Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production
    • Takatsu K., Tominaga A., Hamaoka T. Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production. J Immunol 1980, 124(5):2414-2422.
    • (1980) J Immunol , vol.124 , Issue.5 , pp. 2414-2422
    • Takatsu, K.1    Tominaga, A.2    Hamaoka, T.3
  • 105
    • 17744386517 scopus 로고    scopus 로고
    • Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
    • Carr P.D., et al. Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell 2001, 104(2):291-300.
    • (2001) Cell , vol.104 , Issue.2 , pp. 291-300
    • Carr, P.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.