-
1
-
-
19944428928
-
HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells
-
Carbone E, Neri P, Mesuraca M, et al. HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 2005; 105: 251-258.
-
(2005)
Blood
, vol.105
, pp. 251-258
-
-
Carbone, E.1
Neri, P.2
Mesuraca, M.3
-
2
-
-
77957193432
-
Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma
-
Gabriel IH, Sergeant R, Szydlo R, et al. Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma. Blood. 2010; 116: 2033-2039.
-
(2010)
Blood.
, vol.116
, pp. 2033-2039
-
-
Gabriel, I.H.1
Sergeant, R.2
Szydlo, R.3
-
3
-
-
79551615800
-
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy
-
Hsu AK, Quach H, Tai T, et al. The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood 2011; 117: 1605-1613.
-
(2011)
Blood
, vol.117
, pp. 1605-1613
-
-
Hsu, A.K.1
Quach, H.2
Tai, T.3
-
4
-
-
77953385584
-
Drug-mediated and cellular immunotherapy in multiple myeloma
-
Ritchie DS, Quach H, Fielding K, et al. Drug-mediated and cellular immunotherapy in multiple myeloma. Immunotherapy. 2010; 2: 243-255.
-
(2010)
Immunotherapy.
, vol.2
, pp. 243-255
-
-
Ritchie, D.S.1
Quach, H.2
Fielding, K.3
-
5
-
-
84865021329
-
The role of natural killer cells in immunity against multiple myeloma
-
Godfrey J, Benson DM Jr. The role of natural killer cells in immunity against multiple myeloma. Leuk Lymphoma 2012; 53: 1666-1676.
-
(2012)
Leuk Lymphoma
, vol.53
, pp. 1666-1676
-
-
Godfrey, J.1
Benson Jr., D.M.2
-
6
-
-
74249089972
-
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
-
Quach H, Ritchie D, Stewart AK, et al. Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia 2010; 24: 22-32.
-
(2010)
Leukemia
, vol.24
, pp. 22-32
-
-
Quach, H.1
Ritchie, D.2
Stewart, A.K.3
-
7
-
-
0035412366
-
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
-
Davies FE, Raje N, Hideshima T, et al. Th alidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001; 98: 210-216.
-
(2001)
Blood
, vol.98
, pp. 210-216
-
-
Davies, F.E.1
Raje, N.2
Hideshima, T.3
-
8
-
-
29244488561
-
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications
-
Tai YT, Li XF, Catley L, et al. Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications. Cancer Res 2005; 65: 11712-11720.
-
(2005)
Cancer Res
, vol.65
, pp. 11712-11720
-
-
Tai, Y.T.1
Li, X.F.2
Catley, L.3
-
9
-
-
76749162262
-
Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44 (-) ) and T (HLA-DR (-) ) cells
-
Lioznov M, El-Cheikh J. Jr, Hoffmann F, et al. Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44 (-) ) and T (HLA-DR (-) ) cells. Bone Marrow Transplant 2010; 45: 349-353.
-
(2010)
Bone Marrow Transplant
, vol.45
, pp. 349-353
-
-
Lioznov, M.1
El-Cheikh Jr., J.2
Hoffmann, F.3
-
10
-
-
79953238852
-
Lenalidomide: A review of its use in the treatment of relapsed or refractory multiple myeloma
-
Scott LJ, Lyseng-Williamson KA. Lenalidomide: A review of its use in the treatment of relapsed or refractory multiple myeloma. Drugs 2011; 71: 625-649.
-
(2011)
Drugs
, vol.71
, pp. 625-649
-
-
Scott, L.J.1
Lyseng-Williamson, K.A.2
-
11
-
-
84864152607
-
Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib
-
Hassold N, Seystahl K, Kempf K, et al. Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib. Int J. Cancer 2012; 131: E916-E927.
-
(2012)
Int J. Cancer
, vol.131
-
-
Hassold, N.1
Seystahl, K.2
Kempf, K.3
-
12
-
-
80054026109
-
Expansion of highly differentiated CD8 (-) T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation
-
Kreutzman A, Ladell K, Koechel C, et al. Expansion of highly differentiated CD8 (-) T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 2011; 25: 1587-1597.
-
(2011)
Leukemia
, vol.25
, pp. 1587-1597
-
-
Kreutzman, A.1
Ladell, K.2
Koechel, C.3
-
13
-
-
58149267985
-
Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia
-
Kim DH, Kamel-Reid S, Chang H, et al. Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia. Haematologica 2009; 94: 135-139.
-
(2009)
Haematologica
, vol.94
, pp. 135-139
-
-
Kim, D.H.1
Kamel-Reid, S.2
Chang, H.3
-
14
-
-
68749108104
-
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy
-
Mustjoki S, Ekblom M, Arstila TP, et al. Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia 2009; 23: 1398-1405.
-
(2009)
Leukemia
, vol.23
, pp. 1398-1405
-
-
Mustjoki, S.1
Ekblom, M.2
Arstila, T.P.3
-
15
-
-
79957902683
-
Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells
-
ra36
-
Mesecke S, Urlaub D, Busch H, et al. Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Sci Signal 2011; 4: Ra36.
-
(2011)
Sci Signal
, vol.4
-
-
Mesecke, S.1
Urlaub, D.2
Busch, H.3
-
16
-
-
2442679239
-
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells
-
Podar K, Mostoslavsky G, Sattler M, et al. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. J. Biol Chem 2004; 279: 21658-21665.
-
(2004)
J. Biol Chem
, vol.279
, pp. 21658-21665
-
-
Podar, K.1
Mostoslavsky, G.2
Sattler, M.3
-
17
-
-
0037085809
-
Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6
-
Ishikawa H, Tsuyama N, Abroun S, et al. Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6. Blood 2002; 99: 2172-2178.
-
(2002)
Blood
, vol.99
, pp. 2172-2178
-
-
Ishikawa, H.1
Tsuyama, N.2
Abroun, S.3
-
18
-
-
0038235872
-
Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation
-
Ishikawa H, Tsuyama N, Abroun S, et al. Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation. Leuk Lymphoma 2003; 44: 1477-1481.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1477-1481
-
-
Ishikawa, H.1
Tsuyama, N.2
Abroun, S.3
-
19
-
-
51649116942
-
Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: Preclinical efficacy of the novel, orally available inhibitor dasatinib
-
Coluccia AM, Cirulli T, Neri P, et al. Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: Preclinical efficacy of the novel, orally available inhibitor dasatinib. Blood. 2008; 112: 1346-1356.
-
(2008)
Blood.
, vol.112
, pp. 1346-1356
-
-
Coluccia, A.M.1
Cirulli, T.2
Neri, P.3
-
20
-
-
59249093777
-
Dasatinib in relapsed or plateau-phase multiple myeloma
-
Wildes TM, Procknow E, Gao F, et al. Dasatinib in relapsed or plateau-phase multiple myeloma. Leuk Lymphoma 2009; 50: 137-140.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 137-140
-
-
Wildes, T.M.1
Procknow, E.2
Gao, F.3
-
21
-
-
34247470836
-
Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
-
Weisberg E, Manley PW, Cowan-Jacob SW, et al. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer 2007; 7: 345-356.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 345-356
-
-
Weisberg, E.1
Manley, P.W.2
Cowan-Jacob, S.W.3
-
23
-
-
42249088418
-
Profound inhibition of antigen-specifi c T-cell effector functions by dasatinib
-
Weichsel R, Dix C, Wooldridge L, et al. Profound inhibition of antigen-specifi c T-cell effector functions by dasatinib. Clin Cancer Res 2008; 14: 2484-2491.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2484-2491
-
-
Weichsel, R.1
Dix, C.2
Wooldridge, L.3
-
24
-
-
77951692928
-
Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585
-
Stü h mer T, Arts J, Chatterjee M, et al. Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585. Br J. Haematol 2010; 149: 529-536.
-
(2010)
Br J. Haematol
, vol.149
, pp. 529-536
-
-
Stühmer, T.1
Arts, J.2
Chatterjee, M.3
-
25
-
-
33947427988
-
Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/ Reed-Sternberg cells
-
Janz M, Stühmer T, Vassilev LT, et al. Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/ Reed-Sternberg cells. Leukemia 2007; 21: 772-779.
-
(2007)
Leukemia
, vol.21
, pp. 772-779
-
-
Janz, M.1
Stühmer, T.2
Vassilev, L.T.3
-
26
-
-
22544471800
-
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing
-
Siegmund D, Wicovsky A, Schmitz I, et al. Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol 2005; 25: 6363-6379.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6363-6379
-
-
Siegmund, D.1
Wicovsky, A.2
Schmitz, I.3
-
27
-
-
30844465687
-
A simplifi ed method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity
-
Gomez-Roman VR, Florese RH, Patterson LJ, Peng B, Venzon D, Aldrich K, et al. A simplifi ed method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity. J. Immunol Methods 2006; 308: 53-67.
-
(2006)
J. Immunol Methods
, vol.308
, pp. 53-67
-
-
Gomez-Roman, V.R.1
Florese, R.H.2
Patterson, L.J.3
Peng, B.4
Venzon, D.5
Aldrich, K.6
-
28
-
-
0026468366
-
Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation
-
Valiante NM, Rengaraju M, Trinchieri G. Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation. Cell Immunol 1992; 145: 187-198.
-
(1992)
Cell Immunol
, vol.145
, pp. 187-198
-
-
Valiante, N.M.1
Rengaraju, M.2
Trinchieri, G.3
-
29
-
-
34547791385
-
Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions
-
Baltz KM, Krusch M, Bringmann A, et al. Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 2007; 21: 2442-2454.
-
(2007)
FASEB J
, vol.21
, pp. 2442-2454
-
-
Baltz, K.M.1
Krusch, M.2
Bringmann, A.3
-
30
-
-
0033959736
-
RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells
-
Mainiero F, Soriani A, Strippoli R, et al. RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells. Immunity 2000; 12: 7-16.
-
(2000)
Immunity
, vol.12
, pp. 7-16
-
-
Mainiero, F.1
Soriani, A.2
Strippoli, R.3
-
31
-
-
25844464180
-
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
-
Bryceson YT, March ME, Barber DF, et al. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J. Exp Med 2005; 202: 1001-1012.
-
(2005)
J. Exp Med
, vol.202
, pp. 1001-1012
-
-
Bryceson, Y.T.1
March, M.E.2
Barber, D.F.3
-
32
-
-
0142185336
-
Sensitive and viable identification of antigen-specifi c CD8-T cells by a fl ow cytometric assay for degranulation
-
Betts MR, Brenchley JM, Price DA, et al. Sensitive and viable identification of antigen-specifi c CD8-T cells by a fl ow cytometric assay for degranulation. J. Immunol Methods 2003; 281: 65-78.
-
(2003)
J. Immunol Methods
, vol.281
, pp. 65-78
-
-
Betts, M.R.1
Brenchley, J.M.2
Price, D.A.3
-
33
-
-
19944430437
-
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application
-
Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application. Br J. Haematol 2005; 128: 192-203.
-
(2005)
Br J. Haematol
, vol.128
, pp. 192-203
-
-
Hayashi, T.1
Hideshima, T.2
Akiyama, M.3
-
35
-
-
50949124847
-
Human natural killer cells
-
Caligiuri MA. Human natural killer cells. Blood 2008; 112: 461-469.
-
(2008)
Blood
, vol.112
, pp. 461-469
-
-
Caligiuri, M.A.1
-
36
-
-
0031037778
-
Expression and function of CD95 (FAS/APO-1) in leukaemia-lymphoma tumour lines
-
Dirks W, Schone S, UphoffC, et al. Expression and function of CD95 (FAS/APO-1) in leukaemia-lymphoma tumour lines. Br J. Haematol 1997; 96: 584-593.
-
(1997)
Br J. Haematol
, vol.96
, pp. 584-593
-
-
Dirks, W.1
Schone S, UphoffC.2
-
37
-
-
59749083936
-
Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis
-
Balsas P, Lopez-Royuela N, Galan-Malo P, et al. Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis. Biochem Pharmacol 2009; 77: 804-812.
-
(2009)
Biochem Pharmacol
, vol.77
, pp. 804-812
-
-
Balsas, P.1
Lopez-Royuela, N.2
Galan-Malo, P.3
-
38
-
-
0035437171
-
TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
-
Mitsiades CS, Treon SP, Mitsiades N, et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications. Blood 2001; 98: 795-804.
-
(2001)
Blood
, vol.98
, pp. 795-804
-
-
Mitsiades, C.S.1
Treon, S.P.2
Mitsiades, N.3
-
39
-
-
0033370411
-
Apoptosis-induced by TRAIL and TNF-Alpha in human multiple myeloma cells is not blocked by BCL-2
-
Gazitt Y, Shaughnessy P, Montgomery W. Apoptosis-induced by TRAIL and TNF-Alpha in human multiple myeloma cells is not blocked by BCL-2. Cytokine 1999; 11: 1010-1019.
-
(1999)
Cytokine
, vol.11
, pp. 1010-1019
-
-
Gazitt, Y.1
Shaughnessy, P.2
Montgomery, W.3
-
40
-
-
83455220035
-
IPH2101, anovel antiinhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
-
Benson D M Jr, Bakan CE, Zhang S, et al. IPH2101, anovel antiinhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood 2011; 118: 6387-6391.
-
(2011)
Blood
, vol.118
, pp. 6387-6391
-
-
Benson Jr., D.M.1
Bakan, C.E.2
Zhang, S.3
-
41
-
-
33747195574
-
Mcl-1L cleavage is involved in TRAIL-R1-And TRAIL-R2-mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells
-
Menoret E, Gomez-Bougie P, Geffroy-Luseau A, et al. Mcl-1L cleavage is involved in TRAIL-R1-And TRAIL-R2-mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells. Blood. 2006; 108: 1346-1352.
-
(2006)
Blood.
, vol.108
, pp. 1346-1352
-
-
Menoret, E.1
Gomez-Bougie, P.2
Geffroy-Luseau, A.3
-
42
-
-
34250029013
-
Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL
-
Gomez-Benito M, Martinez-Lorenzo MJ, Anel A, et al. Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL. Exp Cell Res 2007; 313: 2378-2388.
-
(2007)
Exp Cell Res
, vol.313
, pp. 2378-2388
-
-
Gomez-Benito, M.1
Martinez-Lorenzo, M.J.2
Anel, A.3
-
43
-
-
80052337651
-
TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms
-
Rauert H, Stühmer T, Bargou R, et al. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis 2011; 2: E194.
-
(2011)
Cell Death Dis
, vol.2
-
-
Rauert, H.1
Stühmer, T.2
Bargou, R.3
-
44
-
-
84857362253
-
Transcriptomic rationale for the synergy observed with dasatinib -bortezomib-dexamethasone in multiple myeloma
-
De Queiroz Crusoe E, Maiso P, Fernandez-Lazaro D, et al. Transcriptomic rationale for the synergy observed with dasatinib -bortezomib-dexamethasone in multiple myeloma. Ann Hematol 2012; 91: 257-269.
-
(2012)
Ann Hematol
, vol.91
, pp. 257-269
-
-
De Queiroz Crusoe, E.1
Maiso, P.2
Fernandez-Lazaro, D.3
-
45
-
-
84868198690
-
Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma
-
Steinbrunn T, Stühmer T, Sayehli C, et al. Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma. Br J. Haematol 2012; 159: 430-440.
-
(2012)
Br J. Haematol
, vol.159
, pp. 430-440
-
-
Steinbrunn, T.1
Stühmer, T.2
Sayehli, C.3
-
46
-
-
54049150430
-
Combined functional and molecular analysis of tumor cell signaling defi nes 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma
-
Zöl linger A, Stü h mer T, Chatterjee M, et al. Combined functional and molecular analysis of tumor cell signaling defi nes 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma. Blood 2008; 112: 3403-3411.
-
(2008)
Blood
, vol.112
, pp. 3403-3411
-
-
Zöllinger, A.1
Stühmer, T.2
Chatterjee, M.3
-
47
-
-
68049132603
-
Clinical-grade ex vivoexpanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells
-
Berg M, Lundqvist A, McCoy P Jr, et al. Clinical-grade ex vivoexpanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells. Cytotherapy 2009; 11: 341-355.
-
(2009)
Cytotherapy
, vol.11
, pp. 341-355
-
-
Berg, M.1
Lundqvist, A.2
McCoy Jr., P.3
|