The Ig-like domain of human GM-CSF receptor α plays a critical role in cytokine binding and receptor activation

Biochemical Journal

Volumn 426, Issue 3, 2010, Pages 307-317

  Mirza, Shamaruh ^a   Walker, Andrew ^a   Chen, Jinglong ^a   Murphy, James M ^b   Young, Ian G ^a  

^a Biology and Environment   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Common subunit ( c); Cytokine receptor; Cytokine receptor homology module (CRM); Dissociation constant; Granulocyte macrophage colony stimulating factor (GM CSF); Immunoglobulin like domain; Interleukin 3 (IL 3); Interleukin 5 (IL 5)

Indexed keywords

COLONY-STIMULATING FACTOR; CYTOKINE RECEPTOR; CYTOKINES; DISSOCIATION CONSTANT; IMMUNOGLOBULIN-LIKE DOMAINS; INTERLEUKIN-3; INTERLEUKIN-5;

DISSOCIATION;

ARGININE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR ALPHA; IMMUNOGLOBULIN; INTERLEUKIN 13 RECEPTOR ALPHA1; LEUCINE; UNCLASSIFIED DRUG; CD131 ANTIGEN; CYSTEINE; CYTOKINE RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ARTICLE; BETA CHAIN; BINDING AFFINITY; CELL GROWTH; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL LINE; CELL PROLIFERATION; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; FLOW CYTOMETRY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE; CYTOKINE RECEPTOR COMMON BETA SUBUNIT; CYTOKINES; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOKINE; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 77951908853     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091745     Document Type: Article

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