Roles of the N and C terminal domains of the interleukin-3 receptor α chain in receptor function

Blood

Volumn 89, Issue 3, 1997, Pages 842-852

  Barry, S C ^b   Korpelainen, E ^b   Sun, Q ^b   Stomski, F C ^b   Moretti, P A B ^b   Wakao, H ^b   D'Andrea, R J ^b   Vadas, M A ^b   Lopez, A F ^b   Goodall, G J ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; RECEPTOR SUBUNIT; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING COMPETITION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0030900022     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.3.842     Document Type: Article

References (56)

1. Metcalf D: The hemopoietic regulators - An embarrassment of riches. Bioessays 14:799, 1992
2. Bazan JF: Haemopoietic receptors and helical cytokines. Immunol Today 11:350, 1990
3. Kaushansky K, Karplus PA: Hematopoietic growth factors: Understanding functional diversity in structural terms. Blood 82:3229, 1993
4. Boulay J-L, Paul WE: Hematopoietin sub-family classification based on size, gene organization and sequence homology. Curr Biol 3:573, 1993
5. Baird P, D'Andrea R, Goodall G: Cytokine receptor genes: Structure, chromosomal location and involvement in human disease. Leuk Lymphoma 18:373, 1995
6. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934, 1990
7. Kaczmarski RS, Mufti GJ: The cytokine receptor superfamily. Blood Rev 5:193, 1991
8. deVos A, Ultsch M, Kossiakoff A: Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 260:1805, 1992
9. Somers W, Ultsch M, de Vos AM, Kossiakoff AA: The X-ray structure of a growth hormone-prolactin receptor complex. Nature 372:478, 1994
10. Cosman D, Lyman SD, Idzerda RL, Beckmann MP, Park LS, Goodwin RG, March CJ: A new cytokine receptor superfamily. Trends Biochem Sci 15:265, 1990
11. Fukunaga R, Ishizaka-Ikeda E, Pan CX, Seto Y, Nagata S: Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 10:2855, 1991
12. Vignon I, Mornon J, Cocault L, Mitjavila M, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterisation of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the haemopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1996
13. Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A: Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci USA 87:9655, 1990
14. Gearing D, King J, Gough N, Nicola N: Expression cloning of a receptor for human granulocyte-macrophage colony stimulating factor. EMBO J 8:3667, 1989
15. Kitamura T, Sato N, Arai K, Miyajima A: Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell 66:1165, 1991
16. Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G: A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 66:1175, 1991
17. Goodall GJ, Bagley CJ, Vadas MA, Lopez AF: A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands. Growth Factors 8:87, 1993
18. Lopez AF, Shannon MF, Barry S, Phillips JA, Cambareri B, Dottore M, Simmons P, Vadas MA: A human interleukin 3 analog with increased biological and binding activities. Proc Natl Acad Sci USA 89:11842, 1992
19. Barry SC, Bagley CJ, Phillips J, Dottore M, Cambareri B, Moretti P, D'Andrea R, Goodall GJ, Shannon MF, Vadas MA, Lopez AF: Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha-and beta-chains of its receptor and participate in function. J Biol Chem 269:8488, 1994
20. Lock P, Metcalf D, Nicola NA: Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 91:252, 1994
21. Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF: Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J 13:5176, 1994
22. Mui AL, Wakao H, O'Farrell AM, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166, 1995
23. Azam M, Erdjument Bromage H, Kreider BL, Xia M, Quelle F, Basu R, Saris C, Tempst P, Ihle JN, Schindler C: Interleukin-3 signals through multiple isoforms of Stat5. EMBO J 14:1402, 1995
24. Gouillex F, Pallard C, Dusanter-fort I, Wakao H, Haldosen I, Norsted G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J 14:2005, 1995
25. Pallard C, Gouilleux F, Charon M, Groner B, Gisselbrecht S, Dusanter Fourt I: Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. J Biol Chem 270:15942, 1995
26. Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci USA 90:8429, 1993
27. Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN: JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 14:4335, 1994
28. Rayner JR, Gonda TJ: A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector. Mol Cell Biol 14:880, 1994
29. D'Andrea R, Rayner J, Moretti P, Lopez A, Goodall GJ, Gonda TJ, Vadas M: A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity. Blood 83:2802, 1994
30. Mosmann T: Rapid colourimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55, 1983
31. Lopez AF, Shannon MF, Hercus T, Nicola NA, Cambareri B, Dottore M, Layton MJ, Eglinton L, Vadas MA: Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding. EMBO J 11:909, 1992
32. Korpelainen EI, Gamble JR, Smith WB, Goodall GJ, Qiyu S, Woodcock JM, Dottore M, Vadas MA, Lopez AF: The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration. Proc Natl Acad Sci USA 90:11137, 1993
33. Qiyu S, Woodcock J, Rapoport A, Stomski F, Korpekainen E, Bagley C, Goodall G, Smith W, Gamble J, Vadas M, Lopez A: Monoclonal antibody 7G3 recognises the N-terminal domain of the Interleukin 3 receptor α-chain and functions as a specific IL-3 receptor antagonist. Blood 87:83, 1996
34. Contreras M, Bale W, Spar I: Iodine monochloride (ICl) iodination techniques. Methods Enzymol 92:277, 1996
35. Elliott MJ, Vadas MA, Eglinton JM, Park LS, To LB, Cleland LG, Clark SC, Lopez AF: Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. Blood 74:2349, 1989
36. Elliott MJ, Moss J, Dottore M, Park LS, Vadas MA, Lopez AF: Differential binding of IL-3 and GM-CSF to human monocytes. Growth Factors 6:15, 1992
37. Scatchard G: The attraction of ions for small molecules. Ann N Y Acad Sci 51:660, 1949
38. Munson P, Rodbard D: LIGAND: A versatile computerised approach for characterisation of ligand-binding systems. Anal Biochem 107:220, 1980
39. McPhearson G: Computer-assisted analysis of complex concentration-response data. J Pharm Methods 13:125, 1985
40. Wakao H, Harada N, Kitamura T, Mui AL, Miyajima A: Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J 14:2527, 1995
41. Stomski F, Sun Q, Bagley C, Woodcock J, Goodall G, Andrews R, Berndt M, Lopez A: Human interleukin 3 (IL-3) induces disulphide-linked IL-3 receptor α and β chain heterodimerization which is required for receptor activation, but not high affinity binding. Mol Cell Biol 16:3035, 1996
42. Kitamura T, Miyajima A: Functional reconstitution of the human interleukin-3 receptor. Blood 80:84, 1992
43. Cornelis S, Fache I, Van der Heyden J, Guisez Y, Tavernier J, Devos R, Fiers W, Plaetinck G: Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction. Eur J Immunol 25:1857, 1995
44. Takaki S, Kanazawa H, Shiba M, Takatsu K: A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor α chain and its function in IL-5 mediated growth signal transduction. Mol Cell Biol 14:7404, 1994
45. Sakamaki K, Miyajima I, Kitamura T, Miyajima A: Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J 11:3541, 1992
46. Sato N, Sakamaki K, Terada N, Arai K, Miyajima A: Signal transduction by the high affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common subunit responsible for different signalling. EMBO J 12:4181, 1993
47. Sakamaki K, Wang HM, Miyajima I, Kitamura T, Todokoro K, Harada N, Miyajima A: Ligand-dependent activation of chimeric receptors with the cytoplasmic domain of the interleukin-3 receptor beta subunit (beta IL3). J Biol Chem 268:15833, 1993
48. Eder M, Ernst TJ, Ganser A, Jubinsky PT, Inhorn R, Hoelzer D, Griffin JD: A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line. J Biol Chem 269:30173, 1994
49. Muto A, Watanabe S, Miyajima A, Yokota T, Arai K: High affinity chimeric human granulocyte-macrophage colony-stimulating factor receptor carrying the cytoplasmic domain of the beta subunit but not the alpha subunit transduces growth promoting signals in Ba/F3 cells. Biochem Biophys Res Commun 208:368, 1995
50. Cornelis S, Plaetinck G, Devos R, Van der Heyden J, Tavernier J, Sanderson CJ, Guisez Y, Fiers W: Detailed analysis of the IL-5-IL-5R alpha interaction: Characterization of crucial residues on the ligand and the receptor. EMBO J 14:3395, 1995
51. Tavernier J, Tuypens T, Verhee A, Plaetinck G, Devos R, Van der Heyden J, Guisez Y, Oefner C: Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. Proc Natl Acad Sci USA 92:5194, 1995
52. Rozwarski DA, Gronenborn AM, Clore GM, Bazan JF, Bohm A, Wlodawer A, Hatada M, Karplus PA: Structural comparisons among the short-chain helical cytokines. Structure 2:159, 1994
53. Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasakawa K, Yamanishi K, Taga T, Kishimoto T: IL-6 induced homodimerisation of gp130 and associated activation of a tyrosine kinase. Science 260:1808, 1993
54. Kishimoto T: Signal transduction through homo-or heterodimers of gp130. Stem Cells Dayt 12:37, 1994 (suppl 1)
55. Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF: Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci USA 89:2140, 1992
56. Watowich SS, Hilton DJ, Lodish HF: Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol Cell Biol 14:3535, 1994