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Volumn 34, Issue 11, 2014, Pages 990-999

Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behavior

Author keywords

Aging; BALB c mice; Broccoli; Inflammation; LPS; Sulforaphane

Indexed keywords

CD11B ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CYTOCHROME B 245 BETA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; NFE2L2 PROTEIN, MOUSE;

EID: 84922271976     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.10.001     Document Type: Article
Times cited : (21)

References (67)
  • 1
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 1993, 90:7915-7922.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 2
    • 0024245469 scopus 로고
    • Free radicals in aging
    • Harman D. Free radicals in aging. Mol Cell Biochem 1988, 84:155-161.
    • (1988) Mol Cell Biochem , vol.84 , pp. 155-161
    • Harman, D.1
  • 3
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J., Buchanan J.B., Sparkman N.L., Godbout J.P., Freund G.G., Johnson R.W. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 2008, 22:301-311.
    • (2008) Brain Behav Immun , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 4
    • 46249110091 scopus 로고    scopus 로고
    • Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
    • Buchanan J.B., Sparkman N.L., Chen J., Johnson R.W. Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology 2008, 33:755-765.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 755-765
    • Buchanan, J.B.1    Sparkman, N.L.2    Chen, J.3    Johnson, R.W.4
  • 5
    • 0020519752 scopus 로고
    • Diminished T-cell response to influenza virus in aged mice
    • Effros R.B., Walford R.L. Diminished T-cell response to influenza virus in aged mice. Immunology 1983, 49:387-392.
    • (1983) Immunology , vol.49 , pp. 387-392
    • Effros, R.B.1    Walford, R.L.2
  • 6
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005, 19:1329-1331.
    • (2005) FASEB J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6
  • 7
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger R.N., Johnson R.W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 2008, 84:932-939.
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 9
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.-M., et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci 2004, 101:3381-3386.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.4    Jaiswal, A.K.5    Liu, R.-M.6
  • 10
    • 80051484050 scopus 로고    scopus 로고
    • Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-κB activation in the nonhuman primate Macaca mulatta
    • Ungvari Z., Bailey-Downs L., Gautam T., Sosnowska D., Wang M., Monticone R.E., et al. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-κB activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci 2011, 66A:866-875.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 866-875
    • Ungvari, Z.1    Bailey-Downs, L.2    Gautam, T.3    Sosnowska, D.4    Wang, M.5    Monticone, R.E.6
  • 11
    • 59249103720 scopus 로고    scopus 로고
    • Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway
    • Riedl M.A., Saxon A., Diaz-Sanchez D. Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway. Clin Immunol 2009, 130:244-251.
    • (2009) Clin Immunol , vol.130 , pp. 244-251
    • Riedl, M.A.1    Saxon, A.2    Diaz-Sanchez, D.3
  • 12
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • Fahey J.W., Zhang Y., Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997, 94:10367-10372.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3
  • 13
    • 36849089479 scopus 로고    scopus 로고
    • Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    • Talalay P., Fahey J.W., Healy Z.R., Wehage S.L., Benedict A.L., Min C., et al. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci 2007, 104:17500-17505.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 17500-17505
    • Talalay, P.1    Fahey, J.W.2    Healy, Z.R.3    Wehage, S.L.4    Benedict, A.L.5    Min, C.6
  • 14
    • 0035943597 scopus 로고    scopus 로고
    • Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    • Heiss E., Herhaus C., Klimo K., Bartsch H., Gerhäuser C. Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 2001, 276:32008-32015.
    • (2001) J Biol Chem , vol.276 , pp. 32008-32015
    • Heiss, E.1    Herhaus, C.2    Klimo, K.3    Bartsch, H.4    Gerhäuser, C.5
  • 15
    • 52949139019 scopus 로고    scopus 로고
    • Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
    • Lin W., Wu R.T., Wu T., Khor T.-O., Wang H., Kong A.-N. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol 2008, 76:967-973.
    • (2008) Biochem Pharmacol , vol.76 , pp. 967-973
    • Lin, W.1    Wu, R.T.2    Wu, T.3    Khor, T.-O.4    Wang, H.5    Kong, A.-N.6
  • 17
    • 58149350422 scopus 로고    scopus 로고
    • Physiological effects of broccoli consumption
    • Jeffery E., Araya M. Physiological effects of broccoli consumption. Phytochem Rev 2009, 8:283-298.
    • (2009) Phytochem Rev , vol.8 , pp. 283-298
    • Jeffery, E.1    Araya, M.2
  • 18
    • 0034718294 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
    • London S.J., Yuan J.-M., Chung F.-L., Gao Y.-T., Coetzee G.A., Ross R.K., et al. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 2000, 356:724-729.
    • (2000) Lancet , vol.356 , pp. 724-729
    • London, S.J.1    Yuan, J.-M.2    Chung, F.-L.3    Gao, Y.-T.4    Coetzee, G.A.5    Ross, R.K.6
  • 19
    • 70350619612 scopus 로고    scopus 로고
    • Content of ascorbic acid, quercetin, kaempferol and total phenolics in commercial broccoli
    • Koh E., Wimalasiri K.M.S., Chassy A.W., Mitchell A.E. Content of ascorbic acid, quercetin, kaempferol and total phenolics in commercial broccoli. J Food Compos Anal 2009, 22:637-643.
    • (2009) J Food Compos Anal , vol.22 , pp. 637-643
    • Koh, E.1    Wimalasiri, K.M.S.2    Chassy, A.W.3    Mitchell, A.E.4
  • 20
    • 2442587889 scopus 로고    scopus 로고
    • Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    • Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr 2004, 134:1134-1138.
    • (2004) J Nutr , vol.134 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3    Marshall, J.R.4    Zhang, Y.5    Shields, P.G.6
  • 21
    • 84891825855 scopus 로고    scopus 로고
    • Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis
    • Tse G., Eslick G.D. Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis. Nutr Cancer 2014, 66:128-139.
    • (2014) Nutr Cancer , vol.66 , pp. 128-139
    • Tse, G.1    Eslick, G.D.2
  • 22
    • 84883757782 scopus 로고    scopus 로고
    • Modifying the processing and handling of frozen broccoli for increased sulforaphane formation
    • Dosz E.B., Jeffery E.H. Modifying the processing and handling of frozen broccoli for increased sulforaphane formation. J Food Sci 2013, 78:H1459-H1463.
    • (2013) J Food Sci , vol.78 , pp. H1459-H1463
    • Dosz, E.B.1    Jeffery, E.H.2
  • 23
    • 79651468738 scopus 로고    scopus 로고
    • Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
    • Park S.-E., Dantzer R., Kelley K., McCusker R. Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice. J Neuroinflammation 2011, 8:12.
    • (2011) J Neuroinflammation , vol.8 , pp. 12
    • Park, S.-E.1    Dantzer, R.2    Kelley, K.3    McCusker, R.4
  • 24
    • 84863389813 scopus 로고    scopus 로고
    • Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice
    • Jurgens H.A., Amancherla K., Johnson R.W. Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice. J Neurosci 2012, 32:3958-3968.
    • (2012) J Neurosci , vol.32 , pp. 3958-3968
    • Jurgens, H.A.1    Amancherla, K.2    Johnson, R.W.3
  • 25
    • 78650814146 scopus 로고    scopus 로고
    • Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage
    • Bergström P., Andersson H.C., Gao Y., Karlsson J.-O., Nodin C., Anderson M.F., et al. Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage. Neuropharmacology 2011, 60:343-353.
    • (2011) Neuropharmacology , vol.60 , pp. 343-353
    • Bergström, P.1    Andersson, H.C.2    Gao, Y.3    Karlsson, J.-O.4    Nodin, C.5    Anderson, M.F.6
  • 26
    • 0842304134 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    • Kraft A.D., Johnson D.A., Johnson J.A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci 2004, 24:1101-1112.
    • (2004) J Neurosci , vol.24 , pp. 1101-1112
    • Kraft, A.D.1    Johnson, D.A.2    Johnson, J.A.3
  • 27
    • 5344251653 scopus 로고    scopus 로고
    • Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells
    • Konwinski R.R., Haddad R., Chun J.A., Klenow S., Larson S.C., Haab B.B., et al. Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells. Toxicol Lett 2004, 153:343-355.
    • (2004) Toxicol Lett , vol.153 , pp. 343-355
    • Konwinski, R.R.1    Haddad, R.2    Chun, J.A.3    Klenow, S.4    Larson, S.C.5    Haab, B.B.6
  • 28
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
    • Wynne A.M., Henry C.J., Huang Y., Cleland A., Godbout J.P. Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun 2010, 24:1190-1201.
    • (2010) Brain Behav Immun , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5
  • 30
    • 61649120189 scopus 로고    scopus 로고
    • Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice
    • Abraham J., Johnson R.W. Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav Immun 2009, 23:396-401.
    • (2009) Brain Behav Immun , vol.23 , pp. 396-401
    • Abraham, J.1    Johnson, R.W.2
  • 31
    • 77958133125 scopus 로고    scopus 로고
    • Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice
    • Jang S., Dilger R.N., Johnson R.W. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 2010, 140:1892-1898.
    • (2010) J Nutr , vol.140 , pp. 1892-1898
    • Jang, S.1    Dilger, R.N.2    Johnson, R.W.3
  • 32
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono H., Rusyn I., Yin M., Gäbele E., Yamashina S., et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000, 106:867-872.
    • (2000) J Clin Invest , vol.106 , pp. 867-872
    • Kono, H.1    Rusyn, I.2    Yin, M.3    Gäbele, E.4    Yamashina, S.5
  • 33
    • 84876463910 scopus 로고    scopus 로고
    • NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration
    • Qin L., Liu Y., Hong J.-S., Crews F.T. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia 2013, 61:855-868.
    • (2013) Glia , vol.61 , pp. 855-868
    • Qin, L.1    Liu, Y.2    Hong, J.-S.3    Crews, F.T.4
  • 34
    • 0037947696 scopus 로고    scopus 로고
    • Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats
    • Keck A.-S., Qiao Q., Jeffery E.H. Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats. J Agric Food Chem 2003, 51:3320-3327.
    • (2003) J Agric Food Chem , vol.51 , pp. 3320-3327
    • Keck, A.-S.1    Qiao, Q.2    Jeffery, E.H.3
  • 35
    • 66949123850 scopus 로고    scopus 로고
    • Sulforaphane improves cognitive function administered following traumatic brain injury
    • Dash P.K., Zhao J., Orsi S.A., Zhang M., Moore A.N. Sulforaphane improves cognitive function administered following traumatic brain injury. Neurosci Lett 2009, 460:103-107.
    • (2009) Neurosci Lett , vol.460 , pp. 103-107
    • Dash, P.K.1    Zhao, J.2    Orsi, S.A.3    Zhang, M.4    Moore, A.N.5
  • 37
    • 77957075817 scopus 로고    scopus 로고
    • NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain
    • Kim D., You B., Jo E.-K., Han S.-K., Simon M.I., Lee S.J. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci 2010, 107:14851-14856.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 14851-14856
    • Kim, D.1    You, B.2    Jo, E.-K.3    Han, S.-K.4    Simon, M.I.5    Lee, S.J.6
  • 38
    • 53849124696 scopus 로고    scopus 로고
    • NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?
    • Guichard C., Moreau R., Pessayre D., Epperson T.K., Krause K.H. NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?. Biochem Soc Trans 2008, 36:920-929.
    • (2008) Biochem Soc Trans , vol.36 , pp. 920-929
    • Guichard, C.1    Moreau, R.2    Pessayre, D.3    Epperson, T.K.4    Krause, K.H.5
  • 39
    • 33646831500 scopus 로고    scopus 로고
    • NF-κB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
    • Anrather J., Racchumi G., Iadecola C. NF-κB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem 2006, 281:5657-5667.
    • (2006) J Biol Chem , vol.281 , pp. 5657-5667
    • Anrather, J.1    Racchumi, G.2    Iadecola, C.3
  • 40
    • 65549118899 scopus 로고    scopus 로고
    • Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation
    • Danilov C.A., Chandrasekaran K., Racz J., Soane L., Zielke C., Fiskum G. Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia 2009, 57:645-656.
    • (2009) Glia , vol.57 , pp. 645-656
    • Danilov, C.A.1    Chandrasekaran, K.2    Racz, J.3    Soane, L.4    Zielke, C.5    Fiskum, G.6
  • 41
    • 79957515007 scopus 로고    scopus 로고
    • Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
    • Jazwa A., Rojo A.I., Innamorato N.G., Hesse M., Fernandez-Ruiz J., Cuadrado A. Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Antioxid Redox Signal 2011, 14:2347-2360.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2347-2360
    • Jazwa, A.1    Rojo, A.I.2    Innamorato, N.G.3    Hesse, M.4    Fernandez-Ruiz, J.5    Cuadrado, A.6
  • 42
    • 0026061059 scopus 로고
    • The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain
    • O'Callaghan J.P., Miller D.B. The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain. Neurobiol Aging 1991, 12:171-174.
    • (1991) Neurobiol Aging , vol.12 , pp. 171-174
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 44
    • 78650161998 scopus 로고    scopus 로고
    • Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide
    • Corona A.W., Huang Y., O'Connor J.C., Dantzer R., Kelley K.W., Popovich P.G., et al. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation 2010, 7:93.
    • (2010) J Neuroinflammation , vol.7 , pp. 93
    • Corona, A.W.1    Huang, Y.2    O'Connor, J.C.3    Dantzer, R.4    Kelley, K.W.5    Popovich, P.G.6
  • 45
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
    • Henry C.J., Huang Y., Wynne A.M., Godbout J.P. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines. Brain Behav Immun 2009, 23:309-317.
    • (2009) Brain Behav Immun , vol.23 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3    Godbout, J.P.4
  • 46
    • 0029611121 scopus 로고
    • Interleukin-1, nitric oxide and reactive astrocytes
    • Lee S.C., Dickson D.W., Brosnan C.F. Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav Immun 1995, 9:345-354.
    • (1995) Brain Behav Immun , vol.9 , pp. 345-354
    • Lee, S.C.1    Dickson, D.W.2    Brosnan, C.F.3
  • 47
    • 58049190133 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1): a central regulator of stress responses
    • Goshen I., Yirmiya R. Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 2009, 30:30-45.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 30-45
    • Goshen, I.1    Yirmiya, R.2
  • 48
    • 0030609901 scopus 로고    scopus 로고
    • Defect in interleukin-1β secretion prevents sickness behavior in C3H/HeJ mice
    • Segreti J., Gheusi G., Dantzer R., Kelley K.W., Johnson R.W. Defect in interleukin-1β secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 1997, 61:873-878.
    • (1997) Physiol Behav , vol.61 , pp. 873-878
    • Segreti, J.1    Gheusi, G.2    Dantzer, R.3    Kelley, K.W.4    Johnson, R.W.5
  • 49
    • 0032087053 scopus 로고    scopus 로고
    • Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia
    • Burgess W., Gheusi G., Yao J., Johnson R.W., Dantzer R., Kelley K.W. Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia. Am J Physiol 1998, 274:R1829-R1833.
    • (1998) Am J Physiol , vol.274 , pp. R1829-R1833
    • Burgess, W.1    Gheusi, G.2    Yao, J.3    Johnson, R.W.4    Dantzer, R.5    Kelley, K.W.6
  • 50
    • 84872032765 scopus 로고    scopus 로고
    • Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention
    • Veeranki O.L., Bhattacharya A., Marshall J.R., Zhang Y. Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention. Br J Nutr 2013, 109:25-32.
    • (2013) Br J Nutr , vol.109 , pp. 25-32
    • Veeranki, O.L.1    Bhattacharya, A.2    Marshall, J.R.3    Zhang, Y.4
  • 51
    • 84889011357 scopus 로고    scopus 로고
    • Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation
    • Li Y., Zhang T., Li X., Zou P., Schwartz S.J., Sun D. Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation. Mol Nutr Food Res 2013, 57:2128-2136.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 2128-2136
    • Li, Y.1    Zhang, T.2    Li, X.3    Zou, P.4    Schwartz, S.J.5    Sun, D.6
  • 52
    • 83555173511 scopus 로고    scopus 로고
    • Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    • Clarke J., Hsu A., Williams D., Dashwood R., Stevens J., Yamamoto M., et al. Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res 2011, 28:3171-3179.
    • (2011) Pharm Res , vol.28 , pp. 3171-3179
    • Clarke, J.1    Hsu, A.2    Williams, D.3    Dashwood, R.4    Stevens, J.5    Yamamoto, M.6
  • 53
    • 77649208936 scopus 로고    scopus 로고
    • Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    • Abraham J., Johnson R.W. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res 2009, 12:445-453.
    • (2009) Rejuvenation Res , vol.12 , pp. 445-453
    • Abraham, J.1    Johnson, R.W.2
  • 54
    • 18344381289 scopus 로고    scopus 로고
    • α-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice
    • Berg B.M., Godbout J.P., Chen J., Kelley K.W., Johnson R.W. α-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice. J Nutr 2005, 135:1157-1163.
    • (2005) J Nutr , vol.135 , pp. 1157-1163
    • Berg, B.M.1    Godbout, J.P.2    Chen, J.3    Kelley, K.W.4    Johnson, R.W.5
  • 55
    • 80054869844 scopus 로고    scopus 로고
    • Health benefits and possible risks of broccoli-an overview
    • Latté K.P., Appel K.-E., Lampen A. Health benefits and possible risks of broccoli-an overview. Food Chem Toxicol 2011, 49:3287-3309.
    • (2011) Food Chem Toxicol , vol.49 , pp. 3287-3309
    • Latté, K.P.1    Appel, K.-E.2    Lampen, A.3
  • 56
    • 0141830017 scopus 로고    scopus 로고
    • Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables
    • McNaughton S.A., Marks G.C. Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables. Br J Nutr 2003, 90:687-697.
    • (2003) Br J Nutr , vol.90 , pp. 687-697
    • McNaughton, S.A.1    Marks, G.C.2
  • 57
    • 0033667684 scopus 로고    scopus 로고
    • Bitter taste, phytonutrients, and the consumer: a review
    • Drewnowski A., Gomez-Carneros C. Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 2000, 72:1424-1435.
    • (2000) Am J Clin Nutr , vol.72 , pp. 1424-1435
    • Drewnowski, A.1    Gomez-Carneros, C.2
  • 58
    • 0035543010 scopus 로고    scopus 로고
    • Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile
    • Matusheski N.V., Jeffery E.H. Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. J Agric Food Chem 2001, 49:5743.
    • (2001) J Agric Food Chem , vol.49 , pp. 5743
    • Matusheski, N.V.1    Jeffery, E.H.2
  • 59
    • 0023823920 scopus 로고
    • Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats
    • Ramsdell H.S., Eaton D.L. Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats. J Toxicol Environ Health 1988, 25:269-284.
    • (1988) J Toxicol Environ Health , vol.25 , pp. 269-284
    • Ramsdell, H.S.1    Eaton, D.L.2
  • 61
    • 58149181985 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes
    • Rushworth S.A., MacEwan D.J., O'Connell M.A. Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol 2008, 181:6730-6737.
    • (2008) J Immunol , vol.181 , pp. 6730-6737
    • Rushworth, S.A.1    MacEwan, D.J.2    O'Connell, M.A.3
  • 62
    • 77955412821 scopus 로고    scopus 로고
    • Heme oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release
    • Sierra-Filardi E., Vega M.A., Sánchez-Mateos P., Corbí A.L., Puig-Kröger A. Heme oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. Immunobiology 2010, 215:788-795.
    • (2010) Immunobiology , vol.215 , pp. 788-795
    • Sierra-Filardi, E.1    Vega, M.A.2    Sánchez-Mateos, P.3    Corbí, A.L.4    Puig-Kröger, A.5
  • 64
    • 0032322227 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production
    • Turcanu V., Dhouib M., Poindron P. Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production. Res Immunol 1998, 149:741-744.
    • (1998) Res Immunol , vol.149 , pp. 741-744
    • Turcanu, V.1    Dhouib, M.2    Poindron, P.3
  • 65
    • 0034701113 scopus 로고    scopus 로고
    • Age-dependent increase of heme oxygenase-1 gene expression in the liver mediated by NFkappaB
    • Lavrovsky Y., Song C.S., Chatterjee B., Roy A.K. Age-dependent increase of heme oxygenase-1 gene expression in the liver mediated by NFkappaB. Mech Ageing Dev 2000, 114:49-60.
    • (2000) Mech Ageing Dev , vol.114 , pp. 49-60
    • Lavrovsky, Y.1    Song, C.S.2    Chatterjee, B.3    Roy, A.K.4
  • 66
    • 34447125670 scopus 로고    scopus 로고
    • Consuming broccoli does not induce genes associated with xenobiotic metabolism and cell cycle control in human gastric mucosa
    • Gasper A.V., Traka M., Bacon J.R., Smith J.A., Taylor M.A., Hawkey C.J., et al. Consuming broccoli does not induce genes associated with xenobiotic metabolism and cell cycle control in human gastric mucosa. J Nutr 2007, 137:1718-1724.
    • (2007) J Nutr , vol.137 , pp. 1718-1724
    • Gasper, A.V.1    Traka, M.2    Bacon, J.R.3    Smith, J.A.4    Taylor, M.A.5    Hawkey, C.J.6
  • 67
    • 3042688047 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
    • Hu R., Hebbar V., Kim B.-R., Chen C., Winnik B., Buckley B., et al. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther 2004, 310:263-271.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 263-271
    • Hu, R.1    Hebbar, V.2    Kim, B.-R.3    Chen, C.4    Winnik, B.5    Buckley, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.