Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis

International Journal of Cancer

Volumn 135, Issue 4, 2014, Pages 843-861

  Helm, Ole ^a   Held Feindt, Janka ^b   Grage Griebenow, Evelin ^a   Reiling, Norbert ^c   Ungefroren, Hendrik ^b   Vogel, Ilka ^a   Krüger, Uwe ^a   Becker, Thomas ^b   Ebsen, Michael ^a   Röcken, Christoph ^a   Kabelitz, Dieter ^a   Schäfer, Heiner ^d   Sebens, Susanne ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Department of Neurosurgery UK S H Campus ^*  (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

^d Laboratory of Molecular Gastroenterology and Hepatology   (Germany)

Author keywords

L1CAM; macrophages; pancreatic cancer; tumor stroma; tumor associated inflammation

Indexed keywords

CD163 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; VIMENTIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGICAL FUNCTIONS; CANCER CELL LINE; CELL SHAPE; COCULTURE; COLO357 CELL; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; EX VIVO STUDY; H6C7 CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MACROPHAGE; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PHENOTYPE; PRIORITY JOURNAL; PROINFLAMMATORY ACTIVITY; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE;

L1CAM; MACROPHAGES; PANCREATIC CANCER; TUMOR STROMA; TUMOR-ASSOCIATED INFLAMMATION;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CADHERINS; CARCINOGENESIS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL SHAPE; CELL TRANSFORMATION, NEOPLASTIC; COCULTURE TECHNIQUES; COLONIC NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; PHENOTYPE; RECEPTORS, CELL SURFACE; STROMAL CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902254416     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28736     Document Type: Article

References (37)

1. Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011. CA Cancer J Clin 2011; 61: 212-36.
2. Schneider G, Siveke JT, Eckel F, et al. Pancreatic cancer: basic and clinical aspects. Gastroenterology 2005; 128: 1606-25.
3. Farrow B, Evers BM,. Inflammation and the development of pancreatic cancer. Surg Oncol 2002; 10: 153-69.
4. Luttges J, Kloppel G,. Pancreatic ductal adenocarcinoma and its precursors. Pathology 2005; 26: 12-17.
5. Kleeff J, Beckhove P, Esposito I, et al. Pancreatic cancer microenvironment. Int J Cancer 2007; 121: 699-705.
6. Muerkoster S, Wegehenkel K, Arlt A, et al. Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res 2004; 64: 1331-7.
7. Schäfer H, Geismann C, Heneweer C, et al. Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Carcinogenesis 2012; 33: 84-93.
8. Martinez FO, Sica A, Mantovani A, et al. Macrophage activation and polarization. Front Biosci 2008; 13: 453-61.
9. Mantovani A, Germano G, Marchesi F, et al. Cancer-promoting tumor-associated macrophages: new vistas and open questions. Eur J Immunol 2011; 41: 2522-25.
10. Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008; 454: 436-44.
11. Qian BZ, Pollard JW,. Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141: 39-51.
12. Zhang QW, Liu L, Gong CY, et al. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One 2012; 7: e50946.
13. Kurahara H, Shinchi H, Mataki Y, et al. Significance of M2-polarized tumor-associated macrophage in pancreatic cancer. J Surg Res 2009; 167: e211-19.
14. Kurahara H, Takao S, Maemura K, et al. M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer. Pancreas 2013; 42: 155-59.
15. Bonde AK, Tischler V, Kumar S, et al. Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer 2012; 12: 35.
16. Lin CY, Lin CJ, Chen KH, et al. Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction. FEBS Lett 2006; 580: 3042-50.
17. Thiery JP,. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
18. Geismann C, Morscheck M, Koch D, et al. Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer. Cancer Res 2009; 69: 4517-26.
19. Liu N, Furukawa T, Kobari M, et al. Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma. Am J Pathol 1998; 153: 263-69.
20. Ouyang H, Mou L, Luk C, et al. Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol 2000; 157: 1623-31.
21. Sebens Muerkoster S, Werbing V, Koch D, et al. Role of myofibroblasts on innate chemoresistance in pancreatic carcinoma-epigenetic down-regulation of caspases. Int J Cancer 2008; 123: 1751-60.
22. Grage-Griebenow E, Zwatzky R, Kahlert H, et al. Identification of a novel dendritic cell-like subset of CD64(+)/CD16(+) blood monocytes. Eur J Immunol 2001; 31: 48-56.
23. Schäfer H, Struck B, Feldmann E-M, et al. TGF-β1 dependent L1CAM expression plays an essential role in macrophage induced apoptosis resistance and cell migration of human intestinal epithelial cells. Oncogene 2013; 32: 180-89.
24. Verreck FAW, de Boer T, Langenberg DML, et al. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-a and CD40L-mediated costimulation. J Leuk Biol 2006; 79: 285-92.
25. Krausgruber T, Blazek K, Smallie T, et al. IRF5 promotes inflammatory macrophages polarization and Th1-Th17 responses. Nat Immunol 2011; 12: 231-38.
26. Sebens Muerkoster S, Werbing V, Sipos B, et al. Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Oncogene 2007; 26: 2759-68.
27. Hattermann K, Held-Feindt J, Lucius R, et al. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates anti-apoptotic effects. Cancer Res 2010; 70: 3299-3308.
28. Held-Feindt J, Hattermann K, Sebens Müerköster S, et al. CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). Exp Cell Res 2010; 316: 1553-466.
29. Tong Y, Mentlein R, Buhl R, et al. Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas. J Neurochem 2007; 100: 1097-107.
30. Sica A, Schioppa T, Mantovani A, et al. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006; 42: 717-27.
31. Ino Y, Yamazaki-Itoh R, Shimada K, et al. Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer 2013; 108: 914-23.
32. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V,. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012; 12: 253-68.
33. Kawata M, Koinuma D, Ogami T, et al. TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J Biochem 2013; 151: 205-16.
34. Li Q, Liu BC, Lv LL, et al. Monocytes induce proximal tubular epithelial-mesenchymal transition through NF-kappa B dependent upregulation of ICAM-1. J Cell Biochem 2011; 112: 1585-92.
35. Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation. Cell 2012; 148: 349-61.
36. Hagemann T, Lawrence T, McNeish I, et al. "Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med 2008; 205: 1261-68.
37. Germano G, Frapolli R, Belgiovine C, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 2013; 23: 249-62.