Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice

Experimental Gerontology

Volumn 73, Issue , 2016, Pages 42-48

  Townsend, Brigitte E ^a   Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Aging; BV2 microglia; Neuroinflammation; Nrf2; Primary microglia; Sulforaphane

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; AUTACOID; CYTOKINE; DNA BINDING PROTEIN; ISOTHIOCYANIC ACID DERIVATIVE; LIPOPOLYSACCHARIDE; NFE2L2 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; SULFORAFAN;

ADULT; AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOASSAY; MALE; MICROGLIA; MOUSE; NONHUMAN; NRF2 GENE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; AGING; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PRECLINICAL STUDY; PROCEDURES;

AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; ISOTHIOCYANATES; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED BALB C; MICROGLIA; NF-E2-RELATED FACTOR 2; UP-REGULATION;

EID: 84949595685     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.11.004     Document Type: Article

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