Natural killer cell-based therapies targeting cancer: Possible strategies to gain and sustain anti-tumor activity

Frontiers in Immunology

Volumn 6, Issue NOV, 2015, Pages

  Dahlberg, Carin I M ^a,b   Sarhan, Dhifaf ^c,d   Chrobok, Michael ^a,b   Duru, Adil D ^a,b   Alici, Evren ^a,b  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Adoptive cell therapy; Cancer; Clinical trials; Expansion; Genetic modifications; Immunotherapy; Natural killer cells; Tumor microenvironment

Indexed keywords

ALEMTUZUMAB; CD16 ANTIGEN; CD19 ANTIBODY; CD20 ANTIBODY; CD3 ANTIBODY; CD3 ANTIGEN; CD34 ANTIBODY; CD56 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIPHTHERIA TOXIN; FAS ANTIGEN; FLUDARABINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 7; INTERLEUKIN 9; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL KILLER CELL RECEPTOR NKG2A; PICIBANIL; TRASTUZUMAB; UNINDEXED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CELL ACTIVATION; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CYTOTOXICITY; DISEASE FREE SURVIVAL; DOWN REGULATION; GENE EXPRESSION; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HUMAN; IMMUNOSURVEILLANCE; IMMUNOTHERAPY; K562 CELL LINE; KIDNEY METASTASIS; LIVER CELL CARCINOMA; LYMPHOKINE ACTIVATED KILLER CELL; METASTATIC MELANOMA; MULTIPLE MYELOMA; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); REGULATORY T LYMPHOCYTE; REVIEW; SUPPRESSOR CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT;

EID: 84949562429     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00605     Document Type: Review

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