Identification of an IL-10-producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 6251-6260

  Loercher, Amy E ^a   Nash, Micheal A ^a   Kavanagh, John J ^a   Platsoucas, Chris D ^b   Freedman, Ralph S ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CYTOKINE ANTIBODY; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 2; PHYTOHEMAGGLUTININ; RECEPTOR ANTIBODY; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASCITES CELL; ASCITES TUMOR; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE ADHERENCE; LYMPHOCYTE PROLIFERATION; MONOCYTE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD14; ASCITIC FLUID; CARCINOMA; CELL ADHESION; CYTOKINES; FEMALE; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MONOCYTES; OVARIAN NEOPLASMS; PERITONEAL CAVITY; RNA, MESSENGER; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033485743     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Freedman, R. S., B. Tomasovic, S. Templin, E. N. Atkinson, A. Kudelka, C. L. Edwards, and C. D. Platsoucas. 1994. Large scale expansion in interleukin-2 of tumor-infiltrating lymphocytes from patients with ovarian carcinoma for adoptive immunotherapy. J. Immunol. Methods 167:145.
2. Ioannides, C., C. D. Platsoucas, S. Rashed, J. T. Wharton, C. L. Edwards, and R. S. Freedman. 1991. Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites. Cancer Res. 51:4257.
3. Kooi, S., R. S. Freedman, J. Rodriguez-Villanueva, and C. D. Platsoucas. 1993. Cytokine production by T cell lines derived from tumor-infiltrating lymphocytes from patients with ovarian carcinoma: tumor-specific immune responses and inhibition of antigen-independent cy tokine production by ovarian tumor cells. Lymphokine Cytokine Res. 12:29.
4. Halapi, E., Y. Yamamoto, C. Juhlin, M. Jeddi-Tehrani, J. Grunewald, R. Andersson, C. Hising, G. Masucci, H. Melstedt, and R. Kiessling. 1993. Restricted T cell receptor V-β and J β usage in T cells from Interleukin-2 cultured lymphocytes of ovarian and renal carcinomas. Cancer Immunol. Immunother. 36:191.
5. Nash, M. A., R. Lenzi, C. L. Edwards, J. J. Kavanagh, A. P. Kudelka, C. F. Verschraegen, C. D. Platsoucas, and R. S. Freedman 1998. Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumor specimens, peritoneal exudate cells containing tumor, tumor-infiltrating lymphocyte (TIL) derived T cell lines, and established tumor cell lines. Clin. Exp. Immunol. 112:172.
6. Lotzova, E., C. A. Savary, R. S. Freedman, C. L. Edwards, and M. Morris. 1990. Comparison of recombinant interleukin-2 activated peripheral blood and tumor-infiltrating lymphocytes of patients with epithelial ovarian carcinoma: cytotoxicity, growth kinetics, and phenotype. Cancer Immunol. Immunother. 31:169.
7. Viera, P., R. de Waal Malefyt, M. Dand, K. Johnson, R. Kastelein, D. Fiorentino, J. de Vries, M. Roncarolo, T. Mossmann, and K. Moore. 1991. Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL-10) cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. USA 88:1172.
8. + T cell clones and peripheral blood T cells. J. Immunol. 151:171.
9. Fiorentino, D., M. Bond, and T. Mossmann. 1989. Two types of mouse helper T-cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
10. Moore, K. W., P. Viera, D. Fiorentino, M. L. Trounstine, T. Khan, and T. R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr Virus gene BCRFI. Science 248:1230.
11. MacNeil, I., T. Suda, K. Moore, T. Mossmann, and A. Zlotnik. 1990. IL-10: a novel cytokine growth factor for mature and immature T cells. J. Immunol. 145: 4167.
12. de Waal Malefyt, R., J. Abrams, B. Bennet, C. Figdor, and J. de Vries. 1991. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp. Med. 174:1209.
13. Enk, A., and S. Katz. 1992. Identification and induction of keratinocyte-derived IL-10. J. Immunol. 149:92.
14. O'Garra, A., G. Stapleton, V. Dhar, M. Pearce, J. Schumacher, H. Rugo, D. Barbis, A. Stall, J. Cupp, K. Moore, P. Viera, T. Mossmann, A. Whitmore, L. Arnold, G. Haughton, and M. Howard. 1990. Production of cytokines by B cells: B lymphomas and normal B cells produce IL-10. Int. Immunol. 2:821.
15. Benjamin, D., T. J. Knobloch, and M. A. Dayton. 1992. Human interleukin 10: B cell lines derived from patients with AIDS and Burkitt's lymphoma constitutively secrete large quantities of IL-10. Blood 80:1289.
16. Fiorentino, D., A. Zlotnik, P. Viera, T. Mossmann, M. Howard, K. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
17. Ding, L., and E. Shevach. 1992. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148:3133.
18. Taga, K., and G. Tosato. 1992. IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol. 148:1143.
19. Chernoff, A. E., E. V. Granowitz, L. Shapiro, E. Vannier, G. Lonnemann, J. B. Angel, J. S. Kennedy, A. R. Rasbon, S. M. Wolff, and C. A. Dinarello. 1995. A randomized controlled trial of IL-10 in humans: inhibition of inflamatory cytokine production and immune responses. J. Immunol. 154:5492.
20. Pisa, P., E. Halapi, E. K. Pisa, E. Gerdin, C. Hising, A. Bucht, B. Gerdin, and R. Kiessling. 1992. Selective expression of interleukin 10, interferon γ, and granulocyte-macrophage colony stimulating factor in ovarian cancer biopsies. Proc. Natl. Acad, Sci. USA 89:7708.
21. Gotlieb, W., J. Abrams, J. Watson, T. Velu, J. Berek, and O. Martinez-Maza. 1992. Presence of interleukin-10 in the ascites of patients with ovarian and other intra-abdominal cancers. Cytokine 4:385.
22. Marshall, W. H., G. Krikorian, S. Simmons, and F. Stratton. 1975. Counts and characteristics of macrophage precursors in human peripheral blood. Cell. Immunol. 19:22.
23. Engleman, E. G., D. J. Charron, C. J. Benike, and G. J. Stewart .1980. Ia antigen expression on peripheral blood mononuclear leukocytes in man. I. Expression, biosynthesis, and function of HLA-DR antigen on non-T-cells. J. Exp. Med. 152: 99.
24. Loercher, A. E., J. J. Kavanagh, C. D. Platsoucas, and R. S. Freedman. 1999. Induction of IL-10-producing monocytes from the PBMC of patients with ovarian cancer by the addition of rGM-CSF and rIL-2 to culture conditions (A3776). Proc. Am. Assoc. Cancer Res. 40:573.
25. Farrar, W. L., and K. D. Elgert. 1978. Inhibition of mitogen and immune blastogenesis by two distinct populations of suppressor cells present in the spleens of fibrosarcoma-bearing mice: adoptive transfer of suppression. Int. J. Cancer 22: 142.
26. Elgert, K. D., and W. L. Farrar. 1978. Suppressor cell activity in tumor-bearing mice. I. Dualistic inhibition by suppressor T lymphocytes and macrophages. J. Immunol. 120:1345.
27. Luscher, U., L. Filgueira, A. Juretic, M. Zuber, N. J. Luscher, M. Heberer, and C. C. Spagnoli. 1994. The pattern of gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes. Int. J. Cancer 57:612.
28. Coventry, B. J., S. C. Weeks, S. E. Heckford, P. J. Sykes, J. Bradley, and J. M. Skinner. 1996. Lack of IL-2 cytokine expression despite IL-2 mRNA transcription in tumor-infiltrating lymphocytes in primary human breast carcinoma: selective expression of early activation markers. J. Immunol. 156:3486.
29. Yue, F., R. Dummer, R. Geertsen, G. Hofbauer, E. Laine, S. Manolio, and G. Burg. 1997. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class I, HLA class II, and ICAM1 molecules. Int. J. Cancer 71:630.
30. Willems, F., A. Marchant, J. Delville, C. Gerard, A. Delvaux, T. Velu, M. de Boer, and M. Goldman. 1994. Interluekin-10 inhibits B7 and intracellular adhesion molecule-1 expression on human monocytes. Eur. J. Immunol. 24:1007.
31. de Waal Malefyt, R., J. Haanen, H. Spits, M. Roncarolo, A. te Velde, C. Figdor, H. Yssel, and J. de Vries. 1991. IL-10 and viral IL-10 strongly reduce antigen-specific human T-cell proliferation by diminishing the antigen presenting capacity of monocytes. J. Exp. Med. 174:915.
32. Kim, H. S., D. Armstrong, T. A. Hamilton, and J. M. Tebo .1998. IL-10 suppresses LPS-induced KC mRNA expression via a translation-dependent decrease in mRNA stability. J. Leukocyte Biol. 64:33.
33. Brown, C. Y., C. A. Lagnado, M. A. Vadas, and G. J. Goodall. 1996. Differential regulation of the stability of cytokine mRNAs in LPS-activated blood monocytes in response to interleukin-10. J. Biol. Chem. 271:20108.
34. Inge, T. H., S. K. Hoover, B. M. Susskind, and H. D. Bear. 1992. Inhibition of tumor-specific cytotoxic T lymphocyte responses by transforming growth factor β. Cancer Res. 52:1386.
35. Melichar, B. C., C. A. Savary, A. P. Kudelka, C. Verschraegen, J. J. Kavanagh, C. L. Edwards, C. D. Platsoucas, and R. S. Freedman. 1998. Lineage-negative human leukocyte antigen-DR+ cell with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis. Clin. Cancer Res. 4:799.